CYPSD - Bacreria1001-1050

Reference

Cytochrome P450 HomepageNelson, DR (2009) The Cytochrome P450 Homepage. Human Genomics 4, 59-65.AlphafoldJohn Jumper, Richard Evans, Alexander Pritzel, et al. - Highly accurate protein structure prediction with AlphaFold. Nature, 1–11, doi: 10.1038/s41586-021-03819-2 (2021)ColabfoldMirdita M, Ovchinnikov S and Steinegger M. ColabFold - Making protein folding accessible to all. bioRxiv, doi: 10.1101/2021.08.15.456425 (2021)Localcolabfoldhttps://github.com/YoshitakaMo/localcolabfold

Cytochrome P450 HomepageComprehensive Bacterial P450shttps://drnelson.uthsc.edu/comprehensive-bacterial-p450s/
CYP1041, CYP1042, CYP1043, CYP1044, CYP1047Fanele Cabangile Mnguni and Khajamohiddin Syed et al.,More P450s Are Involved in Secondary Metabolite Biosynthesis in Streptomyces Compared to Bacillus, Cyanobacteria, and MycobacteriumInt. J. Mol. Sci. 2020, 21(13), 4814; https://doi.org/10.3390/ijms21134814

D. R. Nelson's

Bacteria_1

Bacteria_2

Bacteria_3

https://twitter.com/P450nelson/status/1501396401317883904

Method

Localcolabfold (model1_ptm, recycle=6 or CaRMSD < 0.4, centerd and rotated around proximal Cys)runner_P450align.py -f CYPs/CYPXXXA1.fasta -nm 5 -mr 6 -alirunner_P450align.py -f CYPs/CYPXXXA1.fasta -nm 5 -mr 6 -ali -upMaestro (Protein preparation Wizard)proPKa pH 7.0, save as pdbHeme was extract from proximal-ligand-aligned crystal structure of CYP101A1-CYP150A1Heme was added hydrogen using maestro builder, save as mol2ES_scoreMaestro output

runner_P450.py

align_P450.py

CYP1001A1

>CYP1001A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MTRAPHTPPG PPVVGNVPRF ADDPLRFLVG VQEAYGGQYP VVRLEPAGGQ 00500051 RIVVILDAAL VHEILADRER FVRPRAGPEA SRREGLLSSR GPLWERQRSV 01000101 IQPELVGGQL AAYADIAARS VEEMLDRWPE NGEIDLVAEL SMLTMQVIAR 01500151 SLLGRDATRE QARTVYEALD TFAEEFEFGA DALLLPDALQ SGPSAAFERA 02000201 DADLEAVARD FVDWQREHED PPDSMLTALI EAERDGVELS EDELIDQTVL 02500251 FLTAGQETTA LTIAYAFHHL SRSPDVRAGV TEEATGVLDG AAPSWEHLSG 03000301 FDLTERVVRE TLRLTPAAWN VTREVRGPTT LGGTRFETDD LVLLPTYAHQ 03500351 REDRVWGDGD AFRPARWTDE VSRSHDSYFP FGSGPRVCIG RQVALTEAQF 04000401 TLAHTLQQYE VDVHGDELAF EPAITLRPAD GLRATVTERE

MMSeqs2

Alphafold2

.fasta

Heme Docked

PDBj

CYP1002

>CYP1002A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MCNPITRSDD DRARQSGGSE RTDTADADVD VADAPPPPDP GGLPVLGNVH 00500051 ELASDALGFY ERRSAEYGGI VRYDVFGTES YLVTDPGAIG RILVEDHDRF 01000101 VKGEMPREQL GGLLGDGLFL AEGEAWREQR TAIRSAFFRE RVAAYGDSMV 01500151 EHAREAVDSW GDGAVVDVHA ASTEYAFAVL AESLLGSDIE GERETVRAAA 02000201 EAITDRFDMS RPTSFLPEWL PTPANRRYRR RLGALRATIR DLVTERRAAG 02500251 PPADPSAADD LLGTLVAAAK LGALDDEELV DNAVTFLFAG HETSALGLTY 03000301 ALYCLARRPA FQDRIRSEIA PLHGDPTPAD LRECPALTAA VDEALRLYPP 03500351 VHSFFREPTE PIALGEYRIP SGVVLTLAPW SVHRDGRWWN APETYRPERW 04000401 LRETEDGGVV HGDDRSGPAV GEHPEHAFFP FGGGPRHCIG MRFARQELRL 04500451 AVATILRRVR LEPVTEELSL QASANTRPDG PVHVRILTRD EPSDPESLDQ 05000501 DEPSKTSW

Alphafold2

.fasta

Heme Docked

PDBj

CYP1003

>CYP1003A10001 MDTQQAIRET PEPVTPGDRP PRLGRVPFVD NTAAMLRDPL GFYDRAGAHE 00500051 ADMVGYSVAG TTGCFVCHPD LVEQVLVTDA DVYEKGQLLQ DTLGQFIGEG 01000101 LFLLEGEEWQ QQRTALQPAF YRERIAAYGD TMTEFADRAA AGWSDGQRID 01500151 VLPHMQSLTL NILGKTLLDV DIETTADALE PLLDALRTRL DPRSLSAYLP 02000201 LWVPTATNRA VTNSLAEFQS TLDDVIAARQ REDEHAREAR DDVLSLLLSL 02500251 DDETMDRERL GHQLLTFLVA GHDTTALTLT YAWFLLANNP KRQQRLHDEL 03000301 DATLGERQPT PEDLFELPYL DAVLNEVLRL YPPAFTVFRQ PTEPVTLGGY 03500351 ELSTDAQLTL PQWLVHRDDR WYDAPDAFRP ERWDDDLEAS LPDYAYYPFG 04000401 GGPRHCIGMR FARMEAKLAL ATIAQQYAVE AVTEPPLSLA MQITLSPTAP 04500451 VEVRLRER

Alphafold2

.fasta

Heme Docked

PDBj

CYP1004

>CYP1004A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSTFSLERVA CDRMLGLAVR GRLADSLLMR ANTARPHLSA AFLATKDDPY 00500051 PAYAELRARG PLTRAELGQW LVTGHGAVSA LLRDGRLESR MPAEYTRLTL 01000101 GDSPGVDFLH RIVLTRTPPE HTRLRRFIGR ALGTPVVRRL HDRIAAATDA 01500151 LLEPALDRGR LDVVTELAVP LPVGVVCDLI GIPTGDRPAV LTRVTALAKV 02000201 FDAANLSPAD LADINTALPW LHDYFGDLLA VRRAGSGGPT LTEMYWEESA 02500251 SDRLAVADFV DNMLFLFHAG FETTMGLVSN GVAALLNNPE QLGRLRADPA 03000301 LVPSAVEEFL RYDAPIQNVI RVARKPVEVA GQKIRAGRTV LLLLGAANRD 03500351 EEVFADAERL DVGRDPNPHL GFGGGLHHCV GTALARLMAV VVFERLVDRV 04000401 TVLGPAAPAV RRRHASLRSY DHLPLAVAAR

Alphafold2

.fasta

Heme Docked

PDBj

CYP1005

>CYP1005A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSAVLFRSWT KTAGTHWPAI TRVADQQGTE HLVVTQHALV RQVLTDQLTY 00500051 RPDNALDAVT PIPVAALRVL AGHRFRLPPT LANNGGVSHP AIRALVADAL 01000101 HPAKVAAQRP WLTGLVAERV AAIRRTLDSG GSTDLHAELN ADLPLLVLAR 01500151 LVELPDAPVS AVKQFARAAL ELFWAPLDAD RQLALADEVG RFHQVLREFA 02000201 DTGGGLAAAL RATGHPPDVL VGALFFLLVA GQETTSQFLT LLLHRLADEP 02500251 TVRAALRADS VSVADVVEEG LRLEPPIVTW RRVAAVDSTL GGSTVAAGTS 03000301 VLLWLARAGR DPAVVPAPDE FRPGQRGSRR HLAFGAGAHR CLGDQLARME 03500351 AAVVVEQVTP LLDGVTVVRP PWYPDNLTFR MPDAFVVRR

Alphafold2

.fasta

Heme Docked

PDBj

CYP1006 (DB is strange Natrialba asiatica DSM 12278)

Sequence ID: ELZ02448.1

>CYP1006A10001 MSSEPSAVTD DHPPGPDGLP LVGNQLAFLR HPYEFMTETA REYGDIAYWE 00500051 DPTGPVYQLN HPDYIEQVLV QNNQHYVKGA RFQNVLGPAT GNGILNSEGA 01000101 VWRRNRHLIQ PAFRPDRIEE YASMMTEFTE EKRETWNEGE TRPFHEDMME 01500151 VTLKIVARAL FGVDIDDDVE TVGSALDEFM LATESLSHMM LPPRVPTPSR 02000201 RRIQRARESL DAVVYRMIEE RRANPTDRDV ISKLLEVTDE DGTKLSDEQI 02500251 RDEVVTLLLA GHETTALSLT FTAYLLATNP AAEERLVDEL DDVLGGETPT 03000301 MADLDDLTYT EQVVEESMRL YPPVPGIVRE PAKPDIIGGY EIEPGATVRM 03500351 HQWVVHRDPR WYDDPLAFRP ARWTDDLKQS LPKLAYFPFA AGPRRCIGDR 04000401 FAMLEARLLL ATIYQDYHLE LVPGTELDLM ATITARPKDE IPMTVRER

Alphafold2

.fasta

Heme Docked

PDBj

CYP1007

>CYP1007A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MLASAADQAE FIDLGVKKMT TIANQKAWTI PGPSPLPLVG RIVNTINFAK 00500051 DSIGYSSELF KTYGKVASIV AGGGTNLYSA ASDCPGTVIA YGPEIVRQVA 01000101 TQSHIYHKAP LSGILYRYKD VSERTKPLKN YGVGLFGVND ETHLKQRKLM 01500151 MPAFHHQQLR SYRDDMVAIT QSELEQIKVN EPCEINQLMK RLTLRIATQS 02000201 LFGEDVIEKD HSAGNLLQEI ISIQISPFTR LLPLDLPGFS FHRYLDLLSL 02500251 FETQMKGIIA EKKAKTTPDS DVLSMLVKAR YEDTGHLLTE DELIAHTGVL 03000301 FLAGHETTAN ALTWILLLLS QHPQVCSDLF DELDSTLHGN SPSVEQLQKL 03500351 PLLERVIKES LRVITSVPWN GRVTSQTTEL GGYVLPKGTE VFVSIYHTHH 04000401 LPDIYPDPEA FNPQRWESIN PSVYEYNPFS AGPRLCLGAA FAMMEIKIVL 04500451 AMLLQRFRWE YLPVQKIDRN GFISIKPKFG MQMKVCSQDR EFMHGVGSVE 05000501 GNVREMVKLP S

Alphafold2

.fasta

Heme Docked

PDBj

CYP1008

>CYP1008A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MTGAPTPEVE DDGWAGANPF APSFRDDPYP AMNQLREKDP VNETPVGPWR 00500051 ISRHADVVDV FRNAPTSQTL ADGSSPNMDD QDRRGSFRDF MLNMDGPEHA 01000101 RLRRLVLGAF TPKALKHIEG EIDRVVDEAM HTALKQGGME VVEDFALRIP 01500151 SRMICRIMGL PEEDIDQFTV WTAARTNAFF ARFLPEDVVE HTRQAGEQMA 02000201 DYFEAQIKLR RANPREDLLT NLIQSEEKGD RLGDVELAIQ AIGLLIAGFE 02500251 TTIGLIGNGT KALIENPDQA ELLKQNPDLA KNTVEECLRY DTPVLFNWRV 03000301 LTEPYEVGGK TLPENAVLWM MLGAANHDPR VHDDPDTMDI TRQGISHASF 03500351 GGGAHTCLGN QLARMEASRA FHAFVSRLPK AEIQYDDCAW SESFFRVLGK 04000401 MPIEFH

Alphafold2

.fasta

Heme Docked

PDBj

CYP1009

>CYP1009A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSSAQIDPSN PDLHSYAFES NPEPTLAWLR EHDPVHWSQH GYWFVTRYED 00500051 VRAVLGDPAR FSSQKAGFGA NNPIGKDAKG PEGKSGKKAS DAEKTMSKGL 01000101 ALSFNQQDPP DHSRVRKLVN QAFSRREISE RADKIQAVVD ALMADVKAKG 01500151 EFDLITDFAF HLPIIVASDI IGIPAEDRDL FRRNFELAAR LMAPKRSDEE 02000201 WAEALTGAKW QSTYMGELIA SRAREPRADL ISALIQTSED DQKLTGGEVA 02500251 SAIMTIFTAA GTTTERMISS GAFLLLTHPE QLAALRADHS LMDNVLEEIL 03000301 RFHHPNQSTS TNRRATQDVE LGGKTIRAGD TVRVSLGSAN RDAAQFDEPD 03500351 AFNIQRTGTK HMSFGFGIHF CLGSALARYE TKAALEALLL GPKSIELITQ 04000401 NPVKDPDRPD RYKEIRVRMS

Alphafold2

.pdb

.fasta

Heme Docked

PDBj

CYP1010

>CYP1010A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MAMRAERFDE EAPEIFIPAR PVPPKEAPGI GAAVFRPQLL ANLIASYPEF 00500051 WYSARSCPFR VGIARGGRGM LVNDPDAIRR ILVSDAEHFP KDDNQLAILK 01000101 PLLGNGLLTA EGATWRRNRK LAAPIFQHSS VRDFAPLFVR AAERSARRAL 01500151 EQQGFFPLDR EMTKLTLEII GETVLSANLE DDIDGISHTV TSVLDKFPAM 02000201 FLASAFLPGQ LRNRVIDTVV RPGRRALDVF ARRIIDEARK SGEETTLLQR 02500251 LMVSQSKAGH EMTLDQVRDE VATFLLAGHE TTATTMSWVW YLLTVHPEWQ 03000301 ERLYEEVWAV TEGRRLTIDD VPALVETRAV IEEALRLYPP VANLMRRAIK 03500351 TTELTPDITI ERGQTVLISP WLLHRHRFFW REPDRFDPTR FLGEEAATRP 04000401 RHLYIPFGGG PRICIGASFA LLEAVLILAT FMQRARVKVI NADQVMPQAR 04500451 IVLRPNVALQ AVVTPRRPGG

Alphafold2

.fasta

Heme Docked

PDBj

CYP2

CYP1011

>CYP1011A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MTKTKKNKTQ NKLVFNPFYR AFHNNPYPIY ERLRNEDPIH WSFLKAWIIT 00500051 RYQDVDTILK DNLFQVDDLP LRLEEKSAYL KQGNFLPLAK TIDKWLFFQQ 01000101 PPNHTRLRSL VNKSFSPASV GNMKEEIEAK VNHLLDKVIP TGKMDLIDDL 01500151 ASPLPAMTVT NILGLPPEDY YKLIHWSYEL FFVFDQPMSL EGYEKQNKMA 02000201 MEAREYLLRF IANIDENSQG LIADLVKAKD EENKLDEDEI LGFCIMLLIV 02500251 GQETTKSFIS NSILALLQHP EKLQELKDNP EIIKEASEEL LRYDTPVQVI 03000301 ARLAREDVEI GGKTILKGDK VILCLGGANR DENKFPNPEK IEFQRSNRNL 03500351 PFGGGIHFCL GAFLARLQGQ ISINRIVQRL PNLQLVNQTP DWRESITLRG 04000401 LKSLPLTFDK NDIKTD

Alphafold2

.fasta

Heme Docked

PDBj

CYP1012

>CYP1012A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MGRLRQVLSI WARPDTFLKS CRAKYGSRFR VTIIPGIRIH VISAPEDVKQ 00500051 MFLAPRDVLH TGSSNGPIEK WIGQNGLAWQ DEDVHTERRR RVMPSFRGDA 01000101 VKRVEQAVGQ LAKETVASLP RDKVVSVHPY AHRYTTKVIL EVLFGEHRPS 01500151 CENEMFEEVM KMLDFNSRPA SMTMFHRMPS WRVKLLRLLR PNGVNEFLTR 02000201 RERVYRMLDA AIEERGRSGK SGDDLLGLML GTTNADGSTP SRIEMRDEIM 02500251 TQFLAGTETT AAAICWALEF LTRSPHVVER VRAEIEEGTG DEYLTAVVHE 03000301 VLRLGPPTQQ IVPREVVKPI EIGGVRYESG DRLWASAYLL HRDEHNYPQP 03500351 DEFRPERFLG VKPASHTWIP FGGGHTRCLG DRIAFVELKA TLTEILTTCD 04000401 VERADPEPEL AHSRTVVNIP KKGARMVFRP RKVKAELGS

Alphafold2

.fasta

Heme Docked

PDBj

CYP1013

>CYP1013A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MTTTAPTTVT TARGKTATGP RGVPVLGNLP QWKGDTAEFL LRVQRDHGEV 00500051 ARLRLGPYTV HLVTEPDAVS RVLKENSANY VRGTLYEQFR TVMGNGLLTT 01000101 DGDDWKAHRR AVQPVFLRKA VAAIEPNVVR ATNEMLDEWE VKACRGEPVD 01500151 LVTETLRLTL VTLSRSLFGY DIRPATPVLK DVVNNVIEVM FKHGSVAEML 02000201 PSWLPTRRNR LISRDRRIFT RLVTEIRDNH AATGEGPLME LIEAATDPVT 02500251 GARWSDEEIR DEMLTIYLAG HETTAVALLW TLVSIANHPG VADEMDEELA 03000301 RELGRATPTA QDVERLSYTN QVVDESLRMY PPIWIYPRDA VADDELAGFH 03500351 IPAKSSVLLS PLASHRNPRY WKNPQAFDPH RFDPDRVKER PRMAYFPFGA 04000401 GARMCIGNFM ALLELRMIVA MIHQRFRLSL VPGDSLRYGD TAISLRPLSK 04500451 VLVVPESRDR GVRA

Alphafold2

.fasta

Heme Docked

PDBj

CYP1014

>CYP1014A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MGDNGPPTPG GLPVLGNTVA FARDPFSFID SAVTTHGDVI RLSMLGRDRY 00500051 IVAHPDLFER ALVTDRDAFV KTEDFRLAFG DSVLAVDGDE WREQRDLLDP 01000101 FFFFRQITDY IPKMRKQADR RAESWTPGQT YSAVEEMKGL TFDILGSTLL 01500151 GQDPGKRSGD DSLRRAADDL NAYFAPTSWA LPGSLPTPSR RRFNRAVTTL 02000201 REEVDRLLAA DHSGDDLLSV LAEARGEEGY PRSETAVSDQ LVGIIFAGHE 02500251 TTALALTYTW YLLSEHPSVR ERVEHEIDEV VGDDPVGAEH LSDLTVLERV 03000301 IKESLRVYPP IHTLPRTTTR EIELGGYSIP EGSEVLLSVR NVHRDERFFE 03500351 HPDQFDPDRW ERNDAPEYAY VPFGAGPRRC IGQSFAMIEA KTALTELMKR 04000401 YRLEWAGNGE LDLSPQMTTQ PRGDVPMIVR ER

Alphafold2

.fasta

Heme Docked

PDBj

CYP1015

>CYP1015A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MTDPQSTADD RSPRTDAEAG TEPARNDGET GSMRATARTP PPGPRGLPLI 00500051 DSTLTFVREP LEFLSDLSTY GDVAGYEAFG REFVAVSDPG LVEEVLVSRD 01000101 DEFWRGEFEN EFSDAVAIEG VFFAEGDRWR RQRVLLQNAF TPARIQSYAD 01500151 DMVDETTRLV ERWSDGDVVD LREASSTLTL RALTRSLFDL EFGDDRAERV 02000201 RRWVHAMGVY NDTEFFGVRA VLPTWLPSGA EREYRRATAD VEALVEGLVA 02500251 DRRQSGTDGD DLLSLLATGA YPDGSRPSAE EITDQLLLFL LAGHETTATA 03000301 LTYACWLLAG DDADVDVDAD IDADADAGAD FDVDVDGGAD ADADFDTASV 03500351 RSQLEREVDA VCGDRNPTFT DLPELSVTEA VSREALRLYP PLPFLQREPH 04000401 ESTAVGGYRI DPGTTVQLNM YGIHRDDRWW SEPDAFRPAR WLSADEDGRP 04500451 VLDARTDTNR PEYAYFPFGG GPRHCIGMRF AMTELQLSLA TLVQHADFDR 05000501 ITESIDPSFK VSLDPGPVEM RVRKR

Alphafold2

.fasta

Heme Docked

PDBj

CYP1016

>CYP1016A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSASHEDLIE KLRNFSSDET TPELAYELFA EAREACPVGR SDKQGGFRLL 00500051 LNYDDVKAAQ GDWKTYASSP SVTRPFAERP AFPPLEQDPP EHTSWRELFS 01000101 RILNNETAAQ IEPLVRADVI TLIDRLRESG SFDLVADFAE ELPLLALCHF 01500151 LGFDAEKRDA VRAKALEMVG SLGDQELAGA TFMALAQLGV EEVLARRDQP 02000201 RDDFLTELST AEIDGELLSV EQIAMTMSSF LVAGHGTTVA ALSSLLCDVL 02500251 SAPEVKARLC ADHDLIPVAI EETLRLHPPF FGLFRRAVKP ATIGDADIAE 03000301 NESVLLCWAA ANRDPKVYDD PDAFSLERKQ SRRNRHLTFG FGIHACPGAP 03500351 IARMQMKVAL EELLTRAPDI ALVDPAAAVY EFRGTETAAI PSLPAVFKS

Alphafold2

.pdb

.fasta

Heme Docked

PDBj

CYP1017

>CYP1017A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSGSRDIDHH AVAFARDHLA IYRDARAHCP VLRSDAHGGF AILTRYADNR 00500051 AALRNHDTFA SGRIRAGDRL GGGVAIPPNG LRIGMIEMDG AEARALRALL 01000101 QPWFTIAAVE AAAPRMAQLS AWLVDRIIAR GACDVVEDLA KPMPSLLILD 01500151 ILGLPLDRWR DYGRVLHEAV AKSSGSIDGL RWLASDLRAS VERREVHPEG 02000201 LIAAMIAAEV DGRPLGDALV CELAMMLLFG GTDTTIAAIG HALRHLTEHP 02500251 ADRAALVARP ALIPAAVEEI LRLYSPSTGV ARTVTAPVEI GGERFEPGQR 03000301 VLCAINSANR DEEMFADAER FDLDRPKRPH LAFGWGVHAC LGQNLARADL 03500351 RILLGELLAR MPDFAVDVAA SERYASIPLV NGHARMPMRF TPGTPAGTGG 04000401 GELPILTAPR LRPLP

Alphafold2

.fasta

Heme Docked

PDBj

CYP1018

>CYP1018A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MTSARTDRDL AALLESYDPF DRDHVEWKYD AFAYARQHCP VVRTETELTG 00500051 PMWMITRYED VRRVLEDPET FSSVGGSPAP APVRLGPLDS DPPEHTGFRA 01000101 LLSPYLTRKF ALTYADEMRK TANELIDGFI ENGKVELLSE FASPFVSRIL 01500151 ARMVFNENDM SKMERAKEIV YRVTEDGTEE SFMNLGMLSA EYLFAAIENP 02000201 PEEDGILRAL ATGTINGERL TNEQALGAIS VLFLGGLDTT RSAIGAIAMY 02500251 MALNPELEQR VRDPRWVRND MDEFIRLTSP VGTFGRTVMK DTEIAGCPVK 03000301 KGERLLIRFD SANRDDAKFP NADQLQFDPP RGGNAGFGLG IHRCIGMHLA 03500351 RVEIAIAFEE LLARVTNFRL DADPADLKWV PGIANYPDRV PLIFDKV

Alphafold2

.pdb

.fasta

Heme Docked

PDBj

CYP1019

>CYP1019A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MHQTLADLRS RCPVGWSDNY GGFWTLTRYD DVVDAARDHS VFTTTQGIMI 00500051 PPTGASMRLV PAEFDPPEHS AYRKMVMPFF TNKVVALNHD AIRELVRECF 01000101 DKFVADGHAD LVSAVSDPVP PAVLAHYLGL DRNRADEMRQ LMMEYLSSAK 01500151 VSLDEKIASA KRFEAFVQRE IDERIDEPGD DTLSKIIGVA LSDENGAPLE 02000201 PAAILGMVRL IISAGHETTV HGISSLCYRI LAEPGLRDRL LADPSLRHVA 02500251 IAEALRLDAP VMHMARTVVT GHEKRGQHLH SGDKVMLCFG AANRDDEVFP 03000301 EPDTFSLDRP RSPSDVTFGT GRHRCLGEHL AVAELSAVVD ELLSRLPDAR 03500351 IAPEAEIRWT GGGNTRGVES LPIVFTPEKT GP

Alphafold2

.fasta

Heme Docked

PDBj

CYP1020

>CYP1020A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MRNTAPRASK GPNQLLTTLL ATLPRPDPFP LYAELHQQGE SFRSPLGTVY 00500051 LVSHARCSES LRDPRLAVED AALRARHRPG WADEAWSPFF DSLLFLNGAD 01000101 HRAVKTVAQS LLVPRALRLL EEGLETATDE VLGALAGAAK AGEAIDVCHD 01500151 VAWPLQLYTL STFLGVGPGE LDFLPGLMPR LVVLGSPLMW HSADDAKHAA 02000201 EASRTLVAFF KRIIEQRSEL AARLGARWEH GLVHRLLASA DAGGLDTSDV 02500251 LATLVAVVVA GVETTIGLIA NAVVEILRDP RGTDFGDLRG PDSTPFVEEV 03000301 IRLAAPIHIV GRRALESGTV VAGHEVPAGA HVVLLLGAAL RDPAMFPEPN 03500351 QIDPTRAAGS SLAFGSGPHY CLGAALARIQ LRAVVGGLFT RYPQLRLSGE 04000401 PQLGRHLNPH SYSSVPVLLA

Alphafold2

.fasta

Heme Docked

PDBj

CYP1021

>CYP1021A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSVTETVPQD QDQDLPSFPF PDTFSPLPSG TLAEIARRAP AIRVRFGPGQ 00500051 IPIWLIVRHS PARAMLSDPR FSRTKTLEFR PPLTGAQIPD PNSLLWLDPP 01000101 DHTRIRRLVS TGFAHRRIEQ LRPWVAETAR RHVTAMTAKD APADLRAALA 01500151 AALPVDVICQ ILGVPEIDRE NVRTWSETLF RFATNREAAA AGQKALYGYM 02000201 DSLVRERQAQ LAAGEPVTKL FDVLITTQDT DDGRLNEVEL RSLALTLLIG 02500251 GFETTAGVIT NAVTTLLTDR SQWESLVGNP ALLPNAVEEL LRYHPLSMTF 03000301 PRVATEDVDL GEFTVRAGEV AIAPFAATNR DPDLYDDPDR LDLTREPVAN 03500351 LAFGHGAHHC IGAHLARVEL TEVLSALIDI VPTLRLAVPV SELRYELAAP 04000401 IGRPEKLPVA W

Alphafold2

.fasta

Heme Docked

PDBj

CYP1022

>CYP1022A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSTQAFEDFD PFDLAQAERH HAVMADMRER CPVARLSSGM IAVTRFADVR 00500051 ATLHEPALRN SHAARAPGVT VPPEDRFFFF EYDPPEHHEL RRLLLDLLSR 01000101 RQSEQLAPSI RALVTELLTP LVGRGGAELV NEFSIPLASR LMMRVAGFPE 01500151 DDAPQWRQWI RDMVRSGFSF TNRNERGAGF EQCYPDVLAY LDGRLASAPA 02000201 TDSAQHGVLA RVRDAQIDGE PLTRTQQRMI LFSVVSAGTN TLANFMSNTL 02500251 ASLTREPGLF ESLRDDRSLV PVVVEESLRR DSPSMHLTRL CAEATTIADV 03000301 PVAPGEKVLL SLASANRDAT VFPDPDEFRT DRRDQPSHVA FGWGAHLCLG 03500351 APVARQAGVT MVDTFLGLVG AITLEPGTSP VPYLSPQGNG LDELRVCLAP 04000401 TRAPARAET

Alphafold2

.fasta

Heme Docked

PDBj

CYP1023

>CYP1023A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MATLPDLGDA DALRDWHTSF RAIREHQRMY WDDAVGAWLV TRHADVEMGL 00500051 YDHRLSSQGP TSFMAQLSAE DLAKFADLQR FYESWMVFSN EPYHTVVRGS 01000101 VQRVLTPRAV QKRQEAVRAA ARSLLDRARA EVVDVNSDFA RPLATAVISE 01500151 VLGVPEQEWD NCSRWSHHII DFISAPQPDA SRAMAAAESY DQMCDYVYHL 02000201 VEEHRRTGRD DSPMLAVADV GAHAVVGTFA QFMTGGCDPI SAAIANAVAT 02500251 LLAHPDQMQR LERDRSLIPT AIEEFIRYES PFTLVPRVVT EPMTVAGQHL 03000301 HEGSRVLFML LAANRDPGVF ERPDEVDVGR SPNPHLGFGK GSHYCIGAGL 03500351 ARLEMTESIE AIIDMAPNLE LAGQVEWSSS LGLRSAVKLP VSVSR

Alphafold2

.fasta

Heme Docked

PDBj

CYP1024

>CYP224A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MTIVETESID LYSLASFEHG HPHALYARLR EHDPVHWNDE PNGPGFWAVT 00500051 RWEDIRAVNR DDENFSHWPV SMIEDFMETE DKSMVNLDPP LHTVIRRAVV 01000101 PGFMPSAVRR RMTRFVDAAE AIVDEIRPAG GCDLAVDVAG KIAAYVTADV 01500151 LRIPREDAVR LYEYIEIGLG GGAYTEQERQ GATEALIRYS IQVWEDRRAH 02000201 PGDDVCSMLA ACEVDGAPMS LENFSANMTL LIVGAGDTTR HLIGGGLHAL 02500251 FTHPDQRELL QADLDGRMPA AVEEMLRWVT PVVYNRRTAL RDVEIGGRSI 03000301 SAGDKVCVYY GAGNRDPREF ADPERFDITR SPNRHLAFSG LGQHFCLGAH 03500351 VARAEAIAMI TTLLRAFPGI HPAGEMEWTR SNFVMGPAHL PVTW

Alphafold2

.fasta

Heme Docked

PDBj

CYP1025

>CYP1025A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MNQMPTPAAA AAPMPDEWCL KDFDHLSTDL AAVFPETMDR MRTLCPVTHT 00500051 GQHGGFWVVT KYGDVLDVAQ DWESFSSAYG LAIPPSTTHV RNIPVEVDPP 01000101 EQRVYKKLVN SHFTPKAIAG WEAPARALVT DLIDEFIERG ECEFMDDFAR 01500151 PFPSLSFFKF ALDAPTEDLD KVSFLASKAS IPNDPIGKEC WAGLSEWING 02000201 FVEQRRQRPP RGDVVDALLK AEFEGRPLTQ KEIVGIVQLL ILGGLETTAG 02500251 ALGLMLLRFS RQPEIPAYLR AHPERIPAGV EELLRLDGPF IAIARTATRD 03000301 IELDGKQISK GDRVLIYWAS ANHDDAEFTN PKTFDIDRSP NRHLAFGAGP 03500351 HRCLGSNVAR LNMRIALEEL LRRMDDIRLR EDADIHFHST LTRAPLHVPI 04000401 TFTPGPRSAP VG

Alphafold2

.pdb

.fasta

Heme Docked

PDBj

CYP1026

>CYP1026A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSVDDTEASA PTTQRGYATA PTLAGFSHAA NERLNADPWG ELDRLRDESP 00500051 TFRSDMPNPL VPGASLWYLL DYESVYTALR DWETFSNVGS AHPFSDSDPY 01000101 SMIPGELDPP DHTKFRRPLN AHFSPGAIRA LEPDIRRTAV ELIESFKDSG 01500151 QCDFVTDFAL HFPTRVFERM FGVPLEDHDQ LTAWVHTFGQ QMATQTAIDK 02000201 AVAAEQEVLA YLGKKLDERE QSPREDLLGA IAFMEVDGAR ISRKEQVAVA 02500251 YLMFQAGMDT VASQLGWSFR HLAENEVDRQ AILADPKLIP STVEELLRSY 03000301 DILSHTMIVA KDVEFNGCPM KKGDRVVTMI SAANRDPNEF PDPDTFDVSR 03500351 KPNRHMAFGV GPHRCIGAHL ARIELNIALE EWHQRIPNYK VAEGAEFGQS 04000401 MKWAVTSMES LPLEWDVEAV N

Alphafold2

.fasta

Heme Docked

PDBj

CYP1027

>CYP1027A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MTTPTTEITD HRIVGVGTVG DAGDRFDALR SLHRIVRVTE PDRSYWMVLD 00500051 HDLARECLQN PAVFSSEVIT PLSPDPPLSM IPIQLDPPEH TQWRRLLAQY 01000101 FSPRTMGLLR PRLEERTTEL VAAIRARGEC DYVEDFALEL PTVVFLELMG 01500151 LPIDELPTFL EWEKQALAPT DSGDFDKDRQ IGGIFSVVGY FQAEIARRRD 02000201 SGERGDGLLG AMLDWELDGA PAPDDALVNC SLLLFLAGLD TVAMSLSFAM 02500251 HHLATHDADR RHVAGLAAAG EPLDGVVEEL LRFYAVPEVG RKVKQDIEIG 03000301 GQQLRAGDLV LFPLVAANRD EALVAGAGTV DLVSRPPAPH LAFGAGPHRC 03500351 LGSHLARIEM NVALAGWHRV IPAYALGEGT APQAYWGNVH GIFSLPLAEF 04000401 GS

Alphafold2

.pdb

.fasta

Heme Docked

PDBj

CYP1028

>CYP1028A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSTVGDRELN GAVGIVHTSI EAVNDGANPY QTLAPLHDYG EAVIMPEGYL 00500051 AVWGHQACMD IMRSSAWGRH LPDSSIRAAW QHDLTAEQAE LLRQEEPPHI 01000101 APWLQTFDGP EHARQRSLVS KPFTPRRLQV MRQRTTEVVG RLAAAAPRGV 01500151 PFDFMSTIAF PIPNQVVGEL VGLPLQDRDW FAERAVLLLA ERDPRSSFDQ 02000201 LRRSTRAIRE LGDYIRGLLR GETCPTEGLA SDLLEAEETG ARLTEPELLS 02500251 LMLLMYVAGH GTTAHSMGNG LYVLLQHPDQ LAALRADRGL TRSAVEEILR 03000301 WDSGVTSVDY SAVEDTDIDG IRVPAGTPAH LFLSAANRDP RVYTDPGSFD 03500351 IRRTEGPTVV FGAGPHFCLG AALARLELEI ALDVLLAGFA SIELATSTPP 04000401 RGDSFNYRYF TQLPIVVSDN

Alphafold2

.fasta

Heme Docked

PDBj

CYP1029

>CYP1029A10001 MDGQGSVRRY INVYRNDNDI RGLENLETRV EESDVVWIIP AVAGGSIRPA 00500051 VQEPKVPEVL PSEFFLNPGP SPHATNAELR SKCPVHQINY PPGSEAYAVL 01000101 GHRAVAEAFT DSRLSKEAEN LPPRFRDRAL SSSLLMVRNL GFADPPDHAR 01500151 LRRPISRAFL PNAIADLRPR IQDVVDDLID TFPAPGEIDL LGAFALPLPL 02000201 TVICEYLGIP VQDRPLFLEW GYILSQDPFQ HAESELKAAT EEFTDYFTRL 02500251 VARRRTDLRK DLLSELVRAA DSDALSEREL LSTILLLLIA GHKTVANLIG 03000301 NGTALLLGHP GQLDLLRTTP ELIPAAVEEM LRFEGSAAWA SMRVAVEDMR 03500351 LAGTEIPRGS FVHLLLSSAG HDPEAYDEPE RFDVTRSPNH HLAFGHGAHF 04000401 CVGAPLGRLQ GDIAFTTLLR RLPGFELAVR QDEVEWLADS SLSRGLRALP 04500451 IRVRERLPR

Alphafold2

.fasta

Heme Docked

PDBj

CYP1030

>CYP1030A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MPVQTMDFAA PSFRTDPFPA WSDLRRAGPL HRDVSGAWIV VSHREVGRLL 00500051 ADPRVGKDLR RLSTYGAQRP YGPDGLAEYY IEQWMECRLP TMHRRWRQLV 01000101 LPGFTHRAVH GLRAELCRTA DDLLTHALTH APSDGQVDLL RDFARPFPVA 01500151 VIVRVLGLTD LDTDRLAQLS RTIAAVLEPN AAVSAREAGD AALAELAGLL 02000201 WDAVRADRGP HPDGFLRRLV DANKGLLSPE QLIATVLLLF LSGNDTITGL 02500251 IANGVLALAS VPDQADRLRA HPELLPMAVE EVLRFDAPAC VAVRTTYEPM 03000301 TIDGVTVERG AALLLAISSA NRDPAAFAEP DVFRVDRRPI RHFAFGSGDH 03500351 TCVGIGLARM EATIALEALL HRFPRLTHDP STLRWSDALY LRSPENLVLL 04000401 CTVPPAPERA CGVPEVGLGR DLG

Alphafold2

.fasta

Heme Docked

PDBj

CYP1031

>CYP1031A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MTDTRTPRAA SGPYVFNPFA DGFAEDPYPH YAQLRENAPA HRHPLGFWLV 00500051 SRYEDVARIQ RSGHSVDERH ITELPEWKSE SRTLGKQNRL MHGLSMLDQD 01000101 PPNHTRLRRL VTKAFTRRAV DALEGRIERI VDDALDRMAE AGRVDLVAEL 01500151 AFPLPFTVIS ELLGIPVLEH GRLRELTGTM VRALEPLPDP GLQAEIRAAN 02000201 DEVAAIMRAV TDWKRDNPGD DLLTALIGAE HDGDVLSAEE LVAQVMLLYV 02500251 AGHETTVNLV AGGILTLLRH PDQMRRLRDE PELAGNAVEE LLRYDSPVHL 03000301 MRRITLEPLS VRGTEIPPGV FVTVCLAAAN RDPDFWGPDA DEVRLDRTDA 03500351 HRHVSFGAGI HHCVGAALAR LEARVAISRF VGRFPAPALE DVRWNGRINV 04000401 RGPASLTVAV R

Alphafold2

.fasta

Heme Docked

PDBj

CYP1032

>CYP1032A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MRFDPTAAAI KADPYPAYAR LRAEAPVEWN DLGFWTVARH QDCLFALRDK 00500051 RLGKEHPFAW AIENPDLPLI QIHDAMMIFH DGQAHRRVRR LFTSAFTTRA 01000101 ADRLRPDIAA IVDELLAELV ERDEFDLVSQ FCYPVTLRTI CYMLGVPRSD 01500151 IDWCHSLTKN VQRLLEQDLS RAELVQISDS TVTLSEYFAE HVRDRRRNPK 02000201 DDLISLLVQA EIDGERLTEE EIIANSILLY LGGEDTNANL MANSTLALLA 02500251 APDQAELLRH DAGVVHATAF DELLRYDSSF QMLTRYANEP VEIGGQRIEE 03000301 GQTVMCLLGS ANRDEREYER PDELDLRRVV KRGVSFGGGP HLCVGAPLAR 03500351 AQLQEALPRL FRAFPWMQNL TEELEYPLLV VRGPKELTLA TGKQRVMA

Alphafold2

.fasta

Heme Docked

PDBj

CYP1033

>CYP1033A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MLKPVQPADR IVGDVDDDVD YVDGQITDFH ARLAALRAEK GVARLRFGPD 00500051 TGLMLLRHAD VVVALRDETR FSKSGAFRPI TFPFLGPNIT GYDGHEHNVK 01000101 RALVSPTFRR TMIPRYIQPV IRPIAEELVA DLATLGEADL MATFAKKYPM 01500151 RITSRLLGIP SDEEDKLASW AFSMLHIAGD PDGAMKANAE FTEYVGPLID 02000201 TRRAHPRDDL LSALLTEEVE GQHLDHDEVL GFLRLLFPAG VDTTWQALGS 02500251 LVHAVLEHPE VHQRLRRDEE ERAWAVEETL RWESPVAADS RLTLQDVVVS 03000301 GVEIAAGELV RLGLSVANRD PDVFPDPDRW NLDRRPTNHI TFGLGRHFCL 03500351 GAHLARVELQ VALDVLLQRL PNLRLLEQPQ ITGIGIRGPK TLRVAWDAPS 04000401 TPGAP

Alphafold2

.fasta

Heme Docked

PDBj

40.99% CYP109B1

CYP1034

>CYP1034A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSTTATLDRE RVRQLFDLRS SYNVHMGGGY RQDPYPVWHR LREQAPVHPG 00500051 IVHELTGFDG PAMFSGLPYP DRPHFSAFSY AACDAAYRDP EVFASAAGPV 01000101 DPNNGPYGAT NSMLSMGGRQ HRRYRGLVQP SFVPGKAKWW ISNWIEETVD 01500151 LLIDGFVDAG RAELNVDFCA AIPVLTITSS FGVPVDRALD IRAALTRPDE 02000201 IVRMLEPIVA ARRADPQDDL ISILVQAEMT DENGVTHRLT DAEIYSFSVL 02500251 LLTAGSGTTW KQMGITLTAL LQHPEALAAV RADRSLLRLA IEESLRWSPT 03000301 DPMFSRWVTE DVDFFGVHMP AGSVLHLCIG AANRDPARWD RPDEYDITRA 03500351 LRPSFAFGGG AHVCLGMHVA RAEMRVGIGA LLDRLPDLRL DPDREAPRFI 04000401 GMYERGATEI PVVFG

Alphafold2

.fasta

Heme Docked

PDBj

CYP1035

>CYP1035A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MGDVVPAPWG GHLLLSHELC DQVLRSKAWA TFDAEWRARQ GDGNRWSAPA 00500051 SQQLSKTLQG LNPPVHTQQR RSLGNVFDRS TLAGLQPFVR QTVEELLDRL 01000101 SDRLRATGEA DFATLVGEEL PVATISHWLK LPQADHALLR ELTHGQAYAQ 01500151 ELLPSASQLV QANAAAEGLR EYFTAVVAER RRSLGDDALS RWIRTWDELE 02000201 PDREVADETL YHLVMFVVIA SLETTSTLLS NMVWLLDQNP RQRSWLLTHP 02500251 EATPNAVEEV LRYDPPIHLT TRVATEDTEL AGTRIERDEV VHVMIAAANH 03000301 DPSQFDDPDT FDIGRTAAHL GFGGGIHFCI GAMLARLEAT ELLQSLNRRF 03500351 PTLRVTTPPE WEPRMAFRRL LALHVAEH

Alphafold2

.pdb

.fasta

Heme Docked

PDBj

CYP1036

>CYP1036A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MKKDLIPDPF EKTREAAGYG EMNDQNDPVT MILRLKDVRK CAHNFKTFQS 00500051 GARPGRIVVP SEVSIRDTRQ IPFEVDPPEH TDYRALVEPW FKRPLEAEYR 01000101 EKLSQQIGYI VEERLARDAV EVVEEFSLPL QSRALTLLLN IPIEEAETWI 01500151 KWGTHVFRSE DSPVDGDKAK ILYDYIDQQI DRALEKPGED LYTVLLNSEI 02000201 NGKKLSREEV KGVMILTFAG GRDTVINAVT NSVAYFAVHP ESLELLRKEP 02500251 EITGRAVEEL IRYFAPLTHM GRVVTEDTQV CEYAVKADSR ISLVWASANR 03000301 DSSVFEKPNE VVLDRKINPH VSFGFSHHNC LGATHARQIM HILLKTLAEK 03500351 VGSIEIQEHE DNIETWGEFE RKVGYDRLKV QFNPLQ

Alphafold2

.fasta

Heme Docked

PDBj

CYP237

>CYP237A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MTDITFTPAD VVDPELHASG EVHRLWRWMR QHAPVHWHEP GDLPGFWSLT 00500051 RYDDIRQVYQ NPAVFSSAQG VLLRPTDLGE DPGSGLTMAL TDPPRHRALR 01000101 GQVADRFSER CARSLAGEMR AEIRSVVTRA VESGTCDVVH DIGARLSSHN 01500151 IGRLLGVAPE DRERLLTWTT EAFESGKPLT SHLELMRYFI DMMYARMEEP 02000201 ADDAMGMFVN NEVQGGLLTE TEILLSCENL VGAAENAGLS MASGILALAA 02500251 YPQAWQRLVR ERDGELVRTA AEEVLRWTSS ATHSMRTATA DTAVQGRRIA 03000301 AGDRVVLWIP SANRDESVFP EPERFDLGRQ PNRHLALGTG EHVCIGSTMA 03500351 RHQMRMLLET LAELVAVIEP AGDVEPLRSI AVNGPAHAPV RLVPR

Alphafold2

.fasta

Heme Docked

PDBj

CYP1038

>CYP1038A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 VVDLLAQARE LGGVSAVRLG PRPTVLVTDP QAVQHVLALH PDRYVKRSHR 00500051 ARVLVGDGVL SAVGEPWKRQ RRLLQAQFTG AGIRRYEQRI VGAARRAADH 01000101 WAECARTGTP TDVGDDMRFF ALDTIWRSLT GHPLDETTNR ELAAVEAVGA 01500151 ALPATPSASA DVAELRAAVA ADLARIDAVA EHAIAAARRG EAGPEGPGLL 02000201 RVLVEAGQTH AEYTDQLIRD ELVTLLAAGH ETTATTLSWL YLLLDRHPEA 02500251 RRWALNAGPA GSPEREKAFR ALASETLRLY PPAWLIPRHA TEDDALAGYH 03000301 IAASTDIYVC PYLTHRDPAL WPEPERFDPE RFTTADEGRP SSRHGAYSPF 03500351 GLGARACLGA QFAMREMTML LEHLLPAFTP SFHTTPPSAV FGLTVRPDGP 04000401 TPATITPTPN GS

Alphafold2

.fasta

Heme Docked

PDBj

CYP1039

>CYP1039A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MMGMGIRGAR TAIKLATFRT MMAGAALTGD PAAKLLGRRQ PANPFPLYEQ 00500051 IREHGDVYRS RLGIFCTVSH AQCRAVLKDP RFGMPVPPSP PAWEMYQGDA 01000101 DTLIHPIERS LLAVNPPEHT RLRRLVAPWF TASALRTRAA RVEKIVHSHL 01500151 DRISDGQDFD LVRDFTAQVP TAVIGDMLGI EIENYEQFGR WGMALATTID 02000201 GVRTMGERRM VRAVLAEMTS FFTQLIEENR RAPRDNAISG LVGAEVDGRP 02500251 VTDEELIGLI GLLLAAGLET TVNLISNSVR FLLEHPDQKR LFLDNPDTAP 03000301 DVVEEALRYD PPAMFTVRMA LEDVELDGRL IPRGGWXGGW LVQLLGGANR 03500351 DPKVFTDPHR FDVTRGNIRE HIAFSAGAHH CVGSGLARLE AEIALRELFA 04000401 RFPDMRIAGD VTMRTARSAR GPQSIPISVA QAVGPDPSRR A
>CYP1039A1v WP_014173125.1 [Streptomyces milbemycinicus]---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MMGMGIRGAR TAIKLATFRT MMAGAALTGD PAAKLLGRRQ PANPFPLYEQ 00500051 IREHGDVYRS RLGIFCTVSH AQCRAVLKDP RFGMPVPPSP PAWEMYQGDA 01000101 DTLIHPIERS LLAVNPPEHT RLRRLVAPWF TASALRTRAA RVEKIVHSHL 01500151 DRISDGQDFD LVRDFTAQVP TAVIGDMLGI EIENYEQFGR WGMALATTID 02000201 GVRTMGERRM VRAVLAEMTS FFTQLIEENR RAPRDNAISG LVGAEVDGRP 02500251 VTDEELIGLI GLLLAAGLET TVNLISNSVR FLLEHPDQKR LFLDNPDTAP 03000301 DVVEEALRYD PPAMFTVRMA LEDVELDGRL IPRGGWLVQL LGGANRDPKV 03500351 FTDPHRFDVT RGNIREHIAF SAGAHHCVGS GLARLEAEIA LRELFARFPD 04000401 MRIAGDVTMR TARSARGPQS IPISVAQAVG PDPSRRA

Alphafold2

.fasta

Heme Docked

PDBj

CYP1040

>CYP1040A1 Streptomyces sp. RK95-74 (taxid:1934390)---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----No accession number

Alphafold2

.fasta

Heme Docked

PDBj

CYP1041

>CYP1041A1 Streptomyces sp. RK95-74 (taxid:1934390)---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----No accession number
>CYP1041A2(2562412111)Streptomyces davawensisInt. J. Mol. Sci. 2020, 21(13), 4814; https://doi.org/10.3390/ijms21134814---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MALDSPAFRF SRMESLLRGH RLRRLTVDGV DAMFVSDPVL VRRILVSDSK 00500051 NYGKGELFRK ARNLSRVGML SEDEAMHRHY RRLANPYLRS TMVDDYVPTM 01000101 RDIARAAVTA WRAGDTVDIQ SEMCRITCAI SVGTLISGLP PETTRELGER 01500151 LSRLAWEMIR KPLYGKSASR AARTSAARRL SRARTEFRDL LADCIAVLLN 02000201 SPEARDGYLS SLLADSDAEG NRILTPDQVC EEAVMMMTAA TVTTASVMSW 02500251 ALYVLSRNPL TEERLLKDLI RRRSGHAAHE HGTSSYTLRF LMEILRLYPP 03000301 VWISCRKTLS DVTLDDHALP AGTNVVFSSY LLHRRPDQYP DPNRFDPDRW 03500351 LTHRIDPAEA SYIPFGIGSK GCIGEPFAWQ ELEVVLDVVT QEWKLSADPD 04000401 RQIRTAPETT LHPRRLLMVP QPR

Alphafold2

.fasta

Heme Docked

PDBj

CYP1042

>CYP1042A1 Streptomyces sp. RK95-74 (taxid:1934390)---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----No accession number
>CYP1042A3(2633775475)Streptomyces xiamenensis Int. J. Mol. Sci. 2020, 21(13), 4814; https://doi.org/10.3390/ijms21134814---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MLDNAFGQEP RWDPRVFPPA SRAPRAVQTA HMLRDPRGFG LSLRRRFGPV 00500051 FSARVHPYRA ALVCATDAAT NRAVLTDHER FVGGRATALL RPALGEGSLI 01000101 CTPPPRHLPH RRLLLPPFQG KQLAGWEDRV REVVRAALPG LLTGGDRPTR 01500151 PWAQRLTLEV VLRVVFGLRD PARVAVFRDA LTAFAGTGNV STLFLPAPLR 02000201 RDLGRLSPGG RFGRLRLHVR ELIREEIAAR REVADRESRD DVLSTLLDRY 02500251 DAGPGDQRLL DELTGLVLAG YETTATTIAW TLHLLAHHGH TRDDLVADLD 03000301 AGSDRLLKAV IKESGRLRPA VYNAMRTAAE DTSLGGHPVP RHAFVAALFP 03500351 ITHLDPELWP QPHAFRPERH LGADPLPYAL TPFGGGLRRC IGVPLAQLEA 04000401 EIVVTEVLAR ALPEPAGPPE PARLAAVTLV PARGGRVRFR RRGTL

Alphafold2

.fasta

Heme Docked

PDBj

CYP1043

>CYP1043A1 Streptomyces sp. RK95-74 (taxid:1934390)---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----No accession number
>CYP1043A2(SHJG_8442)Streptomyces hygroscopicus subsp. jinggangensis 5008Int. J. Mol. Sci. 2020, 21(13), 4814; https://doi.org/10.3390/ijms21134814---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MVSRRTAAAL AAGGALLLSS PAWLPGKVVA LRTKVFARVN GDEGMLLPDA 00500051 TFGPDRFQEV YGHPAAGGRS KGAALSDLFW YWLAPGADVH QEHLEAGPRY 01000101 DEVARRTLAI LSGPSAELYD AAARHTRRAL DAAATGRVRT VRLRDLMMPV 01500151 WAEFFYGLVF GEPCPAEARR LIVAHAEDVV NALKCTRPRR MRRRNRLTRY 02000201 LLRRIAAGDV PHTLPAGLTR RQQAYYLQGT FFNTAVVQMS EAMAHLLLVL 02500251 AQHPDVQERV AATPDDDRYL THVMNETFRL YPLFGVAHRI TTADIALDGL 03000301 PTIPAGSVLT FSYPDYHATG YADPERFDPG RWETLSAKNA HHIPFGVAAN 03500351 RPCPAWRLAP VVMRAATREV LARYVLDSPV SHTRSIPHRA PCLLLPRDRP 04000401 VPDRPRRVLR TALAVRDRAE DVGRSLLQLL FGTWMVLDAR RTRPAATYFA 04500451 RYDTEGRPLD GDHGSPGTAA GPGQAPATCP YTGRSA

Alphafold2

.pdb

.fasta

Heme Docked

PDBj

CYP1044

>CYP1044A1 Streptomyces sp. RK95-74 (taxid:1934390)---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----No accession number
>CYP1044A3 Streptomyces sp. CNH287Int. J. Mol. Sci. 2020, 21(13), 4814; https://doi.org/10.3390/ijms21134814---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSTQPPAPSG TDHAAPLDPQ SESFRTCPYA AYAEVRKTSP VVHQAALDEW 00500051 IVVGRDEIES VQRDHAHFTS RYNLDGAYPF SPEARAVLED SLFFRVALYN 01000101 VEPPAHTRFR TLISEYFSPR NLRALEPAVR RTADRLAQGI SGAGEADLLQ 01500151 EFAYPLPMTV ICDLIGIPEQ DRAQVKEWNN QWLALQVVPL PGEQQVHCAR 02000201 NVVEYERYVL RLLRERRDHP ADDLLTVLAN AAAEEDPVCA VEDAVVALRV 02500251 MIAAGHETTT NLIGNTVWHL LEDRALWEAL VADSALIPAA VEEGLRFDSS 03000301 VQGAPRVATE AVKVGGTEIP AGGQVRVMFA AAGRDPEWVQ DPASFRLDRQ 03500351 GPPRHLGFGH GIHFCVGAGL ARLETRIALE TLTGRFPSLR LAEGFTPEHL 04000401 PGGFVFRGLG ALPVAWS

Alphafold2

.fasta

Heme Docked

PDBj

CYP1045

>CYP1045A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----No accession number
>CYP1045A2 (HM038106.1)---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MTTEATPTFQ QADDALIKLL SPPFPDDPFP IYETLQSVNR VHKSALGIYA 00500051 LSGYEEVTAL LKMPDVHSGA RAAAQMREDW ADHISLRMYL NSMVTLNAPD 01000101 HGRVRGLASR VFTPNKIKKM QPAVERRTDE LINDIIEKSA GGEPVDLVEM 01500151 LAMPFPVAVI SDMLGLPYED GKRTWELADD WSRVFSGIYT EEDLVVADSA 02000201 AEELTGYFRD VIKAVRAEPK DDLMSSLVQE ATNGKLDEEE LLALILFLFT 02500251 AGFAATTNLI ATGVLALMEH PDELKRWRAD KSITPTAVEE LLRHTAHTTA 03000301 SSRLTTRPIT IGGTEIPEGV LVLALLSAAN RDPAKFPDPH RLDLTRDNGT 03500351 HLSFSAGGHF CFGGSLARME AADLFPKLID TFATMELAGT PGRRAIMGLT 0400

Alphafold2

.fasta

Heme Docked

PDBj

CYP1046

>CYP1046A1---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSVDRTACPG QPSVPPGEGM LTHSRALRFW LDPANLAARR EQAGPVVPTR 00500051 TGPATAFQVN DPALLRKIGT DEDTFRFWGP DPSLRDFTED GVVGLEGAAH 01000101 RKRRAVMRPA FSASRLTTLG PAAQARTRRL LAGLPADRPL DMRMEMSRLA 01500151 CGLLVSCVLN SELAPDTLSR IASARSTLSS GMFWRYALAP WPWVPVPRRR 02000201 ACRRALAELD EAVRQLLARH QPHPDGRDLV SVLEAATPEN PRVVQRDVRA 02500251 LLIAGMETSA STLAWACYEL GRHPHYQQAL RDEADAAPDP SRLHADQLPL 03000301 ATAFVQEVTR LHGIPFLVRR TRHQTVQGGV RIPAGAVVTL PLGALRRDRD 03500351 RYRDPDAFDP KRWLPHAEPP PAPTALLAYG LGPRYCPGAA AADAMLPVAL 04000401 ATLAGSRTLR PARPNRKIGM SLELTPTPKG LTMYATPR

Alphafold2

.pdb

.fasta

Heme Docked

PDBj

CYP1047

>CYP1047A1? (WP_030700517.1 Streptomyces griseus)---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MSTQTGPALG TPPRGHAFVP GPRGLPLVGN LPQFGKNPLA FFELLRGHGD 00500051 MVRWRFGRKR CVFLADPDLV GELLTETERT FDQPRLGIAF RTVLGNGMLV 01000101 ARGRDWRRKR SLVQPSVRPK QVTSYATTMA GCAVELADRL ADGQRIDVKR 01500151 EMSALTQKIA VRTIFGVDTP ADSEAMGRAM DVAQMEIGKE FAGLGALLPD 02000201 WVPTPGRTRI RKAAAVIDAE VRRVVARHRD GDEERPDLLS RLLTAVDESG 02500251 TRLSDEEIRD EAVTLYIGGH ETTSTTLVWA WYLLARNPRV REALAEELDR 03000301 VLGDRDPGFG DYAQLTYAQA VVKETLRLFP AVWLITGIAK EGATIGGLPV 03500351 AEGTRVWSSQ WATHRDARWF PEPEEFRPER WDAESGDAIP EYAWFPFGGG 04000401 PRVCIGTRFA MVESVLLLAV LARRFTLDVD PGEITPLTGL TLQPDRDVLA 04500451 TVRAR
>CYP1047A (Streptomyces lysosuperificus ATCC 31396) Int. J. Mol. Sci. 2020, 21(13), 4814; https://doi.org/10.3390/ijms21134814---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 VTATLHPGTR GGGPRRWPLL GNLPAFARDP LAFFESLRDD HGDWVPWSLG 00500051 PKRNVLVSLP EHAGELLGAV ESTFRPTELG WAFHQLLGDG VVVATGDDWR 01000101 RKRALVQPAV RPRQVRSYAA TMVECADALA GGWREGTRID VHREMAGLTQ 01500151 RIAVRTLFGS DAAGREAPIS AAMATAQREL GAEFRGLTLF LPPWVRTPGR 02000201 RRMREAVAVL DREIEHVIRE HEAASAAGAE RDDLLSRLLA ARDEHGGPLS 02500251 RKELRDESIT LYIGGHETTS TTLTWAWQLL SGAPEARARL TEELDRVLGG 03000301 RLPEYDDYAR LPWTRQVVKE TLRIYPPIWL ISAVATEGAT LGGRPVPAGT 03500351 SVWTSPWSVH RDRRWFPEPE AFRPERWDDD APHPVPEHAW FPFGGGPRAC 04000401 LGARFALVEA ALVLAVLGQR FHLDSGSERA GVFPGLTLQP DRPVLATLRR 04500451 PAGAPEA

Alphafold2

.fasta

Heme Docked

PDBj

CYP1048

>CYP1048A1 (MBD9690089.1 Streptomyces caniscabiei)---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MTVPSPLADP SIVPDPYPVY ADLAQRRPVH WVERLNAWAV LTYADCAAGL 00500051 KDPRLTADRG TEVLAAKFPG QPLPPDNIFH RWTKNVVMYT DPPLHDALRR 01000101 SVRAGFTRAA HQHYDQVLQK VAHDLVASIP AGATEIDAVP ALAAELPVRS 01500151 AVHAFGVPEE DLGFLIPRVN TIMTYHSGPK DQPVTQEIIL EKLTDLHTYA 02000201 SELLQGMRGK VLPDTVIARL AAAQDGLTET TPEQTVHQLA LVFIALFAPT 02500251 TPGSLSSGTL AFARNPRQVE RFLADQACVD NTANEVLRYN ASNQFTWRVA 03000301 AKDVEMGGVR IEAGQTLALF LGSANRDANM FERPNDFDLD RPNSARHLSF 03500351 GQGVHACLAA QLISLQLKWF YVALLNRFPG IRTAGEPIWN ENLEFRSLRS 04000401 LPLSLR

Alphafold2

.fasta

Heme Docked

PDBj 1.2Å

4tpn

CYP1048A1 (P450 TxtE)4TPN 1.18A4TPO 1.13A4L36 2.10A5D40 1.51A

CYP1049

>CYP1049A1 (YP_003609334.1)---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MAHQITLRFE DGVTRFIDCE EGERVTDAAI RARINIPLDC RDGVCGTCKA 00500051 VCESGEYVLG DCVEDALSPD EVSARKVLTC QMSPRSDCVI QIATISDVSG 01000101 TGPASHKGRI VACQRASDTT IAFAVELEDR ADLSFLPGQY VNVQVPGTDQ 01500151 TRSYSFSSGP SEPHVSFLVR NVRQGVMSTW LCETAKVGDP IEFRGPMGSF 02000201 YLRAIERPVL FLAGGTGLAP FLSMLDKIVE DGGSPYPIHM ILGVNSDEDL 02500251 VGIDRLETYA QRLPNFTYAC TVSNADSAYP NKGYVTHHIG ASQLNGGDAD 03000301 VYLCGPPPMV DAVRDFLSSE GLTPRNFYYE KFAGTGLVVQ TGEERIAPVD 03500351 VDEALDLRMA LELGAAQLTM GRLSSEQLIT FRQLAEATAP FVRGRHFTDV 04000401 PRYIEANHAF HLFTIEASGN AQLIALYRQL AVQDYIARAL SDQIEIVGDI 04500451 VQQHRDIVAA FELGDLNAAR DVIALHALHS KATMSRALER MATAKTAPVA 05000501 AAAPAPAPVL PAAVPQSAPQ VCPFSGSTLP AYSHELDWPD GLEPFKVVDD 05500551 GSQGDPYEHY RWMREHAPVL RCQSATSDVW FLSRYDDVYQ AIRNPKLFSS 06000601 EVVSPPPLTF LTLFDAPDHS RLRKVVQPSF LPLALDPFID QIAQRAEDLL 06500651 DAMIAKGGGD VVNDFAIPLS ISTISTMIDV PNEDEEKMKF WSDETFSYFG 07000701 RLARNAPGTG TDEQSAKAFF AYLKEAMERL AHTDSQSIGG HIARMWKDGL 07500751 LSEKEAKELC AFVFIAGHDT TTILVANAFR MFAEQPNLLR RLRENPADAE 08000801 RYVEEVARYR GTVQRVSRIT TEATTIAGVD LPKGAVVRLL LSAANRDSRK 08500851 FADGETFDID RDSSGHLGFG NGMHKCLGAP LAKLETLIAT KALARKIGEI 09000901 ALDPARPIQY VRGNNLTNSG PEHLYVKLGA LSA

Alphafold2

.fasta

Heme Docked

PDBj

CYP1050 (may be CYP107 family)

>CYP1050A1 (UPU40837.1 Rhodococcus qingshengii JCM 15477)---- 1234567890 1234567890 1234567890 1234567890 1234567890 ----0001 MTHTVDDTGD LALAVNPFDP TFKADPYPVY ARLRTELPIH RSALGAWIVA 00500051 DYTSCDKVLR SRLFGKDFAN STFFDHLTSM MGEDMPPFLG LGIDGDARPF 01000101 MLTDPPEHTR LRGLVSDAFT RSTTTSMDDI VLSAASSAVR HLEHCTDAVS 01500151 EVAEPFPVEV LSSILGIPDK DRGRFSEWSN LVAGVLDINF AIPKEVADRR 02000201 SAAIEESIDY FRTLATSGNA PEGLVRRLSE VSHGGDQLSV DEIAATCLLI 02500251 TVAGQETTSN TIGNMLITFS RHADQFEQVR ANPQFIENAV AEVLRFEPPA 03000301 HEAGRIALED CEVSGANITK GDAVMVLLAS GNREAVERGD TFSVTRPDVS 03500351 SLSYGRGIHH CLGSALANSM LQHFLRELSQ RYRSIEVAEP INYKPGMGLR 04000401 GPETLSVAVS R
100% to Crystal structure with 3WEC100% to [Rhodococcus erythropolis]Sequence ID: BAN59735.1

Alphafold2

.fasta

Heme Docked

PDBj 2.5Å

3wec

CYP1050A1

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