Senthil is a Tenured Professor in Anesthesiology and Executive Vice-Chair of Clinical Quality, Patient Safety and Clinical Research, Department of Anesthesiology & Perioperative Medicine, University of Pittsburgh Medical Center (UPMC), Pittsburgh, Pennsylvania. Senthil is also the Director of Perioperative Research and Director of Perioperative Genomics at University of Pittsburgh School of Medicine. 

Senthil has conducted >40 clinical research studies on improving perioperative outcomes. Senthil and his team had received NIH, FAER, APSF, foundation, industry and institutional grants for their research projects. He has >150 publications and book chapters, and >10 US and European patents on opioid safety. His current research focus is on opioid pharmacogenetics, improving safety of opioids and personalizing surgical pain relief.