PS 366 Research Laboratory High School for Bioinformatics & Life Sciences, Buffalo, NY
Suzan Habtezion is a junior attending Research Laboratory High School in Buffalo, New York. This was her third year being a part of the UB SEPA research project. She is planning to attend UB as a Biochemistry major.
Armaad Humphrey is a junior attending Research Laboratory High School in Buffalo, New York. He had originally been interested in studying astrophysics, but is now hoping to attend University of Pennsylvania as a in biomedical sciences major.
Annotation of the Bacillus anthracis str. Ames Genome including Locus Tags BA_0053 and BA_2000
Advisor: Kira Mioducki
Student Researchers: Suzan Habtezion and Armaad Humphrey
Abstract: Two genes represented by locus tags BA_0053 and BA_0055 from the bacteria Bacillus anthracis str. Ames were annotated using the collaborative genome annotation website GENI-ACT. This bacterium is a nonmotile bacteria that forms spores which can be used in the Biological weapon, Anthrax. The Genbank proposed gene product name for each gene was assessed in terms of the general genomic information, amino acid sequence-based similarity data, and structure-based evidence from the amino acid sequence. Cellular localization data was also used to determine proper annotation. The Genbank proposed gene product name did not differ significantly from the proposed gene annotation for each of the genes in the group and as such, the genes appear to be correctly annotated by the database. Both genes play a role in spore formation with potential involvement in toxin-antitoxin systems.
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