NExT Study

About

The purpose of the NExT study is to test two different types of TMS and determine whether they can improve the outcomes of Exposure and Response Prevention (ERP). ERP is very effective and is considered the frontline treatment for OCD, though many do not fully benefit from it. TMS has been studied for adults with OCD and for youth with other mental health disorders, but has not yet been tested for youth with OCD. We hope that this study will result in additional treatment options for youth and young adults with OCD.

Who can participate

You may be eligible to participate if you or your child:

• Is 12-21 years old

• Has symptoms of OCD

• Is right-handed

Common OCD symptoms include:

• Thoughts that get “stuck” in your head

• Feeling driven to do or repeat things such as tapping, checking, or hand-washing over and over

• Fears of contamination, germs, or harm

• Concerns related to perfectionism

• Feeling that things are “not just right” unless they are done in a certain way

What is involved

Participants in NExT are randomly assigned to one of three conditions. In two conditions, participants receive different forms of active (real) TMS. In the third condition, participants receive sham (fake) TMS. All participants will receive ERP. Treatment takes place daily (Monday-Friday) for about two weeks. Participants will also complete interviews, questionnaires, two brain scans (MRIs), and computer tasks, for which their time will be compensated.