Reproductive dysfunction

Biomarkers of Chemical Exposure at Aamjiwnaang - This study was co - conducted by researchers at the University of Michigan School of Public Health and the Aamjiwnaang Environment Office (Sharilyn Johnston, Christine Rogers, Wilson Plain Jr.) . We thank the study partic ipants for their interest and time , and Chief Christopher Plain and Band Council members for their support . We also thank Dr. Fiona Miller, Dr. Stuart Batterman, Dr. Sergei Chernyak, Dr. Don Patterson, Dr. Amy Schulz, Dr. Howard Hu, Lisa Letourneau, Mozhgo n Rajaee, Jessica Barno, Caitlyn Kowalsky and Lawrence Kowalsky for technical assistance. Funding for this study was received from the University of Michigan Rackham Graduate Program, the U.S. NIEHS Environmental Toxicology Research Training Grant (T32 ES 07062) , the Great Lakes Commission’s GLAD program, the Michigan Institute of Clinical Health Research’s CTSA program (UL1RR024986) , and the University of Michigan School of Public Health

Co-Formulants in Glyphosate-Based Herbicides Disrupt Aromatase Activity in Human Cells below Toxic Levels - Nicolas Defarge, Eszter Takács, Verónica Laura Lozano, Robin Mesnage, Joël Spiroux de Vendômois, Gilles-Eric Séralini and András Székács

Contribution of environmental factors to the risk of male infertility - Study shows that environmental factors contribute to the severity of infertility, and that this may worsen the effects of pre-existing genetic or medical risk factors.[Oliva A, et al. 2001. Hum Reprod;16(8):1768-76]

Effect of Endosulfan on Male Reproductive Development - Male school children exposed to the highly toxic insecticide endosulfan showed delayed sexual maturity compared with similar children who were not exposed. [Saiyed, H et al. 2003. Environ Health Perspect 111:1958-1962]

Effects of neonicotinoid insecticides on hormone production during pregnancy - Elyse Caron-Beaudoin, J Thomas Sanderson, Rachel Viau, Cathy Vaillancourt, Andrée-Anne Hudon-Thibeault

Exposure to nonpersistent insecticides and male reproductive hormones. - Study found high levels of the urinary metabolites of chlorpyrifos (TCPY) and carbaryl and naphthalene (1N) correlate directly with low levels of testosterone in male subjects.[Meeker JD, et al. 2006. Epidemiology;17(1):61-8]

Geographic differences in semen quality of fertile U.S. males. - F irst study in the United States to compare semen quality among study centers using standardized methods and strict quality control. Data suggest that sperm concentration and motility may be reduced in semirural and agricultural areas relative to more urban and less agriculturally exposed areas.[Swan, S. et al. 2003. Environ Health Perspect; 111(4): 414–420]

Glyphosate exposure in pregnancy and shortened gestational length: a prospective Indiana birth cohort study - S. Parvez, R. R. Gerona, C. Proctor, M. Friesen, J. L. Ashby, J. L. Reiter, Z. Lui and P. D. Winchester

Methoxychlor Disrupts Uterine Hoxa10 Gene Expression. - One common mechanism by which endocrine disrupting chemicals produce lasting reproductive tract defects is through permanent alteration of developmental gene expression.  [Fei, X. et al. 2005. Endocrinology 146(8): 3445-3451]

Organochlorine Pesticides and Risk of Endometriosis: Findings from a Population-Based Case–Control Study - Citation: Upson K, De Roos AJ, Thompson ML, Sathyanarayana S, Scholes D, Barr DB, Holt VL. 2013. Organochlorine pesticides and risk of endometriosis: findings from a population-based case–control study. Environ Health Perspect 121:1319–1324;  http://dx.doi.org/10.1289/ehp.1306648

Risk factors for female infertility in an agricultural region. - Mixing and applying herbicides 2 years before attempting conception was more common among infertile women. These results suggest that certain agricultural, residential and lifestyle choices may modify the risk of female infertility. [Greenlee AR, et al. 2003. Epidemiology;14(4):429-36]

Semen quality in relation to biomarkers of pesticide exposure. - Findings  suggest associations between current-use pesticides and reduced semen quality suggest that agricultural chemicals may have contributed to the reduction in semen quality in fertile men from mid-Missouri reported previously. [Swan, S.H. et al. 2003. Environ Health Perspect; 111(12): 1478–1484]

Synergistic Disruption of External Male Sex Organ Development by a Mixture of Four Antiandrogens - Study found the effect of combined exposure to four selected chemicals on malformations of external sex organs was synergistic, and the observed responses were greater than would be predicted from the toxicities of the individual chemicals.  [Christiansen, S. et al. 2009. Environ Health Perspect 117:1839-1846]