NIH AG study & farmer-related research

A cohort study of pesticide poisoning and depression in colorado farm residents - Finds pesticide poisoning was significantly associated with depression in three years of follow-up; Beseler CL, Stallones L., Department of Epidemiology, Department of Environmental, Agricultural and Occupational Health, University of Nebraska Medical Center, Omaha (C.L.B.) and Colorado State University, Fort Collins (L.S.); Annals of Epidemiology. 2008 Oct;18(10):768-74.

Agricultural pesticide use and pancreatic cancer risk in the Agricultural Health Study cohort - Finds the herbicides EPTC and pendimethalin are associated with pancreatic cancer.  [Andreotti, G., et al. 2009. Int J Cancer. 124(10):2495-500.]

Agricultural pesticide use and risk of t(14;18)-defined subtypes of non-Hodgkin lymphoma. - Finds the risk of t(14;18)-positive NHL subtype is significantly elevated among farmers who used animal insecticides, crop insecticides, herbicides and fumigants . No increased risk of t(14;18)-negative NHL subtype for these pesticides, which may explain some of the inconsistencies in epidemiological study of NHL and pesticide exposure. Find risk increases with longer duration of use. [Chiu, B., et al. 2006. Blood 108(4):1363-1369]

Association of occupational exposures with cardiovascular disease among US Hispanics/Latinos - Catherine M Bulka, Martha L Daviglus, Victoria W Persky1, Ramon A Durazo-Arvizu, James P Lash, Tali Elfassy, David J Lee, Alberto R Ramos, Wassim Tarraf, Maria Argos

Cancer incidence among male pesticide applicators in the Agricultural Health Study cohort exposed to diazinon - Using the Agricultural Health Study cohort, an association is found for lifetime exposure days to diazinon and lung cancer cases. [Beane Freeman, L.E., et al. 2005. American Journal of Epidemiology 162(11):1070-1079.]

Cancer incidence among male pesticide applicators in the Agricultural Health Study cohort exposed to diazinon - Using the Agricultural Health Study cohort, an association is found for lifetime exposure days to diazinon and leukemia cases.[Beane Freeman, L.E., et al. 2005. American Journal of  Epidemiology 162(11):1070-1079]

Cancer incidence among pesticide applicators exposed to dicamba in the Agricultural Health Study - [Samanic, C., et al. 2006. Environ Health Perspect 114(10):1521-1526.]

Cancer mortality among Iowa farmers: recent results, time trends, and lifestyle factors (United States) - Cancer mortality among farmers shows an excess of deaths for cancers of the rectum (1.29 PMR). [Cerhan, J.R., et al. 1998. Cancer Causes Control 9(3):311-319.]

Carbaryl exposure and incident cancer in the Agricultural Health Study. - Finds that carbaryl exposure is associated with an elevated risk to melanoma, even after adjusting for sunlight exposure. [Mahajan, R., et al. 2007. Int J Cancer  121(8):1799-1805.]

Chemical predictors of wheeze among farmer pesticide applicators in the Agricultural Health Study. - [Hoppin, JA, DM Umbach, SJ London, et al. 2002. M J Respir Crit Care Med 165: 683-689]

Depression and pesticide exposures among private pesticide applicators enrolled in the agricultural health study - Finds  that both acute high-intensity and cumulative pesticide exposure may contribute to depression in pesticide applicators;Beseler CL, Stallones L, Hoppin JA, Alavanja MC, Blair A, Keefe T, Kamel F.; Colorado Injury Control Research Center, Department of Psychology, Colorado State University, Fort Collins, CO, USA. Environmental Health Perspectives. 2008 Dec; 116(12):1713-9.

Exposure and Interaction: The Potential Health Impacts of Using Multiple Pesticides - Sustainable Technology & Policy Program (STPP) at UCLA

Exposure to non-arsenic pesticides is associated with lymphoma among farmers in Spain - A case-control study in Spain finds that crop and animal farmers exposed to non-arsenic pesticides (carbamates, organophosphates, chlorinated hydrocarbons, triazines and triazoles, phenoxy herbicides, chlorophenols, dibenzodioxin, and dibenzofuran) have an increased risk of lymphoma [van Balen, E., et al. 2006. Occupational and Environmental Medicine 63:663-668]

Farming, pesticide use and hairy-cell leukemia. - A significant association is found between HCL and exposure to pesticides used in farming . Orgaonphosphates were positively associated with HCL.[Clavel, J., et al. 1996. Scand J Work Environ Health 22(4):285-293]

Glyphosate Exposure Linked to Respiratory Problems in Farmers - Jane A. Hoppin, David M. Umbach, Stuart Long, Stephanie J. London, Paul K. Henneberger, Aaron Blair, Michael Alavanja, Laura E. Beane Freeman, and Dale P. Sandler

Heterocyclic aromatic amine pesticide use and human cancer risk: results form the U.S. Agricultural Health Study - A prospective cohort study of the Agricultural Health Study evaluated imazethapyr, a heterocyclic aromatic amine herbicide, finding significant trend in risk with increasing lifetime exposure for bladder cancer, limited to proximal cancers.  [Koutros, S., et al. 2009. Int J Cancer 124(5):1206-1212.]

High Pesticide Exposure Events and Olfactory Impairment among U.S. Farmers - Srishti Shrestha, Freya Kamel, David M. Umbach, Laura E. Beane Freeman, Stella Koutros, Michael Alavanja, Aaron Blair , Dale P. Sandler , and Honglei Chen

Human Oral Buccal Microbiomes Are Associated with Farmworker Status And Azinphos-methyl Agricultural Pesticide Exposure - Ian B. Stanaway, James C. Wallace, Ali Shojaie, William C. Griffith, Sungwoo Hong, Carly S. Wilder, Foad H. Green, Jesse Tsai1, Misty Knight, Tomomi Workman, Eric M. Vigoren, Jeffrey S. McLean, Beti Thompson and Elaine M. Faustman

Incident Diabetes and Pesticide Exposure among Licensed Pesticide Applicators: Agricultural Health Study, 1993–2003. - Finds pesticide applicators with regular exposure to pesticides to be at a greater risk of type-2 diabetes. Seven different pesticides produced an increase in risk.  [Montgomery et al. American Journal of Epidemiology 2008 167(10):1235-1246]

Newly Disclosed Documents Show FDA Allows Livestock Antibiotics Use Despite “High Risk” to Humans - FDA’s own Review of Livestock Antibiotics Support Federal Court Decision Ordering Agency to Initiate Process to Pull Drugs from Market

Occupational exposure to organochlorine insecticides and cancer incidence in the Agricultural Health Study - Finds a significant increase in risk for NHL and lindane.[Purdue, M.P., et al. 2007. Int J Cancer 120(3):642-649]

Occupational exposure to terbufos and the incidence of cancer in the Agricultural Health Study. - A prospective cohort study of licensed pesticide applicators in Iowa and North Carolina show a suggestive association between terbufos and leukemia. [Bonner, M.R., et al. 2010. Cancer Causes Control 21(6):871-7]

Occupational pesticide exposure and subclinical hypothyroidism among male pesticide applicators - Catherine C Lerro, Laura E Beane Freeman, Curt T DellaValle, Muhammad G Kibriya, Briseis Aschebrook-Kilfoy, Farzana Jasmine, Stella Koutros, Christine G Parks, Dale P Sandler, Michael C R Alavanja, Jonathan N Hofmann, Mary H Ward

Occupational Pesticide Use and Risk of Renal Cell Carcinoma in the Agricultural Health Study - Gabriella Andreotti, Laura E. Beane Freeman, Joseph J. Shearer, Catherine C. Lerro, Stella Koutros, Christine G. Parks, Aaron Blair, Charles F. Lynch, Jay H. Lubin, Dale P. Sandler, and Jonathan N. Hofmann

Pesticide Exposure and Self-Reported Gestational Diabetes Mellitus in the Agricultural Health Study - Finds exposure of pregnant women to agricultural pesticides during the first trimester may double the risk of gestational diabetes[Saldana, T., et al. Diabetes Care. March 2007 30:529-534]

Pesticides and Atopic and Nonatopic Asthma among Farm Women in the Agricultural Health Study - [Hoppin, J.et al. 2008. American Journal of Respiratory and Critical Care Medicine Vol 177. pp. 11-18]

Pesticides and lung cancer risk in the Agricultural Health Study Cohort - Four agricultural pesticides are associated with a significant excess lung cancer risk.  [Alavanja, M.C.R., et al. 2004. American Journal of Epidemiology 160(9):876-885.]

Pesticide use and colorectal cancer risk in the Agricultural Health Study - Chlorpyrifos shows significant exposure response trend for rectal cancer.  [Lee, W.J., et al. 2007. Int J Cancer 121(2):339-346.]

Rhinitis associated with pesticide exposure among commercial pesticide applicators in the Agricultural Health Study - [R E Slager, J A Poole, T D LeVan, et al. 2009. Occup Environ Med 2009 66: 718-724]

Use of agricultural pesticides and prostate cancer risk in the Agricultural Health Study cohort - Finds significant increase risk for prostate cancer linked to butylate); coumaphos , fonofos , chlorpyrifos and phorate ; and a pyrethroid, permethrin. [Alavanja, M., et al. 2003. American Journal of Epidemiology 157:800-814.]