People

Welcome to the Keck Laboratory for Network Physiology

About

The human organism is an integrated network where complex physiologic 
systems, each with its own regulatory mechanisms, continuously interact, 
and where failure of one system can trigger a breakdown of the entire network. 
A new field, Network Physiology, is needed 
to probe the network of interactions among diverse physiologic systems.



Our research program is supported by a generous award from the W. M. Keck Foundation.


Who we are

We are a unique team of statistical physicists, neuroscientists, applied mathematicians and biomedical engineers. 

We develop new data science methodology, perform empirical analysis on large-scale physiological databases and model the dynamics of complex physiological systems.

We aim to understand basic mechanisms of physiologic control and address the fundamental question of how organ systems dynamically interact and collectively behave as a network to produce health or disease. 



In the Media




http://blog.physicsworld.com/2016/02/01/the-february-2016-issue-of-physics-world-is-now-out/

http://live.iop-pp01.agh.sleek.net/2016/01/27/revealing-the-network-within/




https://www.bostonglobe.com/ideas/2015/11/11/bringing-big-data-bear-organ-failure/Ce4o59gMx265w7UtdofooJ/story.html

https://www.bostonglobe.com/ideas/2015/11/11/bringing-big-data-bear-organ-failure/Ce4o59gMx265w7UtdofooJ/story.html




https://15c8f063-a-62cb3a1a-s-sites.googlegroups.com/site/labnetworkphysiology/NetworkPhysiology-HealthyOrbit-Nov2015.png?attachauth=ANoY7coEg58sZViTGt6THFJCWrzjEkOmvicZuv6fzgwtVTDh0IG5mWR41xv4lpeKjyYNBVcie9c4z_Imgm4XGQuqCCMccq9F8cGACabZbLe_GQhG1sbxmP0HuFNdGsEYbwXAk5BdYqHRWgtXAS9TVcvIvEN505MPRZUzUEYv8iSrqVD2ux-vgeQRzAIo2j2-zCELuPXwXEAtT2MLI1RgRgrRfjKqDNfm8PPWYcawmCxdiSVItRsJOKhhEx9XsyBFcTUGK4yOdGqR&attredirects=0  
Research lead by Plamen Ch. Ivanov credited with founding the field of Network Physiology

https://15c8f063-a-62cb3a1a-s-sites.googlegroups.com/site/labnetworkphysiology/NetworkPhysiology-HealthyOrbit-Nov2015.png?attachauth=ANoY7crd7R-sMa3aYudwwbxHFeERXKMYqoHFGEZ-NQJrd5H90qM9c2mM3oU-2bovxBycZcX6EsBXLv5i1G-BMU1OXURzqoF_ERreYIyNtYWWz3mqfbGWwyTVtTyaTh4MsJsYg-LqLO8uDzVuGBv71CadXKAC2wN8nmtsxy45AJO4oZ0EdFSJh6HyOI3NXODru6LDIytocUCcxpuTtmcCSb0-v94O2XhczDLeSdM6jMDlaXmUpDX7kRL0rtrt_hojiDPwYyulLazZ&attredirects=0



http://dailyfreepress.com/2015/09/29/interview-bu-physicist-on-creating-new-math-driven-field-of-medicine/   
BU Physicists creating a new, math-driven field of medicine

http://dailyfreepress.com/2015/09/29/interview-bu-physicist-on-creating-new-math-driven-field-of-medicine/



http://www.futurity.org/organ-atlas-1013522-2/
First Atlas of Dynamic Interactions among Organ Systems
http://www.futurity.org/organ-atlas-1013522-2/



Boston University Research Story:
http://www.bu.edu/research/articles/plamen-ivanov-network-physiology/



Other Media Reports
Media


News and Updates
http://www.wmkeck.org

                                                                
http://isinp.lakecomoschool.org/files/2016/12/Nuovo-poster-ISINP-Como-July2017-Poster.pdf

With support from the Alessandro Volta Foundation and the journal Physiological Measurement, the summer institute we organize at the Lake Como School for Advanced Studies, Como, Italy,  July 24-29, 2017 aims to address a diverse audience of graduate students, postdoctoral fellows, research scientists and faculty across a broad range of disciplines, and will discuss the challenges, current frontiers and future developments in the emerging interdisciplinary field
of Network Physiology.
"ISINP 2017 is now announced by SIAM".


http://www.dgsm.de/downloads/veranstaltungen/dgsm-kongress/DGSM2016_Programmheft.pdf
Prof. Plamen Ch. Ivanov gave the keynote opening talk entitled "The New Field of Network Physiology: Redefining Sleep and Wake Through Networks of Organ Interactions", at the 24th Annual Meeting of the German Sleep Society, 2016, Dresden, Germany, 2 Dec. 2016, to an  audience of 2300 medical and clinical specialists and health industry representatives.



Community




http://iopscience.iop.org/1367-2630

Special Issue (2014-2016):


The first focus issue in the literature devoted to Network Physiology
and Network Medicine. Including 26 original publications it was one of the largest and most successful focus issues published in NJP .


http://www.openscholar.org.uk  
The Laboratory for Network Physiology actively supports openness and transparency in scientific communication. Our close collaboration with Open Scholar (http://www.openscholar.org.uk), an international organisation of research scholars promoting open science, testifies to our commitment to ethical and socially responsible academic practices.



Visitors and Seminars

Mayu Kamide, Associate Producer, and Yuji Maruyama, Director of Science
and Environment at NHK Japan Broadcasting Corporation, who work on a new  ``NHK Special'' documentary TV series with focus on the human body, visited our lab to discuss Network Physiology on July 21st, 2016.

and gave a talk on "Approaches to cerebral autoregulation: time-variability
and repeatability of the cerebral autoregulation measures" on June 27th, 2016.

Prof. Arthur McDonald, Department of Physics, Engineering Physics and Astronomy, Queen's University, Kingston, Ontario, Canada, and Nobel Prize Laureate in Physics (2015) for the discovery of neutrino oscillations and for demonstrating that neutrinos have mass, visited our group on April 26th, 2016 
to discuss the emerging field of Network Physiology.

Prof. Chung-Chuan Lo, Director, Laboratory of Theoretical Neuroscience, Institute of Systems Neuroscience, National Tsing Hua University, Taiwan, visited our group and gave a talk on "The fruit fly connectome project: efficiency and stability in a neural circuit model of the drosophila" on March 16th, 2016.

Prof. Arkady Pikovsky, Chairman, Institute of Physics and Astronomy, University of Potsdam, Germany, visited our group and gave a talk on "Collective dynamics of oscillator populations: Multifrequency ensebles and chimera states" on February 19th, 2016.

Prof. Predrag Civtanovic from the Georgia Institute of Technology visited our group and gave a talk on "Noise is your friend, how well can we resolve state space?" on November 18th, 2015.


Recent Publications

Ivanov PCh, Liu KKL, Lin A and Bartsch RP
Network Physiology: From Neural Plasticity to Organ Network Interactions.
Springer Proceedings in Physics 191
Pages 145-165   Published: 2015 

Ivanov PCh, Liu KKL, and Bartsch RP
Focus on the emerging new fields of network physiology and network medicine. 
[ PDF ]   New Journal of Physics, 2016; 18:100201. 

Lin A, Liu KKL, Bartsch RP, and Ivanov PCh. 
Delay-correlation landscape reveals characteristic time delays of brain rhythms and heart interactions [ PDF ]   Phil. Trans. R. Soc. A 374: 20150182. 

Bartsch RP, Liu KKL, Bashan A, and Ivanov PCh. 
PLOS ONE, 2015; 10(11): e0142143

Liu KKL, Bartsch RP, Lin A, Mantegna RN, and Ivanov PCh. 

Liu KKL, Bartsch RP, Ma QDY, and Ivanov PCh. 
[ PDFJournal of Physics: Conference Series2015; 640, 012013

Bartsch RP, Liu KKL, Ma QDY, and Ivanov PCh. 

Bartsch RP and Ivanov PCh.
[ PDF
Communications in Computer and Information Science 2014; 438: 270-287

Ivanov PCh and Bartsch RP. 
edited by D'Agostino G and Scala A. 
Book Series: Understanding Complex Systems Springer Complexity
Pages: 203-222   Published: 2014

Lo C-C, Bartsch RP, Ivanov PCh.
Europhysics Letters (EPL) 2013; 102(1): 10008

Bartsch RP, Schumann AY, Kantelhardt JW, Penzel T, Ivanov PCh.
Phase transitions in physiologic coupling.  [ PDF ]
Proc Natl Acad Sci USA 2012; 109(26): 10181-10186.

Bashan A, Bartsch RP, Kantelhardt JW, Havlin S, Ivanov PCh. 
Nature Communications 2012; 3: 702 doi: 10.1038/ ncomms1705.