Welcome to the Keck Laboratory for Network Physiology


The human organism is an integrated network where complex physiologic 
systems, each with its own regulatory mechanisms, continuously interact, 
and where failure of one system can trigger a breakdown of the entire network. 
A new field, Network Physiology, is needed 
to probe the network of interactions among diverse physiologic systems.

Our research program is supported by a generous award from the W. M. Keck Foundation.

Who we are

We are a unique team of statistical physicists, neuroscientists, applied mathematicians and biomedical engineers. 

We develop new data science methodology, perform empirical analysis on large-scale physiological databases and model the dynamics of complex physiological systems.

We aim to understand basic mechanisms of physiologic control and address the fundamental question of how organ systems dynamically interact and collectively behave as a network to produce health or disease. 

In the Media

Study in Nature Communication Biology identifies an "alphabet" of coupling forms among cortical rhythms and their network communications.
Distinct brain waves interact as a network to generate physiological states and functions
 On Lake Como is born a new science which reveals the secrets of the human body

Network Physiology: prominent scientists from different fields of medicine and science meet at Lake Como School to start a new discipline. 

(English translation by Francesco Mastromatteo)  
Research lead by Plamen Ch. Ivanov credited with founding the field of Network Physiology   
BU Physicists creating a new, math-driven field of medicine
First Atlas of Dynamic Interactions among Organ Systems

Boston University Research Story:

Other Media Reports

News and Updates

The focus of this summer institute is to integrate empirical and theoretical knowledge across disciplines with the aim to understand in different contexts -- from extensive data analyses and modeling approaches to clinical practice -- how diverse physiological systems and subsystems dynamically interact as a network to produce health and disease.
Prof. Plamen Ch. Ivanov gave the keynote opening talk entitled "The New Field of Network Physiology: Redefining Sleep and Wake Through Networks of Organ Interactions", at the 24th Annual Meeting of the German Sleep Society, 2016, Dresden, Germany, 2 Dec. 2016, to an  audience of 2300 medical and clinical specialists and health industry representatives.


Special Issue (2014-2016):

The first focus issue in the literature devoted to Network Physiology
and Network Medicine. Including 26 original publications it was one of the largest and most successful focus issues published in NJP .  
The Laboratory for Network Physiology actively supports openness and transparency in scientific communication. Our close collaboration with Open Scholar (, an international organisation of research scholars promoting open science, testifies to our commitment to ethical and socially responsible academic practices.

Visitors and Seminars

Prof. Barry C. BarishLIGO Lab, Division of Physics, Mathematics and Astronomy, Caltech, and Nobel Prize Laureate in Physics (2017) for decisive contributions to the LIGO detector and the observation of gravitational waves, visited our group on April 24th, 2018 to discuss the emerging field of Network Physiology.

Prof. Arkady Pikovsky, Chairman, Institute of Physics and AstronomyUniversity of Potsdam, Germany, visited our lab and discussed Network Physiology on March 15th, 2018.

Prof. Jörn Dunkel, Department of Mathematics, Massachusetts Institute of Technology, visited our lab and discussed Network Physiology on November 28th, 2017.

Prof. Alexander Neiman, Department of Physics and Astronomy, Neuroscience Program, Ohio University, visited our lab and gave a talk on "Collective stochastic oscillations and signal detection in tree networks of excitable elements" on November 6th, 2017.

Prof. Louis M. Pecora, head of section for Magnetic Materials and Nonlinear Dynamics in the Materials and Sensors branch, United States Naval Research Laboratory, visited our lab and gave a talk on "How to Synchronize Chaotic Systems" on October 17th, 2017.

Mayu Kamide, Associate Producer, and Yuji Maruyama, Director of Science
and Environment at NHK Japan Broadcasting Corporation, who work on a new  ``NHK Special'' documentary TV series with focus on the human body, visited our lab to discuss Network Physiology on July 21st, 2016.

and gave a talk on "Approaches to cerebral autoregulation: time-variability
and repeatability of the cerebral autoregulation measures" on June 27th, 2016.

Prof. Arthur McDonald, Department of Physics, Engineering Physics and Astronomy, Queen's University, Kingston, Ontario, Canada, and Nobel Prize Laureate in Physics (2015) for the discovery of neutrino oscillations and for demonstrating that neutrinos have mass, visited our group on April 26th, 2016 
to discuss the emerging field of Network Physiology.

Recent Publications

Garcia-Retortillo S, Rizzo R, Wang JWJL, Sitges C, Ivanov PCh. 
Journal of Applied Physiology. 2020; 129(3):419-41.

Lin A, Liu KKL, Bartsch RP, and Ivanov PCh. 
Nature Communications Biology, 2020; 3: 197. 

Podobnik B, Korošak D, Klemen MS, Stožer A, Dolenšek J, Rupnik MS, Ivanov PCh, Holme P, and Jusup M.
Biophysical Journal, 2020; 118: 1-8   

Lombardi F, Gómez-Extremera M, Bernaola-Galván P, Vetrivelan R, Saper CB, Scammell TE, and Ivanov PCh 

Wang JWJL, Lombardi F, Zhang X, Anaclet C, and Ivanov PCh. 

dos Santos Lima GZ, Lobao-Soares B, Corso G, Belchior H, Lopes SR, de Lima Prado T, Nascimento G, de França AC, Fontenele-Araújo J, and Ivanov PCh 

Dvir H, Elbaz I, Havlin S, Appelbaum L, Ivanov PCh, and Bartsch RP.     
Neuronal noise as an origin of sleep arousals and its role in sudden infant death syndrome[PDF]  Science Advances, 2018:Vol. 4, no. 4, eaar6277

Ivanov PCh, Liu KKL, Lin A and Bartsch RP
Network Physiology: From Neural Plasticity to Organ Network Interactions.
in "Emergent Complexity from Nonlinearity, in Physics, Engineering and the Life Sciences", [ PDFedited by Mantica G, Stoop R, and Stramaglia S. Springer Proceedings in Physics 191. Pages 145-165   Published: 2017 

Ivanov PCh, Liu KKL, and Bartsch RP
Focus on the emerging new fields of network physiology and network medicine. [ PDF ]   New Journal of Physics, 2016; 18:100201. 

Lin A, Liu KKL, Bartsch RP, and Ivanov PCh. 
Delay-correlation landscape reveals characteristic time delays of brain rhythms and heart interactions [ PDF ]   Phil. Trans. R. Soc. A, 2016; 374: 20150182. 

Bartsch RP, Liu KKL, Bashan A, and Ivanov PCh. 
PLOS ONE, 2015; 10(11): e0142143

Liu KKL, Bartsch RP, Lin A, Mantegna RN, and Ivanov PCh. 

Liu KKL, Bartsch RP, Ma QDY, and Ivanov PCh. 
[ PDF ]  
Journal of Physics: Conference Series2015; 640, 012013

Bartsch RP, Liu KKL, Ma QDY, and Ivanov PCh. 

Bartsch RP and Ivanov PCh.
[ PDF ]  
Communications in Computer and Information Science 2014; 438: 270-287

Bartsch RP, Schumann AY, Kantelhardt JW, Penzel T, Ivanov PCh.
Phase transitions in physiologic coupling. PDF ] (Supporting Information [PDF])
Proc Natl Acad Sci USA 2012; 109(26): 10181-10186.

Bashan A, Bartsch RP, Kantelhardt JW, Havlin S, and Ivanov PCh.
Network physiology reveals relations between network topology and physiologic functionPDF ] 
Nature Communications 2012; 3: 702 doi: 10.1038/ ncomms1705.