Welcome to the Keck Laboratory for Network Physiology
Director: Prof. Plamen Ch. Ivanov
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The human organism is an integrated network where complex physiologic
systems, each with its own regulatory mechanisms, continuously interact,
and where failure of one system can trigger a breakdown of the entire network.
A new field, Network Physiology, is needed
to probe the network of interactions among diverse physiologic systems.
Our research program is supported by a generous award from the W. M. Keck Foundation.
,Who we are
We are a unique team of statistical physicists, neuroscientists, applied mathematicians and biomedical engineers.
We develop new data science methodology, perform empirical analysis on large-scale physiological databases and model the dynamics of complex physiological systems.
We aim to understand basic mechanisms of physiologic control and address the fundamental question of how organ systems dynamically interact and collectively behave as a network to produce health or disease.
News and Updates
Led by Prof. Plamen Ch Ivanov of Boston University, Frontiers in Network Physiology aims to establish a new conceptual framework to investigate the physiological coordination and network interactions among diverse organ systems and sub-systems. Learn more:
The focus of the ISINP summer institute is to integrate empirical and theoretical knowledge across disciplines with the aim to understand in different contexts -- from extensive data analyses and modeling approaches to clinical practice -- how diverse physiological systems and subsystems dynamically interact as a network to produce health and disease.
Hosted by Prof. Jurgen Kurths, PIK Institute, Germany and Prof. R. I. Sujith, IIT Madras, India, the prestigious Critical Transitions in Complex Systems (CTCS) Webinar Series brings cutting-edge interdisciplinary research to an audience from Europe and India interested in complexity science and networks
Webinar Series ‘Network Physiology: Mapping Physiological Networks in Health and Disease’ (26 March, 27 March, 02 April, 03 April 2025) hosted by The Physiological Society, UK, and organized by Dr Alireza Mani (University College London, UK), Dr Tope Oyelade (Keele University, UK and University College London, UK) and Professor Plamen Ch. Ivanov (Boston University, USA) will present four sessions (two talks per session) with a focus on the multidisciplinary field of Network Physiology, discussing novel approaches and advances in understanding health and disease through investigations of the complex coordination and dynamic network interactions of diverse physiological systems and organs, and will outline new frontiers in physiology and medicine. [PDF]
Community
Special Issue (2019-2020)
( > 400,000 views/Downloads, 65 articles, 505 authors )
Special Issue (2017-2019)
Special Issue (2014-2016)
Focus on Network Physiology and Network Medicine
The first focus issue in the literature devoted to Network Physiology and Network Medicine. Including 26 original publications it was one of the largest and most successful focus issues published in NJP .
( > 125,000 Downloads )
The Laboratory for Network Physiology actively supports openness and transparency in scientific communication. Our close collaboration with Open Scholar (http://www.openscholar.org.uk), an international organization of research scholars promoting open science, testifies to our commitment to ethical and socially responsible academic practices.
In the Media
The American Physiological Society acknowledges the Keck Laboratory for Network Physiology for distinction in scholarship in the Journal of Applied Physiology for the article Universal spectral profile and dynamic evolution of muscle activation: a hallmark of muscle type and physiological state [PDF]
Distinct brain waves interact as a network to generate physiological states and functions
Study in Nature Communication Biology identifies an "alphabet" of coupling forms among cortical rhythms and their network communications.
On Lake Como is born a new science which reveals the secrets of the human body
Other Media Reports
Visitors and Seminars
Prof. Barry C. Barish, LIGO Lab, Division of Physics, Mathematics and Astronomy, Caltech, and Nobel Prize Laureate in Physics (2017) for decisive contributions to the LIGO detector and the observation of gravitational waves, visited our group on April 24th, 2018 to discuss the emerging field of Network Physiology.
Prof. Arkady Pikovsky, Chairman, Institute of Physics and Astronomy, University of Potsdam, Germany, visited our lab and discussed Network Physiology on March 15th, 2018.
Prof. Jörn Dunkel, Department of Mathematics, Massachusetts Institute of Technology, visited our lab and discussed Network Physiology on November 28th, 2017.
Prof. Alexander Neiman, Department of Physics and Astronomy, Neuroscience Program, Ohio University, visited our lab and gave a talk on "Collective stochastic oscillations and signal detection in tree networks of excitable elements" on November 6th, 2017.
Prof. Louis M. Pecora, head of section for Magnetic Materials and Nonlinear Dynamics in the Materials and Sensors branch, United States Naval Research Laboratory, visited our lab and gave a talk on "How to Synchronize Chaotic Systems" on October 17th, 2017.
Mayu Kamide, Associate Producer, and Yuji Maruyama, Director of Science and Environment at NHK Japan Broadcasting Corporation, who work on a new ``NHK Special'' documentary TV series with focus on the human body, visited our lab to discuss Network Physiology on July 21st, 2016.
Prof. David Simpson, Head of Human Sciences Group, Engineering and the Environment Department, University of Southampton, UK, visited our group and gave a talk on "Approaches to cerebral autoregulation: time-variability and repeatability of the cerebral autoregulation measures" on June 27th, 2016.
Prof. Arthur McDonald, Department of Physics, Engineering Physics and Astronomy, Queen's University, Kingston, Ontario, Canada, and Nobel Prize Laureate in Physics (2015) for the discovery of neutrino oscillations and for demonstrating that neutrinos have mass, visited our group on April 26th, 2016 to discuss the emerging field of Network Physiology.
Recent Publications
Plamen Ch. Ivanov and Ronny P. Bartsch Future of Sleep Medicine: Novel Insights on Sleep Regulation from Network Physiology (Part II) [PDF]
Sleep Medicine Clinics, 2024; 20: 149–164
Plamen Ch. Ivanov and Ronny P. Bartsch Future of Sleep Medicine Novel Approaches and Measures Derived from Physiologic Systems Dynamics (Part I) [PDF]
Sleep Medicine Clinics, 2024; 20: 107–120
Garcia-Retortillo S, Ivanov PCh. Dynamics of cardio-muscular networks in exercise and fatigue [PDF]
The Journal of Physiology, 2024; doi: 10.1113/JP286963 .
Garcia-Retortillo S, Abenza Ó, Vasileva F, Balagué N, Hristovski R, Wells A, Fanning J, Kattula J, and Ivanov PCh. Age-related breakdown in networks of inter-muscular coordination [PDF]
GeroScience, 2024; 1-25.
Huo C, Lombardi F, Blanco-Centurion C, Shiromani PJ, and Ivanoc PCh. Role of the Locus Coeruleus Arousal Promoting Neurons in Maintaining Brain Criticality across the Sleep-Wake Cycle [PDF]
Journal of Neuroscience, 2024; 44(35): e1939232024.
Garcia-Retortillo S, Romero-Gómez C, and Ivanov PCh. Network of muscle fibers activation facilitates inter-muscular coordination, adapts to fatigue and reflects muscle function. [PDF]
Communications Biology, 2023; 6(1): 891.
Rizzo R, Wang JWJL, Hohler AD, Holsapple JW, Vaou OE, and Ivanov PCh. Dynamic networks of cortico-muscular interactions in sleep and neurodegenerative disorders. [PDF]
Frontiers in Network Physiology, 2023; 3: 1168677.
Rizzo R, Garcia-Retortillo S, and Ivanov PCh. Dynamic networks of physiologic interactions of brain waves and rhythms in muscle activity. [PDF]
Human Movement Science, 2022; 84: 102971.
Garcia-Retortillo S, Ivanov P Ch. Inter-muscular networks of synchronous muscle fiber activation. [PDF].
Frontiers in Network Physiology, 2022; 2: 1059793.
Chen B, Ciria L, Hu C, and Ivanov PCh. Ensemble of coupling forms and networks among brain rhythms as function of states and cognition. [PDF] (Supporting Information [PDF])
Communications Biology, 2022; 5: 82.
Lin A, Liu KKL, Bartsch RP, and Ivanov PCh. Dynamic network interactions among distinct brain rhythms as a hallmark of physiologic state and function. [PDF] (Supporting Information [PDF])
Communications Biology, 2020; 3: 197.
Ivanov PCh. The New Field of Network Physiology: Building the Human Physiolome. [PDF]
Frontiers in Network Physiology, 2021; 1:711778.
Bartsch RP, Liu KKL, Bashan A, and Ivanov PCh. Network Physiology: how organ systems dynamically interact. [PDF]
PLOS ONE, 2015; 10(11): e0142143
Bashan A, Bartsch RP, Kantelhardt JW, Havlin S, Ivanov PCh. Network physiology reveals relations between network topology and physiologic function. [PDF]
Nature Communications 2012; 3: 702.
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