研究業績（2000年〜2009年）
2009年
Kimiko Kadohara, Michiko Nagumo, Shun Asami, Yoshinori Tsukumo, Hikaru Sugimoto, Masayuki Igarashi, Kazuo Nagai, Takao Kataoka
Caspase-8 mediates mitochondrial release of pro-apoptotic proteins in a manner independent of its proteolytic activity in apoptosis induced by protein synthesis inhibitor acetoxycycloheximide in human leukemia Jurkat cells
Journal of Biological Chemistry, 284(9), 5478-5487 (2009)
Yohei Takada, Kentaro Matsuo, Hirotsugu Ogura, Liming Bai, Asami Toki, Liyan Wang, Masayoshi Ando, Takao Kataoka
Odoroside A and ouabain inhibit Na+/K+-ATPase and prevent NF-κB-inducible protein expression by blocking Na+-dependent amino acid transport
Biochemical Pharmacology, 78(9), 1157-1166 (2009)
Susumu Inaba, Tadashi Eguchi, Atsushi Motegi, Kazutoshi Mizoue, Takeo Usui, Kazuo Nagai, Takao Kataoka
The cytotoxic macrolide FD-891 induces caspase-8-dependent mitochondrial release of cytochrome c and subsequent apoptosis in human leukemia Jurkat cells
Journal of Antibiotics, 62(9), 507-512 (2009)
Chieko Tsutsui, Yuriko Yamada, Masayoshi Ando, Daisuke Toyama, Jian-lin Wu, Liyan Wang, Shigeru Taketani, Takao Kataoka
Peperomins as anti-inflammatory agents that inhibit NF-κB signaling pathway
Bioorganic & Medicinal Chemistry Letters, 19(15), 4084-4087 (2009)
Takao Kataoka
Chemical Biology of inflammatory cytokine signaling
Journal of Antibiotics, 62(12), 655-657 (2009) (review)
Masayoshi Sakaino, Takao Kataoka, Shigeru Taketani
Post-transcriptional regulation of the expression of ferrochelatase by its variant mRNA
Journal of Biochemistry, 145(6), 733-738 (2009)
2008年
Yohei Takada, Kentaro Matsuo, Takao Kataoka
Gramicidin A directly inhibits mammalian Na+/K+-ATPase
Molecular and Cellular Biochemistry, 319 (1-2), 99-103 (2008)
Hirotsugu Ogura, Yoshinori Tsukumo, Hikaru Sugimoto, Masayuki Igarashi, Kazuo Nagai, Takao Kataoka
ERK and p38 MAP kinase are involved in downregulation of cell surface TNF receptor 1 induced by acetoxycycloheximide
International Immunopharmacology, 8(6), 922-926 (2008)
Hirotsugu Ogura, Yoshinori Tsukumo, Hikaru Sugimoto, Masayuki Igarashi, Kazuo Nagai, Takao Kataoka
Ectodomain shedding of TNF receptor 1 induced by protein synthesis inhibitors regulates TNF-α-mediated activation of NF-κB and caspase-8
Experimental Cell Research, 314(6), 1406-1414 (2008)
Liyan Wang, Liming Bai, Takashi Nagasawa, Toshiaki Hasegawa, Xiaoyang Yang, Jun-ichi Sakai, Yuhua Bai, Takao Kataoka, Seiko Oka, Katsutoshi Hirose, Akihiro Tomida, Takashi Tsuruo, Masayoshi Ando
Bioactive triterpene saponins from the roots of Phytolacca americana
Journal of Natural Products, 71(1), 35-40 (2008)
2007年
Ming Zhao, Liming Bai, Liyan Wang, Asami Toki, Toshiaki Hasegawa, Midori Kiuchi, Mariko Abe, Jun-ichi Sakai, Ryo Hasegawa, Yuhua Bai, Tomokazu Mitsui, Hirotsugu Ogura, Takao Kataoka, Seiko Oka, Hiroko Tsushima, Miwa Kiuchi, Katutoshi Hirose, Akihiro Tomida, Takashi Tsuruo, Masayoshi Ando
Bioactive cardenolides from the stems and twigs of Nerium oleander
Journal of Natural Products, 70(7), 1098-1103 (2007)
Na Li, Jian-lin Wu, Toshiaki Hasegawa, Jun-ichi Sakai, Liming Bai, Liyan Wang, Saori Kakuta, Yumiko Furuya, Hirotsugu Ogura, Takao Kataoka, Akihiro Tomida, Takashi Tsuruo, Masayoshi Ando
Bioactive polyketides from Peperomia duclouxii
Journal of Natural Products, 70(6), 998-1001 (2007)
Na Li, Jian-lin Wu, Toshiaki Hasegawa, Jun-ichi Sakai, Liming Bai, Liyan Wang, Saori Kakuta, Yumiko Furuya, Hirotsugu Ogura, Takao Kataoka, Akihiro Tomida, Takashi Tsuruo, Masayoshi Ando
Bioactive lignans from Peperomia duclouxii
Journal of Natural Products, 70(4), 544-548 (2007)
Liming Bai, Liyan Wang, Ming Zhao, Asami Toki, Toshiaki Hasegawa, Hirotsugu Ogura, Takao Kataoka, Katutoshi Hirose, Junichi Sakai, Jiao Bai, Masayoshi Ando
Bioactive pregnanes from Nerium oleander
Journal of Natural Products, 70(1), 14-18 (2007)
Ming Zhao, Liwei Fu, Na Li, Wanxia Tang, Minjie Li, Toshiaki Hasegawa, Hirotsugu Ogura, Takao Kataoka, Katutoshi Hirose, Masayoshi Ando
The ursane-, oleanane-, dammarane-, lupene-, and taraxasterane-type triterpenes isolated from Nerium oleander and their biological activities
Recent Progress in Medicinal Chemistry. Studium Press LLC, USA, 16, 83-107 (2007)
2006年
Shujun Zhang, Ming Zhao, Liming Bai, Toshiaki Hasegawa, Jinlan Wang, Liyan Wang, Hongyan Xue, Qiagang Deng, Fenglan Xing, Yuhua Bai, Jun-ichi Sakai, Jiao Bai, Rei Koyanagi, Yoshinori Tsukumo, Takao Kataoka, Kazuo Nagai, Katutoshi Hirose, Masayoshi Ando
Bioactive guaianolides from Siyekucai (Ixeria chinensis)
Journal of Natural Products, 69(10), 1425-1428 (2006)
Ming Zhao, Shujun Zhang, Liwei Fu, Na Li, Jiao Bai, Junichi Sakai, Liyan Wang, Wanxia Tang, Toshiaki Hasegawa, Hirotsugu Ogura, Takao Kataoka, Seiko Oka, Miwa Kiuchi, Katutoshi Hirose, Masayoshi Ando
Taxasterane- and ursane-type triterpenes from Nerium Oleander and their biological activities
Journal of Natural Products, 69(8), 1164-1167 (2006)
Jian-lin Wu, Na Li, Toshiaki Hasegawa, Jun-ichi Sakai, Tomokazu Mitsui, Hirotsugu Ogura, Takao Kataoka, Seiko Oka, Miwa Kiuchi, Akira Tomida, Takashi Tsuruo, Minjie Li, Wanxia Tang, Masayoshi Ando
Bioactive secolignans from Peperomia dingygulensis
Journal of Natural Products, 69(5), 790-794 (2006)
2005年
Tomokazu Mitsui, Yasunobu Miyake, Hideaki Kakeya, Yujiro Hayashi, Hiroyuki Osada, Takao Kataoka
RKTS-33, an epoxycyclohexenone derivative that specifically inhibits Fas ligand-dependent apoptosis in CTL-mediated cytotoxicity
Bioscience, Biotechnology, and Biochemistry, 69(10), 1923-1928 (2005)
Kimiko Kadohara, Yoshinori Tsukumo, Hikaru Sugimoto, Masayuki Igarashi, Kazuo Nagai, Takao Kataoka
Acetoxycycloheximide (E-73) rapidly induces apoptosis mediated by the release of cytochrome c via activation of c-jun N-terminal kinase
Biochemical Pharmacology, 69(4), 551-560 (2005)
Austin Dohrman, Takao Kataoka, Solange Cuerin, Jennifer Q Russell, Jürg Tschopp, Ralph C. Budd
c-FLIPL regulates CD8+ T cell activation through caspase-8-dependent NF-κB activation
Journal of Immunology, 174(9), 5270-5278 (2005)
Takao Kataoka
The caspase-8 modulator c-FLIP
Critical Reviews in Immunology, 25(1), 31-58 (2005) (review)
Jian-lin Wu, Na Li, Toshiaki Hasegawa, Jun-ichi Sakai, Saori Kakuta, Wanxia Tang, Seiko Oka, Miwa Kiuchi, Hirotsugu Ogura, Takao Kataoka, Akihiro Tomida, Takashi Tsuruo, Masayoshi Ando
Bioactive tetrahydrofuran lignans from Peperomia dindygulensis
Journal of Natural Products, 68(11), 1656-1660 (2005)
Liwei Fu, Shujun Zhang, Na Li, Jinlan Wang, Ming Zhao, Junichi Sakai, Toshiaki Hasegawa, Tomokazu Mitsui, Takao Kataoka, Seiko Oka, Miwa Kiuchi, Katutoshi Hirose, Masayoshi Ando
Three new triterpenes from Nerium oleander and biological activity of the isolated compounds
Journal of Natural Products, 68(2), 198-206 (2005)
2004年
Takao Kataoka, Jürg Tschopp
N-terminal fragment of c-FLIP(L) processed by caspase-8 specifically interacts with TRAF2 and induces activation of the NF-κB signaling pathway
Molecular and Cellular Biology, 24(7), 2627-2636 (2004)
Tomokazu Mitsui, Yasunobu Miyake, Hideaki Kakeya, Hiroyuki Osada, Takao Kataoka
ECH, an epoxycyclohexenone derivative that specifically inhibits Fas ligand-dependent apoptosis in CTL-mediated cytotoxicity
Journal of Immunology, 172(6), 3428-3436 (2004)
Lorraine A. O’Reilly, Upulie Divisekera, Kim Newton, Karen Scalzo, Takao Kataoka, Hamsa Puthalakath, Mika Ito, David C. S. Huang, Andreas Strasser
Modification and intracellular trafficking of FADD/MORT1 and caspase-8 after stimulation of T lymphocytes
Cell Death and Differentiation, 11(12), 724-736 (2004)
Tanapat Palaga, Takao Kataoka, Kazuo Nagai
Extracellular ATP inhibits apoptosis and maintains cell viability by inducing autocrine production of interleukin-4 in a myeloid progenitor cell line
International Immunopharmacology, 4(7), 953-961 (2004)
Shin-ichiro Takayanagi, Takao Kataoka, Osamu Ohara, Michio Oishi, M. Tien Kuo, and Toshihisa Ishikawa
Human ATP-binding cassette transporter ABCC10: expression profile and p53-dependent upregulation
Journal of Experimental Therapeutics and Oncology, 4(3), 239-246 (2004)
Takao Kataoka
Cell-permeable small compounds that modulate Fas-mediated apoptosis
Recent Research Development in Biochemistry, 5, 129-140 (2004) (review)
満井 智和, 片岡 孝夫
CTLによる細胞傷害におけるFas依存性アポトーシスの制御
臨床免疫, 42(4), 481-484 (2004)
2003年
Masashige Bando, Makoto Hasegawa, Yasunori Tsuboi, Yasunobu Miyake, Masashi Shiina, Mika Ito, Hiroshi Handa, Kazuo Nagai, Takao Kataoka
The mycotoxin penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8 in death-inducing signaling complex
Journal of Biological Chemistry, 278(8), 5786-5793 (2003)
Yasunobu Miyake, Hideaki Kakeya, Takao Kataoka, Hiroyuki Osada
Epoxycyclohexenone inhibits Fas-mediated apoptosis by blocking activation of pro-caspase-8 in the death-inducing signaling complex
Journal of Biological Chemistry, 278(13), 11213-11220 (2003)
Hideaki Kakeya, Yasunobu Miyake, Satoshi Kishida, Mitsuru Shoji, Yujiro Hayashi, Takao Kataoka, Hiroyuki Osada
Novel non-peptide inhibitors targeting death receptor-mediated apoptosis
Bioorganic & Medicinal Chemistry Letters, 13(21), 3743-3746 (2003)
Yohsuke Higuchi, Fumio Shimoma, Rei Koyanagi, Kouji Suda, Tomokazu Mitsui, Takao Kataoka, Kazuo Nagai, Masayoshi Ando
Synthetic approach to exo-endo cross-conjugated cyclohexadienones and its application to the syntheses of dehydrobrachylaenolide, isodehydrochmaecynone, and trans-isodehydrochamaecynone
Journal of Natural Products, 66(5), 588-594 (2003)
2002年
Takao Kataoka, Mika Ito, Ralph C. Budd, Jürg Tschopp, Kazuo Nagai
Expression level of c-FLIP versus Fas determines susceptibility to Fas ligand-induced cell death in murine thymoma EL-4 cells
Experimental Cell Research, 273(2), 256-264 (2002)
Masashige Bando, Yasunobu Miyake, Masashi Shiina, Masaaki Wachi, Kazuo Nagai, Takao Kataoka
Actin cytoskeleton is required for early apoptosis signaling induced by anti-Fas antibody but not Fas ligand in murine B lymphoma A20 cells
Biochemical and Biophysical Research Communications, 290(1), 268-274 (2002)
Susanne M. A. Lens, Takao Kataoka, Karen A. Fortner, Antoine Tinel, Isabel Ferrero, Robson H. MacDonald, Michel Hahne, Friedrich Beermann, Antoine Attinger, Hans-Acha Orbea, Ralph C. Budd, Jürg Tschopp
The caspase-8 inhibitor c-FLIPL modulates T cell receptor-induced proliferation but not activation-induced cell death of lymphocytes
Molecular and Cellular Biology, 22(15), 5419-5433 (2002)
Izuru Ando, Yoshinori Tsukumo, Tetsuya Wakabayashi, Sachiko Akashi, Kensuke Miyake, Takao Kataoka, Kazuo Nagai
Safflower polysaccharides activate the transcription factor NF-κB via Toll-like receptor 4 and induce cytokine production by macrophages
International Immunopharmacology, 2(8), 1155-1162 (2002)
Takao Kataoka, Kazuo Nagai
Molecular dissection of cytotoxic functions mediated by T cells. In Molecular Anatomy of Cellular Systems
I. Endo et al., (editors), Elsevier Science B. V. pp. 13-23 (2002)
片岡 孝夫
T細胞による細胞殺傷機能発現の制御機構に関する研究
日本農芸化学会誌, 76(10), 922-929 (2002)
2001年
Takao Kataoka, Nils Holler, Olivier Micheau, Fabio Martinon, Antoine Tinel, Kay Hofmann, Jürg Tschopp
Bcl-rambo, a novel Bcl-2 homologue that induces apoptosis via its unique C-terminal extension
Journal of Biological Chemistry, 276(22), 19548-19554 (2001)
Alois Fürstner, Jaroslaw Grabowski, Christian W. Lehmann, Takao Kataoka, Kazuo Nagai
Synthesis and biological evaluation of nolylprodigiosin and macrocyclic prodigiosin analogues
ChemBioChem, 2(1), 60-68 (2001)
2000年
Takao Kataoka, Ralph C. Budd, Nils Holler, Margot Thome, Fabio Martinon, Martin Irmler, Kim Burns, Michael Hahne, Norman Kennedy, Magdalena Kovacsovics, Jürg Tschopp
The caspase-8 inhibitor FLIP promotes activation of NF-κB and Erk signaling pathways
Current Biology, 10(11), 640-648 (2000)
Takao Kataoka, Atsushi Yamada, Masashige Bando, Tsuyoshi Honma, Kazutoshi Mizoue, Kazuo Nagai
FD-891, a structural analogue of concanamycin A that does not affect vacuolar acidification or perforin activity, yet potently prevents cytotoxic T lymphocyte-mediated cytotoxicity through the blockage of conjugate formation
Immunology, 100(2), 170-177 (2000)
Takao Kataoka, Kazuo Nagai
Involvement of FK506-sensitive and insensitive granule exocytosis pathways in perforin-dependent target cell lysis mediated by a CD8+ CTL clone
Immunology Letters, 72(1), 49-52 (2000)
Hikaru Sugimoto, Takao Kataoka, Masayuki Igarashi, Masa Hamada, Tomio Takeuchi, Kazuo Nagai
E-73, an acetoxyl analogue of cycloheximide, blocks the tumor necrosis factor-induced NF-κB signaling pathway
Biochemical and Biophysical Research Communications, 277(2), 330-333 (2000)
Shigeto Kawai, Takao Kataoka, Hikaru Sugimoto, Akito Nakamura, Takafumi Kobayashi, Kei Arao, Yohsuke Higuchi, Masayoshi Ando, Kazuo Nagai
Santonin-related compound 2 inhibits the expression of ICAM-1 in response to IL-1 stimulation by blocking the signaling pathway upstream of IκB degradation
Immunopharmacology, 48(2), 129-135 (2000)
Nils Holler, Takao Kataoka, Jean-Luc Bodmer, Pedro Romeo, Jacqueline Romero, David Deperthes, Jürgen Engel, Jürg Tschopp, Pascal Schneider
Development of improved soluble inhibitors of FasL and CD40L based on oligomerized receptors
Journal of Immunological Methods, 237(1-2), 159-173 (2000)
Mi-Heon Lee, Takao Kataoka, Nobuko Honjo, Junji Magae, Kazuo Nagai
In vivo rapid reduction of alloantigen-activated CD8+ mature cytotoxic T cells by inhibitors of acidification of intracellular organelles, prodigiosin 25-C and concanamycin B
Immunology, 99(2), 243-248 (2000)
Atsushi Yamada, Takao Kataoka, Kazuo Nagai
The fungal metabolite gliotoxin: immunosuppressive activity on CTL-mediated cytotoxicity
Immunology Letters, 71(1), 27-32 (2000)
Hidekazu Matsuya, Masayuki Okamoto, Takahiro Ochi, Asako Nishikawa, Sakae Shimizu, Takao Kataoka, Kazuo Nagai, Harry H. Wasserman, Shoji Ohkuma
Reversible and potent uncoupling of hog gastric (H++K+)-ATPase by prodigiosins
Biochemical Pharmacology, 60(12), 1855-1863 (2000)
Kazuo Nagai, Takao Kataoka
Immune cell functions. In Bioprobes: Biochemical tools for investigating cell function
H. Osada, (Ed.) Springer-Verlag Tokyo, pp. 97-123 (2000)