RKTS-33

細胞傷害性T細胞の細胞殺傷経路において、パーフォリン依存性経路を阻害せず、Fasリガンド依存性経路を選択的に阻害する。

【発表論文】

Tomokazu Mitsui, Yasunobu Miyake, Hideaki Kakeya, Yujiro Hayashi, Hiroyuki Osada, Takao Kataoka

RKTS-33, an epoxycyclohexenone derivative that specifically inhibits Fas ligand-dependent apoptosis in CTL-mediated cytotoxicity

Bioscience, Biotechnology, and Biochemistry, 69(10), 1923–1928 (2005)

Hideaki Kakeya, Yasunobu Miyake, Mitsuru Shoji, Satoshi Kishida, Yujiro Hayashi, Takao Kataoka, Hiroyuki Osada

Novel non-peptide inhibitors targeting death receptor-mediated apoptosis

Bioorganic & Medicinal Chemistry Letters, 13(21), 3743–3746 (2003)