Concanamycin A

18員環マクロライド(macrolide)化合物であり、液胞型H+-ATPaseを特異的に阻害する。

細胞傷害性T細胞やナチュラルキラー細胞によるパーフォリン依存性細胞傷害経路を特異的に阻害する。

【発表論文】

Takao Kataoka, Ken-ichi Togashi, Hajime Takayama, Kazuaki Takaku, Kazuo Nagai

Inactivaiton and proteolytic degradation of perforin within lytic granules upon neutralization of acidic pH

Immunology, 91(3), 493–500 (1997)

Takao Kataoka, Michihiko Sato, S Kondo, Kazuo Nagai

Estimation of pH and the number of lytic granules in a CD8+ CTL clone treated with an inhibitor of vacuolar H+-ATPase concanamycin A

Bioscience, Biotechnology, and Biochemistry, 60(10), 1729–1731 (1996)

Takao Kataoka, Nobukata Shinohara, Hajime Takayama, Kazuaki Takaku, S Kondo, Shin Yonehara, Kazuo Nagai

Concanamycin A, a powerful tool for characterization and estimation of contribution of perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity

Journal of Immunology, 156(10), 3678–3686 (1996)

Takao Kataoka, Kazuaki Takaku, Junji Magae, Nobukata Shinohara, Hajime Takaku, S Kondo, Kazuo Nagai

Acidification is essential for maintaining the structure and function of lytic granules of CTL. Effect of concanamycin A, an inhibitor of vacuolar H+-ATPase, on CTL-mediated cytotoxicity

Journal of Immunology, 153(9), 3938–3947 (1994)