研究業績（2015年〜）
2025年
Yuka Yokota , Piimwara Yarangsee , Kosuke Baba , Saki Sasaki , Hiroyuki Hirano , Hiroyuki Osada , Takao Kataoka
Podophyllotoxin and α-peltatin inhibit nuclear factor κB activation and gene expression stimulated by a double-stranded RNA analogue in human umbilical vein endothelial cells
Bioscience, Biotechnology, and Biochemistry, published in July 21 (2025)
Yuto Ueno, Rikako Yamaguchi, Yumiko Tanaka, Yasunobu Miyake, Keiko Takaki, Ayaka Nakao, Ryota Ozaki, Yuka Yokota, Itsuki Fukai, Sara Kuwada, Natsuki Fukuoka, Naoaki Okuda, Ai Nishida, Tomoo Shiba, Takao Kataoka
Expression and localization of lysosomal-associated membrane protein 1- and perforin-based hybrid molecules in the murine cytotoxic T cell line CTLL-2.
Cytotechnology, 77,129 (2025)
Tanpitcha Yodweerapong, Yuto Ueno, Rikako Yamaguchi, Piimwara Yarangsee, Ken-Ichi Kimura, Takao Kataoka
Kujigamberol inhibits IFN-γ and IL-2 mRNA expression and NFATc2 binding to their promoters in response to a phorbol ester and ionomycin stimulation.
Molecules, 30, 2724 (2025)
Chihiro Moriwaki, Shingo Takahashi, Nhat Thi Vu, Yasunobu Miyake, Takao Kataoka
1'-Acetoxychavicol acetate selectively downregulates tumor necrosis factor receptor-associated factor 2 (TRAF2) expression.
Molecules, 30, 1243 (2025)
2024年
Quy Van Vu, Nhat Thi Vu, Kosuke Baba, Saki Sasaki, Ryuichi Tamura, Kyoko Morimoto, Hiroyuki Hirano, Hiroyuki Osada, Takao Kataoka
Porphyrin derivatives inhibit tumor necrosis factor α-induced gene expression and reduce the expression and increase the cross-linked forms of cellular components of the nuclear factor κB signaling pathway
European Journal of Pharmacology, 977, 176747 (2024)
Kaori Nakano, Yuka Yokota, Quy Van Vu, Francesca Lagravinese, Takao Kataoka
Structure-activity relationship of oleanane-type pentacyclic triterpenoids on nuclear factor κB activation and intracellular trafficking and N-linked glycosylation of intercellular adhesion molecule-1
International Journal of Molecular Sciences, 25, 6026 (2024)
Yuka Yokota, Keiko Takaki, Kosuke Baba, Saki Sasaki, Hiroyuki Hirano, Hiroyuki Osada, Takao Kataoka
Amiodarone inhibits the Toll-like receptor 3-mediated nuclear factor κB signaling pathway by blocking organelle acidification
Biochemical and Biophysical Research Communications, 708, 149801 (2024)
Quy Van Vu, Shinsei Sayama, Masayoshi Ando, Takao Kataoka
Sesquiterpene lactones containing an α-methylene-γ-lactone moiety selectively down-regulate the expression of tumor necrosis factor receptor 1 by promoting its ectodomain shedding in human lung adenocarcinoma A549 cells
Molecules, 29, 1866 (2024)
Quy Van Vu, Kosuke Baba, Saki Sasaki, Koichiro Kawaguchi, Hiroyuki Hirano, Hiroyuki Osada, Takao Kataoka
Alantolactone derivatives inhibit the tumor necrosis factor α-induced nuclear factor κB pathway by a different mechanism from alantolactone
European Journal of Pharmacology, 969, 176458 (2024)
2023年
Jinghong Xu, Takuya Hashino, Reiji Tanaka, Koichiro Kawaguchi, Hideki Yosida, Takao Kataoka
The BCL-2 protein BCL-RAMBO interacts and cooperates with GRP75 to promote its apoptosis signaling pathway.
Scieintific Reports, 13, 14041 (2023)
Chiharu Okuda, Yuto Ueda, Makoto Muroi, Emiko Sanada, Hiroyui Osada, Yoshihito Shiono, Ken-ichi Kimura, Kenji Takeda, Koichiro Kawaguchi, Takao Kataoka
Allantopyrone A interferes with the degradation of hypoxia-inducible factor 1α protein by reducing proteasome activity in human fibrosarcoma HT-1080 cells
The Journal of Antibiotics, 76, 324–334 (2023)
Koichiro Kawaguchi, Tsubasa Ohashi, Narumi Kobayashi, Kotoya Kanemoto, Makoto Nose, Rin Shinozaki, Takao Kataoka, Hiroshi Fujii
Aberrant DNA methylation-mediated NF-κB/fatty acid-binding protein 5 (FABP5) feed-forward loop promotes malignancy of colorectal cancer cells
BBA - Molecular and Cell Biology of Lipids, 1868, 159362 (2023)
2022年
Biological properties of the BCL-2 family protein BCL-RAMBO, which regulates apoptosis, mitochondrial fragmentation, and mitophagy
Takao Kataoka
Frontiers in Cell Devepment and Biololgy, 10, 1065702 (2022)
Takuya Hashino, Hisanori Matsubara, Jinhong Xu, Reiji Tanaka, Eiichi Kusagwa, Yuto Ueda, Hideki Yoshida, Takao Kataoka
PGAM5 interacts with Bcl-rambo and regulates apoptosis and mitophagy
Experimental Cell Research, 420, 113342 (2022)
Eiichi Kusagawa, Chiharu Okuda, Rikako Yamaguchi, Kaori Nakano, Yasunobu Miyake, Takao Kataoka
Cucurbitacin B down-regulates TNF receptor 1 expression and inhibits the TNF-α-dependent nuclear factor κB signaling pathway in human lung adenocarcinoma A549 cells
International Journal of Molecular Sciences, 23, 7130 (2022)
Kaori Nakano, Saki Sasaki, Takaok Kataoka
Bioactive evaluation of ursane-type pentacyclic triterpenoids: β-boswellic acid interferes with the glycosylation and transport of intercellular adhesion molecule-1 in human lung adenocarcinoma A549 cells
Molecules, 27, 3073 (2022)
2021年
Yumiko Tanaka, Ayaka Nakao, Yasunobu Miyake, Yukina Higashi, Riho Tanigaki, Takao Kataoka
Small molecule inhibitors targeting NF-κB activation markedly reduce expression of interleukin-2, but not interferon-γ, induced by phorbol esters and calcium ionophores
International Journal of Molecular Sciences, 22, 13098 (2021)
Chihiro Moriwaki, Riho Tanigaki, Yasunobu Miyake, Nhia Trong Vo, Mai Thanh Thi Nguyen, Nhan Trung Nguyen, Truong Nhat Van Do, Hai Xuan Nguyen, Nguyen, H.X., Takao Kataoka
Isopanduratin A inhibits tumor necrosis factor κB signaling pathway by promoting extracellular signal-regulated kinase-dependent ectodomain shedding of TNF receptor 1 in human lung adenocarcinoma A549 cells.
BioChem, 1, 174–189 (2021)
Nghia Trong Vo, Eiichi Kusagawa, Kaori Nakano, Chihiro Moriwaki, Yasunobu Miyake, Sayaka Haruyama, Sayuri Fukuhara, Nhan Trung Nguyen, Phu Hoang Dang, Mai Thanh Thi Nguyen, Takao Kataoka
Biological evaluation of alkyl triphenylphosphonium ostruthin derivatives as potential anti-inflammatory agents targeting the nuclear factor κB signaling pathway in human lung adenocarcinoma A549 cells
BioChem, 1, 107–121 (2021)
Nghia Trong Vo, Saki Sasaki, Yasunobu Miyake, Nhan Trung Nguyen, Phu Hoang Dang, Mai Thanh Thi Nguyen, Takao Kataoka
α-Conidendrin inhibits the expression of intercellular adhesion molecule-1 induced by tumor necrosis factor-α in human lung adenocarcinoma A549 cells
European Journal of Pharmacology, 890, 173651 (2021)
2020年
Misuzu Harada, Vo Trong Nghia, Ayaka Nakao, Riho Tanigaki, Natsuki Fukuoka, Ai Nishida, Takao Kataoka
Eomesodermin promotes interaction of RelA and NFATc2 with the Ifng promoter and multiple conserved noncoding sequences across the Infg locus in mouse lymphoma BW5147 cells
Immunology Letters, 225, 33–43 (2020)
Kusuke Baba, Sara Kuwada, Ayaka Nakao, Xuebing Li, Naoaki Okuda, Ai Nishida, Satoshi Mitsuda, Natuki Fukuoka, Hideaki Kakeya, Takao Kataoka
Different localization of lysosomal-associated membrane protein 1 (LAMP1) in mammalian cultured cell lines.
Histochemistry and Cell Biology, 153, 199-213 (2020)
2019年
Hisanori Matsubara, Reiji Tanaka, Tatsuya Tateishi, Hideki Yoshida, Masamitsu Yamaguchi, Takao Kataoka
The human Bcl-2 family member Bcl-rambo and voltage-dependent anion channels manifest a genetic interaction in Drosophila and cooperatively promote the activation of effector caspases in human cultured cells
Experimental Cell Research, 381, 223-234 (2019)
Tetsuya Kondo, Kenji Takeda, Ryo Muko, Akihiro Ito, Young-Chae Chang, Junji Magae, Takao Kataoka
4-O-Methylascochlorin inhibits the prolyl hydroxylation of hypoxia-inducible factor-1α, which is attenuated by ascorbate
Journal of Antibiotics, 72, 271–281 (2019)
Riho Tanigaki, Riku Takahashi, Mai Thanh Thi Nguyen, Nhan Trung Nguyen, Truong Nhat Do, Hai Xuan Nguyen, Takao Kataoka
4-Hydroxypanduratin A and isopanduratin A inhibit tumor necrosis factor α-stimulated gene expression and the nuclear factor κB-dependent signaling pathway in human lung adenocarcinoma A549 cells
Biological and Pharmaceutical Bulletin, 42, 26–33 (2019)
2018年
Kosuke Baba, Reiko Hiramatsu, Benjamart Suradej, Riho Tanigaki, Sayaka Koeda, Tomonori Waku, Takao Kataoka
Asiatic acid, corosolic acid, and maslinic acid interfere with intracellular trafficking and N-linked glycosylation of intercellular adhesion molecule-1
Biological and Pharmaceutical Bulletin, 41, 1757–1768 (2018)
Sayuri Fukuhara, Riho Tanigaki, Ken-ichi Kimura, Takao Kataoka
Kujigamberol interferes with pro-inflammatory cytokine-induced expression of and N-glycan modifications to cell adhesion molecules at different stages in human umbilical vein endothelial cells
International Immunopharmacology, 62, 313–325 (2018)
2017年
Misuzu Harada, Kyoko Morimoto, Tetsuya Kondo, Reiko Hiramatsu, Yuji Okina, Ryo Muko, Iyo Matsuda, Takao Kataoka
Quinacrine Inhibits ICAM-1 Transcription by Blocking DNA Binding of the NF-κB Subunit p65 and Sensitizes Human Lung Adenocarcinoma A549 Cells to TNF-α and the Fas Ligand
International Journal of Molecular Sciences, 18, 2603 (2017)
Hue Tu Quach, Tetsuya Kondo, Megumi Watanabe, Ryuichi Tamura, Yoshiki Yajima, Shinsei Sayama, Masayoshi Ando, Takao Kataoka
Eudesmane-type sesquiterpene lactones inhibit nuclear translocation of the nuclear factor κB subunit RelB in response to a lymphotoxin β stimulation
Biological and Pharmaceutical Bulletin, 40, 1669–1677 (2017)
Hue Tu Quach, Riho Tanigaki, Junpei Yokoigawa, Yuriko Yamada, Masamitsu Miwa, Seiya Hirano, Yoshihito Shiono, Ken-ichi Kimura, Takao Kataoka
Allantopyrone A interferes with multiple components of the TNF receptor 1 complex and blocks RIP1 modifications in the TNF-α-induced signaling pathway
Journal of Antibiotics, 70, 929–936 (2017)
Takao Kataoka
Adaptimve and innate immune systems
Bioprobes: Biochemical tools for investigating cell function
2nd Edition, pp115–147 (2017)
2016年
Mako Nakazawa, Hisanori Matsubara, Yuka Matsushita, Megumi Watanabe, Nicole Vo, Hideki Yoshida, Masamitsu Yamaguchi, Takao Kataoka
The human Bcl-2 family member Bcl-rambo localizes to mitochondria and induces apoptosis and morphological aberrations in Drosophila
PLoS ONE 11, e0157823 (2016)
Natsuki Fukuoka, Misuzu Harada, Ai Nishida, Yuko Ito, Hideki Shiota, Takao Kataoka
Eomesodermin promotes interferon-γ expression and binds to multiple conserved noncoding sequences across the Ifng locus in mouse thymoma cell lines
Genes to Cells, 21, 146–162 (2016)
2015年
Reiko Hiramatsu, Sayuri Fukuhara, Satoshi Mitsuda, Tomonobu Yokomichi, Takao Kataoka
Betulinic acid and oleanolic acid, natural pentacyclic triterpenoids, interfere with N-linked glycan modifications to intercellular adhesion molecule-1, but not its intracellular transport to the cell surface
European Journal of Pharmacology, 761, 126–134 (2015)
Hue Tu Quach, Seiya Hirano, Sayuri Fukuhara, Tsubasa Watanabe, Naoki Kanoh, Yoshiharu Iwabuchi, Takeo Usui, Takao Kataoka
Irciniastatin A induces potent and sustained activation of extracellular signal-regulated kinase and thereby promotes ectodomain shedding of tumor necrosis factor receptor 1 in human lung carcinoma A549 cells
Biological and Pharmaceutical Bulletin, 38(6), 941–946 (2015)
Seiya Hirano, Hue Tu Quach, Tsubasa Watanabe, Naoki Kanoh, Yoshiharu Iwabuchi, Takeo Usui, Takao Kataoka
Irciniastatin A, a pederin-type translation inhibitor, promotes ectodomain shedding of cell-surface tumor necrosis factor receptor 1
Journal of Antibiotics, 68(6), 417–420 (2015)
Yuji Okina, Fumihiko Takeuchi, Tomonobu Yokomichi, Yohei Takada, Takao Kataoka
Cardenolide aglycones inhibit tumor necrosis factor α-induced expression of intercellular adhesion molecule-1 at the translation step by blocking Na+/K+-ATPase
Biological and Pharmaceutical Bulletin, 38(1), 39–47 (2015)
Junpei Yokoigawa, Kyoto Morimoto, Yoshihito Shiono, Shota Uesugi, Ken-ichi Kimura, Takao Kataoka
Allantopyrone A, an α-pyrone metabolite from an endophytic fungus, inhibits the tumor necrosis factor α-induced nuclear factor κB signaling pathway
Journal of Antibiotics, 68(2), 71–75 (2015)