Cardamonin

NF-κBサブユニットRelAの作用して核移行やDNA結合を阻害する。

ヒト肺がん腫A549細胞においてTNF-αで誘導されるICAM-1発現を阻害する。

【発表論文】

Nhat Thi Vu, Quy Van Vu, Nghia Trong Vo, Riho Tanigaki, Hue Tu Quach, Yasunobu Miyake, Tomoo Shiba, Takao Kataoka

Cardamonin inhibits the nuclear translocation and DNA binding of RelA in the tumor necrosis factor-α-induced NF-κB signaling pathway in human lung adenocarcinoma A549 cells

Molecules, 30, 4324 (2025)

Riho Tanigaki, Riku Takahashi, Mai Thanh Thi Nguyen, Nhan Trung Nguyen, Truong Nhat Do, Hai Xuan Nguyen, Takao Kataoka

4-Hydroxypanduratin A and isopanduratin A inhibit tumor necrosis factor α-stimulated gene expression and the nuclear factor κB-dependent signaling pathway in human lung adenocarcinoma A549 cells

Biological and Pharmaceutical Bulletin, 42, 26–33 (2019)