Acetoxycycloheximide

（別名：E-73）

グルタールイミド(glutarimide)系抗生物質の一つであり、真核生物のタンパク質合成を阻害する。

リボトキシックストレス応答を誘導し、ERK、JNK、p38 MAPキナーゼの活性化を誘導する。

ヒト白血病Jurkat細胞において、強力にアポトーシスを誘導する。

ヒト肺がん腫A549細胞において、TNFレセプター1のエクトドメインシェディングを誘導する。

【発表論文】

Kimiko Kadohara, Michiko Nagumo, Shun Asami, Yoshinori Tsukumo, Hikaru Sugimoto, Masayuki Igarashi, Kazuo Nagai, Takao Kataoka

Caspase-8 mediates mitochondrial release of pro-apoptotic proteins in a manner independent of its proteolytic activity in apoptosis induced by the protein synthesis inhibitor acetoxycycloheximide in human leukemia Jurkat cells

Journal of Biological Chemistry, 284(9), 5478–5487 (2009)

Hirotsugu Ogura, Yoshinori Tsukumo, Hikaru Sugimoto, Masayuki Igarashi, Kazuo Nagai, Takao Kataoka

ERK and p38 MAP kinase are involved in downregulation of cell surface TNF receptor 1 induced by acetoxycycloheximide

International Immunopharmacology, 8(6), 922–926 (2008)

Hirotsugu Ogura, Yoshinori Tsukumo, Hikaru Sugimoto, Masayuki Igarashi, Kazuo Nagai, Takao Kataoka

Ectodomain shedding of TNF receptor 1 induced by protein synthesis inhibitors regulates TNF-α-mediated activation of NF-κB and caspase-8

Experimental Cell Research, 314(6), 1406–1414 (2008)

Kimiko Kadohara, Yoshinori Tsukumo, Hikaru Sugimoto, Masayuki Igarashi, Kazuo Nagai, Takao Kataoka

Acetoxycycloheximide (E-73) rapidly induces apoptosis mediated by the release of cytochrome c via activation of c-Jun-N-terminal kinase

Biochemical Pharmacology, 69(4), 551–600 (2005)

Hikaru Sugimoto, Takao Kataoka, Masayuki Igarashi, Masa Hamada, Tomio Takeuchi, Kazuo Nagai

E-73, an acetoxyl analogue of cycloheximide, blocks the tumor necrosis factor-induced NF-κB signaling pathway

Biochemical and Biophysical Research Communications, 277(2), 330–333 (2000)