• Class: Antiemetic

• Action: blocks serotonin receptors centrally and peripherally at the vagal nerve terminal in the intestine

• Indications: vomiting

• Adverse Effects: agitation, anxiety, ataxia, dizziness, drowsiness, dystonia, fever, headache, hypotension, arrhythmias, chest pain, palpitations, prolonged QT interval, shock, tachycardia, torsades de pointes, bronchospasm, shortness of breath,  

• Contraindications: Pregnant

• Special Considerations: Pregnancy category B

Dosages:

Adults: 

Active nausea/vomiting:

• 4-8mg IV/IM/PO

Pediatrics:

Active nausea/vomiting

• 0.1mg/kg IV/PO (MAX 4mg)