• Class: Antiarrhythmic (class 3)

• Action: Acts directly on the myocardium to delay repolarization and increases the duration of the action potential

• Indications: Ventricular arrhythmias (V-Fib or V-Tach); second line agent for Atrial arrhythmias (A-Fib or A-Flutter).

• Adverse Effects: Burning at the IV site, hypotension and bradycardia

• Contraindications: Sick sinus syndrome (abnormal heart rhythms), second and third degree heart blocks, cardiogenic shock, sensitivity to benzyl alcohol and iodine.

• Special Considerations: Pregnancy Class D

Dosages:

Adults:

V-Fib and V-Tach:

• 300mg IV/IO; 2nd dose of 150 in 3-5 mins.

PVC's or Wide Complex Tach:

• 150 mixed in 100ml D5W over 10 mins.

Pediatrics:

• None