Protease Inhibitors

Introduction
Illustrated mechanism of action
Examples of Medication Brand Names (with Images)1
Indication
Side Effects
Precautions & Contraindications
Monographs
Reference

c406fe61-8b2e-4e80-9df0-22c9258d5ca4.mp4

Introduction

The antiretroviral protease inhibitors act by binding to the catalytic site of the HIV protease, thereby preventing the cleavage of viral polyprotein precursors into mature, functional proteins that are necessary for viral replication.

HISTORY

Protease inhibitors were the second class of antiretroviral drugs developed. The first members of this class, saquinavir, ritonavir, and indinavir, were approved in late 1995–1996

MOA

Atazanavir

Atazanavir is in a class of medications called protease inhibitors. It works by decreasing the amount of HIV in the blood. Although atazanavir does not cure ...

Saquinavir

The design of the first protease inhibitor saquinavir (SQV, Ro-31-8959, marketed by Hoffman-La Roche), which was approved by the FDA in December 1995 under the ...

Crixivan

CRIXIVAN* (indinavir sulfate) is an inhibitor of the human immunodeficiency virus (HIV) protease. CRIXIVAN Capsules are formulated as a sulfate salt and are ...

Darunavir

Darunavir is in a class of medications called protease inhibitors. It works by decreasing the amount of HIV in the blood. Although darunavir does not cure HIV ...