• Introduction 

• Illustrated mechanism of action 

• Examples of Medication Brand Names (with Images)

• Indication

• Side Effects 

• Precautions & Contraindications 

• Monographs

• Reference 

Mechanism of Action (MOA):

• Ceftaroline is a β-lactam antibiotic that inhibits bacterial cell wall synthesis.

• It binds to Penicillin-Binding Proteins (PBPs)—specifically PBP2a, which is found in MRSA.

• PBP2a is usually resistant to most β-lactams, but ceftaroline can bind to it strongly.

• This binding blocks the cross-linking of peptidoglycan chains in the bacterial cell wall.

• As a result, the bacterial cell wall becomes weak and the cell lyses (bursts) and dies

Examples of Medication Brand Names :

Indications: 

Ceftaroline is indicated for the treatment of serious bacterial infections, including:

• Community-Acquired Pneumonia (CAP)

• Complicated Skin and Soft Tissue Infections (cSSTIs)

• Infections caused by Methicillin-Resistant Staphylococcus aureus (MRSA)

Side effect : 

  • Gastrointestinal:

• Nausea

• Vomiting

• Diarrhea

• Abdominal pain

• Skin Reactions:

• Rash

• Itching

• Hypersensitivity Reactions:

• Allergic reactions

• Cross-reactivity with penicillins in allergic patient

• Hematologic:

• Eosinophilia

• Thrombocytopenia

• Liver and Kidney:

• Elevated liver enzymes

• Rare nephrotoxicity

• Others:

• Headache

• Superinfection (e.g., Clostridium difficile infection)

 Precaution :

     • Use with caution in patients with a history of penicillin allergy (cross-reactivity may occur).

• Monitor renal function in elderly or renally impaired patients.

• Long-term use may lead to superinfections (e.g., C. difficile).

• Caution in patients with history of gastrointestinal disease, especially colitis.

• Adjust dose in cases of renal impairment.

Contraindication :

• Known hypersensitivity to cephalosporins or other β-lactam antibiotics.

• Severe allergic reaction (e.g., anaphylaxis) to penicillins, due to possible cross-allergy.

• Avoid in patients with a history of cephalosporin-associated hemolytic anemia.

Monograph :

REFRANCE :

1. Medscape – Drug Monograph for Ceftaroline (Teflaro)

https://reference.medscape.com/drug/teflaro-ceftaroline-999606

2. RxList – Ceftaroline Side Effects & Uses

https://www.rxlist.com/ceftaroline-drug.htm

3. Pfizer Product Info – Zinforo (Ceftaroline fosamil)

https://www.pfizerpro.co.uk/medicines/zinforo

4. Drugs.com – Ceftaroline fosamil

https://www.drugs.com/monograph/ceftaroline-fosamil.html

5. Adis Insight – Drug Profile for Ceftaroline fosamil

https://adisinsight.springer.com/drugs/800018104

6.Drugs.com – Cephalosporins Overview

https://www.drugs.com/drug-class/cephalosporins.html

7. Merck Manual – Cephalosporins (Professional Version)

https://www.merckmanuals.com/professional/infectious-diseases/bacteria-and-antibacterial-medications/cephalosporins

8. Mayo Clinic – Cephalexin (as an example)

https://www.mayoclinic.org/drugs-supplements/cephalexin-oral-route/description/drg-20073325

9. Medsafe NZ – Cephalosporin Neurotoxicity Alert

https://www.medsafe.govt.nz/profs/PUArticles/March2023/Risk-of-neurotoxicity-with-cephalosporins.html