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Lipoprotein testing is commonly used in medical practice to assess lipid metabolism and evaluate the risk of cardiovascular diseases. These tests help determine the levels of different lipoproteins in the blood, such as LDL, HDL, VLDL, and lipoprotein(a) [Lp(a)].
Clinical Indications for Lipoprotein Testing:
1. Cardiovascular Risk Assessment
To evaluate the risk of atherosclerosis, coronary artery disease (CAD), heart attack, and stroke.
Especially important in patients with family history or other risk factors like smoking, diabetes, or hypertension.
2. Monitoring Hyperlipidemia and Dyslipidemia
To diagnose and monitor abnormal lipid levels (elevated LDL or triglycerides, low HDL).
Used to guide treatment decisions, such as starting statins or other lipid-lowering medications.
3. Assessing Effectiveness of Lipid-Lowering Therapy
To monitor how well treatments (e.g., statins, lifestyle changes) are working to lower LDL or raise HDL.
4. Early Screening in Individuals with a Family History of Cardiovascular Disease
Particularly important if there is a history of premature heart disease or inherited lipid disorders like familial hypercholesterolemia.
5. Evaluation of Metabolic Syndrome and Diabetes Mellitus
Lipoprotein abnormalities are common in metabolic syndrome and diabetes, so testing helps in comprehensive metabolic evaluation.
6. Pre-operative Risk Evaluation
To assess cardiovascular risk before surgeries, especially in older adults or those with risk factors.
7. Screening for Lipoprotein(a) Levels
Lp(a) is a genetic risk factor for cardiovascular disease and may be measured in select patients with a strong family history or unexplained early heart disease.
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