Tedizolid 

• Introduction 

• Illustrated mechanism of action 

• Examples of Medication Brand Names (with Images)

• Indication

• Side Effects 

• Precautions & Contraindications 

• Monographs

• Reference 

1. Introduction:

Tedizolid is a next-generation oxazolidinone antibiotic, developed as an improved version of Linezolid. It has enhanced potency and a longer half-life, allowing once-daily dosing. Like linezolid, it’s used to treat Gram-positive bacterial infections, including resistant strains like MRSA and VRE.

llustrated Mechanism of Action:

Tedizolid works by inhibiting bacterial protein synthesis. It binds to the 23S rRNA of the 50S ribosomal subunit, just like linezolid, preventing the formation of the initiation complex necessary for translation.

6. Precautions & Contraindications:

Precautions:

• Monitor complete blood count (CBC) during prolonged therapy.
  
  

• Use caution in patients on serotonergic or adrenergic agents.
  
  

• Monitor for vision changes during long-term therapy.
  
  

Contraindications:

• Hypersensitivity to linezolid or any of its components.
  
  

• Concomitant use with monoamine oxidase inhibitors (MAOIs) or within 2 weeks of their discontinuation.
  
  

• Patients taking serotonergic psychiatric medications (unless benefits outweigh risks).
  
  

• .
  
  

8. Refer:

Key References:

• Lexicomp Online Database
  
  

• Micromedex Drug Information
  
  

• FDA Label for Zyvox: FDA Link
  
  

• CDC Guidelines for MRSA/VRE Management
  
  

• Infectious Diseases Society of America (IDSA) Guidelines