The arteria profunda brachii (also known as deep artery of the arm and the deep brachial artery) is a large vessel which arises from the lateral and posterior part of the brachial artery, just below the lower border of the Teres major.
It follows closely the radial nerve, running at first backward between the medial and lateral heads of the triceps brachii, then along the groove for the radial nerve (the radial sulcus), where it is covered by the lateral head of the triceps brachii, to the lateral side of the arm; there it pierces the lateral intermuscular septum, and, descending between the brachioradialis and the brachialis to the front of the lateral epicondyle of the humerus, ends by anastomosing with the radial recurrent artery.