Search Pubmed for publications authored by Starr TK
Law EK, Levin-Klein R, Jarvis MC, Kim H, Argyris PP, Carpenter MA, Starrett GJ, Temiz NA, Larson LK, Durfee C, Burns MB, Vogel RI, Stavrou S, Aguilera AN, Wagner S, Largaespada DA, Starr TK, Ross SR, Harris RS. APOBEC3A catalyzes mutation and drives carcinogenesis in vivo. J Exp Med. 2020 Dec 7;217(12):e20200261. PMID: 32870257
Tiwari A, Tashiro K, Dixit A, Soni A, Vogel K, Hall B, Shafqat I, Slaughter J, Param N, Le A, Saunders E, Paithane U, Garcia G, Campos AR, Zettervall J, Carlson M, Starr TK, Marahrens Y, Deshpande AJ, Commisso C, Provenzano PP, Bagchi A. Loss of HIF1A From Pancreatic Cancer Cells Increases Expression of PPP1R1B and Degradation of p53 to Promote Invasion and Metastasis.” Gastroenterology. 2020 Aug 3:S0016-5085(20)35009-5. Online ahead of print. PMID: 32768595
Layek B, Shetty M, Nethi SK, Sehgal D, Starr TK, Prabha S. Mesenchymal Stem Cells As Guideposts for Nanoparticle-Mediated Targeted Drug Delivery in Ovarian Cancer. Cancers (Basel). 2020;12(4):965. Published 2020 Apr 14. PMID: 32295145
Pomeroy, EJ, Hunzeker, JT, Kluesner, MG, Lahr, WS, Smeester, BA, Crosby, MR, Lonetree, CL, Yamamoto, K, Bendzick, L, Miller, JS, Geller, MA, Walcheck, B, Felices, M, Webber, BR, Starr, TK, Moriarity, BS. A Genetically Engineered Primary Human Natural Killer Cell Platform for Cancer Immunotherapy. Mol Ther. 2020 Jan 8;28(1):52-63. Epub 2019 Oct 15. PMID: 31704085
Woo J, Winterhoff BJ, Starr TK, Aliferis C, Wang J. De novo prediction of cell-type complexity in single-cell RNA-seq and tumor microenvironments. Life Sci Alliance. 2019 Jul 2;2(4). pii: e201900443. Print 2019 Aug. PMID: 31266885
Desir S, Wong P, Turbyville T, Chen, Shetty M*, Clark C*, Zhai E, Romin Y, Manova-Todorova K, Starr TK, Nissley DV, Steer CJ, Subramanian S, Lou E. Intercellular Transfer of Oncogenic KRAS via Tunneling Nanotubes Introduces Intracellular Mutational Heterogeneity in Colon Cancer Cells. Cancers (Basel). 2019 Jun 26;11(7). pii: E892. PMID:31247990
Conboy CB, Vélez-Reyes GL, Tschida BR, Hu H, Kaufmann G, Koes N, Keller B, Alsinet C, Cornellà H, Pinyol R, Abrahante JE, Temiz NA, Linden MA, Amin K, Kuka TP, Keng VW,6, Llovet JM, Starr TK, Largaespada DA. R-spondin 2 Drives Liver Tumor Development in a Yes-Associated Protein-Dependent Manner. Hepatol Commun. 2019 Sep 3;3(11):1496-1509. eCollection 2019 Nov. PMID: 31701073
Glasgow MA, Argenta P, Abrahante JE, Shetty M, Talukdar S, Croonquist PA, Khalifa MA, Starr TK. Biological Insights into Chemotherapy Resistance in Ovarian Cancer. Int J Mol Sci. 2019 Apr 30;20(9). PMID: 31052165
Skubitz APN, Boylan KLM, Geschwind K, Cao Q, Starr TK, Geller MA, Celestin J, Bast RC Jr, Lu KH, Koopmeiners JS. Simultaneous Measurement of 92 Serum Protein Biomarkers for the Development of a Multiprotein Classifier for Ovarian Cancer Detection. Cancer Prev Res (Phila). 2019 Mar; 12(3):171-184. PMID: 30709840
Winterhoff B, Talukdar S, Chang Z, Wang J, Starr TK. Single-cell sequencing in ovarian cancer: a new frontier in precision medicine. Curr Opin Obstet Gynecol. 2019 Feb; 31(1):49-55. PMID: 30507625
Rahrmann EP, Wolf NK, Otto GM, Heltemes-Harris L, Ramsey LB, Shu J, LaRue RS, Linden MA, Rathe SK, Starr TK, Farrar MA, Moriarity BS, Largaespada DA. Sleeping Beauty screen identified RREB1 and other genetic drivers in human B-cell lymphoma. Mol Cancer Res. 2019 Feb; 17(2):567-582. PMID: 30355676
Kinzy TG, Starr TK, Tseng GC, Ho YY. Meta-analytic framework for modeling genetic coexpression dynamics. Stat Appl Genet Mol Biol. 2019 Feb 9; 18(1). PMID: 30735484.
Clark CR, Maile M, Blaney P, Hellweg SR, Strauss A, Durose W, Priya S, Habicht J, Burns MB, Blekhman R, Abrahante JE, Starr TK. Transposon mutagenesis screen in mice identifies TM9SF2 as a novel colorectal cancer oncogene. Sci Rep. 2018 Oct 17; 8(1):15327. PMID: 30333512 PMCID: PMC6193042
Winterhoff BJ, Maile M, Mitra AK, Sebe A, Bazzaro M, Geller MA, Abrahante JE, Klein M, Hellweg R, Mullany SA, Beckman K, Daniel J, Starr TK. Corrigendum to "Single cell sequencing reveals heterogeneity within ovarian cancer epithelium and cancer associated stromal cells: [Gyncol. Oncol. 144(2017) 598-606)]. Gynecol Oncol. 2018 Oct;151(1):182-186. PMID: 30097329
Burns MB, Montassier E, Abrahante J, Priya S, Niccum DE, Khoruts A, Starr TK, Knights D, Blekhman R. Colorectal cancer mutational profiles correlate with defined microbial communities in the tumor microenvironment. PLoS Genet. 2018 Jun 20;14(6):e1007376. PMID: 29924794 PMCID: PMC6028121
Becker JR, Gallo D, Leung W, Croissant T, Thu YM, Nguyen HD, Starr TK, Brown GW, Bielinksy AK. Flap endonuclease overexpression drives genome instability and DNA damage hypersensitivity in a PCNA-dependent manner. Nucleic Acids Res. 2018 Jun 20; 46(11):5634-5650. PMID: 29741650 PMCID: PMC6009675
Boylan KLM, Geschwind K, Koopmeiners JS, Geller MA, Starr TK, Skubitz APN. A multiplex platform for the identification of ovarian cancer biomarkers. Clin Proteomics. 2017 Oct 10;14:34. doi: 10.1186/s12014-017-9169-6. eCollection 2017. PMID: 29051715 PMCID: PMC5634875
Zhao X, Li L, Starr TK, Subramanian S. Tumor location impacts immune response in mouse models of colon cancer. Oncotarget. 2017 Jun 9;8(33):54775-54787. eCollection 2017 Aug 15. PMID: 28903381
Than BLN, Linnekamp JF, Starr TK, Largaespada DA, Rod A, Zhang Y, Bruner V, Abrahante J, Schumann A, Luczak T, Walter J, Niemcyzk A, O’Sullivan MG, Medema JP, Fijneman RJA, Meijer GA, Van den Broek E, Hodges CA, Scott PM, Vermeulen L, Cormier RT. CFTR is a tumor suppressorgene in murine and human intestinal cancer. Oncogene. 2017 Jun 15;36(24):3504. doi: 10.1038/onc.2017.3. epub 2017 Feb 13. PMID: 28192405
Iizuka Y, Mooneyham A, Sieben A, Chen K, Maile M, Hellweg R, Schütz F, Teckle K, Starr T, Thayanithy V, Vogel RI, Lou E, Lee MK, Bazzaro M. UNC-45A is Required for Neurite Extension via ControllingNMII activation. Molecular Biology of the Cell. 2017 Mar 29. [Epub ahead of print]. PMID: 28356421
Winterhoff BJ, Maile M, Mitra A, Sebe A, Bazzaro M, Geller MA, Abrahante JE, Klein M, Hellweg R, Mullany SA, Beckman K, Daniel J, Starr TK. Single cell sequencing reveals heterogeneity within ovarian cancerepithelium and cancer associated stromal cells. Gynecol Oncol. 2017 Mar;144(3):598-606. doi:10.1016/j.gyno.2017.01.015. epub 2017 Jan 19. PMID: 28111004
Morris SM, Davison J, Carter KT, O’Leary RM, Trobridge P, Knoblaugh SE, Myeroff LL, Markowitz SD, Brett BT, Scheetz TE, Dupuy AJ, Starr TK, Grady WM. Transposon mutagenesis identifies candidate genesthat cooperate with loss of transforming growth factor-beat signaling in mouseintestinal neoplasms. Int J Cancer. 2016 Oct 28. doi: 10.1002/ijc.30491. [Epub ahead of print]. PMID: 27790711
Heltemes-Harris LM, Larson JD, Starr TK, Hubbard GK, Sarver AL, Largaespada DA, Farrar MA. Sleeping beauty transposon screen identifies signaling modules thatcooperate with STAT5 activation to induce B-cell acute lymphoblasticleukemia. Oncogene. 2016 Jun 30;35(26):3454-64. doi: 10.1038/onc.2015.405. Epub 2015 Oct 26. PMID: 26500062
Ho YY, Starr TK, LaRue RS, Largaespada DA. Case-oriented pathways analysis in pancreatic adenocarcinoma using datafrom a sleeping beauty transposon mutagenesis screen. BMC Med Genomics. 2016 Apr 1;9(1):16. doi: 10.1186/s12920-016-0176-7. PubMed PMID: 27038937; PubMed Central PMCID: PMC4818883.
Clark CR, Starr TK. Mouse models for thediscovery of colorectal cancer driver genes. World J Gastroenterol. 2016 Jan 14;22(2):815-22. doi: 10.1186/s12920-016-0176-7. PubMed PMID: 26811627.
Than BL, Linnekamp JF, Starr TK, Largaespada DA, Rod A, Zhang Y, Bruner V, Abrahante J, Schumann A, Luczak T, et al. CFTR is a tumor suppressor gene in murine and human intestinal cancer. Oncogene. 2016 Jan 11. doi: 10.1038/onc.2015.483. [Epub ahead of print] PubMed PMID: 26751771.
Dorr C, Janik C, Weg M, Been RA, Bader J, Kang R, Ng B, Foran L, Landman SR, O'Sullivan MG, Steinbach M, Sarver AL, Silverstein KA, Largaespada DA, Starr TK. Transposon Mutagenesis Screen Identifies Potential Lung Cancer Drivers and CUL3 as a Tumor Suppressor. Mol Cancer Res. 2015 Aug;13(8):1238-47. doi: 10.1158/1541-7786.MCR-14-0674-T. Epub 2015 May 20. PubMed PMID: 25995385; PubMed Central PMCID: PMC4543426.
Burns MB, Lynch J, Starr TK, Knights D, Blekhman R. Virulence genes are a signature of the microbiome in the colorectal tumor microenvironment. Genome Med. 2015 Jun 24;7(1):55. doi: 10.1186/s13073-015-0177-8. eCollection 2015. PubMed PMID: 26170900; PubMed Central PMCID: PMC4499914.
Abbott KL, Nyre ET, Abrahante J, Ho YY, Isaksson Vogel R, Starr TK. The Candidate Cancer Gene Database: a database of cancer driver genes from forward genetic screens in mice. Nucleic Acids Res. 2015 Jan;43(Database issue):D844-8. doi: 10.1093/nar/gku770. Epub 2014 Sep 4. PubMed PMID: 25190456; PubMed Central PMCID: PMC4384000.
Been RA, Linden MA, Hager CJ, DeCoursin KJ, Abrahante JE, Landman SR, Steinbach M, Sarver AL, Largaespada DA, Starr TK. Genetic signature of histiocytic sarcoma revealed by a sleeping beauty transposon genetic screen in mice. PLoS One. 2014 May 14;9(5):e97280. doi: 10.1371/journal.pone.0097280. eCollection 2014. PubMed PMID: 24827933; PubMed Central PMCID: PMC4020815.
Than BL, Goos JA, Sarver AL, O'Sullivan MG, Rod A, Starr TK, Fijneman RJ, Meijer GA, Zhao L, Zhang Y, Largaespada DA, Scott PM, Cormier RT. The role of KCNQ1 in mouse and human gastrointestinal cancers. Oncogene. 2014 Jul 17;33(29):3861-8. doi: 10.1038/onc.2013.350. Epub 2013 Aug 26. PubMed PMID: 23975432; PubMed Central PMCID: PMC3935979.
Hwang TH, Atluri G, Kuang R, Kumar V, Starr T, Silverstein KA, Haverty PM, Zhang Z, Liu J. Large-scale integrative network-based analysis identifies common pathways disrupted by copy number alterations across cancers. BMC Genomics. 2013 Jul 3;14:440. doi: 10.1186/1471-2164-14-440. PubMed PMID: 23822816; PubMed Central PMCID: PMC3703268.
Janik CL, Starr TK. Identification of Sleeping Beauty transposon insertions in solid tumors using linker-mediated PCR. J Vis Exp. 2013 Feb 1;(72):e50156. doi: 10.3791/50156. PubMed PMID: 23407503; PubMed Central PMCID: PMC3596955.
Seshagiri S, Stawiski EW, Durinck S, Modrusan Z, Storm EE, Conboy CB, Chaudhuri S, Guan Y, Janakiraman V, Jaiswal BS, Guillory J, Ha C, Dijkgraaf GJ, Stinson J, Gnad F, Huntley MA, Degenhardt JD, Haverty PM, Bourgon R, Wang W, Koeppen H, Gentleman R, Starr TK, Zhang Z, Largaespada DA, Wu TD, de Sauvage FJ. Recurrent R-spondin fusions in colon cancer. Nature. 2012 Aug 30;488(7413):660-4. doi: 10.1038/nature11282. PubMed PMID: 22895193; PubMed Central PMCID: PMC3690621.
Sarver AL, Erdman J, Starr T, Largaespada DA, Silverstein KA. TAPDANCE: an automated tool to identify and annotate transposon insertion CISs and associations between CISs from next generation sequence data. BMC Bioinformatics. 2012 Jun 29;13:154. doi: 10.1186/1471-2105-13-154. PubMed PMID: 22748055; PubMed Central PMCID: PMC3461456.
Bergemann TL, Starr TK, Yu H, Steinbach M, Erdmann J, Chen Y, Cormier RT, Largaespada DA, Silverstein KA. New methods for finding common insertion sites and co-occurring common insertion sites in transposon- and virus-based genetic screens. Nucleic Acids Res. 2012 May;40(9):3822-33. doi: 10.1093/nar/gkr1295. Epub 2012 Jan 12. PubMed PMID: 22241771; PubMed Central PMCID: PMC3351147.
Starr TK, Scott PM, Marsh BM, Zhao L, Than BL, O'Sullivan MG, Sarver AL, Dupuy AJ, Largaespada DA, Cormier RT. A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesis. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5765-70. doi: 10.1073/pnas.1018012108. Epub 2011 Mar 21. PubMed PMID: 21436051; PubMed Central PMCID: PMC3078351.
Dupuy AJ, Rogers LM, Kim J, Nannapaneni K, Starr TK, Liu P, Largaespada DA, Scheetz TE, Jenkins NA, Copeland NG. A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in mice. Cancer Res. 2009 Oct 15;69(20):8150-6. doi: 10.1158/0008-5472.CAN-09-1135. Epub 2009 Oct 6. PubMed PMID: 19808965; PubMed Central PMCID: PMC3700628.
Starr TK, Allaei R, Silverstein KA, Staggs RA, Sarver AL, Bergemann TL, Gupta M, O'Sullivan MG, Matise I, Dupuy AJ, Collier LS, Powers S, Oberg AL, Asmann YW, Thibodeau SN, Tessarollo L, Copeland NG, Jenkins NA, Cormier RT, Largaespada DA. A transposon-based genetic screen in mice identifies genes altered in colorectal cancer. Science. 2009 Mar 27;323(5922):1747-50. doi: 10.1126/science.1163040. Epub 2009 Feb 26. PubMed PMID: 19251594; PubMed Central PMCID: PMC2743559.
Keng VW, Villanueva A, Chiang DY, Dupuy AJ, Ryan BJ, Matise I, Silverstein KA, Sarver A, Starr TK, Akagi K, Tessarollo L, Collier LS, Powers S, Lowe SW, Jenkins NA, Copeland NG, Llovet JM, Largaespada DA. A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma. Nat Biotechnol. 2009 Mar;27(3):264-74. doi: 10.1038/nbt.1526. Epub 2009 Feb 22. PubMed PMID: 19234449; PubMed Central PMCID: PMC2712727.
McNeil LK, Starr TK, Hogquist KA. A requirement for sustained ERK signaling during thymocyte positive selection in vivo. Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13574-9. Epub 2005 Sep 8. PubMed PMID: 16174747; PubMed Central PMCID: PMC1224638.
Starr TK, Largaespada DA. Cancer gene discovery using the Sleeping Beauty transposon. Cell Cycle. 2005 Dec;4(12):1744-8. Epub 2005 Dec 5. PubMed PMID: 16294016.
Troy Baldwin, Timothy Starr, and Kristin Hogquist. Central tolerance of T cells in the mouse. 2005. The Mouse in biomedical research, second edition, volume 3: Normative Biology, Immunology and Husbandry.
Mick VE, Starr TK, McCaughtry TM, McNeil LK, Hogquist KA. The regulated expression of a diverse set of genes during thymocyte positive selection in vivo. J Immunol. 2004 Nov 1;173(9):5434-44. PubMed PMID: 15494490.
Starr TK, Daniels MA, Lucido MM, Jameson SC, Hogquist KA. Thymocyte sensitivity and supramolecular activation cluster formation are developmentally regulated: a partial role for sialylation. J Immunol. 2003 Nov 1;171(9):4512-20. PubMed PMID: 14568924.
Hogquist KA, Starr TK, Jameson SC. Receptor sensitivity: when T cells lose their sense of self. Curr Biol. 2003 Mar 18;13(6):R239-41. PubMed PMID: 12646152.
Starr TK, Jameson SC, Hogquist KA. Positive and negative selection of T cells. Annu Rev Immunol. 2003;21:139-76. Epub 2002 Oct 16. Review. PubMed PMID: 12414722.