Spentensemble

Sirtuins Simulating Stimulating Spentensemble of Health-Span Extension Aspiring Lifestyle (SHEAL) objective.

1. Stolid Superb Sleep [ BRAIN-MUSLE] & Senile Sarcopenia Stalling (Sarcoplasmic Surplus Storage via Sauna Schilling Sessions)

2. Sinoatrial Sublime Sensitization [HEART-LUNGS] & Samadhi Skill Sittings or Sessions. (Ventilatory Excursion Focussed Attention (VEFA) or Phrenic Excursion Focussed Attention (PEFA) are better alternatives to meditation which carries a faith or religious connation while VEFA & PEFA connote ) Sinoatrial Sublime Sensitization acquired through modulated breathing exercises of WASHAIRS as supplemented with ELOGEX – the diluted, subtoxic but excitation generation therefore a toned down version or a physiological and trophic counterpart of hormesis canvassed in toxicology

3. Stress Slicing-Slashing [ADRENALS-ANS] & Sharp Smartness Supplanting (there exists a strong bidirectional relationship between the two as is true of all other pairs of the spentensemble such that lucky ones enjoy a virtuous cycle of escalating stress smashing and sharpness or smartness elevation which in turn lowers stress while the unlucky ones who get trapped in the vicious cycle keep getting dumber and progressively more stressed. Stress management can be viewed as central point of the spentensemble and rest 9 items can be used to curb stress and thrive in life)

4. Sincere Synciatiating Sociability or [S-KIN] Sultry Sensuality Savouring (This involves sustaining or retention of libido past age 69 in line with philanthropic procreative preparedness pliantropy).

5. Satisfying Sigmoid Squeeze [GUT] & Sacral Symphony Silencing FOR Promotion Optimization & of Diversification Enteric Microbiome (PODEM).

WASHAIRS expands to Wellness Associated Sinus Arrhythmic Holistic Inherent Rhythmogenesis Synchronically.

A well-crafted and faithfully adhered to evening/bedtime routine is more important than the daytime routine and the morning routine because it sets the stage for developing the other two routine. All three of these need harmonizing for the Spentensemble of Health-Span Extension Aspiring Lifestyle (SHEAL) objective.

Spentensemble -I

1. Sustained sincere supreme singlemindedness in life-purpose of Ikigai. (ACE & OCA triads)

2. Sports surrounding with sexercise.

3. Sinfree sauerkraut synbiotic/symbiotic diet,

4. Sincere spiced sociability soldering (solidarity),

5. Samadhi spirituality stress slaying for sleep supplementation etc.,

Spentensemble -II

[Subordinate supplemental spentensemble]

1. Smirnoff & Soda shakes sparing

2. Sustained serial (chain) cigarette smoking succession,

3. Starbucks soup and related ACIFFIBs

4. Soil surround via solar strolls or Sveta effect savouring – links with Samadhi (gardening style hobbies)

5. Satyavad or satyagraha sincerity (orderliness, conscientiousness & authenticity or OCA triad)

Sirtuins Stimulate Sustainability

Sirtuins are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity.[2][3][4] The name Sir2 comes from the yeast gene 'silent mating-type information regulation 2',[5] the gene responsible for cellular regulation in yeast.

From in vitro studies, sirtuins are implicated in influencing cellular processes like aging, transcription, apoptosis, inflammation[6] and stress resistance, as well as energy efficiency and alertness during low-calorie situations.[7] As of 2018, there was no clinical evidence that sirtuins affect human aging.[8]

Yeast Sir2 and some, but not all, sirtuins are protein deacetylases. Unlike other known protein deacetylases, which simply hydrolyze acetyl-lysine residues, the sirtuin-mediated deacetylation reaction couples lysine deacetylation to NAD+ hydrolysis.[9] This hydrolysis yields O-acetyl-ADP-ribose, the deacetylated substrate and nicotinamide, which is an inhibitor of sirtuin activity itself. The dependence of sirtuins on NAD+ links their enzymatic activity directly to the energy status of the cell via the cellular NAD+:NADH ratio, the absolute levels of NAD+, NADH or nicotinamide or a combination of these variables.

Sirtuins that deacetylate histones are structurally and mechanistically distinct from other classes of histone deacetylases (classes I, IIA, IIB and IV), which have a different protein fold and use Zn2+ as a cofactor.[10][11]

Grabowska et al published Sirtuins, a promising target in slowing down the ageing process in Biogerontology. 2017; 18(4): 447–476.

2017 Mar 3. doi: 10.1007/s10522-017-9685-9

Ageing is a plastic process and can be successfully modulated by some biomedical approaches or pharmaceutics. In this manner it is possible to delay or even prevent some age-related pathologies. There are some defined interventions, which give promising results in animal models or even in human studies, resulting in lifespan elongation or healthspan improvement. One of the most promising targets for anti-ageing approaches are proteins belonging to the sirtuin family. Sirtuins were originally discovered as transcription repressors in yeast, however, nowadays they are known to occur in bacteria and eukaryotes (including mammals). In humans the family consists of seven members (SIRT1-7) that possess either mono-ADP ribosyltransferase or deacetylase activity. It is believed that sirtuins play key role during cell response to a variety of stresses, such as oxidative or genotoxic stress and are crucial for cell metabolism. Although some data put in question direct involvement of sirtuins in extending human lifespan, it was documented that proper lifestyle including physical activity and diet can influence healthspan via increasing the level of sirtuins. The search for an activator of sirtuins is one of the most extensive and robust topic of research. Some hopes are put on natural compounds, including curcumin. In this review we summarize the involvement and usefulness of sirtuins in anti-ageing interventions and discuss the potential role of curcumin in sirtuins regulation.