Lucywilkure

Myths of a true placebo , nocebo effect and myth of objectivity

The term “study participants” or “trial enrolees” is superior to and more precise than the term “volunteers”. By default, volunteers don’t expect to benefit from their participation in a process or philanthropic act. Were the vaccine to offer them the immunity those who get the real vaccine would profit by securing immunity. The placebo controls would benefit from the psychological benefits of their generosity and a small fraction would actually develop which is called sympathetic immunity which is called placebo effect and works like pseudopregnancy that some husbands experience when their wives are pregnant. I am not being facetious here. The words carry deep meanings and need to be used with caution in such circumstances. Due to what is term Lucywilkure and Alia Crum effect there is no such thing as true placebo controls such that all placebo controlled studies are flawed to an extent There is no such beast as absolute objectivity in science, All conclusions are bias tainted but there is concurrence of biases. There is also a nocebo effect you can kill someone by scaring that person. See details here

A disclaimer on Lucywilkure.

The closest to neuropsychoimmunology this magical remedy that borders on quackery what the mainstream healthcare professionals view non-traditional health practitioners (hypnotherapists, acupunturists, holistic medicine or lifestyle medicine practitioners ) comes to is outlined by Danna Pycher is a certified Neuro-Linguistic Hypnotherapist in his TED talk Healing illness with the subconscious mind. A close look at the capacity of an individual to build that resilence in the body whereby the body rejects and squeezes out the conditions like cancer, lupus, diabetes, chronic pain and even Alzheimer’s disease from their bodies would be accomplished by exceptional individuals only. That does not imply that the resiliency of Psycho-Endo-Neuro-Immunological System (PENIS) is a non-entity. It only means that those who have this resilience and can rely on it to keep those chronic ailments would not suffer from them in the first place such that the exceptional nature of those who did not have this resilience but managed to create it must be seen as exceptional such that benefits of Lucywilkure would be exploited by only by rare and exceptional individual and not everyone.

Lucywilkure (syn: 1. quickery – implying speeding up of the healing process through engagement of mind in the process along the lines of Alia Crum effect; 2. “sinpostering” derived from sincere+impostering or 3. “charlatreatment” real treatment that appears charlatanism depicting non-fraudulent deception or lying.) The etymology of Lucywilkure is inspired by the contents of TED talk named by What medicine can learn from art by Dr. Lucie Wilk MD turned a fiction writer, currently writing her second novel. She obtained both her specialist medical training and her MFA in creative writing from the University of British Columbia. Dr. Wilk has practised and taught as faculty of Medicine - Department of Internal Medicine at UBC. In 2010, she moved to the UK, where she has worked as a consultant in several NHS Hospital Trusts.

Dr. Shamini Jain a psychologist, scientist, and social entrepreneur an Assistant Professor in the Department of Psychiatry at UC San Diego, where she is also Chair of the Center for Integrative Medicine’s Research Committee, in her highly insightful TED talk asks What is healing emphasizes the need to begin to think outside the box and adopt novel approaches as the conventional ones are not working. [ Add from her talk in Touch ]

Lena Kay Three Steps to Transform Your Life presents an anecdote of a Kurdish boy who grew up to be successful and then had a serious downfall but picked himself up out of that state by using his own mental efforts. By changing his cognitive style, he is said to have transformed his life. She depicts mind as the most powerful asset by asserting “people do not value their minds until they see someone who has lost theirs.” Focus and effort lead to result creation and is the hardest hurdle and often get distracted or discouraged. By focussing on the implausibility, the negative outcome immediately ensues. Savouring the thought is important. All that is created by humans on the planet was at some point was an idea or thought. Wishing is not enough, you need to pursue the objectives. Odds of realizing what you believe in firmly tend to be high. You are designed to win but programmed to lose but you tend to yield to the program and consent to losing out. In the end it is action that matters. Reality creation is often within reach. By imagining you are already there and taking action is very helpful. Negative self talk adversely impacts the immune system and hormones. Succumbing to judging, complaining, whining and justifying failures are strategies to insure losing. Stagnation and procrastination halt growth. It is foolish to expect the circumstances to become favourable to start to take action. Negative self talk can darken thoughts, beliefs, expectations and stall action insuring failure.

Despite slight loosening on the tenacity of the grip traditional medicine continues to have a very tight grip on the tangible-only evidence based (TOEB) science model of medicine with serious harm being inflicted to the public through this faulty and outdated viewpoint, suggesting the urgent need to “fictionalize” medical care of humans by making it different from the small or large animal medicine practice. In concluding her talk she advocates the strategy of boosting stress resilience or Psychocerebrally Resilient Elational Steadystate Through Optimism (PRESTO) as a strongly desirable general application intervention because as would be explained that CHICAS or superfluous sinister social stress is ubiquitous. What would be powerfully helpful in dissipating the conflict is admission that the relationship between tangible-only evidence based (TOEB) science and non-TOEB medicine is not binary and mutually exclusive. In reality the two invariably coexist but to varying degree of apportioning of the participation and we must shun the cleanly dichotomous viewpoint. That requires cultivation of a lumper or marrying mindset and shunning the overly popular splitter or divorce mindset. Objective of medicine would be best served by marrying TOEB with non-TOEB medicine and grasping how one feeds upon and feeds into the other such that mind is not only something that matters, it is matter per se, and that while we can let matter be matter we need to also mind the matter diligently upon recognizing the unpredictability of mind which can be assumed to have a ‘mind of its own’ such that all generalization about mind would always be shaky, fairly speculative or uncertain.

This approach would help best to savour the drama, which we can concede to be the sole purpose of existing on the planet as a human. This conclusion is based on the semi-true assumption that animals do not savour the drama or at least not the extent that humans do and even if they do they have very sketchy memory of the drama, something that we can assign to toddlers below age 5 prior to permanent memory registration age and to those with dementias. A fuller savouring of the drama of life with the happy and sorrowful spans of time, it is better to assume the heroic active protagonist role and produce results and refrain from being passive spectator or the target of actions of environment or of others upon the inert passive self which the corporate universe, the policy makers and the public health care paradigm urges people to adopt. One take home message is that abandoning control and become a passive log that drifts wherever the waves might take it is not only devoid of fun and excitement it often forms a nidus for them and myriads of suffering become attached. So whenever feeling ill or unwell attempt quickery, and make frantic efforts using a hybrid approach of both the TOEB with non-TOEB medicine to obtain the optimal fitness level to be able to continue to play the assertive/aggressive protagonist role full of excitement even if while trying new things success comes less often that failures. The key strategy ought to be shunning or taming timidity.

John Francis Leader who has recently started to use an ex-military 1976 Series III Land Rover fitted with a virtual reality system that overlays a graphically-rendered version of the vehicle's interior as his therapy tool in his TED talk Therapy of Tomorrow refers to the cognitive aspects of the act of reading a novel or book, whereby the psychological impact or affect modification from the act of reading the text is contingent upon the interpretation of the text into a mental graphic or video that is played on the screen of mind to produce those effects. In that regard reading text is a special type of visual input analogous to the linguistic auditory perception which is distinct from the music and noise. A fact extremely worthy of note in the context of the psychological interpretations of the sensory input in the nature of text-based content which is distinct from touch, sound, sight etc.., is that the entire purpose of human existence ought to be viewed as an exercise in experiencing the human experience. The view that humans roam about on the planet purely in search of pleasures or happiness is seriously flawed. It is the work of the corporate universe bent on boosting profits through increasing consumption to beyond astronomical levels. Humans must enjoy even the suffering to complete their experience which can come from mourning the demise of a loved one etc. Remarks of famous neurologist-psychiatrist and Auschwitz inmate Dr. Viktor Frankl on the meaning of suffering are particularly apt in this context. Public must not be misled to view human experience as entirely pain free or even disease free. Some level of pathology is to be anticipated and prepared for. In fact the situation with Alzheimer’s disease is such that everyone must nearly look forward to become personally afflicted as one finds in the TED talk of Alanna Shaikh How I'm preparing to get Alzheimer’s; or at a minimum prepare train, and equip oneself to become a care provider for a close friend or member of the family who becomes Struggling Humans Afflicted by Progressively Evolving Dementia (SHAPED). This objective is intended to be served through popularization of the slogan in the public - Get Alzheimer’s Disease – one benign meaning of which is to study and grasp this medical condition while overlooking the disease portion of the term which is a misnomer given that the correct name would be Alzheimer’s Syndrome.

Historical ignorance of neurobiology as the driver of a skewed medical model. The popular tangible-only evidence based (TOEB) science model of medicine has ruled the realm of public health delivery because of the enigmatic nature of the brain for the past 5000 years human civilization with a primitive medical delivery system. Things are beginning to shift with the recent revolution in the neurosciences, through recognition of Psycho-Endo-Neuro-Immunological System (PENIS) and more recent identification of DeMoNe, the combination of which can reasonable serve as neuroanatomical substrate for mind. Functional neuro-imaging is breathing some life into the concepts of mind-brain connectivity and offering a tangibility traction to the previously non-tangible. Due to the ignorance of functional neuroanatomy and the propensity towards downplaying of the Lucywilkure approach modern physicians in the moderately technology driven have operated akin to robot repairmen. Reasonable hopes can now be pegged that further advances in technology would help bring a shift from this robot repairman paradigm towards a compassionate, affectionate humanitarian medicine with rewarding results.

Psychocerebral strands are recognized and presumed to exist without need for tangible evidence, as running down from the affectio-cognitive cloud tethered to various points on the cerebral hemispheres especially the hypothalamus and possibly even cerebellum and medulla oblongata. They can be visualized akin to the strings used to cause movements of pupettes by the puppet masters. Their nature is understood to be analogous to the Wi Fi signal in the internet. The mind or psyche is understood as a cluster of large number of videoclips akin to those stored in the YouTube. Mind and these psychocerebral strands are non-matter therefore not susceptible to any neuroradiological imaging modality but its shadows can be found in the fMRI, SPECT and FDG-PET type functional scans. But the mind itself is a ghost and cannot be stored by any graphic modality. Progress in linkage of chronic anxiety state to inflammaging that underlies several chronic health conditions gives further reality of tangibility to previously intangible such that the gap is quickly shrinking. Proponents of Lucywilkure accept no burden to establish the reality of the psychocerebral strands and assume that they would remain invisible. An analogy can be offered arguing that human mind is incapable of recognizing them just as the eye is incapable of seeing itself or own cheek or ears without using a reflecting surface. The best one is capable of is a distorted view of own nose. In short human mind is inherently incapable of comprehending precisely the operation of human mind at the existential level which must be presumed to exist without need of proof.

TOEB & Non-TOEB medicines. While tangible-only evidence based (TOEB) science model of medicine likely holds true of veterinary medicine, humans are extremely cognizance and affect rich animals due to their remarkably oversized brain in relation to the spinal cord. While subhuman primates do possess traces of affect (ability to enjoy and to suffer) and even cognizance (intelligence, memory etc.), and both are almost non-existence or practically negligible in comparison to the degrees exhibited by humans. Even if the existence of affect and cognizance is conceded in the sub-primates, it is nearly impossible to establish the key human traits of optimism-pessimism gradient, introspection etc. Leaving out the non-TOEB component of engaging the cognitive-affective component of the human downgrades medicine to veterinarian practice. Term tangible here refers not only to physical entities visible under electron microscope, molecules that can be shown to exist through making them fluoresce upon appropriate binding ligands, or even through chemical interactions but also to the entities show existence can be proved by study of the wave patterns such that even sound and light are tangible. Non-tangible begins beyond these limits such that even the wi fi analogy is only partially true. A serious trouble with TOEB medicine is its fatally flawed motto stated as “if it not matters, it does not matter “because non-matter or non-TOEB science does matter. Lucywilkure requires trusting the non-TOEB science as a credible entity without demanding evidence.

Dr. Lucie Wilk describes the power of mind and cognition in the causing and relieving of chronic mental and physical health conditions and answers the question - Can imagination and art bring us closer to truth than science. Troubled by patients being viewed as victims of their diseases, she explores the scientific evidence for the importance of a paradigm shift: away from pure victim role and toward empowerment through personal responsibility at the etio-pathological status and curative-rehabilitative stage. She is among thousand other physicians who believe that by ignoring the effect of the mind on our bodies, brain and even mind; we are missing an important ingredient in rewarding and meaningful healthcare delivery. In an amazingly creative interpretation of etymology of the term responsibility she splits the word into ability to make a response, something that is both onus accepting and empowering thus control enhancing. That would end the current modal of patients as passive protagonist who surrender their personal agency to the healthcare team which she finds to be a very disturbing paradigm which led her to view that robotic repairer job of illness fixing model of medical practice problematic. Upon noting an ICU physician simply ‘fixing’ the numbers of the patients laboratory result one can readily see the parallel between his work and that of a 747 Jet pilot which even shows a rather superficial insight into the human physiology or pathophysiology where the laboratory reported numbers are the result of complex interaction among several events going on and that fixing the numbers of the laboratory results is a seriously flawed approach even for the traditional medicine but a vast majority of physicians are guilty of simply piloting the human body or undertaking robotic repairs not managing it as a compressive whole. What is interesting here is that even installation of prosthetic limb is a profoundly involved psychological intervention, even without the psycho-kinetic controlling of the artificial limb which might be confused by the patient with the phantom limb.

Jill Sonke a dancer, a competitive gymnast, engaged in helping people living with Sickle Cell and Parkinson’s diseases attempts to explain in her TED talk Why Medicine Needs Art Potential interventions all of which would remain based on non-TOEB science in the realms of Lucywilkure would be:

1. Touch based therapies. - Brain Therapy - Light Touch Can Heal Ann House, Pet contact therapy.

2. Light based therapies.

3. Sound based therapies including music therapy.

4. Logotherapy version of sound-based therapy.

5. Transcranial magnetic therapy.

Evidentiary categories that insert legitimacy into Lucywilkure

1. Alia Crum effect – visualizing or law of attracting affirmative outcomes.

2. Kinesiopsychotropism (KPT) & Kinesioencephalotropism (KET)

3. Adaptive rewarding experiences - Profoundly Rewarding Events Occurring Frequently as Boluses (PREOFAB)

4. Mindfulness and CBT type practices including martial arts training and phrenoplasty and therapeutic hippocampal atrophy reversal.

5. Psychocerebrally Resilient Elational Steadystate Through Optimism (PRESTO).

Conceded limits of Non-TOEB medicine distinguishing it from tangible-only evidence based (TOEB) medicine.

1. Given that it exploits the placebo/nocebo effect in a very prominent fashion these interventions are not subject to placebo control and blinded studies. It might be possible to partially blind the procedure.

2. The outcomes of interventions are so individual and patient specific that their inapplicability to a cohort studies is admitted to be their characteristic rendering them to anecdotal-only variant of therapeutic interventions.

3. Given the characteristics of anecdotal nature and impossibility of blinding and controlling the unknown variables, the generalizations are tainted with vagueness and lack the affirmation or general applicability and the remarks are limited only as suggestive statements indicting that intervention might prove beneficial to carefully selected cases which only a modest likelihood of success without any guarantees.

4. The concept of risk/benefit ratio or cost effectiveness are inapplicable given that there is no real risk and there is no cost involved.

5. While a reasonable likelihood of even remarkable and magical seeming success of making cancer disappear can be presented to the individual under care it is made clear that the extent of success is entirely random and relies entirely on the effort invested by the patient himself while using the assistance of the care team and the treating physician. The patient or client is also advised that to endeavour non-TOEB medicine or not do so is entirely within his choice there is no cost or risk involved so it is a worthwhile consideration to attempt. In some cases there might be a need to combine TOEB with non-TOEB medicine where the offer is slightly modified and the connection between the two explained and the patient advised that the likelihood of TOEB component to succeed heavily relied on adding in the non-TOEB medicine.

Civilizational Hazards Induced Chronic Anxiety State (CHICAS) or superfluous sinister social stress. Engaging the participation of non-TOEB medicine to the presently practiced TOEB medicine would be strongly facilitated upon recognition of the ubiquitous presence of civilization chronic anxiety state which can be presumed to be absent only among the primitive tribes where modern civilization has not invaded. There exists even a dose response relationship such that harm inflicted on the psychological and mental wellness through residence in a civilization is proportional to the intensity of civilization and the level of technology. This means that residing in rural settings would impact you less severely. Part of remediation therefore could come from shunning the technology to the extent one can by switching from car to bicycle, from Facebook to telephone and face-to-face only contact etc. Evidence of CHICAS is offered by Dr. Wilks by herself being a prime target of public speaking anxiety. There are several such stressors manifesting in embarrassment, humiliation, dignity loss, damage to prestige, non-recognition etc. that were unknown pre-historic man. The list of civilizational hazards or social stressors is actually very long and includes heartbreak from failing an academic test, making a major mistake, being unfriended or blocked on Facebook, financial worries, being caught engaged in unbecoming conduct or crime, public nudity, social scorn of being seen in public when not presentable, spousal infidelity, psychologically restrictive effects of variety of sexual taboos, being yelled at by an abusive superiors or colleagues at work, threat of becoming unemployed, social stigmas etc. The existence of CHICAS is not readily susceptible to be tested by empiricism, rationalism, reason, hypothesis testing. The reality of being chronically ill through living in a metropolitan city is not truly a foreign concept when research is currently underway studying the link of air pollution to Alzheimer’s disease, autism etc. on the TOEB side of the coin. The psychological pressure of relationships alone is enough to generate a sizable non-TOEB triggered morbidity. Term stress sits on the fence however and can build connection to the TOEB side through the linkage of stress to top half of the Psycho-Endo-Neuro-Immunological System denial of which is prevalent in the classic traditional Western tangible-only evidence based (TOEB) science driven medicine in offering interventions healthcare providers are rendering a serious disservice to the humanity.

Implications of CHICAS to NCD, cardiometabolic syndrome and to Alzheimer’s disease. CHICAS model for the NCD, cardiometabolic syndrome and to Alzheimer’s disease implicates the lifestyle or being a resident in a developed civilization as the basis for these conditions and the individual responsibility for having been reckless with choices of life having led to the condition would be necessary for taking the leadership role in remediation and rehabilitation. Additional inferences are that the conditions would defy being controlled unless humanity takes steps to regress in the process of civilization and also that serious reservations must be held respecting finding ultimate remedies to these conditions without addressing the true cause namely CHICAS at the population scale. Individuals who can antagonize the adverse impact of CHICAS would manage to create a niche for themselves and escape harm by taking matters in their own hand and not rely on the public health system which is unable to adopt the non-TOEB medicine. The accidental coining of the term CHICAS which has all the necessary characteristics of a good meme that could catch on means Civilizational Hazards Induced Chronic Anxiety State (CHICAS) understood as a ubiquitous social stressor operational in all chronic illnesses including the upcoming tsunamic of dementias including Alzheimer’s disease now carries the potential to be viewed as a legitimate risk factor for heart disease, Cyclical Arteriosclerotic-Inflammaging Reverberating Operation (CAIRO), Old-age Related Cumulative Inflammaging Driven Syndromes (ORCHIDS) or the cardiometabolic syndrome etc. and facilitate the adoption of non-TOEB medicine.

Need of a discussion with the patient (or the parent if the patient is a child) of the Sir Edmond Hillary and Sherpa Tenzing Norgay (at minute 13:00 onwards) successfully climbing the Mt. Everest for the first time in 1953 spoken of by neurosurgeon Dr. Charlie Teo in his TED talk False Hope There’s No Such Thing. The patient is to be persuaded to take the role of the principle climber (or the Golfer) Sir Edmond Hillary and the medical team headed by the physician or surgeon to take the role of guide/caddy or Sherpa Tenzing. The motivation, courage and vision to succeed must reside within and preferably come from the primary player. The role of the Sherpa or caddy in the assistant position is vital in informing the circumstances in detail and even instill the motivation, courage and vision in the mind of the primary player as he is anticipated to be in possession of expertise, talent and experience but he does not call the final shots or hit the golf ball. This set up permits the mind of the patient who is the only afflicted with the medical condition to properly address it and exploit the benefits of the non-TOEB medicine as a human being as he is now not being treated passively like a veterinarian treating a horse, livestock or a pet, imposing his own will upon the subject of his professional medical care.

Dr. Wilks points out the illogical aspect of passivity of protagonist of a story around whom the drama is unfolding and that agency is integral to human experience, a chorally of which is that an human individual under coma, anesthesia etc., is entirely indistinguishable from an animal in coma or anesthesia. While the mind has been dissected away from the otherwise alive body in both cases the loss suffered by the human is enormously greater than that by the animal. Unlike human’s animals do not engage in breath holding or in regulated breathing behaviour; their copulatory behaviour is entirely hormonal and lacking mental excitation and morality etc. Unlike animals mentally intact human’s adults are profoundly aware of cause and effect relationship and ability to control their own environment and even the behaviour of others to a fair extent. This is referred to as will and will power. When placed under circumstances like imprisonment with removal of the power to control the environment (acontrollia) humans experience despair, stress and depression. With rare exceptions detention style acontrollia tends not to bother animals to a similar extent, which has operated as a criterion of successful domestication. She goes on to point to the acontrollia or domesticated livestock style passivity in the model of medical care offered by the public sector wherein the style of administration of healthcare to humans is indistinguishable from that for the clients of a veterinarian. While she points being disturbed by the patient passivity aspect of this healthcare delivery model, she overlooks to mention that the patients are active accomplices in abandoning their control by handing it over to the “experts”. That relieves them of their onus of appropriate lifestyle choices and the outcome of the interventions etc., so they are more than happy to abandon onus and control which go together.

The topmost needs listed in Maslow’s hierarchy of needs, namely unique identity, esteem, public image, prestige and personal growth needs (self-actualization). which are unique to humans that play a role in CHICAS, would continue to create gaps between the tangible and intangible. Experiencing various forms of art which includes reading a novel or book, watching a dance or listening to music etc., nourishes these higher Maslowian needs of humans such that art has the power to move the mind and impact the body through neuroendocrine mechanisms that transforms non-matter or intangible to tangible. Brain undergoes structural changes from merely learning information from books, maps and meditation etc.

Active role, mixed onus or purely passive disease models. Disease as purely passive victimization would be akin to a criminal act of random violence of body being ransacked or vandalized or at best a natural disaster with no role of the individual or self which can be held largely true in the case of an infant with meningitis. The example of lung cancer from smoking is now widely viewed as an active disease model which can also be said to some extent for alcoholism and recreational drug dependence etc. The situation of sedentariness linked and dietary indiscretions linked health conditions are somewhat complex and problematic and fall in the category of the mixed onus disease models. As a rule of thumb, the passive role of the patient in the passive disease model would seem entirely justified and in the active role played in disease generation a similarly active role in remediation and rehabilitation would also make sense. What requires explicit acknowledgement is that the mixed onus category is huge and both CHICAS and Cyclical Arteriosclerotic-Inflammaging Reverberating Operation (CAIRO) is a large player in this such that adopting the five golden rules would prove amply beneficial. In many cases of infections ranging from flu, STD to HIV etc., it is now possible to place a sizable fraction of blame on the patient through having failed to taken the vaccination or barrier protection during sex. In other words, there is a need to actively search for the personal onus and popularize the concept of active role of the individual in maintaining person health. That extends even to the carrier state of disease generating genes where environmental modification through the process of epigenetics has been shown to modify the effect of the genes such that the genes are not the absolutely immutable destiny. There is some rare exception to this like Huntington’s Disease, Narcolepsy and some childhood storage diseases. The remark that oral medications for a chronic condition is entirely within the power of the physician requires amendment in that the efficacy would rely heavily on patient compliance and there is an onus to provide feedback to the physician about efficacy and side effects etc. The role of physician as an advisor or consultant is a lot narrower than generally perceived. Physicians themselves are also to be blamed for misapprehending their role as they tend to be overly controlling and ruthlessly exclude the patient from the decision-making process in order to rush through the process due to time scarcity. Folly of the physicians gets tremendously compounded through their ignorance about higher Maslowian needs of humans to they end up treating humans like pets and cattle. The ignorance about DeMoNe and functioning of Psycho-Endo-Neuro-Immunological System also contributed to the problem. As a rule, physicians who are not neurologists tend to be largely obligations to the complex and sophisticated by nature neurobiological sciences.

Recognition of the higher Maslowian needs of humans who do clearly possess an individuality and begin to treat humans different from pets and cattle forms the thrust of the talk of Dr. Wilks is to include the thus far nebulous and therefore excluded partly by the expediency or time scarcity considerations. Noteworthy here is the fact that the element of individuality that Maslow speaks of in detail, is present even among toddlers and is retained in Alzheimer’s disease and psychoses until very late.

Interplay between PRESTO, CHICAS and CAIRO. A clearly observed fact of resistance to chronic health condition among those with high level of innate or acquired optimism permits a conclusion that the adverse impact of CHICAS that manifests in the form of Cyclical Arteriosclerotic-Inflammaging Reverberating Operation (CAIRO) that leads to several chronic illnesses including Alzheimer’s disease can be minimized by acquiring a higher level of optimism. Just as the innate genetic predispositions, the innate optimism level is also subject to being amended in a positive as well in the negative direction. Thus, PRESTO is a powerful tool to immunize oneself against the chronic diseases of the middle age and even against Alzheimer’s disease such that mindfulness training would lower the risk of dementias akin to the dietary modifications and physical activity. Recent Medical News Today reports recommend that individuals with a APOEe4 gene can lower their risk of Alzheimer's disease by consuming 80-100 mg of curcumin twice-daily — found in turmeric — which has been found to improve memory and mood in older adults; and that even 30 minutes of fairly light exercise or moderate-vigorous physical aerobic activity (MVPA) each day via doing housework, walking, standing, or any such similar low-intensity activity for about 150 minutes per week in the bouts of at least 10 minutes at a time or just a short walk of about 4000 steps each day can help brain health and maintain cognitive functioning. Building psychocerebral resilience is so profitable an undertaking that ignoring PRESTO is the most serious folly one can make but it is done by some 99% of modern humans while they need to invest time for it as they are continually suffering CHICAS.

Evidence of willingness with classical conventional medicine to recognize non- TOEB medicine or Lucywilkure is found in a short list of recent shifts

1. Recognition by NHS of legitimate nature of therapeutic interventions by CBT, mindfulness.

2. Mayo clinic recognition of meditation as a modality

3. Harvard University Center engaged in study of placebo effect

4. Studies on mindfulness by Dr. Amishi Jha and others

5. Emerging insights into DeMoNe linked to Psycho-Endo-Neuro-Immunological System as the seat of mind.

Highlights or characteristics of Lucywilkure.

1. The individual wishing to bring the personal mental or physical transformation must take the lead and assume the protagonist role akin to Sir Edmond Hillary and accept responsibility for both the success and failure and not attempt to attribute it to the medical consultant recommending Lucywilkure.

2. The extent or degree of success would be largely determined by the profundity in which the power of Lucywilkure to help with that transformation is believed in by the individual and one who is powerfully skeptical would be highly unlikely to benefit and is bound to fail so he she ought not bother attempting it. Lucywilkure would not help the skeptics.

3. While the cure is not guaranteed the success, rates are likely comparable to evidence based traditional medicine when it is applied to.

4. Lucywilkure is pertinent only to circumstances where Psycho-Endo-Neuro-Immunological System can be viewed as playing a role and is not advised as primary mode of cure in situations of minors, advanced dementias, severe psychoses, trauma, burns, poisonings, drowning etc., although a limited supplemental role in pain management is available through this modality in burns, trauma etc.

5. Special challenges would need to be overcome for those with speech, hearing and communication problems, dyslexias etc., which are amenable to Lucywilkure if accommodation is made to circumvent the communication hurdle. The role of communication between the healthcare providing consultant and the protagonist is so critical that the protagonist must be able to entirely trust the consultant with every single detail of the most intimate aspects of life including sexuality, gaps in which would pose a serious hurdle to success.

Need for refraining from adopting the TOEB science basis or robot repair paradigm. Fundamental to success of Lucywilkure is the successful acquisition of the protagonist role by the patient willing to boost personal wellness. That requires shunning the robot repair or veterinary medicine attitude where the patient places oneself entirely at the whim of the medical practitioner and hopes to be fixed or repaired akin to the car left with the mechanic to diagnose and repair. The very act of demanding even a precise tangible diagnosis and pathogenesis underlying the illness is incompatible with the protagonist role of the patient. There is a need to exhibit a partial blindness to the precise nature of what is really wrong. The only facts that need to be known where one now is i.e. a suboptimal level of fitness and wellness and where one wishes to arrive i.e. a much higher level of fitness and wellness. In the Mt. Everest analogy the two foci for the protagonist are the instantaneous location at the base camp and the target in focus the tip of the Mt. Everest. Energy need not be dissipated in acquiring information on irrelevant and superfluous details of all the points in between. That energy is best applied to insuring the transition from the basecamp to the destination tip. Seeking specifics that render the paradigm to the robot repair insures failure rendering the entire adventure an exercise in futility.

Evidence of astonishingly tremendous power of mind to impact body especially the brain and its sensory and motor capabilities.

1. Instantaneous bursts of extra-ordinary capacity (e.g. strength to lift a car in order to save a child crushed under it.)

2. Pain erasure adventures (Conversion reaction including surgery under hypnosis, acts of cheek and limb piercing adventures without anesthesia, self crucifying rituals by Catholic devotees)

3. Fugue state, characterized by genuine protracted amnesic spells and acquisition of a new personality during that bout.

4. Acupuncture therapeutics.

5. Placebo effect & Nocebo effect.

Mary Young a concussion grade but surprizingly severely disabling head injury victim at age 16 turned young successful entrepreneur, as the CEO & Designer of her self-titled clothing line that launched in 2014, Mary Young offers her profound insight about How changing your mindset can change your future

She faced a decade long fight with her brain malfunction. She took a winner approach during her post-concussion life and developed key lessons for journey on road to recovery and success. In the spring of 2017, her company introduced the Self Love Club, a movement powered by the company to open up the dialogue within communities to focus on self love and acceptance. She envisions female empowerment and boosting personal individuality notwithstanding any disability.

Fabienne Fredrickson poses a powerful question for living a purpose driven life where the purpose can be revealed by asking: What if nothing in your life up to now has been a coincidence and each one is here to serve a special purpose? In her TED talk Activating Your Potential for Greatness

She fosters a view that every person is born with a purpose; on purpose and for a purpose and that purpose is linked to greatness.

It does add a spice of novelty to shift the self talk to ask: What if you have been preparing for a unique role all along and that each individual was created to become great but most fail to realize that potential? Fabienne urges people to polish up the potential for greatness that is already within each of us, and gives a clear pathway to activate that potential, knowing the world will never be the same since you walked this earth.

The hypothesis of scripted innate greatness of every human existence that a vast majority of humans succeed in destroying can be a powerful tool in injecting purpose into life. The flip side of the concept of purpose of life is that we owe a moral obligation as a social society that has survived during the past 2 million years of evolution merely through collaboration and pooling our resources and wisdom to contribute to the society in a spirit of servitude. It carries substantial benefits to the person so contributing such that the donor receives far more than he or she donates of himself or herself. Actually, the propensity to not offer oneself in servitude tends to be penalized through loneliness, sulkiness, diseases, disability, depression, dementia, premature death etc. Even those who are not of a generous mindset and take a strategic business approach to life should weigh things correctly and notice that harm from being self focussed far outweigh the likelihood that the time devoted in servitude would be a form of personal loss.

The hypothesis of scripted innate greatness of every brain which includes those with Down’s syndrome, Autism etc., has several share-worthy gifts. In some cases, the mere propensity to obtain compassion or generosity of others operates as a gift such that even sick role or being crippled has societal value and purpose. For one thing it helps researchers understand neuroscience better given that evolutions of disease models are a powerful approach to explore neurobiology. We would risk seriously offending guinea pigs by saying that they serve no purpose. It is not only humans but even all apes and white sharks are deemed great, as also oak trees.

She is an inspirational mentor to thousands of clients worldwide, an author, international speaker and founder of The Client Attraction Business School and ClientAttraction, ranked repeatedly as one of America’s fastest growing private companies as recipient of the 2013 Stevie Award for Entrepreneur of the Year.

As one of the most influential and highly acclaimed success mindset speakers and mentors in the world, Fabienne believes in the capacity for each and every person to become the full expression of their purpose here on earth by taking a no-excuses approach to growing within and having a willingness to “play a bigger game.” Her empowered mindset teachings, born from her own personal experiences and challenges while originally intended for entrepreneurs, have now generalized and are being embraced by women globally as they seek a catalyst for their personal and professional growth and to live a love filled life.

What would I attempt if I could not fail?

Activation your greatness potential is a choice that most people do not make.

Maximizing the gifts owned is critical after figuring out personal unique strengths

Declaration of the goals repeatedly to yourself as well as to the world to boost personal accountability because then propensity to accept defeat and abandon is lowered by the feared shame of abandonment of the stated goals.

Denial of personal frailties or notions of unworthiness or worthlessness and believing immensely in personal power to create greatness around yourself.

Cautiously guard yourself from the critiques and negative talkers upon being vigilant about them given that they tend to come as enemies disguised as “friends” or frenemies. Assume everyone to be not a friend unless that can be disproved through noting their actions supporting of your goals. Modern civilized society is made up largely of molasses like sticklers who take pride in and invest tremendous energy in dragging back into conformity anyone who attempts progressive thinking and action and refuses to collaborate or honor that until he or she succeeds.

It is necessary to abandon the tendency to live a mundane mediocre life and forgetting about greatness.

Commit to your greatness and goals. W. H. Murray, The Scottish Himalayan Expedition

"Until one is committed, there is hesitancy, the chance to draw back, always ineffectiveness.

Concerning all acts of initiative (and creation) there is one elementary truth, the ignorance of which kills countless ideas and splendid plans: that the moment one definitely commits oneself, then Prominence moves too."

Tame timidity, inflict discomfort upon yourself and be daring and attempt things that you mistakenly believe you are incapable of succeeding in. You would likely surprise yourself with your results because magic (Lucywilkure) does not happen within the outdated and stale personal comfort zone which must be abandoned or stepped outside of. To succeed with the timidity that tends to be rooted in apprehensions about failure, amplify exponentially the expectancy of superb results of becoming great. I am positively expecting great results, no matter what I see in front of me. The Universe is rearranging itself for my best interests right now. It does help to be clear about personal best interests. This line when chanted regularly to oneself amplifies the power of positive expectancy principle and secures some version of magical, extraneous, paranormal or Divine guidance which actually need not exist. All that is needed is a firm belief in it and the placebo effect of Alia Crum Effect would take over. There is no requirement for the Universe to do anything. Mere utterance of this phrase five times a day does tricks on your mind that helps tame timidity.

Sarra Jiwa a grade 12 student at Bur Oak Secondary School in Markham, Ontario who with passion for travel and hopes to become a neuroscientist (and appears to be smart enough to succeed in that objective!, Additional Blessings dear blessed child.) sends out a very insightful message in her TED talk Changing Your Mindset Can Change Your Future Upon beginning in a rather dull style she picks up in her wisdom grade towards the end. She points out that the chore of adolescence in the modern civilization is to excel academically and in the extra curriculum etc. That requires to be in an excellent control of our own lives and the life circumstances. Each one of us must operate in an extremely uncertain and unpredictable world and own frailties. Excessive dwelling on the honor associated with the goals being pursued has a build in fatal flaw of impeding success. There emerges a powerful temptation to concoct excuses or lame excuses that are not supportable by facts. Brutal honest by confronting what is really preventing success in attaining the goals is the sole rescue. It requires a strict transformation from self deception towards honesty and bring a shift in mindset to take a much better control over the current status over the current hour and the day. Only via diligently operating on the present can one shape the future in a desirable manner not by simply remaining excessively focussed on the future. On first brush it would appear to run counter to the visualization that dictates keeping eye on the goal or desired outcome but there is no conflict or inconsistency. While staying fixated on the wished dream and visioning the badge of success being attached is essential and advisable, that alone is not enough. In fact, the very purpose of having that fixation on final goal is a devise to focus resources towards that objective alone and not be distracted upon losing sight of the really desired goal. And unless work is done in the present the final success would not magically happen. While there is a magic to the process, work needs to go into building the magic.

Personal transformation requires some version of cognitive behaviour therapy (CBT) or transformation of the mindset. There is support from medical research in obesity control context to support this view. Without a metamorphosis a pupa cannot become a butterfly. It is reasonable to view CBT as a cognitive metamorphosis and obesity elimination as a remorphing into a slender form. Sarra Jiwa in her TED talk Changing Your Mindset Can Change Your Future seems to hint at a self serving, bias tainted thus a dysfunctional mindset reminiscent of a mental health condition. A version of self-deception in the form of a bias or delusion invariably lies at the root of failed outcome. A related observation is that the sufferer of bias is invariably unaware of that bias and is unable to correct it without external input in the form of, say, CBT. The ‘lame excuse’ that is advanced to justify failure or inability to succeed is the product of that bias or distorted reality. It is an attempt to externalize a truly internal flaw of having failed to plan and execute it effectively etc. The external and by default out of one’s control factors are profoundly trusted to be the real reason for failure and that distortion, upon resolving the cognitive dissonance, permits acceptance of the unacceptable reality of failure without hope of reversal of that failure e.g. of losing weight. Timidity or icantism where one depicts a personal psychological or physical disability to succeed as the real (but in reality, biases, delusional or fake) reason for failure is almost always operational. The real task therefore boils down to timidity taming. To excel, one must develop a mindset that external controllers never operate perfectly and endlessly. They have time limits and do cease to exist at some point and they are always imperfect such that gaps in their armours would begin to show at some point under constant strain so through applying sustained pressure through perseverance it is always and without exception possible to create those fractures in the armour of the external determinants that are manifestly and genuinely inflicting failure. Spend a fair bit of time on becoming better aware of own resources and capabilities helps masterfully use them to create those cracks in the armour of the external troublemakers. This all boils down to the reality that while they seem to be uncontrollable, all external factors are in reality at least partially controllable given enough perseverance and duration for the duel to continue. All that is needed and is helped by the envisioning principle of law of attraction is that the duel be sustained and resource based broadened to continue the wrestling because giving up or not giving up is always personal and fully controllable element. The external resistors cannot compel anyone unwilling to do so to give up. There are techniques to amplify will power through self temptation in conjunction with CBT.

Using the example of a self imposed high target of a certain scholastic score that acted as an inhibitor for her action of studying diligently and systematically, Sarra Jiwa explains how that intense desire led to a paralysis of action, which was a dysfunctional style of high stress or chronic anxiety state. She diffused that landmine style pressure button by gradually studying the wiring pattern and cut some of them to deactivate it and lifted the pressure. The granting of the score was in the power of the professor alone. All she had control over was her performance in the test and that would be amended by the practice she put into studying the subject being scored. There are tools to improve success in studying again using CBT and relaxation exercises and mindfulness. Her success came from shifting her mental focus away from the score to learning each chapter diligently and gradually with a partial disregard for the score. Such periodic hiding the dream from the vision is permissible. What helps retain interest and persevere is self-rewarding given that others are not going to reward until the ultimate score or diploma is not secured. In the interim one must carry the torch alone, relying entirely on self-appreciation. Societal mores tend to heavily promote criticisms which need to be fought.

She has relied on a masochistic approach of inflicting suffering upon herself to succeed and used the acronym PAIN which here stands for Personal Achievements, via Initiating Now. Over 99% of failures result from failing to initiate now and procrastinating to find a more appropriate opportunity e.g. in asking a girl out for a drink hesitation amounts to abandonment of the idea for good because the perfect moment never arises and then she begins to date someone else. The entitlement to reward oneself can then come from the simple fact of having initiated the work towards the objective instantly. It can then be topped by more mediocre successes of merely having completed a quarter, then half and finally the entire running distance. It need not be a medal for the 100m spring to be able to reward oneself given that rewarding oneself is entirely self controllable. The initiating now however needs to be repeated daily or several times a day and that begins to count for several personal achievements of simple having read the entire chapter, one paragraph at a time while staying fully focussed and retaining it as much as possible. There is no pressure to remember it all because that would come when repetitions are undertaken.

In using her PAIN strategy, she used a smart trick of self-distraction. The mindset shift acquired through CBT can help train the mind to tolerate a fair bit of suffering without truly appreciating the whole pain through distracting oneself. Sarra used the pleasure or reward she could offer to her mind of the pleasant warm weather and the sensation she felt in her hair to distract herself from the suffering of the distress coming from the exertion. Even if the air was biting cold and she was afflicted with a bad hair day, it is still possible to fool oneself by simply imagining lying on a warm Cancun beach. With some training that is not too difficult trick to master. In one episode the toothache of Moe was reduced through hitting on the big toe, using this masterful technique of distraction. Remembering a joke or allowing an erotic image to cross the mind work equally well. Thought of a beer afterwards has also been effectively used as a pain killer during the workout, whether the beer was later consumed or not is immaterial. Having an attritive running partner of the opposite gender and “chasing after” that person works equally well. The whole theme is to make the suffering seem fun. Once that is accomplished the PAIN goes away and helps succeed. What she did was suppressed the thought “I can’t wait until this all is over” to “I am so proud of myself for carrying on and not giving up.” That is a 180° mindset shift. Despite the circumstances remaining the same using the CBT principles she was successful in turning a pain into pleasure. The art of self reward and self pride taking is the crux of CBT. We live in a negativity biased culture and praising is exception but propensity of criticism rules. We need to exploit CBT to train ourselves to fight that and ignore that propensity. By beginning to praise others it becomes easier to self-praise. Parents too tend to be overly critical of the performances of their offspring. It would help, when that is a reasonable statement to start saying – “I am so proud of you for having done that.”

The external controller that tends to tempt people to abandon their efforts and accept defeat is infliction of some version of suffering or duress e.g. shame of talking to stranger, physical exertion, or focussing on studying while resisting the temptation to party etc., needs to be defeated by taking the steps like going ahead and risking being shamed or turned down, the cramps in the legs or the boredom of continuing to read while focussing and denying oneself the fun of the party etc., but taking pride in that act of having talked to the stranger or having studied etc. The “process perseverance pride” is the skill that can be mastered through CBT or mindfulness. That pride can be made rewarding and pleasure inducing enough that the pain from the adverse immediate outcome can be overcome or neutralized. It helps to engaged in the positive self talk to the effect, “the immediate outcome of this proposes plan is inconsequential, all I propose to do is take pride in the fact of persisted with the process that is likely to lead to success.” Become blind or immune to the immediate outcome is crucial and even if the big reward of ultimate huge success remains too far ahead to be invisible that too is not to be made an immediate concern which must be restricted to process perseverance pride. Here those with a positive outlook or an optimistic personality are at a big advantage and that art can be mastered through PRESTO. This theory or approach of process perseverance pride carries the magic of producing the desired result rather spontaneously and without actively chasing after it. That seems to run counter to the envisioning but there is a need to remind oneself that the process perseverance pride is the offshoot or child of that vision to begin with.

Synergistic cumulative effect of SSANITY.

a friendship style relationship with death

The DeMoNe mischief of generating the human negativity biased mindset.

a friendship style relationship with death

Danna Pycher is a certified Neuro-Linguistic Hypnotherapist specializing in chronic illness and trauma from the perspective of sub-conscience with several years experience in broadcasting as an on-camera host, reporter, and producer working in the fields of health reporting and corporate productions opens novel therapeutic frontiers in his TED talk Healing illness with the subconscious mind. The scientific support for her views are rooted in psychoneuroimmunology. For her surviving an accident was the easy part to live through but coping with the lingering chronic pain would proved harder. She shares her story about trauma and the transformative insight she gained that allowed her to harness the healing power of the subconscious mind a nebulous concept tangible evidence for which would never come.

She aptly explains that one's self identity both in health and in disease is manufactured in the subconscious mind, one example of which can be found among transgendered adolescents struggling to secure the mindset appropriate genital anatomy. It is essential to view the conscious and some of the subliminal mind as synonymous with the human experience or human life as we know it. Her argument that childhood is a period analogous to a hypnotic trance and the superb cognitive skills that a human child acquires at superfast speed is the result of a genetically programmed skilled brain in a state of hypnosis and the learning process is merely an awakening of the inherited talents that are already there since birth in the subconscious mind. Her crippling chronic fatigue syndrome that evolved into fibromyalgia, that emerged at age of 18, which was misdiagnosed as stress or depression. A near fatal automobile accident was the next assault on her wellbeing and she was labelled with PTSD which was magically remedied through hypnosis. Through not giving up and retaining hope which is the essence of Alia Crum Effect she realized the benefits of Lucywilkure to resolve all her chronic pain symptoms, something that not everyone would succeed in doing at least not without proper help.

Through pinning pathogenesis of several common health disturbances on the nexus of stress with the process of oxidative-assault-cum-inflammaging smoldering (OACIS) - the pathway of accelerated or pathological aging - and pathogenesis of cardiometabolic and neurodegenerative syndromes namely Cyclical Arteriosclerotic-Inflammaging Reverberating Operation (CAIRO) production of a large number of chronic disabling diseases of later half of life can be linked with or blamed upon psychological stress or trauma or Automatic Negative Self Talk (ANTS). Default Mode Network (DeMoNe) the older name for which is the subconscious mind, clearly plays the role of a demon here and plays a key role in civilizational hazard induced chronic anxiety state (CHICAS), which is a uniquely human experience.

Several examples of Lucywilkure are presented in the discussion of Touch therapy

Lucywilkure (syn: sinpostering derived from sincere imposteringal or charlatreatment real treatment that appears charlatanism)

Dr. Lucie Wilk MD turned a fiction writer, currently writing her second novel. She obtained both her specialist medical training and her MFA in creative writing from the University of British Columbia. Dr. Wilk has practised and taught as faculty of Medicine - Department of Internal Medicine at UBC. In 2010, she moved to the UK, where she has worked as a consultant in several NHS Hospital Trusts.

What medicine can learn from art

Answers the question - Can imagination and art bring us closer to truth than science.

Troubled by patients being viewed as victims of their diseases, Dr. Lucie Wilk explores the scientific evidence for the importance of a paradigm shift: away from victimisation and toward empowerment. Via the popular denial of top half of the Psycho-Endo-Neuro-Immunological System (PENIS) the classic traditional Western tangible-only evidence based (TOEB) science in offering interventions healthcare providers are rendering a serious disservice to the humanity.

While TOEB science model of medicine likely holds true of veterinary medicine humans are extremely cognizance and affect rich animals. While subhuman primates do possess some cognizance and affect it is negligeble in compraison to the degrees exhibited by humans. Leaving out the non-TOEB component of engaging the cognitive-affective component of the human downgrades medicine to veterinarian practice.

by ignoring the effect of the mind on our bodies, we are missing an important ingredient in successful healthcare.

passive protagonist who surrender their personal agency

patient passivity is a disturbing paradigm

if it does matter, it does not matter

illness fixing model of medical practice is problematic

Disease as an act of random violence, a natural disaster or body being ransacked.

CBT mindfulness as modifier or risk factors.

Jill Sonke a dancer, a competitive gymnast, child hospital volunteer and a medical researcher as the director of the University of Florida Center for Arts in Medicine, and Assistant Director of the UF Health Shands Arts in Medicine program that puffers masters degree in arts in medicine and is engaged in helping people living with Sickle Cell and Parkinson’s diseases attempts to explain in her TED talk Why Medicine Needs Art

Elements that insert legitimacy into

1. Alia Crum effect – visualizing or law of attracting affirmative outcomes.

2. Kinesiopsychotropism (KPT)

3. Kinesioencephalotropism (KET)

4. Psychocerebrally Resilient Elational Steadystate Through Optimism (PRESTO).

5. Mindfulness type practices including martial arts training.

Michael Morgan a LMT, CST-D who has been a Cranio Sacral Therapy instructor advocates a three-pronged intervention of diet, exercise, and CST as both preventive and therapeutic regime in his TED talk 2 Deaths, 1 Disease His step-mother and sister-in-law were afflicted with Alzheimer’s disease. He begins by pointing out the differentiates brains of “normal” patients and those of patients suffering from dementia and Alzheimer's disease. He has played role in coordinating research in the application of Craniosacral Therapy to Dementia and Alzheimer’s disease and served as a consultant for a study published in the American Journal of Gerontological Nursing. He asserts that those who undergo regular Cranial Sacral Therapy (CST) tend to regained lost cognitive capacities. Theoretical underpinning of this intervention revolves around improving the flow of CSF which might help mobilize amyloid. That appears implausible. Observed benefits are likely transient and introduced by other elements than CST per se. Some miracle component must intervene for any symptom resolution. Miracles do happen but that would be the exception not the rule. It is inadvisable to rely solely on Cranio Sacral Therapy as a meaningful intervention for Alzheimer’s disease.