Fetal-workout Pliantropy Plus

By taking an antipleotropy principle I propose that we can exploit the fact of adaptive and selective forces that favour procreative prowess over fitness we can attain longer healthspan by tricking the body into viewing that fitness is for procreative success. This is summarized in the principle I call procreative pliantropy see https://bit.ly/Pliantropy

Alarming Data on Early Cognitive Decline in Transgender Adults supports this hypothesis based on the inadequacy of the type of their sexual maturity, procreative prowess etc.

It is very plausible that the current physical exercise mimetics or kinesiotropomimetic-caloric restriction or restraint mimetic strategies (exercise plus intermittent fasting) under study as anti-aging strategies produce their desirable effects through the pleotropogenome

USE IT OR LOSE IT APPLIES TO FEMALE GENITALIA. Women not having even one orgasm per month would see their ovaries pack up and leavce far sooner than those who do get some form of erotical arousal weekly or at least monthly. Women who engage in sexual activity weekly or monthly have a lower risk of entering menopause early relative to those who report having some form of sex less than monthly, according to a new UCL study. https://www.eurekalert.org/pub_re…/2020-01/ucl-hls011320.php

By taking an antipleotropy principle I propose that we can exploit the fact of adaptive and selective forces that favour procreative prowess over fitness we can attain longer healthspan by tricking the body into viewing that fitness is for procreative success. This is summarized in the principle I call procreative pliantropy see https://bit.ly/Pliantropy

https://bit.ly/Pliantropy

Arnot and Mace published Sexual frequency is associated with age of natural menopause results from the Study of Women's Health Across the Nation published in Royal Society Open Science Jan 2019, reporting that women who engage in sexual activity weekly or monthly have a lower risk of entering menopause early relative to those who report having some form of sex less than monthly, according to a new UCL study. Women, who reported engaging in sexual activity weekly, were 28% less likely to have experienced menopause at any given age than women who engaged in sexual activity less than monthly. Sexual activity includes sexual intercourse, oral sex, sexual touching and caressing or self-stimulation. The nourishing or trophic factor for the ovaries that would keep the ovulation process to endure seems to be the pelvic vascular congestion from erotica arousal and possibly male body fluids, but exposure to male pheromones alone failed to delayed menopause in the absence of pelvic congestion from sexual arousal which maxes at the time of orgasm. The mode of orgasm does not make a difference. To women it is desirable to delay menopause to the extent possible given the adverse health effects of the post-menopausal status. Retaining interest in sex and attempting to secure orgasm at least on weekly interval is medically prescribed

Harvard Health Publishing published an article Resuming sex within months of a heart attack linked to longer survival in Heart Health on 1 Dec 2020 citing a study published online on 23 Sept 2020, by the European Journal of Preventive Cardiology, included 495 sexually active sub-seniors (mean age 53 all younger than 65-90% were men) hospitalized for their first heart attack between 1992 and 1993. . With a median follow-up of 22 years as 43% of the participants had died the data revealed that adults who maintained or increased the frequency of their sexual activity within the first six months after a heart attack had a 35% lower death risk relative to the sex-abstainer or those who reduced their sexual activity substantially after the cardiac event discharge. With due regard to the compounding variables like improved post MI relationship with a more empathetic spouse living in fear of losing the partners or the effect of post-MI rehabilitation therapy induced health improved, the data still permitted attributing return to coital behavior with improved outcome showing a cardioprotective effect of coitus. A plausible explanation for this divergence between the post MI coitally active and post MI coitally inactive adults would be pleotropogenome - pleantropogenome or fortification of pliantropic powers. Maintaining/increasing the frequency of sexual activity within the first six months after a heart attack was associated with a 35% lower risk of death compared with abstaining/reducing the frequency of sexual activity. The survival benefit linked with maintaining/increasing the frequency of sexual activity was mostly attributable to a reduction in non-cardiovascular mortality such as cancer.

Strategizing striving for continually elevate the quality of life with the objective of living well and keeping suffering, misery and pain at bay.

Longevity research concludes that longevity traits are associated with living a high quality, misery free, productive, enthusiastic life where one awakens each day to welcome and savour the pleasure generating events from the time of leaving the bed to returning to bed to sleep at the end of a productive philanthropic pleasantly lived day. There is two-way relationship between longevity and productivity such that it can be stated nature i.e., metabolic cellular biology processes operate in a manner to provide or in the alternative shave of years or decades of life if there is no real purpose being served through the sustaining of life which is in line with the Proactively procreativity preparedness promoting philanthropically plus propelled pliantropy philosophy postulate, than can be seen as bargain or trickery with nature to secure additional years of stay alive in the guise that the procreative purpose is still pending and being undertaken. Three hallmarks of pliantropy include robust libido, high monthly and annual orgasm count and continued contact with the youth and toddlers. In the words of Benjamin Zendel, professor at Memorial University of Newfoundland and Canada Research Chair in Aging and Auditory Neuroscience nature take into consideration in allocating decades of life based on this principle “Longevity is useless if it means more years incapacitated in a home.” What follows is that insertion of vitality into each day amplifies vitality an translates to better quality and longer their life between the 69^th and 99^th birthday. Being gentle compassionate and caring or the youth and toddlers and interacting with them regularly is strongly helpful in promoting pliantropy.

Inflammaging is a redundant and morbid – vaguely SEL mimicking - senile variant of juvenile inflammation essential for repair with the distinctive element of antagonistic pleiotropy proposed by George C. Williams in 1957 as an evolutionary explanation for senescence. A more rational ageing retardation starategy being proposed should therefore be one of Philanthropic Procreative Preparedness Pliantropy (PLIANTROPY) that aims to stave off or inhibit the antagonistic pleiotropy and maintain the pleiotropy for several additional decades of life. Pliantropy presumes that stress lowering hippocampal neurogenesis is promoted by the tropic effect of trophic afferents that activate reward center and upregulate the Oxyto-Opioidergic Output or tonus which is fostered by the LoCeNaDe from meditation type practices and related flow state Placid Pleasure Producing Processes Platitude subsumed in the Self-Administered Cognitive Behavioural Therapy (SACBT) mimicking concept Behavioral Activation/ De-activation Transitions Offered Affect Deflections (“do happy - be happy” – “do bad – be sad” ) aka BADTOAD and its group version named Cognitive Harmonized Operant Behavioral Activation Therapy Hedonism & Eudaimonism (CHOBATHE) - offered in groups as workshops; as well as from eubiosis or absence of dysbiosis which in addition to diet and exercise is highly responsive to meditation type practices hence the concept meditabiome is pertinent to bear in mind. Mindful Movement Mindset of body if associated with placidity and serenity tends to bring positive health impact partly through fostering pliantropy via psychokinesisotripism and encelphalokinesiotropism. With a robustly altruistic compassionate and empathetic mind mere visualization of the movement especially dance rhythm is capable of half strength benefits of actual physical benefits.

Pleotropogenome. Despite the somewhat misleading name akin to sugar alternatives this is not true genome but behaves like genome in somewhat limited ways thus it is only a pseudogenome The gonadal endocrine receptor mediate para-genomic or extra-genomic regulation of these three functions 1) cytoskeleton integrity (possibly mediated via protein and mucopolysaccharide synthesis regulation), 2) neurotransmitter output modulation or regulation and 3) energy production related mitochondrial calcium ion transfer regulation can be viewed as the fourth element and supplemental to the non-X & Y chromosomal genome, the enterobiomic genome and the epigenome – a distillation extract of life experiences and exposures. This nomenclature would attempt to involve this set of behavior of sex hormone receptors isolated from several brain regions in the antagonistic pleotropic hypothesis the in-built mechanism to work towards ending the life of the adult animal after the end of procreation purpose that creature comes to existence and matures to procreative prowess. Ability to downregulate the signals from pleotropogenome would then support the pliantropy hypothesis that tends to partly negate the antagonistic pleotropic hypothesis by slowing it down and thus regarding aging, causing a SHEAL effect and desired-dreamed after demise delaying. It is very plausible that the current physical exercise mimetics or kinesiomimetic-caloric restriction or restraint mimetic strategies (exercise plus intermittent fasting) under study as anti-aging strategies produce their desirable effects through the pleotropogenome supportable by observation of restoration of procreative power among laboratory rodents exhibit success in interventions that reverse their age. At the gene modulation level exercise and caloric restriction operate almost identically.

Exercise and dieting in a pill

Caloric restriction analogous pharmacotherapetics.

Gubert & Hannan published Exercise mimetics: harnessing the therapeutic effects of physical activity

in Nature Reviews Drug Discovery (2021)

Exercise mimetics are a proposed class of therapeutics that specifically mimic or enhance the therapeutic effects of exercise. Increased physical activity has demonstrated positive effects in preventing and ameliorating a wide range of diseases, including brain disorders such as Alzheimer disease and dementia, cancer, diabetes and cardiovascular disease. This article discusses the molecular mechanisms and signalling pathways associated with the beneficial effects of physical activity, focusing on effects on brain function and cognitive enhancement. Emerging therapeutic targets and strategies for the development of exercise mimetics, particularly in the field of central nervous system disorders, as well as the associated opportunities and challenges, are discussed.

Swimming in the fountain of youth

https://newsinfo.iu.edu/news/page/normal/4030.html

Jeanne Johnston, assistant professor in the Department of Kinesiology, studied the role of physical activity in healthy aging University Bloomington's Counselman Center for the Science of Swimming. Results reported under the title Fountain of youth : Relationship between swimming and aging in USMS Swimmer July Aug 2006, the official magazine of United States Masters Swimming from the work done by The Indiana University researchers who tested United States Masters Swimmers elite swimmers. Their data showed that age markers and physiological functional capacity typically decline by 0.5% to 1% annually from age 36 onwards, and compared their findings with similar data collected on the general population. The decline in general population ranged between 3% and 5% annually. Regular intensive swimming substantially slowed the decline of age-related physiological markers as blood pressure, muscle mass, blood chemistry and lung function. Physical activity especially if intensive and conducted in horizontal body position and in water tends to preserves physiological function very well. Many of the elite intensive swimmers delayed this natural decline until the age of 69 by regularly swimming 2 to 3 miles 3 to 5 times a week. The dominant determinant of glycemic peak induced inflammaging is rate of development of sarcopenia such that loss of muscle mass is the predominant determinant of rate of aging, and the aging process speeds up the muscle mass shrinkage, setting up a self-feeding cycle such that ability to stem the muscle mass decline is the key to slowing down aging or rejuvenation past 59. While mild to moderate walking of half hour etc., advised to the public would slow down the aging to stem the decline past 69 beyond which no intervention operates with good efficacy, for which it is critical to enter the 7^th decade with ample muscle bulk that dampens the insulin spikes and douses the Inflammging sufficiently to retain independence past 99. The elational or ELOGEX aspect of intensive swimming could have a link to reminiscence to the amniotic fluid during the fetal life.

Regular intensive swimmers are able to delay aging of their internal systems and their facial appearance by 20 years and look younger than their driver's licenses say they are, according to research from Indiana University. Even up until age 69 they have the systems operating comparable to 49 years of healthy seeming non-swimmer people.

It’s no secret that remaining sexually active has been linked to life satisfaction and, in some cases, longer life. One celebrated study, published in the British Medical Journal in 1997, followed 918 men in a Welsh town for 10 years and found that those with a higher frequency of orgasm had a 50% reduced risk of mortality. Friedman and his colleagues, working with the Terman group, found something similar–though not quite as dramatic–for women.

A 2016 study from Michigan State University was less sanguine, finding that older men who had sex once a week or more were almost twice as likely to suffer a cardiovascular event than men who had less sex; that was especially so if the more active men were satisfied with the sex, which often means they achieved orgasm. For older women, sex seemed to be protective against cardiovascular event.

The problem for the men was likely overexertion, but there are ways around that. “Older adults have to realize that it’s intimacy that’s important,” says

Dr. Gary Kennedy, director of geriatric psychiatry at Montefiore Medical Center in New York. “If the focus is on pleasure rather than achieving orgasm each time, it can be fulfilling.”

Stellar Cex Life ingredients - all founded on the first ingredient) are:

1. Ample candid fearless and authentic sexual communication - the foundation

2. Enjoyable and ample frequency penile-vaginal orgasming (10-12/mo)

3. High degree of mutual affection, altruism, empathy & compassion.

4. High level of trust between the partners especially on sexual fidelity

5. Quantity of time spent with each other outside of the bedroom and particularly outside of doors engaged in same act. (Read details at www.bit.ly/SatiSEX )

Nature (God) has put in place a design to promote honesty, morality and ethics and attempts to impede in the procreative power of the dishonest people. While lying, fraud and deceit can empower it does invariably seriously harm sex life.

To enjoy stellar sex life commit to a life of conscionability and authenticity.

Cheng and Smyth published Sex and Happiness in Journal of Economic Behavior & Organization 2014: Vol 112 (1): 26-32 and in Journal of Monash University 2014, reporting their findings on relationship between sexual activities and happiness using a sample of 3800 adults from China and establish some results about the contribution of sexual activities and relationships to happiness for China a major and important country other than the United States. Our main finding is that those who have more sex and better-quality sex, proxied by frequency of orgasm and emotional and physical satisfaction with one’s primary sex partner, are happier. Another major finding is that the happiness maximizing number of sexual partners is one. We also identify important gender differences between men and women. For men, there is a stronger relationship than for women, between the frequency, and physical aspects, of sexual intercourse and happiness. For women, there is a stronger relationship than for men between giving, and receiving, affection to/from their primary sexual partner and happiness.

Authors conclude there is a sizeable economics of happiness literature, but the effect of sexual activities and sexual behaviour on happiness has been relatively underexplored in the economics literature.

Yet, sexual behaviour and activities are an important component of people’s lives and can be addressed with standard econometric tools. Blanchflower and Oswald (2004) is the only study, n the economics literature that directly tackles the relationship between sexual activity and happiness. A limitation of that study is that the authors do not address the endogeneity of sexual activities. Thus, they are unable to identify if sexual activities cause happiness or vice-versa. The fundamental problem is that it is very difficult, if not impossible, to think of an appropriate IV.

We address this issue using the Lewbel (2012) method to construct an internal IV, based on the heteroskedasticity in the data. Several conclusions emerge from the results. The first is that having sexual intercourse has a positive effect on happiness.

Those who had regular sex (at least once a week) with a primary partner in the past 12 months are happier than those who do not and those who had frequent sex (once a day or more) with a primary partner in the past 12 months are happier than those who have infrequent, or no sex.

Source : https://www.sciencedirect.com/science/article/abs/pii/S0167268115000050

Heiman et al published Sexual Satisfaction and Relationship Happiness in Midlife and Older Couples in Five Countries in Archives of Sexual Behavior Aug 2011; 40(4):741-53 start by pointing out a flaw that sexuality research focuses almost exclusively on individuals rather than couples, though ongoing relationships are very important for most people and cultures. Therefore, these authors studied sexual and relationship parameters of middle-aged and older couples in committed relationships of 1–51 years duration majority were about 25 years in duration. Survey research was conducted in Brazil, Germany, Japan, Spain, and the U.S. targeting 200 men aged 40–70 and their female partners in each country, with 1,009 couples in the final sample. Key demographic, health, physical intimacy, sexual behavior, sexual function, and sexual history variables were used to model relationship happiness and sexual satisfaction. The median ages were 55 for men and 52 for women; median relationship duration was 25 years. Men’s relationship satisfaction depended on personal fitness level, amount of physical intimacy, and sexual frequency, while surprisingly something that is not openly expressed by them women sole relationship and life satisfaction criteria was their sexual contentment and male sexual functioning. Models predicting sexual satisfaction included significant physical intimacy and sexual functioning for both genders and, for men, more frequent recent sexual activity and fewer lifetime partners. Longer relationship duration predicted greater relationship happiness and sexual satisfaction for men. Women tend to experience greater relationship monotony such that women in relationships longer than 30 years tend to be bored or only modestly satisfied with less happy than their male counterparts in the same relationship. It might be an expression of being tired of having made compromises for this long while not enjoying enough sexuality. Women tend to experience lower sexual satisfaction than men in early stages of their relationship with close to 40% of erotic encounters being pleasant and after 6-7 years into the relationship they begin to notice a greater sexual satisfaction in the range of 80-90% a change not reported by me. But this late onset sexual interest among women endures for only 10-14 years and begins to fade and tend to revert to the earlier 40% satisfaction level.

Pliantropy ELOGEX Elational Low-Grade Excitation Controlled Stressing

[Mother in Law Effect ]

Grand mother Effect

Pliantropy can be argued to have likely developed along the human evaluation and its reality must be conceded without demanding empirical objective and reproducible evidence because the arguments are so strongly intuitive persuasive. The observations to the effect that decline of body towards grave proceeds very quickly soon after the end of reproductive period in all animals and to a large extent also in humans although with good nutrition and excellent support from the community the rate of decline is lot less marked. This aligns with the natures design of optimal notional and residential resource utilization for the maintenance of species such that the senile members of the species are eliminated to make the resources available for the young to grow. Central to the pliantropy postulate is the concept that the sole purpose molecular biological elements e.g. genes, epigenome, enzymes, neuropeptides, endocrines get generate or evolve is to insure the sustenance of the species and there is an self-destruct button inbuilt therein such that beyond the procreative purpose the trophic factors turn dystrophic and induce morbidity and death and the preventive health application of this principle is to revere or at least sufficiently delay the antagonistic pleiotropy with autophagy and the way to evade this potentially lethal attack of nature or to prevent the genes, epigenome, enzymes, neuropeptides, endocrines from becoming autoclastic or attempt to delay it for 3-4 decades and engineer a Deferred Endocrino-metabolic Self-Immolation (DESI) because an eternal postponement of antagonistic pleiotropy with autophagy will never be permitted by natural biological doctrines.

Eustress versus Stresstragic Overwhelm Paralysis (STOP) is the difference between a bucketful of snow versus an avalanche. A plunge in the icy water stream on a summer day versus frostbite, warmth of sauna versus third degrees scalding. In many situations the actual temperature is misread by the mind due to highly prevalent human exaggeration propensity and even when the degree of threat has been estimated fairly precisely on first brush a re-evolution of the status is possible whereby the gravity (the degree of warmth or cold) can be downsized to manageable level. As a result through reliance on internal buffering insulation blanket of the mind it is possible in many situations to re-measure the threat and view it as adaptive and thriving compatible grade as opposed to leaving the measurement at the stresstragic overwhelm grade and allow it to inflict harm on the mind and body. The use of term stresstragic overwhelm is helpful to bring attention to the intervention that strategic underwhelming of that situation is often possible. It can be understood as insertion of cotton wool or ear plugs in the ears when thrown into a noisy musical concert that is causing distress. With the muffling of the music with the insertion of the partial barrier it might be possible to not only continue to remain in that room but even enjoy the music better. Several authors have spoken on that on of the is Dr. Dawn Huebner a famed clinical psychologist in private practice who in her TED talk Rethinking anxiety: Learning to face fear

Remarks that humans have evolved to become hard-wired to promptly flee from or freeze in front of threats and have become heavily conditioned to and efficient at flight, or freeze and lack the trick of gratification delay to use the stress for enhancement, progress, thrive and emerge as super-victor. The hurried life where no pause is permitted between the stimulus and reaction all threats are permitted to provoke massive anxiety, all threats are perceived to be a nuclear diester grade ones such that there is no ability to distinguish that the perceived stress is the result of multiplication or division of the real danger and the propensity to measure the level of stress to invoke in relation to actually gravity of distress. Pursuit of superlative levels of pleasures alone and unwillingness to expose the body and mind to even the slightest distress which is the result of several fracturs or conditionings (JACOBs) and the market forces delivered by the barrage of PR firms advertising to sell products that not the slightest stress need be tolerated. Modern humans are being stressed more from their desperate attempt to avoid even the slightest discomfort and uncertainty all of which fuel an unjustified level of anxiety, and the quality of life suffers because of enormous energy spent in avoidance of even the minor stressors. Even the meal preparation or washing dishes is mistakenly seen as a stressful chore as is the case with all other household chores, which are in reality health promoting activities. Control has been surrendered to the comfort goods vendors and there is a foolish willingness to pay for the use of an appliance like a dishwasher or laundry machine instead of doing that chore manually which has many mental wellness and health benefits. There are authors and experts urging that effort be invested to take that erroneously surrendered control back but the social climate stands as a major obstacle in the way. A person trying to do the dishes manually would expose oneself to being scolded and shamed. Transformation can proceed only if there are public policy and social value shifts that permit the restoration of the lost control at a community wide scale and everyone participates in the transition. Time has come that humans begin to invites minor distress and learn novel tactics to face the fears and distresses and refrain from taking refuge in some gadget, gismo, pill or other means of running away from the moderate level suffering stemming from them. A major benefit from this confrontational attitude towards distresses or suffering is that tolerance builds and it becomes possible to take on higher level stressors. An example here is that of cold conditioning. Starting with 30-second-long ice water shower it is possible to gradually build that to 5 or 10 minutes and finally to the world level setting records of half hour or so. But the vendors of hot water tanks would be threatened by that approach and would impede the process at a mass scale as they would not wish the public to start taking cold showers at large scale.

Dr. Huebner believes humans can and must master the skill to manage fear better and not experience anxiety when confronted with every single stress by training the mind of the cognitive pause spoken of by Dr. Viktor Frankl. The marker forces and advertisers profit from and have successfully conditioned (brainwashed) the minds of the modern consumers that they must refuse to suffer the slightest personal pause and label it as a boredom and in order to cure that boredom purchase one of their recreational products from music, films to Netflix and continually attempt to immerse their minds in the ocean of comforts. That weakens the inner resilience to tolerate stressors which do show up their nasty heads from time to time when there is no soothing devise sold by the comfort industry vendors is at hand or would be effective. One such trauma could be a romantic breakup or divorce which would tend to lead those naïve at managing stress to resort to alcohol, drugs (prescription or recreational) with serious long-term adverse outcomes from the remedy used to solve their stress.

Dr. Huebner like thousands of other psychologists explains how anyone, at any age, can conquer debilitating fear.

Huebner is the author of “The What To Do Guides for Kids” series, which not only reflect her beliefs about cognitive empowerment, but also provide advice for parents and children.Personal journey as a parent, however, led Huebner on a quest to find ways of using cognitive-behavioral therapy as an approach. With simple language and humor, she presents sophisticated concepts in a way easily understood by everyone. These concepts, in book form, have been translated and sold in 12 different languages worldwide.

Pyrestress (Inflastress or lupistress) that operates like a heap of combustible material, often used one for burning a corpse as part of a funeral ceremony.

ELOGEX Elational Low-Grade Excitation Controlled Stressing A lion approach is not pyrestress for a lion tamer and high tight rope walking is elogex not pyrestress for a professional.

When engaged in procreative preparation of the body during adolescence, sexual activity for fertilisation and the subsequent child raising the organism is undergoing Elational Low-Grade Excitation Controlled Stress (ELOGEX). It is a safe assumption that does not require empirical evidence that those tribes, communities of races of humans got selected to prevail and not be eliminated through tribal elimination which was a constant threat in the days of relatively low fertility rates, high infant mortality and childhood mortality and a brief lifespan of little pas the reproductive phase that did render tribal viability a real threat, that only those tribes that were mutually supportive of other tribe members, cratering to infant needs and bonded well with other members in altruistic, compassionate and empathetic manner and were in posse ion of trails of organization, conscientiousness and authenticity who prevailed and that are instinctive traits of modern humans.

Extremely high degree of overlap between the concepts Pliantropy and ELOGEX both of which can be advanced as comprehensive aging-reversal hypotheses, permit them to be viewed as synonyms. The serious caloric restraint, physico-sexual activity, mental activity is essential for procreative prowess in manners that they can be viewed as the ELOGEX in action in the process of philanthropic procreation. It seems intuitive that in circumstances of nutrient scarcity parents tolerated hunger or semi-starvation to feed their offspring and toiled physically and mentally to harvest natural resources for the food, shelter and bodily warmth needs of life. Protection of the young from predators must have required security system installations and the need to run, lift weights, swim etc., which are aspects of ELOGEX but likely evolved for the purposes of procreative preparation and perpetuation.

These traits of successful procreation prowess are still present in the modern humans even if subdued in intensity. They also have genetic, endocrine and enzymatic underpinning permitting the recognition of pliantropy. Additional clues to its pro-survivalistic powers come from the

1. Health promoting effects on the older adults who participate in childcare of grandchildren.

2. The grandmother effect whereby a mother helped by the grandmother attains superior reproductive success. Grand-mothering decreases senescence Hawkes et al 2004

3. Interventions that produce rejuvenation in female rodents include in the characteristic of restoration of lost procreative power. The Grandmother Hypothesis says our mothers' mothers are why we live so long.

https://www.theatlantic.com/health/archive/2012/10/the-evolutionary-importance-of-grandmothers/264039/

4. Superior immune system and fitness level including protection against diabesity among children who receive higher quality mothering from their biological mother via breast feeding and cuddling etc.

5. Immunity of mothers to breast cancer through ample breast-feeding period.

6. Retention of youthfulness and superior health of older adults who play with young children even if they are not their grandchildren due to a rejuvenating effect of spending time with young children.

7. Youthful look and superior vitality of older adults who continue to remain sexually active.

8. A sharp decline in vitality and intensification of IAcODcIM intensity after gonadal involution at the end of procreative years. The state of lifespan shorter than procreative prowess is logical incompatible with the sustaining a species which would mark it for extinction if the members of the species were to become deceased prior to been able to reproduce offspring.

Hawkes and Smith have published a pioneering paper entitled Evaluating Grandmother Effects in American Journal of Physiology and Anthropology 2009 Sep; 140(1): 173–176 outlining that women who have outlived child-bearing have long been described as post-reproductive. But contributions they make to the survival or fertility of their descendants enhance the reproduction of their genes. Consequently natural selection affects this characteristic stage of human life history. Grandmother effects can be measured in data sets that include births and deaths over several generations, but unmeasured covariates complicate the task. Here we focus on two complications: cohort shifts in mortality and fertility, and maternal age at death. We use the Utah Population Database to show that longevity of grandmothers may be associated with fewer grandchildren, as reported by Madrigal and Melendez-Obando (2008) for a Costa Rican sample, even when grandmother effects are actually positive. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745839/

Experience Corps®, mentoring projects help with wisdom-generating opportunities for both older and younger generations. Parisi et al published a paper Can the Wisdom of Aging be Activated and Make a Difference Societally? in Educational Gerontology 2009;35(10):867-879 pointing out that The Experience Corps®, a community-based intergenerational program, was developed to promote the health of older adults, while simultaneously addressing unmet social and academic needs in public elementary schools. The model was designed to draw on, and potentially activate, the wisdom of older adults. This paper explores the nature of wisdom-related knowledge and how older adults may apply such knowledge when tutoring and mentoring young children, as well as the potential for the intergenerational transmission of wisdom from the older adult volunteers to the school children being mentored by them. Developing an understanding of these issues may provide a basis for the creation of more extensive wisdom-generating opportunities for both older and younger generations.

https://www.ncbi.nlm.nih.gov/pubmed/21998491

Neurogenesis enhancement stimulated by Elational Low-Grade Excitation Controlled Stress (ELOGEX) likely mediated their effect via Brain-Derived Neurotrophic Factor (BDNF) and Heat-Shock Proteins (HSP) esp. when co-occurring with Cryothereapeutic Brown Cell Activation (CBCA).is associated with these five major types of lifestyle options that permit them to be viewed as anti-aging or aging retardation lifestyle and telomere length restorative (sometimes via telomerase activity and at others by alternative techniques) choices which must be ongoing from puberty onwards for full efficacy. Noteworthy is the component of anxiety or stress which requires escalation of the existing fairly high skill level to even higher levels in the Status Flow hypothesis of Stress Shattering and enduring happiness creating formula of Mihaly Csikszentmihaly (pronounced Chick Sent me Hi - Ecstasy) is A person can make himself happy or miserable, regardless of what is actually happening outside just by changing the contents of consciousness.

1.Socio-cognito-sexual activity effected through substantial contact boosting environmental enrichment, specifically including child rearing and child-play procreative activities which

2. Physico-sexual activity that mimics both Significant Caloric Restraint socio-cognito-sexual activity permitting exposure of the mind, body and brain to erotic coital stress.

3. Significant Caloric Restraint (SCR) or fasting permitting these to be viewed as neurotrophic interventions and they likely produce their neurogenetic effects through inducing an adaptive pliantropic stress. Severe caloric restriction or semi-starvation is neither necessary nor neurogenerative in humans due to distinction of human metabolism from subhuman primates and other animals.

4. Heat exposure therapy (a.k.a. Hyperthermic Conditioning of Dr. Rhonda Patrick) preferably concomitant and alternating with Cryothereapeutic Brown Cell Activation. (CBCA) which mimics exercise via cardiovascular excitation analogous to Physico-sexual activity during rest. which has been slightly Misnamed as Cryotherapy induced neuron-regeneration by Dr. Rhonda Patrick

5. Suxaglymph sleep conducive to restoration of the cleansed up extranerunonal milieu or glymphatic region which tens to be positively impacted by heightened attention focus through these sub-strategies

5a. Mindful type meditative practices which has substantial overlap with VELVE &

5b. Volitional Effortful Laborious Ventilatory Exertion (VELVE) breathing induced WASAR neurocardiac harmonizing which appears amplified through MANTRA chanting or other types of faith based chanting or even communal singing dancing etc.

5c. MIXPFZEE. Mihaly Csikszentmihalyi Prescribed Flow State Zonal Ecstasy Engaging of (2004) or optimal experiences that amounts to a bald denial of adverse effects of stress and even misery (“Sorrow Does not Exist”) and reliance on the “cognitive pause” of Viktor Frankl. Who stated “Between stimulus and response there is a space. In that space is our power to choose our response. In our response lies our growth and our freedom.” in Man's Search for Meaning.

5d Microbiome health which has a bidirectional link with stress and sleep. Flow state goes with names like “The Zone”, “high performance mind”, “peak experiences”, “runners high”, “a abandon state”, optimal performance state of mind etc.

5e. Trophic epigenetic effect can be viewed to impact the wellness at this point.

Stress Shattering formula of Mihaly Csikszentmihaly is A person can make himself happy or miserable, regardless of what is actually happening outside just by changing the contents of consciousness.

Neural correlates or substrates of the flow state are being discovered that overlap with DeMoNe.

In text of Author Ria Cheruvu entitled The Neuroscience of Flow (May 2018)one notes that flow is a state of deep absorption when individuals are able to function at their optimal capacity and tackle challenging endeavors with ease (Csikszentmihalyi, 1996). Empirical research demonstrating neural correlates of the flow state has developed over the past decade (Harmat, L., Andersen, F. Ø, Ullén, F., Wright, J., & Sadlo, G., 2016), and attempts to provide evidence of changes in neural activity in response to participation in flow. This study sought to summarize what is known about neuroscientific literature on flow by mapping findings from existing neuroscientific literature to explain psychological claims regarding flow experiences. It was found that there is no conclusive evidence for the neuroscience of flow, as neuroimaging studies demonstrate contradictory findings on key brain hubs for flow that vary according to the activity being performed during flow. The paper proposes that the difficulties associated with measuring the neurophysiological correlates of multiple sub-systems/networks associated with flow states could be avoided by adopting the lens of complexity theory and disaggregating flow into attentional and motivational processes. Future studies should include validation of claims regarding the behavioral outcomes associated with activation/deactivation of key hubs for flow in the brain. The growing neuroscientific research addressed in this paper proposes exciting discoveries targeted at answering questions on the neural correlates of flow. The answers to these questions will catalyze a greater understanding of the brain’s unique responses to optimal experiences.

SCR can reduce risk of AD, PD, and stroke, three of the most devastating neurodegenerative conditions in the elderly and data provide strong evidence for this thesis.

SCR tends to increase neurogenesis in rodent brains

BDNF levels augmentation induced by SCR plays an important role in promoting the survival of newly generated neurons.

a low-calorie intake may reduce risk of stroke and neurodegenerative disorders

individuals with the lowest daily calorie intakes had the lowest risk of AD and PD.

Luchsinger et al published Caloric intake and the risk of Alzheimer disease in Archives of Neurology 2002 Aug; 59(8):1258-63 reporting that high fat and caloric intake tends to be associated with higher risk of AD in but only among individuals carrying the apolipoprotein E epsilon4 allele. Their study cohort consisted of 242 incident cases of AD during 4023 years of follow-up (6 cases per 100 person-years). Compared with individuals in the lowest quartile of caloric intake, those in the highest quartile had an increased risk of AD. When compared with the lowest quartiles Among individuals with the apolipoprotein E epsilon4 allele, the hazard ratios of AD for the highest quartiles of fat & calorie or energy overload. The hazard ratios of AD for the highest quartiles of calorie and fat intake compared with the lowest quartiles in individuals without the apolipoprotein E epsilon4 allele were close to 1 implying that without the genetic predisposition energy overload does not escalate risk of Alzheimer’s disease.

Logroscino et al published Dietary lipids and antioxidants in Parkinson’s disease: a population-based, case-control study. in Annals of Neurology 1996; 39: 89–94 to report that energy-adjusted fat intake was significantly higher among patients with Parkinson’s disease than control subjects and that intake of protein and carbohydrates were not different in patients and control subjects. A high animal fat consumption was strongly related to PD. No protective role of vitamins or of antioxidant intake was observed. The higher risk of PD associated with higher consumption of animal fats is viewed as evidence that oxidative stress and lipid peroxidation are important in the pathogenesis of Parkinson’s disease and possibly all neurodegenerative diseases. Inefficacy of vitamins with antioxidant activity, either from food or supplements, can not be relied upon to negate the role of oxidative duress in the pathogenesis because the pathogenesis is highly complex, multifactorial and not yet fully explored. Oxidative duress ensuing from energy production is distinct from vitamin deficiency states such that even an ample supply of antioxidants at least not in the encapsulated format does not protect against release of active oxidative particles because the system is not dependent on the presence of antioxidants as cofactors, coenzymes or enzyme potentiators. Even if the vitamins with anti-oxidant efficacy are in vicinity and do mop up the active oxygen elements the neuronal or neurogenetic damage having already taken place is neither prevented nor reversed. It is also likely that the antioxidant effect gets overly diluted and rendered irrelevant in the presence of intense oxidative assault inflicted by the fat & caloric overload.

Mattson’s paper Prophylactic Activation of Neuroprotective Stress Response Pathways by Dietary and Behavioral Manipulations published in NeuroRx: (The Journal of the American Society for Experimental NeuroTherapeutics) 2004 Jan; 1(1): 111–116.

Three major mechanisms underlying neurogenesis and possibly endothelioguarding effects of dietary restriction, and physical and mental exercise on neurons. All three environmental factors impose a mild stress on neurons, which results from increased activity in neuronal circuits and/or metabolic stress. The cellular stress involves increased levels of intracellular calcium and reactive oxygen species which, in turn, activate kinases and transcription factors. The transcription factors induce the expression of genes that encode stress resistance proteins (SRPs), neurotrophic factors such as BDNF, and anti-apoptotic genes such as Bcl-2. Kinases may phosphorylate substrate proteins involved in maintenance of ion homeostasis, energy metabolism, and stress resistance.

Installation of global GOESTREND movement aiming for Global Optimism-Empathy enhancement, sleep mediated, Telomere Restitution (repair, recovery of lost length, restoration of lost base pairs) Endothelioguarding (Endothelioshielding) Neurogenesis Designing Day can be made the “TREND that GOES” around the globe to sweep away the global Non-Communicable Disease (NCD) epidemic.

Subsuming and comprehensive ELOGEX cluster. Emerging data suggest that activation of BDNF and serotonergic pathways may provide protection against a variety of neurodegenerative conditions, and possibly disorders linked to obesity, including type 2 diabetes and cardiovasco-metabolic syndrome cluster of diseases and this is likely mediated through or linked to Cyclical Arteriosclerotic-Inflammaging Reverberating Operation (CAIRO) and all of them impacting IAcODcIM process that drives aging permitting a view that ELOGEX is the sum of all lifestyle grounded non-pharmacological and non gene engineering style aging reversal strategies

Mattson’s paper on Prophylactic Activation of Neuroprotective considered the possible impact of dietary and behavioral interventions in improving the healthspan of the brain by focusing on four of the most prominent age-related neurological disorders. Ischemic stroke is the third leading cause of death killing 200,000 Americans annually and strokes are the leading of neuro-disability as reported by American Stoke Association. Over 4 million Americans currently have Alzheimer’s disease (AD) and over 1.5 million Americans have Parkinson’s disease (PD). As life expectancy continues to increase, the prevalence rates of victims of AD and PD is also on course to continue increasing. Huntington’s disease (HD) currently affects approximately 30,000 Americans and an additional 150,000 have a 50% risk of developing the disease as per HD foundation. Despite their distinct principal cause all age-related neurodegenerative disorders share cellular and molecular abnormalities pivotal to the dysfunction and ultimate neuronal death. The abnormalities include increased oxidative stress, impaired energy metabolism, and calcium homeostasis disruption predominantly in the hippocampus, and BDNF plays a role in this effect of SCR. have been shown to induce neurogenesis.

MESS, ADDRESS & ELOGEX definitions: Stress with some qualifications can safely be viewed as the process that sends larger animals generally and humans particularly to grave. It is well established that when mammalian cells, including neurons, are exposed to an Elational Low-Grade Excitation Controlled Stress (ELOGEX) they increase their ability to resist the deleterious effect of Morbidogenic Endotoxic Sustained Stress (MESS). A predominant aspect or components of MESS is Augmented Depressogenic Delational Ruminative Emotive Simmering Stewing (ADDRESS). Healthspan thus emerges as the net effect of the tug-of-war between these two. Interventions of ELOGEX style can be viewed as pliantrophic or pliantropic in nature and due to their protective effect on procreative prowess it is intuitive that the humans have been selected for and have evolved such that genes, enzymes and endocrines of humans are well harmonized with ELOGEX and their key role lies in resisting antagonistic pleiotropy or autophagy where cells turn against themselves or start a version of slow suicide that overtly expresses as aging. comprehensive nomenclature of pliantropy is philanthropically plus procreativity propelled pliantropy postulate

This “preconditioning” phenomenon involves up-regulation of genes that encode cytoprotective proteins such as heat-shock proteins and growth factors. We found that a similar beneficial cellular stress response can be induced in neurons throughout the brain by a “meal-skipping” Significant Caloric Restraint (SCR) regimen in rats and mice. SCR is effective in protecting neurons and improving functional outcome in models of stroke, Alzheimer’s, Parkinson’s and Huntington’s diseases. SCR induces an increase in the levels of Brain-Derived Neurotrophic Factor (BDNF) and Heat-Shock Proteins (HSP) esp. when co-occurring with Cryothereapeutic Brown Cell Activation (CBCA) in neurons. SCR also stimulates neurogenesis in the hippocampus, and BDNF plays a role in this effect of SCR. Physical exercise and environmental enrichment are two other manipulations that have been shown to induce BDNF expression in the brain, presumably because it is a mild cellular stress. When taken together with epidemiological and clinical studies in humans, the data from animal studies suggest that it may be possible to reduce the risk for age-related neurodegenerative disorders through lifestyle choice or dietary and behavioral modifications that act by promoting neuronal plasticity and survival.

Synaptic webwork enhancement & complexity intensification (SWECI) constitutes an aspect of neurogenesis that builds upon BDNF overexpression and is associated with an increased dendritic density and complexity which likely forms the substrate of semantic density or vocational complexity capacity (VCC) in a manner that a substantial neuronal dropout can be well tolerated without overt expression of cognitive deficit.

Mechanisms underlying beneficial effects of Pliantropy-ELOGEX of which dietary restriction, and an altruistic straining of the system are the predominant features involves a mild stressing of the neuroendocrine system that operates as the conductor of all other organ systems issuing them instructions. Due to its disproportionately massive size brain and its major trophic marker BDNF take a dominant position and role in this process wherein neurogenesis becomes the major independent variable or driver of changes and is itself fuelled by ELOGEX. An intensified neuronal activity and/or endocrino-metabolic stress of the central nervous system with its manifestation in the autonomic nervous system therefore take a prominent role in the process wherein the relationship with the and the autonomic nervous system and the central nervous system is very actively bidirectional and the two exert a mutually tropic effect.

The SHEAL promoting neuronal ELOGEX stress at a molecular level gets played out via 1) intracellular calcium increase, 2) intracellular potassium decrease 3) reactive oxygen species reduction, 4) gene transcriptional shifts that produce 5) kinase enzymes’ activation. Gene transcriptional shifts impact predominantly the expression of genes that encode 4A) stress resistance proteins (SRPs), 4B) BDNF and other neurotrophic factors, 4C) Bcl-2 and other anti-apoptotic genes. Kinase activity transitions tend to phosphorylate proteins involved in 5A) maintenance of ion homeostasis, 5B) energy metabolism in the direction of effective carbon burning and lowered free radicals, and 5C) stress resistance generating phosphorylases. The effect of ELOGEX thus stabilizes ionic homeostasis, reduces oxidative duress and immunizes the organism against severe sinister stress the summated effect of which is dousing of inflammaging and retardation of aging leading to prolongation of healthspan such that lifestyle options relied upon to trigger this aspect of metabolism are subsumed in the term Healthspan Enhancement Aspiring Lifestyle (SHEAL)

Role of sublistressinng and CHOBATHE pleasurable experiences in amplifying the serotonergic and BDNF signaling loop. A zero or negligible stress level lifestyle acquires SHEAL characteristics while the converse of extreme distress living abbreviates both healthspan and lifespan. Serotonergic system stimulating experiences are those characterized as Cognitive Harmonized Operant Behavioral Activation Therapy Hedonism Eudaimonically (CHOBATHE) with synonyms like Profoundly Rewarding Events Occurring Frequently As Boluses (PREOFAB) that find clinical application in Pleasurable/Positive Event Exposure Therapy (PEET) or as Behavioural Activation Therapy of Hedonism Eudaimonically (BATHE) and are neuropsychologically grounded in the principles of Rationalized Emotion Construction Knowledge (RECK) while the human negativity bias and vague generalized timidity, insecurity and timidity powerfully persuades humans to at “RECKlessly” or irrationally thus inhibiting the Serotonergic system unless this is excited pharmcologically through ingestion of the category of medications called antidepressants. The nemesis or anti-thesis of or remedy against the RECKlessly is the Mihaly Csikszentmihalyi Prescribed Flow State Zonal Ecstasy Engaging (MIXPFZEE).

The hypothesized mutually enhancing relationship or interaction between serotonergic and BDNF signaling likely play a dominant role in responses of progenitor neurons to environmental stimuli. Serotonergic raphe nucleus neurons that are known to innervate neurons of the entire cerebral cortex, including the dominantly active regions namely hippocampus, and striatum when activated effect A) an enhanced transcription of the BDNF gene; B) the cyclic AMP production amplification, and C) CREB activation. Stimulation of serotonin receptors on the striato-hippocampal neurons causes BDNF augmentation which, in turn, tends to activate its high-affinity receptor trkB in serotonergic neurons, resulting in activation of Akt kinase and transcription factors (TF) and further increased production of serotonin completing the self agentive loop. This hypothesis permits projecting that CHOBATHE, MIXPFZEE, PEET etc., are powerful tools for elevating subjective wellness score which would lead to SHEAL enhancement. SHEAL by increasing synaptic serotonin augmentation inducing BDNF production and promoting both serotonergic status of the brain and the propensity towards SHEAL is thus highly desirable. In the individuals wherein the loop has downregulated both the serotonergic and the BDNF pharmacotherapy with antidepressants tends to ameliorate the situation but at the risk of side effects and a higher relapse rates.

Extended Post‐procreative Life span runs counter to the nature’s biological principles of natural selection and resource conservation given the nature’s design driven by restricting the post reprodutive phase.

Gurven and Kaplan published Longevity Among Hunter‐ Gatherers: A Cross‐Cultural Examination in Population and Development Review June 2007; 33(2):321-365 Post‐reproductive longevity is a robust feature of human life and not only a recent phenomenon caused by unatrual and artefactual improvements in sanitation, public health, and medical technological advances. Their artefactual nature is becoming exposed from the observations that the industrial evolution is falling victim to its own success through climatic pollution and global warming which is expected to reverse the extension of post-procreative lifespan. To retain the post procreative life adaptive principles of pliantropy must be resorted to failing which the gains made in the past century would be lost.

Kirby et al published Acute stress enhances adult rat hippocampal neurogenesis and activation of newborn neurons via secreted astrocytic FGF2. in eLife. 2013 Apr 16;2:e00362 Stress is a potent modulator of the mammalian brain. The highly conserved stress hormone response influences many brain regions, particularly the hippocampus, a region important for memory function. The effect of acute stress on the unique population of adult neural stem/progenitor cells (NPCs) that resides in the adult hippocampus is unclear. We found that acute stress increased hippocampal cell proliferation and astrocytic fibroblast growth factor 2 (FGF2) expression. The effect of acute stress occurred independent of basolateral amygdala neural input and was mimicked by treating isolated NPCs with conditioned media from corticosterone-treated primary astrocytes. Neutralization of FGF2 revealed that astrocyte-secreted FGF2 mediated stress-hormone-induced NPC proliferation. 2 weeks, but not 2 days, after acute stress, rats also showed enhanced fear extinction memory coincident with enhanced activation of newborn neurons. Our findings suggest a beneficial role for brief stress on the hippocampus and improve understanding of the adaptive capacity of the brain.

Biologists have been puzzled by the long postmenopausal life of human females. From a purely evolutionary perspective, grandmothers can be considered a failure of reproductive fitness: What biological function is served by an organism that procreate and is rendered vestigial for the primary biological process of species perpetuation. Biological purpose and necessity of grandmothers who do not directly perpetuate the species is linked to the lengthy pre-pubertal life of humans creating a need for assistance to the parents in child raising and forms one of the reasons why human lifespan is so long and lengthening. Child raising assisting duties are discharged by other mammals with long maturation periods of the offspring like orca whales, elephants with long post-reproductive life spans.

Preventing divorcing or divergence of somatic and reproductive senescence that tend to follow separate trajectories is the essence of pliantropy driven healthspan extension. While in lower phyla of animals than mammals there is no such dissociation mammalian lifespans tend to exhibit this divorcing. Preponement of procreative senescence or termination of reproductive function has been explained by Cohen has published Female post-reproductive lifespan: a general mammalian trait in Biol Rev Camb Philos Soc. 2004 Nov;79(4):733-50 by suggesting that biological energy cost conservation is the basis for dispensing with the unnecessary burden of production and/or maintenance of oocytes. The dissociation of procreative senescence and somatic senescence is however imperfect because of the rapid decline in the vitality of post menopausal women and post andropause men and partial restoration of vitality through replacement of estrogens in women and testosterone in men. While side effects of pharmaceutical administration of the sex hormones as rejuvenating intervention limit their use because their side effects including carcinogenesis and coronary artery disease limit their role as rejuvenating agents, a more physiological and biologically driven perpetuation of procreative prowess through mimicry of lifestyle that would signal the neuroendocrine conductor of the body that the organism is still in procreative life phase and the reproductive senescence has not taken place would effect a rejuvenation of somatic senescence. Thus pliantropy becomes synonymous with ELOGEX. Genuine rejuvenation would proceed if the genetic, enzymatic and endocrinal orchestra would continue to operate in status quo despite the menopause or andropause such that somatic senescence not ensue the procreative senescence that does seem to ensue given that the dissociation of these two is not perfect but intertwined because phraseological or other routes attained somatic recurvation does tend to restore the lost procreative prowess.

Ample post-reproductive lifespan which functions as grand-offspring raising role is observed only in primates esp. great apes and toothed whales that exhibit menopause that happen to be long lived large mammals which is somewhat anomalous in that longevity tends to be a characteristic of smaller sized animals compared to their larger peers.

Nattrass et al published Post-reproductive killer whale grandmothers improve the survival of their grandoffspring in Proceedings of the National Academy of Sciences, Dec. 9, 2019 draw attention to the concern that why humans and some species of whales go through menopause remains an evolutionary puzzle. In humans, postreproductive females gain genetic benefits by helping family members—particularly increasing their number of surviving grandoffspring. The extent to which these grandmother benefits are important in the evolution of menopause in whales remains unclear. Here, we test the grandmother effect in resident killer whales, where females can live for decades after their last reproductive event. We show that grandmothers increase the survival of their grandoffspring, and these effects are greatest when grandmothers are no longer reproducing. These findings can help explain why killer whales have evolved the longest postreproductive life span of all nonhuman animals.

Grandmother Hypothesis was developed when in the 1980s, Kristen Hawkes and James O'Connell spent time with Hadza hunter-gatherers. They noticed that the older women in the society spent their days collecting tubers and other food for their grandchildren. that humans evolved to live so long because grandmothers were around to help take care of the infants and toddler. The Grandmother Hypothesis goes further than to establish the importance of grandmas. In our early years as a species, the theory goes, older women helped gather food for their grand-offspring. In so doing, they were freeing up their daughters to have more children. So, the most evolutionarily fit grandmothers have the most grandchildren, to whom they pass on their longevity-promoting genes.

Kachel et al published Grandmothering and natural selection in Proceedings of the Royal Society 2010 Humans are unique among primates in that women regularly outlive their reproductive period by decades. The grandmother hypothesis proposes that natural selection increased the length of the human post-menopausal period—and, thus, extended longevity—as a result of the inclusive fitness benefits of grandmothering. However, it has yet to be demonstrated that the inclusive fitness benefits associated with grandmothering are large enough to warrant this explanation. Here, we show that the inclusive fitness benefits are too small to affect the evolution of longevity under a wide range of conditions in simulated populations. This is due in large part to the relatively weak selection that applies to women near or beyond the end of their reproductive period. However, we find that grandmothers can facilitate the evolution of a shorter reproductive period when their help decreases the weaning age of their matrilineal grandchildren. Because selection favours a shorter reproductive period in the presence of shorter interbirth intervals, this finding holds true for any form of allocare that helps mothers resume cycling more quickly. We conclude that while grandmothering is unlikely to explain human-like longevity, allocare could have played an important role in shaping other unique aspects of human life history, such as a later age at first birth and a shorter female reproductive period.

Dhabhar et al published Stress-induced redistribution of immune cells--from barracks to boulevards to battlefields: a tale of three hormones in Psychoneuroendocrinology. 2012 Sep;37(9):1345-68. concluding that stress hormones orchestrate a large-scale redistribution of immune cells in the body. NE and EPI mobilize immune cells into the bloodstream, and EPI and CORT induce traffic out of the blood possibly to tissue surveillance pathways, lymphoid tissues, and sites of ongoing or de novo immune activation. Immune cell subpopulations appear to show differential sensitivities and redistribution responses to each hormone depending on the type of leukocyte (neutrophil, monocyte or lymphocyte) and its maturation/functional characteristics (e.g., non-classical/resident or classical/inflammatory monocyte, naïve or central/effector memory T cell). Thus, stress hormones could be administered simultaneously or sequentially to induce specific leukocyte subpopulations to be mobilized into the blood, or to traffic from blood to tissues. Stress- or stress hormone-mediated changes in immune cell distribution could be clinically harnessed to: (1) Direct leukocytes to sites of vaccination, wound healing, infection, or cancer and thereby enhance protective immunity. (2) Reduce leukocyte traffic to sites of inflammatory/autoimmune reactions. (3) Sequester immune cells in relatively protected compartments to minimize exposure to cytotoxic treatments like radiation or localized chemotherapy. (4) Measure biological resistance/sensitivity to stress hormones in vivo. In keeping with the guidelines for Richter Award manuscripts, in addition to original data we also present a model and synthesis of findings in the context of the literature on the effects of short-term stress on immune cell distribution and function.

Dr. Sherly Kingsberg: Hypoactive Sexual Desire Disorder

Pam Costa Reclaiming Female Sexual Desire

Keesha Ewers Have you Heard From Your Libido Lately?

Grace Wetzel Let's Talk About Sex: The Reality of the Sexual Pleasure Disparity

Laurie Betito The Pleasure Principle: The Secret to a Better Sex Life

Maria Røsok The unknown greatness of the clitoris

Uma Subramanian It's okay to masturbate - sex lessons to unlearn

Keeley Olivia Masturbation is the New Meditation

Madhavi Jadhav What teens need to know about sex

Jane Epstein Why we need to talk to girls about sex

Amy Color Better Intimacy For Her, Better Sex For Him & Vice Versa

Maïa Mazaurette Ce que l'on a oublié de vous dire sur le sexe

1. Making sex normal Dr. Debby Herbenick

2. Your Bedroom as the Ultimate Treehouse Dr. Debby Herbenick the founder and Editor-in-Chief of My Sex Professor of with The Kinsey Institute for Research in Sex, Gender and Reproduction and Associate Director of the Center for Sexual Health Promotion in the School of Health, Physical Education and Recreation at Indiana University.

3. The New Frontier of Sex Intimacy Dr. Sue Johnson a Clinical psychologist and distinguished sexology research professor at University of California San Diego, the author of best sellers like Hold Me Tight and Love Sense; creator of a novel relationship repair methodology known as “emotionally focussed couple’s therapy”

4. Sex education by MacKercher & Sophia Simon - two driven young women both junior at Community High School Frances who work as Peer Educator in Planned Parenthood.

5. Putting pleasure on the Sex Ed agenda by Michelle Chakkalackal an Indo-Canadian sex education advocate the co-founder and head of Love Matters a NGO that provides information on love, sex and relationships through mobile and web sites.

6. No Sex Marriage – Masturbation, Loneliness, Cheating and Shame by Maureen McGrath a Registered Nurse, Sex Educator and author of “Sex & Health” and a local clinical sexologist.

7. The sex talk by Dr. Marnie Goldenberg, who is equipped with background in law, sex advocacy and as a sexual health counselling calls herself a Superb sex Sexplainer

8. Why we need to talk to girls about sex by Jane Epstein a nurse practitioner who specializes in adolescent medicine since 1989; who emphasizes the need to work towards closing the orgasm gap.

9. A motion for masturbation - the naked truth Jane Langton an adult sexual health educator who aims to transform the views and promote conversations on healthy sexuality and committed to educating people about how general health and sexual health are intertwined. She candidly admits in her TED talk that she masturbates regularly.

10. ITEM linked informational videoclips and TED talks

11. Sigogem Pigogem & Coitus and their role in ITEM.

12. Joy of masturbation by Julie Gaia Poupětová

13. Mission of ITEM movement

14. Let's get naked ladies. A talk about men, women and the erotic creatures, Sheila Kelley

15. Sigogem Videoclips and Video lectures

16. The nature of sexual inhibitions & fulfillment: By Dr. Carol Queen [website] a noted erotica writer and cultural sexologist and co-founder of the San Francisco Center for Sex & Culture.

17. Masturbation Myths by Dr. Teesha Morgan a Local sexologist and a Sex Therapist and Couples Counsellor, author, sexual educator and co-founder of The Westland Academy of Clinical Sex Therapy

18. Children and sexuality protection or education? Dr. Sanderijn van der Doef a famous Dutch sex educator and sexologist

19. The secret to desire in a long-term relationship By Esther Perel

20. We all do it, we just don't talk about it Cindy Gallop a graduate of Somerville College, Oxford, with a reputation as a highly compelling and inspirational speaker at conferences and events around the world on a variety of topics who wants to talk about and wants others to talk about sex.

21. Casual (stranger) Sex is not evil and can be good for you Dr. Zhana Vrangalova a renowned sex researcher with a Ph.D. in Developmental Psychology from Cornell University. The unsexy truth of the hookup culture by Lisa Bunnage

22. Libido, Hormones & Your Health Dr. Mary Caire, MD, a practicing functional medicine physician.

23. Why we shouldn’t shy away from sexual education Dr. V. Chandra-Mouli an expert in adolescent sexual and reproductive health and public health who is employed with the World Health Organization in Geneva since 1993

24. How to improve your sex life Agnieszka Wroczynska a Polish clinical sexologist talks in Polish about how you can improve your sex life. (For English captions please click on the captions button)

25. Creating extraordinary intimacy in a shutdown world by Michael J. Russe an international speaker and author of several books on sexuality.

26. Passion vs. sex: ensuring the viability of your relationship by Laurie Betito

27. Reinventing our approach to sex: by Barbara Lee

28. How to activate your inner power with sexual energy by Alexandra Miu

29. Skills for Healthy Romantic Relationships by Dr. Joanne Davila with PhD in Clinical Psychology from UCLA and a widely published Professor of Psychology, Editor for the Journal of Consulting and Clinical Psychology; and the Director of Clinical Training in the Department of Psychology at Stony Brook University.

30. The Pleasure Principle: The Secret to a Better Sex Life Dr. Laurie Betito a clinical psychologist with a specialty in sexuality in private practice;

31. The Effect of Stress on Healthy Sex Hormone Levels by Jessica Drummond, MPT, CCN, CHC,

32. The Importance of Erotic Intelligence by Mal Harrison an opera singer and clit-feminism pioneering sexologist and founder of the Center for Erotic Intelligence with passion for about freeing people from shame, stigma, and fear

33. Still Going Strong: Sexuality in Older Adults by Dr. Tuuli Kukkonen a clinical psychologist, assistant professor, and director of the psychophysiology of sexual health laboratory at the University of Guelph in Guelph, Ontario, Canada.

34. Have You Heard from Your Libido Lately? by Dr. Keesha Ewers, a doctor of sexology, who holds that libido is a powerful indicator of general vitality and wellbeing

35. In Search of Erotic Intelligence (26 Nov 2017) by Esther Perel a clinical psychologist and couple’s therapist

36. Self-Pleasure for maximum orgasmic results Jacqueline Hellyer in her video points out that it is a common mistake by women to leave their orgasms up to others mostly the men they are with and explains that orgasms should sprout out of yourself instead of imposed on you.

37. Is Sex Necessary? by Rachel Hills an Australian writer living in New York City

38. Owning Your Sexual Power . by Amy Jo Goddard who has dedicated her life to offer a strong sexual empowerment coaching service via her Women’s Sexually Empowered Life Program.

39. Sexuality Education by Al Vernacchio

It’s not “just sex”, it’s JUST sex! by Al Vernacchio a nationally recognized openly gay person, a sexuality educator and author, who teaches sexuality at Friends’ Central School in Wynnewood, PA where he also organizes sexuality programming, provides parent education on human sexuality, and is the faculty advisor for the Gender and Sexual Orientation Alliance; the author of For Goodness Sex: Changing the Way We Talk to Teens about Sexuality, Values, and Health illustrates how our most private behaviors create a ripple effect

Lisa Welling It’s not you, it’s my hormones Testosterone Influences

My research finds that increases in testosterone is associated with increased preferences for sexually dimorphic (i.e., masculinity in males and femininity in females) characteristics and changes in self-perception. Specifically, research shows that testosterone influences perceptions by increasing preferences for masculine men and feminine women, and influencing men's perceptions of their own dominance. This research demonstrates that, far from being arbitrary, our preferences and perceptions are at least in part governed by biological processes and that beauty is not just in the eye of the beholder.

Dr. Lisa Welling is an Assistant Professor at Oakland University. Her Ph.D., entitled Individual Differences in Face Preferences, was completed in 2008 and was funded by the Natural Sciences and Engineering Research Council of Canada. Grounded in evolutionary reasoning, Dr. Welling’s research generally surrounds three related areas: hormonal influences on behavior, sources of adaptive mate preferences, and interpersonal relationships. In addition to having co-edited a book entitled Evolutionary Perspectives on Social Psychology, Dr. Welling has published five book chapters and more than fifty scientific journal articles. Her research has been featured in the media multiple times on programs including lthe Oprah Winfrey Show and the Discovery Channel documentary Curiosity.

Marwa Azab The brain and ovarian hormones

Brain chemicals covertly direct female hormones, but their effects on behaviors, emotions, cognitive abilities and relationships can make us vulnerable. The more we become aware and understand these vulnerabilities, the more we can transform them to actually empower us…

Marwa Azab has been interested in human behavior and why we do what we do since she was a child. Her interest compelled her to complete two advanced degrees in Psychology and a PhD in Neuroscience. She has been teaching in the Psychology, Biology and Human Development departments, presenting to various audiences ranging from first graders to seniors and is a frequent contributor to the Huffington Post. Her approach to understanding any human behavior—or misbehavior—is unique because it is Gestalt. This interdisciplinary background allows her to intersect fields and come up with innovative ways to understand “why we do what we do”. She is a firm believer that it is at these intersection foci that creativity and novelty find fertile grounds. She practices this holistic approach in individual and group life-coaching.

Dr. Tuuli Kukkonen Sexuality in Older Adults

The importance of sexual expression in older adults remains a controversial topic despite the positive relationship between sexual functioning and quality of life across the lifespan. In this talk, Dr. Kukkonen encourages us to examine and discuss sexuality in older adults and challenges some of the societal biases that limit our understanding of sex and aging. Dr. Kukkonen is a clinical psychologist, assistant professor, and director of the psychophysiology of sexual health laboratory at the University of Guelph in Guelph, Ontario, Canada.

Alexandra Miu How to activate your inner power with sexual energy

Alexandra shares her wisdom on how human beings can take sexuality to deeper levels. From a very young age, Alexandra was ready to take the world by storm, always questioning, exploring, expressing curiosity for all sorts of things and feeling like there is more than meets the eye. Alexandra's vision is to see a world where we are empowered and empower others to live authentically and accordingly to our inner truth.

Diana Richardson The Power of Mindful Sex

Diana Richardson is one of today’s leading authorities on human sexuality. She has written 8 books on how in practical ways a person can experience a more fulfilling sex and love life. One of her bestsellers was translated and published under the title "Zeit für Weiblichkeit", a book well celebrated in the German speaking world. Born in South Africa in 1954, she first qualified as a lawyer (B.A.LLB), and then she trained as a massage therapist (ITEC) in the UK. Her interest in the body and healing prompted an intense personal exploration into the union of sex and meditation - the essence of Tantra. Since 1993, together with her partner, she has been sharing her insights and experiences with couples who travel from many different parts of the world to participate in their informative and life changing workshops in Switzerland. Awareness in sex creates love and connection, says author Diana Richardson. She has spent 25 years teaching couples about sex as a form of meditation where longing and attraction don’t die. Are you open minded? Are you open to explore? Learn how sex can bring healing and connection to your relationship in this thought-provoking talk.

Nicole Daedone Orgasm: The Cure for Hunger in the Western Woman

https://www.youtube.com/watch?v=s9QVq0EM6g4&t=6sNicole Daedone is a sought-after speaker, author, and educator focusing on the intersection between orgasm, intimacy, and life. She is the founder of OneTaste, a cutting-edge company bringing a new definition of orgasm to women. The practice at the heart of her work is called OM or Orgasmic Meditation. OM uniquely combines the tradition of extended orgasm with Nicole's own interest in Zen Buddhism, mystical Judaism and semantics. Helping to foster a new conversation about orgasm —one that's real, relevant, and intelligent—she has inspired thousands of students to make OM a part of their everyday lives. Nicole graduated from San Francisco State University with a degree in semantics and gender communication. She went on to found the popular avant garde art gallery 111 Minna Gallery in SoMa before moving on to OneTaste. Nicole is the author of Slow Sex: The Art and Craft of the Female Orgasm (Grand Central/Hachette, May 2011) and has appeared on ABC's Nightline. Her work has been featured in the New York Times, the New York Post, the San Francisco Chronicle, and 7x7 Magazine, among others, and her writing has appeared in Tricycle magazine. In his #1 New York Times Bestseller The 4-Hour Body Timothy Ferriss calls the OM practice "required education for every man on the planet."

We need to substitute the Hypoactive female sexuality desire disorder with the puritanical social prohibition Female pleasure deficit disorder.

Deepika Bharadwaj True gender equality is when both women and men have a voice

Deepika talks about the issue of Men’s right and abuse of one-sided gender centric laws in the Indian Penal Code. Deepika Narayan Bhardwaj is a journalist, anchor and a documentary filmmaker. Her first documentary ‘Gramin Dak Sevak’ was Jeevika All Asia Livelihood Film Festival 2009, student film winner. Her second documentary ‘Youth Count’ was broadcast on India’s leading News channel NDTV 24×7. Her third project ‘Garima’ was a commissioned, short documentary film by USAID and Counterpart International. A software engineer-turned-journalist, she was one of the 10 media professionals selected from around the world for ‘Future Media Leaders Course’ conducted by Thomson Foundation, UK.

Amy Jo Goddard Owning Your Sexual Power

Amy Jo's Event Photos are here - https://www.flickr.com/photos/tedxnap...

Find out more about Amy Jo and her work here - http://amyjogoddard.com/

This video was produced by 360 Kreative Services (http://360kreative.com) in conjunction with 3 rock marketing (http://www.3rockmarketing.com)

After nearly two decades of working in the sexuality field with every audience you could imagine, from first graders to adult professionals to college students, Amy Jo Goddard dedicated herself to building a successful sexual empowerment coaching practice for women and couples and facilitating her Women’s Sexually Empowered Life Program. She co-authored the highly successful “Lesbian Sex Secrets for Men” and was chosen as one of GO! Magazine’s “100 Women We Love 2010.” She is currently working on her forthcoming book on sexual empowerment and is directing the film “At Your Cervix” about medical education and pelvic exams. Amy Jo believes sexuality is where our energy begins; if we work on that, it impacts everything else.

Keeley Olivia Masturbation is the New Meditation

Keeley Olivia is a Female Sexuality Expert on a mission to revamp the sexual experiences of women and couples the world over. In this talk she shares her own story of discovering orgasm, explains why she wrote a masturbation memoir and announces the arrival of the second wave sexual revolution - one that will close the gender orgasm gap and place the pursuit of female orgasm and deep sexual connection as a powerful portal for personal and relationship transformation and empowerment. Keeley is the founder of Self Pleasure School which gives women a foundation in self and body love that allows them to enjoy a thriving sexuality throughout their lives regardless of their relationship status.

Pocket #Prosperity #Plenties Prolong #Healthspan

#Practice PliantropyPlus https://bit.ly/Pliantropy

In thinking of how to live longer everyone remember that pre-pubertal period is immutable as also the procreative phase. What medicine has succeeded with is elongation of the post menopausal or andropausal lifespan. So, lengthening of lifespan is essentially lengthening of your life as non reproductive and often impotent and libidoless person. What is the fun of that other than having to help with baby sitting the grandchildren but given that nature dictates selection and favours the FIT to continue to go on, the key to living longer is remaining sexually fit and sexually active? See pliantropy - a theory based on procreative prowess preservation. It works. The ability to have a robust erection without help from Viagra at 59 is great. https://sites.google.com/view/sleep-smart-smash-stress/home/arcade/fetalworkout-pliantropy

Let us face it cancer will get you. Humans MUST die. If you escape the prostate or testicular cancer, then there is always the cancer of lung, colon, pancreas. Prostatic cancers tend not to be very lethal. If you escape cancer and reach 89 you are going to get Alzheimer’s Disease. The idea is to slow down aging or stall aging by lowering the level of inflammation in the body. Then you can dream of dying in sleep or have no longer than 3-month preterminal morbidity. Prostate cancer prevention with frequent plumbing is old new and not complicated science. The theory that I am working on is to boost the weekly or monthly orgasm rate. I aim for 20 per week or >500 orgasms a month. That is the way to stay young. The theory I am developing is called Pliantropy. I hope it gets some attention of big-name anti-aging researchers. With both the ejaculations and orgasms masturbation is only half as good as coitus. I am looking for support in bringing the concept of Pliantropy to mainstream medical attention. Some old data does show that women who had a high orgasm rate and quality lived longer. It cures headaches too so women need to be more generous with leg spreading to boost health and live longer. Due to social medial couples are having half as much sex now. There is a sex draught happening. Anyone interested contact me from my website that aims at longevity through sleep superior zing and stress smashing both are helped by frequent orgasming like thrice a day. The job of boosting orgasm rate needs to be taken seriously not to poke fun with but there is room to have fun while poking. https://bit.ly/Pliantropy