Major or Mild Neurocognitive Disorder due to Huntington's Disease
Major or Mild Neurocognitive Disorder due to Huntington's Disease
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Prevalence
Prevalence
The worldwide prevalence is estimated to be 2.7 per 100,000.
Risk factors
Risk factors
Genetic and physiological
Genetic and physiological
The genetic basis of Huntington's disease is a fully penetrant autosomal dominant expansion of the CAG trinucleotide, often called a CAG repeat in the huntingtin gene.
A CAG repeat length of 36 or more is invariably associated with Huntington's disease, with longer repeat lengths associated with early age at onset.
Symptoms
Symptoms
The criteria are met for major or mild neurocognitive disorder.
There is insidious onset and gradual progression.
There is clinically established Huntington’s disease, or risk for Huntington’s disease based on family history or genetic testing.
The neurocognitive disorder is not attributable to another medical condition and is not better explained by another mental disorder.
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