Approach to pantcytopenia 

Aplastic anemia - when bone marrow does not produce enough blood cells

Genetic causes 

Fanconi Anemia - cafe au late spots, appear short

paroxysmal nocturnal hematuria 

Acquired causes 

Hapetic causes - infection 

Autoimmune causes 

Treatment 

hemapoeitic stem cell transplant = young patient 

+ cyclosporin A

rise in eosinophil common after stopping cyclosporin 

15% of those after transplant - mDS -> leukemia