Land of Lilyplant - restless leg syndrome

restless leg syndrome

clinical diagnosis

uncontrollable urge to move the legs due to an uncomfortable or unpleasant feeling, which is worse at night and at rest, and temporarily relieved by movement.

diagnostic criteria

urge to move leg
symptoms worse at night
worsened with prolonged rest
relieved by movement.
The occurrence of the above features is not solely accounted for as symptoms primary to another medical or a behavioural condition (eg myalgia, venous stasis, leg oedema, arthritis, leg cramps, positional discomfort, habitual foot tapping)

Iron deficiency

dopamine dysfunction

Iron repletion is a cornerstone of management in RLS. Consensus opinion suggests targeting ferritin levels >75 µg/L and/or aiming for transferrin saturations >20%.43,44 The latter is important to measure because ferritin might be artificially elevated in the setting of an acute phase response.45 A common oral iron regime is 325 mg ferrous sulfate (65 mg elemental iron) in combination with 100–200 mg vitamin C to enhance absorption. Intravenous iron is recommended if ferritin is close to 75 µg/L due to the inverse correlation between oral iron absorption and ferritin levels.46 It is worth noting that the response to oral and intravenous iron is not immediate, and might take one to three months to see clinical improvements.47

treatment

magnesium supplement

dopamine agonist :promipraxole

pregabalin