Respiratoire Oncologie

Actief (open voor inclusie van patienten) :

  1. ORION TRIAL : patienten met uitgezaaide niet-kleincellige longkanker : A Phase II Randomized, Multi-Center, Double-Blind, Global Study to Determine the Efficacy and Safety of Durvalumab plus Olaparib Combination Therapy Compared with Durvalumab Monotherapy as Maintenance Therapy in Patients whose Disease has not Progressed Following Standard of Care Platinum-Based Chemotherapy with Durvalumab in First-Line Stage IV Non-Small Cell Lung Cancer (ORION).
  2. ADRIATIC TRIAL : voor patienten met vroegstadium kleincellige longkanker : Phase III, Randomised, Double-blind, Placebo-controlled, Multi-centre, International Study of Durvalumab or Durvalumab and Tremelimumab as Consolidation treatment for Patients with Stage I/III Limited Disease Small Cell Lung Cancer Who Have Not Progressed Following Concurrent Chemoradiation Therapy.
  3. PACIFIC 4 TRIAL : voor patienten met vroegstadium longkanker die in opzet curatief bestraald worden : Phase III, Randomized, Placebo-controlled, Double-blind, Multi-center, International Study of Durvalumab Following Stereotactic Body Radiation Therapy (SBRT) for the Treatment of Patients with Stage I/II Non-Small Cell Lung Cancer (PACIFIC-4/RTOG-3515)
  4. PROLUNG TRIAL : voor patienten met vroegstadium longkanker die geopereerd worden : Prospective, open label, interventional study to investigate if early disease recurrence in patients with NSCLC who will undergo surgery with curative intent, can be predicted, through metabolic phenotyping by proton-nuclear magnetic resonance (H-NMR) spectroscopy - Towards better therapy for resectable lung cancer: Metabolomics predict therapy response
  5. PACIFIC REAL WORLD STUDIE : voor patienten met stadium III longkanker die chemo-radiotherapie en immunotherapie krijgen : First real-world data on unresectable stage III NSCLC patients treated with durvalumab after chemoradiotherapy
  6. VALUE BASED HEALTH CARE PROJECT : voor alle patienten met longkanker die therapie krijgen : opvolging van de levenskwalilteit aan de hand van 'patient reported outcomes' - PROMS


Afgesloten:

  1. SPLENDOUR TRIAL : effect van denosumab bij patienten met uitgezaaide longkanker (gepubliceerd)
  2. PACIFIC TRIAL : effect van durvalumab immunotherapie bij patienten met locaal gevorderde longkanker na chemo-radioteherapie (wordt gepubliceerd)
  3. Quality of Life trial SWOG schema (gepubliceerd)
  4. Quality of Life trial Adjuvante chemotherapie (data in analyse)