El NCBI es el National Center for Biotechnology Information, que es parte de la Librería nacional de Medicina de los Estados Unidos (NLM, National Institutes of Health)
Su origen data de 1988, está localizado en Maryland y contiene una serie de bases de datos
La más conocida en el GenBank.
Aprendamos a usar GenBank http://www.ncbi.nlm.nih.gov/genbank/
Busquemos el Alcohol deshidrogenasa
Paso 1. Busquemos la accesión AH001409.1
GenBank: AH001409.1
The displayed sequence is a segmented set.
LOCUS SEG_HUMADH6A0 1925 bp DNA linear PRI 17-OCT-2000 DEFINITION Homo sapiens alcohol dehydrogenase 6 (ADH6) gene, complete cds. ACCESSION AH001409 M68895 VERSION AH001409.1 GI:178145 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1925) AUTHORS Yasunami,M., Chen,C.S. and Yoshida,A. TITLE A human alcohol dehydrogenase gene (ADH6) encoding an additional class of isozyme JOURNAL Proc. Natl. Acad. Sci. U.S.A. 88 (17), 7610-7614 (1991) PUBMED 1881901COMMENT On Oct 17, 2000 this sequence version replaced gi:178135.
FEATURES Location/Qualifiers source 1..1925 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /sex="male" /tissue_type="liver" regulatory 34..48 /regulatory_class="other" gene 287..1859 /gene="ADH6" mRNA join(287..396,422..523,549..690,716..803,829..1045, 1071..1331,1357..1492,1518..1859) /gene="ADH6" /product="alcohol dehydrogenase 6" exon 287..396 /gene="ADH6" /number=1 CDS join(379..396,422..523,549..690,716..803,829..1045, 1071..1331,1357..1492,1518..1660)
OBSERVACION . Si damos click a CDS, automáticamente se marcará abajo la secuencia
/gene="ADH6" /codon_start=1 /product="alcohol dehydrogenase 6" /protein_id="AAA35509.1" /db_xref="GI:178146" /translation="MSTTGQVIRCKAAILWKPGAPFSIEEVEVAPPKAKEVRIKVVAT GLCGTEMKVLGSKHLDLLYPTILGHEGAGIVESIGEGVSTVKPGDKVITLFLPQCGEC TSCLNSEGNFCIQFKQSKTQLMSDGTSRFTCKGKSIYHFGNTSTFCEYTVIKEISVAK IDAVAPLEKVCLISCGFSTGFGAAINTAKVTPGSTCAVFGLGGVGLSVVMGCKAAGAA RIIGVDVNKEKFKKAQELGATECLNPQDLKKPIQEVLFDMTDAGIDFCFEAIGNLDVL AAALASCNESYGVCVVVGVLPASVQLKISGQLFFSGRSLKGSVFGGWKSRQHIPKLVA DYMAEKLNLDPLITHTLNLDKINEAVELMKTGKW" exon 422..523 /gene="ADH6" /number=2 exon 549..690 /gene="ADH6" /number=3 exon 716..803 /gene="ADH6" /number=4 exon 829..1045 /gene="ADH6" /number=5 exon 1071..1331 /gene="ADH6" /number=6 exon 1357..1492 /gene="ADH6" /number=7 exon 1518..1859 /gene="ADH6" /number=8 ORIGIN 1 tgtattttga aaacaacaga aaagaaatac ttttgtacac tctgttagaa attttaagtt 61 tggacattta aaagtccaaa tttaaaactc aaaaaaatgg ataataagag ggacctgttt 121 gattaaggga gaaaaaaata gtttgcattt tcaccttttg gctctttcac tgagatgagc 181 ctatttcaga ttacacttag gaacttccat caagcacggg agagcctact tttcctgttt 241 aataattacc agactacaga gaaggtcgga ccagccttct gatctacagt cgcctgtgta 301 cctttgtact ttctacagtg aaagttgcta caggatctcc ctttctcaat aaattcatct 361 gcggtggaga aaatcagcat gagtactaca ggccaagtag gtgcagtatt ctatttccca 421 ggtcatcaga tgcaaagcag ccatactctg gaagcctggt gcaccatttt ctattgaaga 481 ggtagaagtg gccccaccaa aggcaaagga ggttcgcata aaggtaaaaa aaattgcctt 541 ccatacaggt tgtggccacc ggactgtgtg gtacagagat gaaagtgttg gggagtaaac 601 acttggacct cttgtatccc accatcttgg gccatgaagg ggctggaatc gttgagagta 661 ttggagaagg agtaagcaca gtgaaaccag gtaggaatta attttgctct tttaggtgac 721 aaagttatca cactctttct gccacagtgt ggagaatgta cctcttgcct gaattctgag 781 ggcaattttt gtatacaatt caagtaagtt tttttttgtc tataaaagac agtcaaaaac 841 ccaactgatg tctgatggta ccagcaggtt tacctgcaag ggaaaatcaa tatatcactt 901 tggtaatacc agcaccttct gtgaatacac agtgataaag gaaatctcag ttgccaagat 961 tgatgcagtc gctcctctag agaaagtatg cctaattagc tgtggctttt ccactgggtt 1021 tggtgctgca atcaatactg ccaaggtgag gggcacctgt atgtgtttag gtgactccag 1081 gttctacctg tgctgtgttt ggcctgggag gagtcggctt gtctgttgtc atgggttgta 1141 aagcagcagg agcagccagg atcattggag tggatgtcaa caaggagaaa tttaagaagg 1201 cacaggaatt gggtgcgact gagtgcctca accctcagga cttaaagaaa cccattcaag 1261 aagttttatt tgatatgaca gatgctggta tagacttctg ctttgaggcc attggaaatc 1321 tggacgttct ggtatgtaat ccgtcacttc taacaggcag ctgccctcgc ctcctgcaat 1381 gagagctatg gggtctgtgt ggttgttggg gtgttgcctg ccagtgttca actcaaaatc 1441 agtggccagt tgttcttctc aggacgttct ttgaagggtt ctgtttttgg aggtatggat 1501 gaaatctgta tttccaggct ggaagagcag acagcacatc cctaaactgg ttgctgatta 1561 tatggcagag aagttgaatc tagatccact aattactcat actctgaatc ttgataaaat 1621 caatgaagca gttgaattaa tgaaaactgg aaaatggtaa actgcccaca taaattttat 1681 gtctgtgtgt ttgagaccaa gagaaagggt gtattggctt gggagtagaa gaagggtcgt 1741 ccctgctgca gaagctgtat actgataatt gaagaggctt tcaggaattt gtaaagcatc 1801 tccttcccct ctgcattttg ttttatttct agctaataaa atacataatc ctgaaagtat 1861 ttaagtgttc acctaccgtt acttttgcca attagcattg tatttccaat atggattttt 1921 ttttt
Busquemos un gen más complejo con el de cáncer de seno
Paso 2. Busquemos la accesión NM_007294.3 que codifica para el gen BRCA1 Breast Cancer 1
Paso 3. Obtengamos la secuencia en formato FASTA
NCBI Reference Sequence: NM_007294.3
>gi|237757283|ref|NM_007294.3| Homo sapiens breast cancer 1, early onset (BRCA1), transcript variant 1, mRNA GTACCTTGATTTCGTATTCTGAGAGGCTGCTGCTTAGCGGTAGCCCCTTGGTTTCCGTGGCAACGGAAAAGCGCGGGAATTACAGATAAATTAAAACTGCGACTGCGCGGCGTGAGCTCGCTGAGACTTCCTGGACGGGGGACAGGCTGTGGGGTTTCTCAGATAACTGGGCCCCTGCGCTCAGGAGGCCTTCACCCTCTGCTCTGG///
TACAAAATACGTTTTGTAAATGTTGTGCTGTTAACACTGCAAATAAACTTGGTAGCAAACACTTCCAAAAAAAAAAAAAAAAAA
OBSERVACION 2. El tamaño del ARNm es de 7224pb
LOCUS NM_007294 7224 bp mRNA linear PRI 25-MAY-2015 DEFINITION Homo sapiens breast cancer 1, early onset (BRCA1), transcript variant 1, mRNA.
OBSERVACION 3. Hay más variantes, esta es la primera, variante 1
ACCESSION NM_007294 VERSION NM_007294.3 GI:237757283
OBSERVACION 4. Es la versión 3 de la misma secuencia y se actualizó en mayo del 2015
OBSERVACION 5. Tiene un Gi que es un Gene Index que es un código único para la secuencia y una accesión que es el código que se repite en todas las bases de datos que tienen esta secuencia.
KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
OBSERVACION 6. Este es el órden taxonómico.
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OBSERVACION 7. Abajo están los Features que son información importante .
FEATURES Location/Qualifiers source 1..7224 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="17" /map="17q21"
OBSERVACION 8. Se muestra la ubicación en el cromosoma 17q21
gene 1..7224 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /note="breast cancer 1, early onset" /db_xref="GeneID:672" /db_xref="HGNC:HGNC:1100" /db_xref="HPRD:00218" /db_xref="MIM:113705"
OBSERVACION 9. Se muestran otros vínculos importantes como el MIM que es el Mendelian Inheritance in Men
exon 1..213 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /inference="alignment:Splign:1.39.8" misc_feature 93 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /note="alternative transcription start site" STS 184..1651 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /db_xref="UniSTS:482866" misc_feature 209..211 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /note="upstream in-frame stop codon" exon 214..312 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /inference="alignment:Splign:1.39.8" CDS 233..5824
OBSERVACION 10. Se la ubicación del Coding sequence CDS, que es importante porque el ARNm tiene secuencias no codificantes en sus extremos 5prima y 3prima conocidos como UTRs Untranslated sequences.
/gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /note="isoform 1 is encoded by transcript variant 1; BRCA1/BRCA2-containing complex, subunit 1; RING finger protein 53; breast cancer type 1 susceptibility protein; breast and ovarian cancer susceptibility protein 1; protein phosphatase 1, regulatory subunit 53; breast and ovarian cancer sususceptibility protein 1; Fanconi anemia, complementation group S; truncated breast and ovarian cancer susceptibility protein 1" /codon_start=1 /product="breast cancer type 1 susceptibility protein isoform 1" /protein_id="NP_009225.1" /db_xref="GI:6552299" /db_xref="CCDS:CCDS11453.1" /db_xref="GeneID:672" /db_xref="HGNC:HGNC:1100" /db_xref="HPRD:00218" /db_xref="MIM:113705" /translation="MDLSALRVEEVQNVINAMQKILECPICLELIKEPVSTKCDHIFC KFCMLKLLNQKKGPSQCPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYA NSYNFAKKENNSPEHLKDEVSIIQSMGYRNRAKRLLQSEPENPSLQETSLSVQLSNLG TVRTLRTKQRIQPQKTSVYIELGSDSSEDTVNKATYCSVGDQELLQITPQGTRDEISL DSAKKAACEFSETDVTNTEHHQPSNNDLNTTEKRAAERHPEKYQGSSVSNLHVEPCGT NTHASSLQHENSSLLLTKDRMNVEKAEFCNKSKQPGLARSQHNRWAGSKETCNDRRTP STEKKVDLNADPLCERKEWNKQKLPCSENPRDTEDVPWITLNSSIQKVNEWFSRSDEL LGSDDSHDGESESNAKVADVLDVLNEVDEYSGSSEKIDLLASDPHEALICKSERVHSK SVESNIEDKIFGKTYRKKASLPNLSHVTENLIIGAFVTEPQIIQERPLTNKLKRKRRP TSGLHPEDFIKKADLAVQKTPEMINQGTNQTEQNGQVMNITNSGHENKTKGDSIQNEK NPNPIESLEKESAFKTKAEPISSSISNMELELNIHNSKAPKKNRLRRKSSTRHIHALE LVVSRNLSPPNCTELQIDSCSSSEEIKKKKYNQMPVRHSRNLQLMEGKEPATGAKKSN KPNEQTSKRHDSDTFPELKLTNAPGSFTKCSNTSELKEFVNPSLPREEKEEKLETVKV SNNAEDPKDLMLSGERVLQTERSVESSSISLVPGTDYGTQESISLLEVSTLGKAKTEP NKCVSQCAAFENPKGLIHGCSKDNRNDTEGFKYPLGHEVNHSRETSIEMEESELDAQY LQNTFKVSKRQSFAPFSNPGNAEEECATFSAHSGSLKKQSPKVTFECEQKEENQGKNE SNIKPVQTVNITAGFPVVGQKDKPVDNAKCSIKGGSRFCLSSQFRGNETGLITPNKHG LLQNPYRIPPLFPIKSFVKTKCKKNLLEENFEEHSMSPEREMGNENIPSTVSTISRNN IRENVFKEASSSNINEVGSSTNEVGSSINEIGSSDENIQAELGRNRGPKLNAMLRLGV LQPEVYKQSLPGSNCKHPEIKKQEYEEVVQTVNTDFSPYLISDNLEQPMGSSHASQVC SETPDDLLDDGEIKEDTSFAENDIKESSAVFSKSVQKGELSRSPSPFTHTHLAQGYRR GAKKLESSEENLSSEDEELPCFQHLLFGKVNNIPSQSTRHSTVATECLSKNTEENLLS LKNSLNDCSNQVILAKASQEHHLSEETKCSASLFSSQCSELEDLTANTNTQDPFLIGS SKQMRHQSESQGVGLSDKELVSDDEERGTGLEENNQEEQSMDSNLGEAASGCESETSV SEDCSGLSSQSDILTTQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDS SALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVE RSSPSKCPSLDDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSY LPRQDLEGTPYLESGISLFSDDPESDPSEDRAPESARVGNIPSSTSALKVPQLKVAES AQSPAAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYKF ARKHHITLTNLITEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKER KMLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMV QLCGASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAPVVTREWVLDSV ALYQCQELDTYLIPQIPHSHY" misc_feature 233..235 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /experiment="experimental evidence, no additional details recorded" /note="N-acetylmethionine. {ECO:0000269|PubMed:22814378}; propagated from UniProtKB/Swiss-Prot (P38398.2); acetylation site" misc_feature 572..574 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000269|PubMed:20068231, ECO:0000269|PubMed:21406692}; propagated from UniProtKB/Swiss-Prot (P38398.2); phosphorylation site" misc_feature 1154..1156 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine, by AURKA. {ECO:0000269|PubMed:14990569}; propagated from UniProtKB/Swiss-Prot (P38398.2); phosphorylation site" misc_feature 1415..1417 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000269|PubMed:18669648, ECO:0000269|PubMed:19690332}; propagated from UniProtKB/Swiss-Prot (P38398.2); phosphorylation site" misc_feature 1424..1426 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000269|PubMed:18669648, ECO:0000269|PubMed:19690332}; propagated from UniProtKB/Swiss-Prot (P38398.2); phosphorylation site" misc_feature 1499..1501 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000269|PubMed:20068231}; propagated from UniProtKB/Swiss-Prot (P38398.2); phosphorylation site" misc_feature 2312..2314 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000269|PubMed:20068231}; propagated from UniProtKB/Swiss-Prot (P38398.2); phosphorylation site" misc_feature 2489..2491 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000269|PubMed:18669648}; propagated from UniProtKB/Swiss-Prot (P38398.2); phosphorylation site" misc_feature 2750..2752 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000250|UniProtKB:P48754}; propagated from UniProtKB/Swiss-Prot (P38398.2); phosphorylation site" misc_feature 3194..3196 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine, by CHEK2. {ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:20364141}; propagated from UniProtKB/Swiss-Prot (P38398.2); phosphorylation site" misc_feature 3659..3661 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine, by ATR, in vitro. {ECO:0000269|PubMed:11114888}; propagated from UniProtKB/Swiss-Prot (P38398.2); phosphorylation site" misc_feature 3863..3865 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000269|PubMed:18669648}; propagated from UniProtKB/Swiss-Prot (P38398.2); phosphorylation site" misc_feature 3881..3883 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000269|PubMed:18669648}; propagated from UniProtKB/Swiss-Prot (P38398.2); phosphorylation site" misc_feature 3884..3886 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000269|PubMed:18669648, ECO:0000269|PubMed:21406692}; propagated from UniProtKB/Swiss-Prot (P38398.2); phosphorylation site" misc_feature 4070..4072 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine, by ATR, in vitro. {ECO:0000269|PubMed:11114888}; propagated from UniProtKB/Swiss-Prot (P38398.2); phosphorylation site" misc_feature 4214..4216 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000269|PubMed:20068231}; propagated from UniProtKB/Swiss-Prot (P38398.2); phosphorylation site" misc_feature 4238..4240 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000269|PubMed:17081983, ECO:0000269|PubMed:20068231, ECO:0000269|PubMed:21406692}; propagated from UniProtKB/Swiss-Prot (P38398.2); phosphorylation site" misc_feature 4256..4258 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine. {ECO:0000269|PubMed:20068231, ECO:0000269|PubMed:21406692}; propagated from UniProtKB/Swiss-Prot (P38398.2); phosphorylation site" misc_feature 4391..4393 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine, by ATM and ATR. {ECO:0000269|PubMed:11114888}; propagated from UniProtKB/Swiss-Prot (P38398.2); phosphorylation site" misc_feature 4412..4414 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine, by ATR, in vitro. {ECO:0000269|PubMed:11114888}; propagated from UniProtKB/Swiss-Prot (P38398.2); phosphorylation site" misc_feature 4421..4504 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P38398.2); Region: Interaction with PALB2" misc_feature 4499..4501 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine, by ATM and ATR. {ECO:0000269|PubMed:11114888}; propagated from UniProtKB/Swiss-Prot (P38398.2); phosphorylation site" misc_feature 4601..4603 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine, by ATR, in vitro. {ECO:0000269|PubMed:11114888}; propagated from UniProtKB/Swiss-Prot (P38398.2); phosphorylation site" misc_feature 4802..4804 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine, by ATM. {ECO:0000269|PubMed:21144835}; propagated from UniProtKB/Swiss-Prot (P38398.2); phosphorylation site" exon 313..366 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /inference="alignment:Splign:1.39.8" exon 367..444 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /inference="alignment:Splign:1.39.8" exon 445..533 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /inference="alignment:Splign:1.39.8" exon 534..673 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /inference="alignment:Splign:1.39.8" exon 674..779 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /inference="alignment:Splign:1.39.8" exon 780..825 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /inference="alignment:Splign:1.39.8" exon 826..902 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /inference="alignment:Splign:1.39.8" exon 903..4328 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /inference="alignment:Splign:1.39.8" STS 909..1077 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /standard_name="GDB:454227" /db_xref="UniSTS:157424" STS 996..1234 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /standard_name="GDB:454278" /db_xref="UniSTS:157425" STS 1159..1436 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /standard_name="GDB:454349" /db_xref="UniSTS:157426" STS 1299..1543 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /standard_name="GDB:454353" /db_xref="UniSTS:157427" STS 1465..1730 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /standard_name="GDB:454372" /db_xref="UniSTS:157428" STS 1685..1947 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /standard_name="GDB:454381" /db_xref="UniSTS:157429" STS 1844..2087 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /standard_name="GDB:454417" /db_xref="UniSTS:157430" STS 2031..2329 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /standard_name="GDB:454421" /db_xref="UniSTS:157431" STS 2255..2510 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /standard_name="GDB:454425" /db_xref="UniSTS:157432" STS 2394..2617 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /standard_name="GDB:454429" /db_xref="UniSTS:157433" STS 2561..2830 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /standard_name="GDB:454433" /db_xref="UniSTS:157434" STS 2748..3061 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /standard_name="GDB:454437" /db_xref="UniSTS:157435" STS 2774..3016 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /standard_name="PMC13918P1" /db_xref="UniSTS:270877" STS 3013..3318 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /standard_name="GDB:454441" /db_xref="UniSTS:157436" STS 3284..3661 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /standard_name="GDB:454446" /db_xref="UniSTS:157437" STS 3526..3850 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /standard_name="GDB:454450" /db_xref="UniSTS:157438" STS 3796..4084 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /standard_name="BRCA1" /db_xref="UniSTS:262743" STS 3799..4072 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /standard_name="GDB:454454" /db_xref="UniSTS:157439" STS 3808..4067 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /standard_name="PMC310899P3" /db_xref="UniSTS:272805" STS 3901..4196 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /standard_name="G60034" /db_xref="UniSTS:137300" STS 3909..4067 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /standard_name="PMC310899P2" /db_xref="UniSTS:272804" STS 3973..4181 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /standard_name="GDB:454458" /db_xref="UniSTS:157440" STS 4109..4326 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /standard_name="GDB:454462" /db_xref="UniSTS:157441" exon 4329..4417 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /inference="alignment:Splign:1.39.8" exon 4418..4589 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /inference="alignment:Splign:1.39.8" exon 4590..4716 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /inference="alignment:Splign:1.39.8" exon 4717..4907 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /inference="alignment:Splign:1.39.8" exon 4908..5218 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /inference="alignment:Splign:1.39.8" exon 5219..5306 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /inference="alignment:Splign:1.39.8" exon 5307..5384 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /inference="alignment:Splign:1.39.8" exon 5385..5425 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /inference="alignment:Splign:1.39.8" exon 5426..5509 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /inference="alignment:Splign:1.39.8" exon 5510..5564 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /inference="alignment:Splign:1.39.8" exon 5565..5638 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /inference="alignment:Splign:1.39.8" exon 5639..5699 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /inference="alignment:Splign:1.39.8" exon 5700..7207 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /inference="alignment:Splign:1.39.8" STS 5746..5881 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /standard_name="PMC310899P11" /db_xref="UniSTS:272801" STS 5872..6109 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /standard_name="RH79896" /db_xref="UniSTS:90392" STS 6374..7203 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /standard_name="BRCA1_4046" /db_xref="UniSTS:464465" STS 6554..6633 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" /standard_name="D5S1597E" /db_xref="UniSTS:151019" regulatory 7182..7187 /regulatory_class="polyA_signal_sequence" /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" polyA_site 7207 /gene="BRCA1" /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53" ORIGIN 1 gtaccttgat ttcgtattct gagaggctgc tgcttagcgg tagccccttg gtttccgtgg 61 caacggaaaa gcgcgggaat tacagataaa ttaaaactgc gactgcgcgg cgtgagctcg 121 ctgagacttc ctggacgggg gacaggctgt ggggtttctc agataactgg gcccctgcgc 181 tcaggaggcc ttcaccctct gctctgggta aagttcattg gaacagaaag aaatggattt 241 atctgctctt cgcgttgaag aagtacaaaa tgtcattaat gctatgcaga aaatcttaga 301 gtgtcccatc tgtctggagt tgatcaagga acctgtctcc acaaagtgtg accacatatt 361 ttgcaaattt tgcatgctga aacttctcaa ccagaagaaa gggccttcac agtgtccttt 421 atgtaagaat gatataacca aaaggagcct acaagaaagt acgagattta gtcaacttgt 481 tgaagagcta ttgaaaatca tttgtgcttt tcagcttgac acaggtttgg agtatgcaaa 541 cagctataat tttgcaaaaa aggaaaataa ctctcctgaa catctaaaag atgaagtttc 601 tatcatccaa agtatgggct acagaaaccg tgccaaaaga cttctacaga gtgaacccga 661 aaatccttcc ttgcaggaaa ccagtctcag tgtccaactc tctaaccttg gaactgtgag 721 aactctgagg acaaagcagc ggatacaacc tcaaaagacg tctgtctaca ttgaattggg 781 atctgattct tctgaagata ccgttaataa ggcaacttat tgcagtgtgg gagatcaaga 841 attgttacaa atcacccctc aaggaaccag ggatgaaatc agtttggatt ctgcaaaaaa 901 ggctgcttgt gaattttctg agacggatgt aacaaatact gaacatcatc aacccagtaa 961 taatgatttg aacaccactg agaagcgtgc agctgagagg catccagaaa agtatcaggg 1021 tagttctgtt tcaaacttgc atgtggagcc atgtggcaca aatactcatg ccagctcatt 1081 acagcatgag aacagcagtt tattactcac taaagacaga atgaatgtag aaaaggctga 1141 attctgtaat aaaagcaaac agcctggctt agcaaggagc caacataaca gatgggctgg 1201 aagtaaggaa acatgtaatg ataggcggac tcccagcaca gaaaaaaagg tagatctgaa 1261 tgctgatccc ctgtgtgaga gaaaagaatg gaataagcag aaactgccat gctcagagaa 1321 tcctagagat actgaagatg ttccttggat aacactaaat agcagcattc agaaagttaa 1381 tgagtggttt tccagaagtg atgaactgtt aggttctgat gactcacatg atggggagtc 1441 tgaatcaaat gccaaagtag ctgatgtatt ggacgttcta aatgaggtag atgaatattc 1501 tggttcttca gagaaaatag acttactggc cagtgatcct catgaggctt taatatgtaa 1561 aagtgaaaga gttcactcca aatcagtaga gagtaatatt gaagacaaaa tatttgggaa 1621 aacctatcgg aagaaggcaa gcctccccaa cttaagccat gtaactgaaa atctaattat 1681 aggagcattt gttactgagc cacagataat acaagagcgt cccctcacaa ataaattaaa 1741 gcgtaaaagg agacctacat caggccttca tcctgaggat tttatcaaga aagcagattt 1801 ggcagttcaa aagactcctg aaatgataaa tcagggaact aaccaaacgg agcagaatgg 1861 tcaagtgatg aatattacta atagtggtca tgagaataaa acaaaaggtg attctattca 1921 gaatgagaaa aatcctaacc caatagaatc actcgaaaaa gaatctgctt tcaaaacgaa 1981 agctgaacct ataagcagca gtataagcaa tatggaactc gaattaaata tccacaattc 2041 aaaagcacct aaaaagaata ggctgaggag gaagtcttct accaggcata ttcatgcgct 2101 tgaactagta gtcagtagaa atctaagccc acctaattgt actgaattgc aaattgatag 2161 ttgttctagc agtgaagaga taaagaaaaa aaagtacaac caaatgccag tcaggcacag 2221 cagaaaccta caactcatgg aaggtaaaga acctgcaact ggagccaaga agagtaacaa 2281 gccaaatgaa cagacaagta aaagacatga cagcgatact ttcccagagc tgaagttaac 2341 aaatgcacct ggttctttta ctaagtgttc aaataccagt gaacttaaag aatttgtcaa 2401 tcctagcctt ccaagagaag aaaaagaaga gaaactagaa acagttaaag tgtctaataa 2461 tgctgaagac cccaaagatc tcatgttaag tggagaaagg gttttgcaaa ctgaaagatc 2521 tgtagagagt agcagtattt cattggtacc tggtactgat tatggcactc aggaaagtat 2581 ctcgttactg gaagttagca ctctagggaa ggcaaaaaca gaaccaaata aatgtgtgag 2641 tcagtgtgca gcatttgaaa accccaaggg actaattcat ggttgttcca aagataatag 2701 aaatgacaca gaaggcttta agtatccatt gggacatgaa gttaaccaca gtcgggaaac 2761 aagcatagaa atggaagaaa gtgaacttga tgctcagtat ttgcagaata cattcaaggt 2821 ttcaaagcgc cagtcatttg ctccgttttc aaatccagga aatgcagaag aggaatgtgc 2881 aacattctct gcccactctg ggtccttaaa gaaacaaagt ccaaaagtca cttttgaatg 2941 tgaacaaaag gaagaaaatc aaggaaagaa tgagtctaat atcaagcctg tacagacagt 3001 taatatcact gcaggctttc ctgtggttgg tcagaaagat aagccagttg ataatgccaa 3061 atgtagtatc aaaggaggct ctaggttttg tctatcatct cagttcagag gcaacgaaac 3121 tggactcatt actccaaata aacatggact tttacaaaac ccatatcgta taccaccact 3181 ttttcccatc aagtcatttg ttaaaactaa atgtaagaaa aatctgctag aggaaaactt 3241 tgaggaacat tcaatgtcac ctgaaagaga aatgggaaat gagaacattc caagtacagt 3301 gagcacaatt agccgtaata acattagaga aaatgttttt aaagaagcca gctcaagcaa 3361 tattaatgaa gtaggttcca gtactaatga agtgggctcc agtattaatg aaataggttc 3421 cagtgatgaa aacattcaag cagaactagg tagaaacaga gggccaaaat tgaatgctat 3481 gcttagatta ggggttttgc aacctgaggt ctataaacaa agtcttcctg gaagtaattg 3541 taagcatcct gaaataaaaa agcaagaata tgaagaagta gttcagactg ttaatacaga 3601 tttctctcca tatctgattt cagataactt agaacagcct atgggaagta gtcatgcatc 3661 tcaggtttgt tctgagacac ctgatgacct gttagatgat ggtgaaataa aggaagatac 3721 tagttttgct gaaaatgaca ttaaggaaag ttctgctgtt tttagcaaaa gcgtccagaa 3781 aggagagctt agcaggagtc ctagcccttt cacccataca catttggctc agggttaccg 3841 aagaggggcc aagaaattag agtcctcaga agagaactta tctagtgagg atgaagagct 3901 tccctgcttc caacacttgt tatttggtaa agtaaacaat ataccttctc agtctactag 3961 gcatagcacc gttgctaccg agtgtctgtc taagaacaca gaggagaatt tattatcatt 4021 gaagaatagc ttaaatgact gcagtaacca ggtaatattg gcaaaggcat ctcaggaaca 4081 tcaccttagt gaggaaacaa aatgttctgc tagcttgttt tcttcacagt gcagtgaatt 4141 ggaagacttg actgcaaata caaacaccca ggatcctttc ttgattggtt cttccaaaca 4201 aatgaggcat cagtctgaaa gccagggagt tggtctgagt gacaaggaat tggtttcaga 4261 tgatgaagaa agaggaacgg gcttggaaga aaataatcaa gaagagcaaa gcatggattc 4321 aaacttaggt gaagcagcat ctgggtgtga gagtgaaaca agcgtctctg aagactgctc 4381 agggctatcc tctcagagtg acattttaac cactcagcag agggatacca tgcaacataa 4441 cctgataaag ctccagcagg aaatggctga actagaagct gtgttagaac agcatgggag 4501 ccagccttct aacagctacc cttccatcat aagtgactct tctgcccttg aggacctgcg 4561 aaatccagaa caaagcacat cagaaaaagc agtattaact tcacagaaaa gtagtgaata 4621 ccctataagc cagaatccag aaggcctttc tgctgacaag tttgaggtgt ctgcagatag 4681 ttctaccagt aaaaataaag aaccaggagt ggaaaggtca tccccttcta aatgcccatc 4741 attagatgat aggtggtaca tgcacagttg ctctgggagt cttcagaata gaaactaccc 4801 atctcaagag gagctcatta aggttgttga tgtggaggag caacagctgg aagagtctgg 4861 gccacacgat ttgacggaaa catcttactt gccaaggcaa gatctagagg gaacccctta 4921 cctggaatct ggaatcagcc tcttctctga tgaccctgaa tctgatcctt ctgaagacag 4981 agccccagag tcagctcgtg ttggcaacat accatcttca acctctgcat tgaaagttcc 5041 ccaattgaaa gttgcagaat ctgcccagag tccagctgct gctcatacta ctgatactgc 5101 tgggtataat gcaatggaag aaagtgtgag cagggagaag ccagaattga cagcttcaac 5161 agaaagggtc aacaaaagaa tgtccatggt ggtgtctggc ctgaccccag aagaatttat 5221 gctcgtgtac aagtttgcca gaaaacacca catcacttta actaatctaa ttactgaaga 5281 gactactcat gttgttatga aaacagatgc tgagtttgtg tgtgaacgga cactgaaata 5341 ttttctagga attgcgggag gaaaatgggt agttagctat ttctgggtga cccagtctat 5401 taaagaaaga aaaatgctga atgagcatga ttttgaagtc agaggagatg tggtcaatgg 5461 aagaaaccac caaggtccaa agcgagcaag agaatcccag gacagaaaga tcttcagggg 5521 gctagaaatc tgttgctatg ggcccttcac caacatgccc acagatcaac tggaatggat 5581 ggtacagctg tgtggtgctt ctgtggtgaa ggagctttca tcattcaccc ttggcacagg 5641 tgtccaccca attgtggttg tgcagccaga tgcctggaca gaggacaatg gcttccatgc 5701 aattgggcag atgtgtgagg cacctgtggt gacccgagag tgggtgttgg acagtgtagc 5761 actctaccag tgccaggagc tggacaccta cctgataccc cagatccccc acagccacta 5821 ctgactgcag ccagccacag gtacagagcc acaggacccc aagaatgagc ttacaaagtg 5881 gcctttccag gccctgggag ctcctctcac tcttcagtcc ttctactgtc ctggctacta 5941 aatattttat gtacatcagc ctgaaaagga cttctggcta tgcaagggtc ccttaaagat 6001 tttctgcttg aagtctccct tggaaatctg ccatgagcac aaaattatgg taatttttca 6061 cctgagaaga ttttaaaacc atttaaacgc caccaattga gcaagatgct gattcattat 6121 ttatcagccc tattctttct attcaggctg ttgttggctt agggctggaa gcacagagtg 6181 gcttggcctc aagagaatag ctggtttccc taagtttact tctctaaaac cctgtgttca 6241 caaaggcaga gagtcagacc cttcaatgga aggagagtgc ttgggatcga ttatgtgact 6301 taaagtcaga atagtccttg ggcagttctc aaatgttgga gtggaacatt ggggaggaaa 6361 ttctgaggca ggtattagaa atgaaaagga aacttgaaac ctgggcatgg tggctcacgc 6421 ctgtaatccc agcactttgg gaggccaagg tgggcagatc actggaggtc aggagttcga 6481 aaccagcctg gccaacatgg tgaaacccca tctctactaa aaatacagaa attagccggt 6541 catggtggtg gacacctgta atcccagcta ctcaggtggc taaggcagga gaatcacttc 6601 agcccgggag gtggaggttg cagtgagcca agatcatacc acggcactcc agcctgggtg 6661 acagtgagac tgtggctcaa aaaaaaaaaa aaaaaaagga aaatgaaact agaagagatt 6721 tctaaaagtc tgagatatat ttgctagatt tctaaagaat gtgttctaaa acagcagaag 6781 attttcaaga accggtttcc aaagacagtc ttctaattcc tcattagtaa taagtaaaat 6841 gtttattgtt gtagctctgg tatataatcc attcctctta aaatataaga cctctggcat 6901 gaatatttca tatctataaa atgacagatc ccaccaggaa ggaagctgtt gctttctttg 6961 aggtgatttt tttcctttgc tccctgttgc tgaaaccata cagcttcata aataattttg 7021 cttgctgaag gaagaaaaag tgtttttcat aaacccatta tccaggactg tttatagctg 7081 ttggaaggac taggtcttcc ctagcccccc cagtgtgcaa gggcagtgaa gacttgattg 7141 tacaaaatac gttttgtaaa tgttgtgctg ttaacactgc aaataaactt ggtagcaaac 7201 acttccaaaa aaaaaaaaaa aaaa //