Mast Cell stabilizer

Mast cell stabilizers are the name given to a group of medicines that prevent the release of histamine and other powerful chemical mediators from mast cells. Mast cells are a type of white blood cell that are part of our immune system and play a key role in our body's response to antigens (a toxic or foreign substance that is perceived as a threat by our body and which induces an immune response.Mast cells are involved in allergic rhinitis, allergic conjunctivitis, anaphylaxis, asthma, autoimmune diseases, eczema, itch, and reproductive disorders. The mast cell stabilizers cromolyn and nedocromil work by blocking a calcium channel that is essential for mast cell degranulation (the release of chemical mediator-containing secretory granules which occurs after exposure to a specific antigen).

 mechanism of action :Mast-cell stabilizers are thought to prevent calcium influx across mast-cell membranes, thereby preventing mast-cell degranulation and mediator release. Traditional mast

used to prevent or treat certain allergic disorders. They block mast cell degranulation, stabilizing the cell and thereby preventing the release of histamine[1] and related mediators. One suspected pharmacodynamic mechanism is the blocking of IgE-regulated calcium channels. Without intracellular calcium, the histamine vesicles cannot fuse to the cell membrane and degranulate.

sides effect : include ocular itching, pruritus, blurred vision, dry eye, tearing, discharge, hyperemia, foreign body sensation, corneal ulcer, eye pain, ocular edema, ocular swelling, corneal abrasion, anterior chamber cells, keratitis, blepharitis, and allergy