. Short overview 

.  Threshold about Statins 

. Some images about statins and groups of Statins 

. Treatment/ Uses of Statins

. Common Brand name of Statins 

. Mechanism of action 

. Common side effects 

. Supplement that recommended to reduce Statin side effects and  Photo Collection about it 

. Pharmacokinetics of Statins 

. Pharmacodynamics of Statin

. How can Statins prevent the Heart 

. Alternative to Statins & Photo Collection about it 

. Statins and risk of Alzheimer's ( A Double-Edged Weapon)

. Final stage about Statins 

 • Cholesterol is a fatty material in your blood which is mainly made in the liver. 

• It plays an important role in how our cells work and helps your body make vitaminD and hormones which keep your bones, teeth and muscles healthy. 

• Having too much cholesterol can clog your arteries, causing problems like heart disease,so we use Statins to treat it. 

- Statins atins are a class of medications primarily used to lower cholesterol levels in the blood. 

 - Medications of Statins used to lower or reduced blood cholesterol levels (Atorvastatin, simvastatin and Rosuvastatin).

- Statins atins may be recommended if you have cardiovascular disease (CVD) or at a high risk of getting it in the next to years.

- Statins can be also used to treat familial hypercholesterolemia. 

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-  The pharmacodynamics of Statins primarily involve inhibiting the enzyme HMG-COA reductase,  which is crucial for cholesterol synthesis in the liver. 

- By blocking this enzyme, Statins reduce  the production of cholesterol, leading  to decreasedecreased levels of LDL cholesterol in the blood stream. 

- Additionally, Statins may have anti-inflammatory and plaqueplaque-stabilizplaqueplaque-stabilizibpng effects, contributing to their cardiovascular benefits beyond just lowering cholesterol levels. 

- Aditionally, Statins may have other beneficial effects on cardiovascular health, including:

1- Reducing inflammation : ( anti-inflammatory).

2- Improving Endothelial Function:  ( lininglining thethe blood vessels, is an early step in the development of atherosclerosis).

3- Stabilizing Plaque: ( in thethe arteries,  makingmaking them less likely to rupture and cause a heart attack and stroke).

4- Antioxidant Effects:( can hhelp reduce oxidative stress and damage to blood vessels).

- For individuals who cannot tolerate Statins or prefer alternative options, there are several alternatives to consider  : 

1- Diet and Exercise: (can help improve cholesterol levels  and overall cardiovascular health).

2- Other Medications: ( there are other classes of medications,  such as Ezetimibe,  Bile acid sequestrants, Fibrates, and PCSK9 inhibitors, thatthat can be used either alone or in combination with Statins to lower cholesterol levels).  

3- Red Yeast  Rice: (this  is  a traditional Chinese supplement that contains naturally occurring Statins).

4- Omega-3 Fatty Acids: ( such as fish oil that have effects on lowering triglyceride levels and offer some cardiovascular benefits).

5- Plant Sterols and Stanols: ( these compounds,  found in certain foods).

6- Lifestyle Changes: ( as Quitting Smoking, Limiting alcohol intake,  and managing Stress).

• It's important to take your medication as prescribed and your doctor may recommend you take your Statin at a certain time every day as this keepkeeps your blood levels even. 

• If you forget to take your medication, take your regular dose the next day. 

• Don't take extra of your medication and if you take too many Statins,  contact a pharmacist or call NHS 111.

• Top tip - many patients take Statins before they brush their teeth at night as part of their routine so they don't forget ( it'sit's also when most of your body's cholesterol is produced).