Cyclophosphamide is used to treat cancer of the ovaries, breast, blood and lymph system, and nerves (mainly in children). Cyclophosphamide is also used for retinoblastoma (a type of eye cancer mainly in children), multiple myeloma (cancer in the bone marrow), and mycosis fungoides (tumors on the skin).
• lower back or side pain
• missing menstrual periods
• painful or difficult urination
With high doses and/or long-term treatment
• dizziness, confusion, or agitation
• swelling of the feet or lower legs
• unusual tiredness or weakness
• pinpoint red spots on the skin
• unusual bleeding or bruising
• redness, swelling, or pain at the injection site
• sores in the mouth and on the lips
• sudden shortness of breath
Cyclophosphamide is bio transformed principally in the liver to active alkylating metabolites by microsomal oxidase system.
These metabolites interfere with the growth of susceptible rapidly proliferating malignant cells. The mechanism of action is thought to involve cross-linking of tumor cell DNA.
Activity 1.docx