uses:

Cyclophosphamide is used to treat cancer of the ovaries, breast, blood and lymph system, and nerves (mainly in children). Cyclophosphamide is also used for retinoblastoma (a type of eye cancer mainly in children), multiple myeloma (cancer in the bone marrow), and mycosis fungoides (tumors on the skin).

side effects:

More common

 • Cough or hoarseness

 • fever or chills

 • lower back or side pain

 • missing menstrual periods

 • painful or difficult urination

With high doses and/or long-term treatment

 • Blood in the urine

 • dizziness, confusion, or agitation

 • fast heartbeat

 • joint pain

 • shortness of breath

 • swelling of the feet or lower legs

 • unusual tiredness or weakness

Less common

 • Black, tarry stools

 • pinpoint red spots on the skin

 • unusual bleeding or bruising

Rare

 • Frequent urination

 • redness, swelling, or pain at the injection site

 • sores in the mouth and on the lips

 • sudden shortness of breath

 • unusual thirst

 • yellow eyes or skin

mechanism of action:

Cyclophosphamide is bio transformed principally in the liver to active alkylating metabolites by microsomal oxidase system.

These metabolites interfere with the growth of susceptible rapidly proliferating malignant cells. The mechanism of action is thought to involve cross-linking of tumor cell DNA.