Potassium Channel Blocker

What is potassium channel blockers: 

A class of drugs that act by inhibition of potassium efflux through cell membranes. Blockade of potassium channels prolongs the duration of ACTION POTENTIALS. They are used as ANTI-ARRHYTHMIA AGENTS and VASODILATOR AGENTS. 

Uses of potassium channel blockers: 

Potassium channel blockers are used for treating: 

●Arrhythmia 

●Movement disorders associated with multiple sclerosis 

Potassium channel blocker drugs: 

Amiodarone 

Dalfampridine

Dofetilide

Tetraethylammonium

Linopirdine

Amifampirdine

Nateglinide

Repaglinide 

What are side effects of potassium channel blockers:

Potassium channel blockers can cause the following side effects:

Urinary tract infection

Insomnia

Headache

Nausea

Back pain

Balance disorder

Constipation

Abdominal pain

Hypertension 

Muscle spasms

Cataract 

Pain in the legs 

Contraindications: 

Concurrent use of drugs that prolong the QT interval; concurrent use of amiodarone, megestrol, prochlorperazine, or verapamil; congenital or acquired prolonged QT syndrome; paroxysmal atrial fibrillation; severe renal impairment