• Family of cisplatin. 

• Use of cisplatin injection.

• Cisplatin side effects. 

• Cisplatin cause hair loss?  

• Cisplatin nephrotoxicity.

• Antidote  for cisplatin. 

• Why give mannitol with cisplatin?

• Cisplatin still used today? 

- Cisplatin injection is used to treat advanced cancer of the bladder, ovaries,  or testicles. 

- Cisplatin is an antineoplastic agent ( cancer medicine).

- It interferes with the growth of cancer cells, which are eventually destroyed by the body. 

- This medicine is to be given only by or under the direct supervision of a doctor. 

- Cisplatin,  you don't usually lose much of your hair. 

- cisplatin nephrotoxicity is the composite result of the transport of cisplatin into renal epithelial cells, injury to nuclear and mitochondrial DNA, activation of a multiple cell death and survival pathways and initiation of a robust inflammatory response. 

- There is no specific Antidote to use in cisplatin toxicity. 

- Treatment must involve hydration with 3 to 6 litres of intravenous fluids per day together with intravenous mannitol, both of which increase urinary volume and output and decrease the effective urinary concentration of cisplatin. 

- Mannitol is an osmotic diuretic that is indicated for the promotion of diuresis; it is a logical choice for reduction of Cisplatin-induced nephrotoxicity as its nontoxic and could reduce the half-life of cisplatin in the kidney. 

- It can be used as a single-agent or combination therapy for induction and neoadjuvant therapy. 

- Cisplatin is FDA approved for the treatment of advanced ovarian cancer,  testicular cancer, and bladder carcinoma.