1976

https://www.newspapers.com/image/653249881/?terms=%22alfred%20hellman%22&match=1 

1986 - A Dr. Alfred Hellman in Washington DC ? 

https://www.newspapers.com/image/406490561/?terms=%22alfred%20hellman%22&match=1

1950

https://www.ancestry.com/imageviewer/collections/1265/images/sid_38356_1950_0030?treeid=&personid=&rc=&usePUB=true&_phsrc=llt715&_phstart=successSource&pId=474007185

1950-usa-washington-dc-collidge-hs-pg-hall-tp-irby.jpg

1950-usa-washington-dc-collidge-hs-pg-hall-tp-irby-clip-hellman.jpg

1955 (Sep 18)

https://www.newspapers.com/image/150267995/?article=e67046f6-a33f-4d55-8171-99b9d4ae0bf9&focus=0.0321797,0.44210795,0.2780595,0.6291357&xid=3398&_ga=2.185511081.1484990603.1632192232-626348538.1618334857

1955-09-18-the-akron-beacon-journal-pg-8c

1955-09-18-the-akron-beacon-journal-pg-8c-clip-wedding-hellman

• Name :   Lt Alfred Hellman

• Gender :    Male

• Employer :   Air Force

• School :   University of Maryland

• Marriage Date :   Abt 1955

• Father :   Friedrich Hellman

• Spouse :   Kiki Bambakidis

https://www.newspapers.com/image/150267995/?article=e67046f6-a33f-4d55-8171-99b9d4ae0bf9&focus=0.0321797,0.44210795,0.2780595,0.6291357&xid=3398&_ga=2.185511081.1484990603.1632192232-626348538.1618334857

1956 (Jan) - 

https://www.ancestry.com/imageviewer/collections/9168/images/45607_b299086-02520?usePUB=true&_phsrc=llt718&_phstart=successSource&usePUBJs=true&pId=26529214 

• Name :   Alfred Hellman

• Gender :   Male

• Marriage Date :   29 Jan 1956

• Marriage Place :   Harris, Texas, USA

• Spouse :   Kiki Bambarkidis

1956-01-29-usa-texas-marriage-records-alfred-hellman-kiki-bambarkidis-full-pg-45607-b299086-02520.jpg

1956-01-29-usa-texas-marriage-records-alfred-hellman-kiki-bambarkidis-clip.jpg

1968 - Research assistance

https://www.pnas.org/content/pnas/61/1/200.full.pdf

"We are pleased to acknowledge the kind assistance of Dr. Alfred Hellman, who tested our tissue cultures for bacterial and PPLO contamination, and Mrs. Joan Reel, who aided in the routine farming of the cultures. Special thanks are also due to Mr. Joseph Kendrick and Mr. Larry Roberson for their helpful assistance in certain phases of these experiments, and to Dr. Carl Wust for his aid in the preparation of antiserum. The cell lines used in this study were made available to us through the courtesy of Drs. Paul Morse and Van R. Potter (H35) and Drs. E. Brad Thompson and Gordon M. Tomkins (HTC)."

SUPERINDUCTION" OF TYROSINE TRANSAMINASE IN HEPATOMA CELL CULTURES: DIFFERENTIAL INHIBITION OF SYNTHESIS AND TURNOVER BY ACTINOMYCIN D* BY JERRY R. REELt AND FRANCIS T. KENNEY NCI-AEC CARCINOGENESIS PROGRAM, BIOLOGY DIVISION, OAK RIDGE NATIONAL LABORATORY, OAK RIDGE, TENNESSEE Communicated by William A. Arnold, July 12, 1968 Continuous breakdown and replenishment of the macromolecular constituents of animal cells was recognized some time ago in the pioneering experiments of Schoenheimer and his colleagues,1 but the significance of degradative processes in regulation of metabolism has become apparent only recently. Schimke, Sweeney, and Berlin have demonstrated' that the physiological level of the enzyme tryptophan pyrrolase can be elevated either by stimulation of its synthesis or by inhibition of its degradation, the former process being initiated by glucocorticoid hormones and the latter by the substrate of the enzyme, tryptophan. In a recent report3 from our laboratory, it was shown that degradation of the tyrosine transaminase of liver was blocked when protein synthesis was inhibited by agents such as cycloheximide or puromycin; under these conditions, the transaminase level was stabilized by concomitant inhibition of both synthesis and degradation of the enzyme. At that time it was suggested3 that certain "paradoxical" effects of inhibitors of RNA or protein synthesis on enzyme levels might result from differential inhibition of the cellular processes involved in forming an enzyme and of those required for its removal. In the present study, we have analyzed the roles of synthesis and degradation in the elevation of tyrosine transaminase, which follows the addition of actinomycin D to hormonally induced cell cultures. We find that transaminase synthesis, initially high due to induction by hydrocortisone, is progressively inhibited by the antibiotic. That the transaminase level rises during this interval, despite inhibition of its synthesis, reflects a marked inhibition of degradation of the enzyme.

1965 ?

paged 164 / 165 

OHIOS TATEU NIVERSITRYE SEARCFHO UNDATI{ONNO l-CPS-3571)

Title: Imllllnobiologic Response of the Cat to Feline Oncornavirus

Contractor's Project Director: Or. Richard G. Olsen

Project Officer {NCI): Or. Alfred Hellman

Objectives: Studies concentrated on development of a regimen for inducing

iffilllln;ty to feline oncornavirus and virus-specified tumor antigens. Specific

objectives are: (1) To solubilize and characterize the feline oncornavirusassociated

cell membranea ntigen {FOCMA()2; ) to prepare purified feline leukemia

virus {FeLV) envelope glycoproteins {gp 69/71); (3) to evaluate the vaccine

potential of FOCMaAnd FeLVg p 69/71 for the prevention of viremia and tumorigenesis

in specific pathogen free cats; (4) to evaluate the lymphocyte blast

transformation responses to defined FOCMaAnd FeLVg p 69/71 antigens in vaccinated

cats and cats infected with virulent feline oncornaviruses; (5) to

determine whether a chemical carcinogen, methylnitrosourea, alters the agerelated

susceptibility of cats to feline oncornavirus disease; (6) to determine

whether ch~mical carcinogens alter the iml1llnobiologic responses of cats to

feline oncornaviruses; (7) to investigate further the relationship of age,

virus strain, route of infection, and other ilTllll.lnologiocr cocarcinogenic

factors which influence the susceptibility of cats to feline oncornaviruses;

(8) to evaluate the mixed lymphocyte-tumor cell assay using sensitized feline

peripheral blood lymphocytes and inactivated lymphoblastoid cells to detect

tumor-associated antigen blast transformation.

Major Findings: During the past year a feline oncornavirus vaccine was

developed and evaluated. Immunization of kittens with virus-inactivated

(FOCMcAo ntaining) FL 74 feline lymphoblastoid cells induced specific

FOCMaAn tibody. These cats were resistant to malignant tumor development

after challenge with oncogenic doses of feline oncornavirus. FOCMA

vaccine, however, did not prevent FeLV viremia.

In studies to prevent FeLV viremia and malignant tumor growth, kittens were

actively i111111Jniwzeitdh a combinedv accine co111>oseodf UV-inactiviated Fel.V

and killed FL-74 cells. After oncogenic challenge, kittens that had been

given a combinedF el.V/FL-74v accine developed lower FOCMaAn tibody titers

than kittens irmunized with FL-74 alone. In additon, kittens given the

combinedF eLV/FL-74v accine appeared to demonstrate tumor enhancementa fter

challenge with oncogenic virus. Inactivated Fel.V also failed to induce

protective i111111Jniint yk ittens suckling on dams that had been given nultiple

imnunizations during gestation.

Since killed virus appeared to cause imrunosuppression in young kittens,

studies were initiated to evaluate the influence on feline T-lymphocyte

function of killed FeLV and FeLV subviral components, pl5, p27, and gp69/71.

Killed FeLV and FeLV pl5 inhibited blast transformation responses of cat

lymphocytes to con A, but FeLV p27, FeLV gp69/71 and RD-114 virus did not.

FOCMaAn tigen has been solubilized by papain digestion from FL-74 cells.

However, higher yields of FOCMhAa ve been obtained from supernatant fluids

from FL-74 cells maintained in serum-free medium. Soluble FOCMiAs being

purified and is being evaluated for vaccine potential.

Investigations into the pathogenesis of FeLV infection showed that susceptibility

to FeLV and to feline sarcoma virus FeSV was age-related (4 strains

tested) and, therefore, had to be considered in designing viral challenge

experiments. Ancillary studies demonstrated that the presence of FeLV

group specific antigen (gsa) in the blood cells of cats correlated with

infectious virus in blood plasma. The viral infectivity and gsa tests were

of comparable sensitivity in detecting the onset of FeLV viremia.

Preliminary studies showed treatment of cats with methylnitrosourea

increased the susceptibility of cats to FeLV infection.

Significance to Biomedical Research and the Program of the Institute:

Prophylactic imnunization protocols in model systems, such as those carried

out under this contract, evaluate prospects for control of cancer induced by

horizontally transmitted viruses. The information obtained in such work may be

applicable to prophylaxis against other animal oncornaviruses and may possibly

have particular future value in control of some human neoplastic diseases.

Proposed Course: A concentrated effort will be made to isolate and purify

FOCMsAol uble vaccines and FeLVp roteins, including gp69/71 and p15. As

these become available, vaccination procedures will be established with regard

to host age, virus strain, imnunization route and dose. Mixed vaccines of

soluble FOCMA-FeeLnVv elope proteins will continue to be investigated. The

biological responses to live and killed virus and viral proteins will be studied

from the point of view of: (a) the primary site for expression of FOCMA(b; )

the etiology of i11111.1nosuppressbioyn F eLVp roteins, including the production of

serum factors, interfering antibodies, etc.; (c) the transmission and excretion

of virus in gsa-positive and -negative cats; macrophage function and other host

defense COff1)onenitns resistance to feline oncornaviruses, as detennined by

mixed lyfl1)hocyte-tumori nteraction, antibody-dependent cellular cytotoxicity,

blocking antibo(b' and suppressor cell formation.

Date Contract Initiated: June 25, 1965

1965 - contract

1977-08-the-virus-vancer-program-progress-report-14-ocr-compressed.pdf

1977-08-the-virus-vancer-program-progress-report-14-ocr-compressed-pg-138 to 140 

OHIOS TATEU NIVERSIRTYES EARFCOHU NDAT(INOONl -CPS-3571)

Title: l11111unobioloRgiecs ponseo f the Cat to Feline Oncornavirus

Contractor's Project Director: Dr. Richard G. Olsen

Project Officer (NCI): Dr. Alfred Hellman

Objectives: Studies concentrated on development of a regimen for inducing

immunity to feline leukemia virus and feline oncornavirus associated tumor

antigens. Specific objectives are as follows: (1) to solubilize and

characterize the feline oncornavirus-associated cell membranea ntigen

(FOCMA()2;) to prepare purified feline leukemia virus (FeLV)e nvelope

glycoproteins (gp 69/71); (3) to evaluate the vaccine potential .of FOCMaAnd

FeLVg p 69/71 for the prevention of viremia (FeLV)a nd tumor1genesis in

specific pathogen free cats; (4) to evaluate the lymphocyte blast transfonnation

responses to defined FOCMaAnd FeLVg p 69/71 antigens in vaccinated

cats and cats infected with virulent feline oncornaviruses; ('5) to detennine

whether a chemical carcinogen, methylnitrosourea, alters the age-related

susceptibility of cats to feline oncornavirus disease; (6) to detennine

whether chemical carcinogens alter the inmunobiologic responses of cats to

feline oncornaviruses; (7) to investigate further the relationship of age,

virus strain, route of infection, and other inmunologic or co-carcinogenic

factors which influence the susceptibility of ca.ts to feline oncornaviruses;

(8) to evaluate the mixed lymphocyte-tumorc ell assay using sensitized feline

peripheral blood lymphocytes and inactivated feline lymphoblastoid cells to

detect tumor-associated antigen blast transfonnation.

Major Findings: Developmenot f a tumor cell vaccine employinga FOCMAcontaining

feline lymphoblastoid cell line (FL-74) has been pursued. A

procedure was developed for inactivating FL-74 tumor cells and the FL-84

cell-associated FeLVw ith heat (560Cf or 3 minutes) treatment. Heat-treated

cells retained the FOCMsAer ologic activity; moreover, 85%o f these cells

remain morphologically intact. Inmunization of 4- to 6-week-old kittens

with inactivated FL-74 cells resulted in resistance to Snyder-Theilen feline

sarcoma virus (FeSV) challenge in vaccinated cats as opposed to age-matched,

non-inmunizedc ontrols. Using a sub-group specific (FeLV)v irus neutralization

(VN) assay it was demonstrated that young kittens responded poorly to

killed feline oncornaviruses and to living feline oncomaviruses. By

contrast, older cats respond to FeSV challenge with significant VN antibody

titers. Kittens that suckled dams inmunized with killed virus did have

protection from FeLV and/or FeSV challenge.

In a study designed to detennine the optimum age at which to evaluate FeLV

inmunoprophylaxis, age-related variation in susceptibility of cats to FeLV

infection and oncogenesis was found. Cats inoculated with virus as newborns

developed persistent viremia and developed FeLV-related disease. Neither

FOCMcAy,t otoxic, nor neutralizing antibody were detected in these cats.

Conversely, persistent viremia occurred in a minority of cats inoculated

with FeLV at 3-4 months or l year of age. All non-viremic cats produced

FOCMcAy,t otoxic, a~d neutralizing antibody, seroconversion occurring

between 5 and 7 weeks post-inoculation, and none of the cats developed

disease. Control cats in contact with the viremic cats developed evidence

of horizontal exposure to FeLV. Integrating the variables of age and

susceptibility to FeLV and FeSV challenge, therefore, is critical to

designing experiments to evaluate the inmunobiologya nd inmunoprophylaxiso f

feline oncornaviruses.

Characteristics of normal and transfonned feline lymphoid cells were studied.

Using a combined rosetting technique, it was found that 10% to 30% of nonnal

feline peripheral blood lymphocytes (PBL) fonn spontaneous erythrocyte (E)

rosettes with guinea pig red blood cells, while 30% to 50% fonn EAC rosettes.

Less than 1% of PBL fonned both types of rosettes. Seventy to 90% of lymphoblastoid

cells from FeLV-inducedth ymic neoplasms fonned E rosettes whereas

less than 1%E ACfo nning cells were present. During the latter stages of

FeLV infection, increased numbers of E rosette-fonning PBL correlated with

increased numbers of circulating lymphoblastic cells. Binding of guinea pig

erythrocytes, therefore, appears to identify thymic dependent (T} lymphocytes,

while the presence of a complemenrt eceptor is a marker of thymic independent

lymphocytes in the cat.

Si~nificance to Biomedical Research and the Program of the Institute: The

tr1als to determine the effectiveness of vaccination in the cat as a protective

measure against oncornavirus-induced neoplasia have a two-fold

purpose. The results provide infonnation concerning the nature of the

i11111urensep onse providing the best degree of protection against infection

or ensuring disease in a genetically heterogeneous population of animals

susceptible to certain oncornaviruses. Secondly, knowledge is obtained of

the nature of the vaccine preparation providing protection to the actively

i11111unizseudb ject and secondarily to newbornp rogeny highly susceptible to

oncogenic viruses.

Pro~osed Course: Concentrated effort at this time is being directed toward

eva uating the i11111unoprophylacteifcf ect of combininga FOCMaAnd killed

virus vaccine. Moreover, soluble FOCM(Apu rified} and purified FeLV-gp6 9/71

are being produced and will be tested for vaccine potential.

A lymphocyte blast transfonnation (LBT} assay for the cats has been developed.

Studies are in progress to evaluate the LBT response in cats to virus antigen

and FOCMA.

Date Contract Initiated: June 25, 1965

1969 (Oct 26) - The Pittsburgh Press : "Front Line in the Cancer Fight" 

Mentioned: Dr. Alfred R. Hellman (born 1931)  /  Dr. Frank Joseph Rauscher II (born 1931) 

1970 (Feb 23)

https://www.newspapers.com/image/642534210/?terms=%22alfred%20hellman%22&match=1 

1971 - No references in this source ..

https://awakenvideo.org/pdf/X/Val%20Valerian%20-%20Matrix%20Series/Matrix%20-%20I%20thru%20IV/Valerian%20-%20Matrix%20III%20Volume%20One.pdf 

After the ban on offensive BW research, the National Cancer Institute and the Office of Naval Research jointly sponsored experiments on the aerosol properties of potentiallyAoncogenic viruses. The NCI project officer and former U.S.Air Force virologist, Dr. Alfred Hellman, worked with Mark Chatigny, a research worker at NBL and a member of the NCI biohazards work group from the NBL.

Hellman also oversaw the 1971 $100,000 study on the "physical and biological characteristics of viral aerosols". In 1961, the NBL had done similar research for Fort Detrick on the "stability and virulence of BW aerosols." Chatigny's NBL research into aerosol distribution of viruses would continue into the 1980's. Such overlapping of purposes raises serious questions about the wisdom of placing control of VCP viruses under the NBL. 

1971

1977-08-the-virus-vancer-program-progress-report-14-ocr-compressed.pdf

paged 238 and 239

SOUTHWFEOSTU NDATFIOORNR ESEARACNHD E DUCATI(ONN01 -CP4-3214)

Title: Study of Latent Virus Infection and Transmission

Contractor's Project Director: Dr • . R. L. Heberling

Project Officer (NCI): Dr. Alfred Hellman

Objectives: To study the viral flora in placentas and embryos of primates

with emphasis on type C viruses.

Major Findin¥s: A xenotropic baboon type C virus, ~7 is being studied

for its ab1l ty to infect and produce· disease in experimenta1 l y inoculated

non-humanp rimates and beagle dogs. Chimpanzees,b aboons, cebus monkeys

and mannosets have been inoculated and under study for 11 to 20 months

with no evidence of neoplastic disease. Three of five marmosets died

14 to 252 days after inoculation, .but no virus was recovered from these

animals nor did pathol_ogic studies indicate a viral etiology for the deaths.

Two sacrificed mannosets were similarly negative. M-7virus was recovered

from tissues of beagle dogs inoculated in utero and a humoral, but not

ce 11-medait ed immunity( CM)I, was demonstrated. No virus was recovered

from dogs inoculated at birth, but humoral and CMI developed.

Autogenous humoral immunity in. the nonnal baboon was demonstrated for

intact, but not disrupted, M-7virions by radioimmunoassay. However, no

neutralizing antibody was found. Naturally occurring antibody was predominantly

in the IgG and lgA fractions of serum and tended to increase

in titer with age; however, both sexes showed similar antibody levels.

Cell-mediated immunity to the virus in nonnal baboons was also demonstrated

by virus-induced lymphocyte blastogenesis.

Maternal serum was shown to block phytohemagglutinin lymphocyte stimulation

and mixed lymphocyte responsiveness of fetal lymphocytes. This suppression

could be adsorbed by M-1 virus.

A virus was isolated from a culture of squirrel monkey lung cells treated

with IUDRa nd cocultivated with fetal canine thymusc ells. This virus

has a morphology and mode of development similar to Mason-Pfizer monkey

virus, an RNA-dependenDt NAp olymerasew ith a Ng++p reference, a density

of 1:16-1.19 g/ml and the ability to fonn syncytia in KC cells.

Si¥nificance to Biomedical Research and the Program of the Institute:

Ev dence was provided for the existence in "nonnal" primate tissue of

vertically transmitted type C viruses. Further study is required to

detennine whether these agents have any direct relationship to the development

of malignancy in any primate.

Proposed Course: Efforts will be continued to detennine the function of

these virus particulates in the primate host.

Date Contract Initiated: June 3, 1971

paged 267

SOUTHWEFSOTU NDATFIOONRR ESEARCAHN DE DUCATIO(NN0 1-CP4-3214)

Title: Study of Latent Virus Infection and Transmission

Contractor's Project Director: Dr. R. L. Heberling

Project Officer (NCI): Dr. Alfred Hellman

Objectives: To study the viral flora in piacentas and embryos of primates

with e111>hasiosn type C viruses.

Major Findings: The pathogenicity of the baboon endogenous virus (BaEV) was

determined in nonhumanp rimates and in beagle dogs. BaEVi nfected dogs when

inoculated in utero or at birth, but no pathology resulted from this infection.

Similarly, marmosets, cebus monkeys, baboons, and chiq,anzees were unaffected

by BaEVi noculation. Fibrosarcomas were induced by a:BaEVp seudotype of Kirsten

1111rinsea rcoma virus [MSV(BaEVi)n] dogs, marmosets, cynomolgusm onkeys, and

chiq,anzees, but not in cebus 9r squirrel monkeys. One baboon inoculated

intracerebrally developed a brain tumor and metastatic lung tumors, all fibrosarcomas.

All the species inoculated with BaEVo r MSV(BaEVe)x, cept the baboon,

developed neutralizing (SN) antibody against BaEV. The baboon showed a partial

tolerance to BaEV by not developing SN antibodies, but did develop a rise in

precipitating antibodies (RIP) following inoculation. Cell-mediated immune

(CMI)r esponses were also observed in MSV(BaEV)-infecteadn imals.

Autogenous CMI to BaEV, as measured by lymphocyte blastogenesis in the presence

of viral angigen, was demonstrated in adult male and female baboons. These

initial studies indicated a greater response in male baboons. Attempts at!!!.

vivo rescue of the Kirsten murine sarcoma genome in dogs were nc:tsuccessful.

A squirrel monkeyR NAv irus (SMRV)w, ith the properties of a type D virus has

been characterized. The morphologyo f SMRVre sembles Mason-Pfizer monkeyv irus

(MPMV)a,n d the virus DNAp olymerase, like that of MPMVp,r eferred magnesium

ions over manganese ions, and a low KCI concentration for optimum activity.

The SMRVpo lymerase had an optimump H of 7.5 coff1)aredt o 8.1 for MPMV.A

70S RNAw as shownb y the sirultaneous detection assay. The SMRVpo lymerase

was partially neutralized by MPMaVn tiserum but no other antigenic relationships

were detected between these viruses. SMRVal so was unrelated to other

mammaliano ncornaviruses (MLVF, eLV, RD114,B aEV,S SAV,a nd GALVw) -hen

tested by immunodiffusion.

Similar SMRVis olates were recovered from various tissues of four adult,

five newborn, and two fetal squirrel monkeys. Virus particles with eccentric

nucleoids resembling type C viruses were seen in the placenta but not in other

fetal or adult tissues. Nucleic acid hybridization and host range studies

indicated SMRVis an endogenous, xenotropic virus of squirrel monkeys.

SMRwVa s inoculated into squirrel monkeys, marmosets, baboons, and beagles

but no overt pathology resulted. Virus was not recovered from beagles that

were inoculated at birth and sacrificed l to 2 months later.

Attempts to isolate virus from a human leukemia patient's placenta. a rhesus

monkey-baboonh ybrid placenta, and tissues from a leukemic chi~anzee were

not successful.

Significance to Biomedical Research and the Program of the Institute: Evidence

was obtained for the existence of vertically transmitted type C viruses

in "normal" primate tissue. Further study is required to determine whether

these agents have any direct relationship to the development of malignancy

in any primate.

Proposed Course: Efforts will be continued to determine the function of

these virus particulates in the primate host.

Date Contract Initiated: June 3, 1971

paged 282 - 284

NAVABLI OMEDICRAELS EARCLHA BORATO(RYYO l-CP-4-0200)

Title: Biohazards of Oncogenic Virus Aerosols

Contractor's Project Director: Mr. Mark Chatigny

Project Officer (NCI): Or. Alfred Hellman .

Objectives: This project involves two task areas in the field of

biocontaminant and environmental control.

Major Findings: The first task involved the systematic assessment of risk

in the oncogenic virus laboratory, particularly as related to physical

protection parameters. During this contract period data that will be used

to identify these protection parameters was obtained by creating conditions

conducive to 1) aerosol generation by malfunctioning laboratory equipment,

or by 2) stressing a biological safety cabinet with outside draft air.

Tests to determine the aerosol output of a ruptured rotor on a Beckman LS

ultracentrifuge located in a containment cabinet showed that the aerosol

output was minimal and·confined to the cabinet. Other studies were performed

to determine the degree of personnel protection provided by the verticle

laminar flow (Class II) safety cabinet. A leakage factor (penetration of

the air barrier) for the Class II, type 1 safety cabinet was calculated to

be less than one particle per 105 particles when the cabinet was in use.

Product protection was of a similar magnitude. Studies with the Class II,

type 2 cabinet showed a penetration rate similar to or less than the

Class II, type 1 cabinet when the access opening of the type 2 was as much

as 15 inches. Performance of the Class II, type 2 cabinet was not

substantially affected by side draft air up to 400 ft . per minute, a cause

of malfunctioning of many other types of safety cabinets.

A study to determine small particle aerosol output utilizing new detector

techniques showed a substantial amount of splattered culture material,

produced by a ballistic spray, was collected from the ilTlllediate work area.

Quantitation of this contamination level as a part of the total spray output .

has facilitated improved assessment of contamination spread vectors.

Additionally, within this task area, the contractor performed service

functions for the Office of Biohazard Safety, Viral Oncology Program, and

the Office of Research, Safety, NCI, in the inspection of laboratories,

testing of equipment, and providing consultation services on matters

related · to bioengineering and biohazards.

The second task area involved biological studies d1rected toward the assessment

of risk in the oncogenic virus laboratory. Studies were specifically

designed to determine the biological stability, susceptibility to

disinfectants and aerosol infectivity of Feline leukemia virus (FeLV) and

Herpesvirus saimiri (HSV). Specific data is as follows: young adult cats

and neonatal kittens exposed to aerosols containing FeLV do not show any

sign of infection to date. Low levels of FeLV were detected in one fecal,

three urine and two oral samples taken from a group of 25 known-leukemic

cats obtained from veterinary practitioners. The following disinfectants

successfully inactivated FeLV within five minutes: sodium hypochlorite

(lOOppm), 70% ethanol, 30-70% isopropanol and wescodyne (37ppm of free

iodine) .

The high titered virus (thought to be HVS) propagated in TC-7 cells was

ultimately found to be a contaminant, probably a silent carrier in the cell

line; therefore, previously reported data concerning HVS propagated in the

TC-7 cell lines should be attributed to the contaminant •

•

Significance to Biomedical Research and the Program of the Institute:

An understanding of the behavior of small particle aerosols will allow the

development of a rational and hopefully less expensive means for control of

cross infection in laboratories conducting research in viral oncology.

Similarly, identification of the physical parameters for the assessment of

risk will permit the more precise evaluation of research facilities, on the

basis of such data.

Proposed Course: To continue the development of a theoretical model to

define the various hazards in a virus laboratory resulting from the

generation of aerosols. Also contractor will continue the physical aerosol

studies by examining the nature of air-borne particles in general. In

addition the contractor will continue its service and support functions for

the Office of Biohazard Safety, Viral Oncology Program, and the Office of

Research Safety, NCI.

Date Contract Initiated: March 1, 1971

https://books.googleusercontent.com/books/content?req=AKW5QadYoEuNnjOkOBeR7LUoXAe23Do6XYCfYaVDOhdbj8e_Nn-_PmpI3Ry1XOoI8Xs8ExZ6fCsHbh4ubsyljNrgAWS4ReHuniuJjtW5WAVgUBz7iPkuWx_1Ivh4-aF5wyx9bl7b3-JQn3SznvlJPiGPqt7vQ4giBmAWCo8DWwzK7vM1Pc9NA8zBeTTEM6NdBOdyf_7iykMGzfi9lx2vMfbQOTcslVKCXonlEyxD3B9XBIyvdJi4TAA

1972 - Etiology / NCI review ...

Etiology: Annual Program Review Document, Fiscal Year ... Prepared for the National Cancer Advisory Council Meeting o

1972-usa-nih-nci-etiology-annual-program-review-document.pdf

Mych info on Hellman ... 

1971

67. Nettesheim , P. , Hanna , M. G. , Doherty , D. G. , Newell , R. F. , and

Hellman , A .: Effect of calcium chromate dust , influenza virus , and 100 R

whole - body X - radiation of lung tumor incidence . J. Nat . Cancer Inst . 47 :

1129-1144 , 1971 .

Fowler , A.K. , Hellman , A.K. , Steinman , H.G. and Ouatrale , A.C .: Studies

on the blastogenic response to muring lymphocytes. I. Quantitative measurements of stimulation by phytophemagglutinin. Proc Soc Exp Biol Med 138 : 35, Oct 1971

Hellman , A. and Fowler , A.K .: Hormonal - activated expression of the C

AND SV40 MENTIONED

1972 (April 26)

https://www.newspapers.com/image/163704649/?terms=%22alfred%20hellman%22&match=1

1972-04-26-the-news-journal-wilmington-pg-6.jpg

1972-04-26-the-news-journal-wilmington-pg-6-clip-researchers.jpg

1975

http://www.originofaids.com/author_defends_embattled_african_presidents.htm 

On March 19, 1975 during a cancer virus research and safety symposium, Dr. Kalter, obviously frustrated by some of his colleagues, and the scientific impropriety of avoiding the truth about the mother of Ebola, testified: "I believe simian-hemorrhagic fever is important. It appears to be a man-made disease." 

Present was Dr. Alfred Hellman, a leading Atomic Energy Commission (AEC) official, and the chairman of the NCI's section on Biohazards Control and Containment. Following Dr. Kalter's stunning but accurate diagnosis of the "man-made" origin of Marburg/Ebola, Hellman, at the helm of the conference's steering committee, felt compelled to redirect discussion to less troubled waters. 

Dr. Hellman, Special Virus Cancer Program reports revealed, was among the world's leading experts in airborne viruses, as Ebola is believed to be. With his links to the AEC,  as well as his work at the U.S. Navy Biomedical Research Lab (NBRL) that included biological warfare research and developments, his intimate links to the CIA and their top secret bioweapons program called Project: MKNAOMI can be surmised. As discussed and documented in Emerging Viruses: AIDS & Ebola, Hellman served as the executive project officer for the NCI in their effort to test the "Aerosol Properties of Potentially Oncogenic Viruses" with the Navy. Hellman, oversaw the NBRL studies in which viruses were spread through the air in an effort to study "virus-host interaction considering both the hazard to humans and animals and the potential for cross contamination." These studies, similar to what had been conducted on the USS Coral Sea and the USS F. D. Bailey in 1950, were apparently a follow-up to the studies conducted by the Special Operations Division of the Army in cooperation with the Navy and the CIA. This time, in 1971, instead of exposing unwitting military personnel to aerosols containing relatively mild, Serratia marcescens and Bacillus globigii bacteria, humans and animals were exposed to carcinogenic viruses. In these reports, Hellman and his colleagues wisely chose to keep the identity of their human and animal test subjects classified.

1975 - NIH newsletter

https://nihrecord.nih.gov/sites/recordNIH/files/pdf/1975/NIH-Record-1975-02-26.pdf 

1976 (May 28) - NYTimes : "Joined Viruses Cause Cancer in Animals"

https://www.nytimes.com/1976/05/28/archives/joined-viruses-cause-cancer-in-animals.html?searchResultPosition=2

1976-05-28-nytimes-joined-viruses-cause-cancer-in-animals.pdfBy Harold M. Schnieck Jr. Special to The New York Times

• May 28, 1976

1976 (June 28)

https://www.newspapers.com/image/653249881/?terms=%22alfred%20hellman%22&match=1

1976-06-28-the-news-and-observer-raleigh-nc-pg-23-clip-virus-danger.jpg

1980 - Dr. Alfred Hellman asking questions at a symposium

1980-symposium-on-biological-effects-and-meas.pdf

https://books.googleusercontent.com/books/content?req=AKW5QafOxk15Od9lT3E6HE50BjqA1QcM-bgkchFxpwV9kX8um5jatE7c0_Lk_AMplipCyhNK_bDOW3u_wOe-VUyIw0ZIwbJwMbbwPxr-22RJ82FPREzK3nWFuBinPD-3tGIMyYzXT-HLe8q3RYJOr3xFR_rid3ki45M8Phqm4VavYQY138tvldfE6M9fAQyx6sdCmTbdvjH0MTzk_IV9FUzhToE4DpN7DUx9AIIClpt1wT6M28vr_GWqHRMYjj1BimC9dOFschKHz26CwyGK4MFehmhKD0CUFQ 

Symposium on Biological Effects and Measurement of Light Sources, Rockville, Maryland, June 9-10, 1980

U.S. Department of Health and Human Services, Public Health Service, Food and Drug Administration, Bureau of Radiological Health, 1981 - Light - 241 pages

2008 (April 13)

https://www.newspapers.com/image/210056220/?terms=%22alfred%20hellman%22&match=1

2008-04-13-the-port-huron-times-herald-pg-1-d.jpg

2016 (April 05) - NYTimes : "Wanted: Cruise Lecturers Who Mingle and Take Good Selfies"

Stephen Wessley, a professor at York College in Pennsylvania, on a cruise ship in Bermuda. He lectures on a variety of topics.

By Julie Weed  /   April 4, 2016

https://www.nytimes.com/2016/04/05/business/wanted-cruise-lecturers-who-mingle-and-take-good-selfies.html?searchResultPosition=3

2016-04-05-nytimes-wanted-cruise-lecturers-who-mingle-and-take-good-selfies.pdf

2016

https://www.newspapers.com/image/422379484/?terms=%22alfred%20hellman%22&match=1

2016-12-11-the-dayton-daily-news-pg-b5-clip-bambakidis.jpg

Birthdate - Oct 11 1931

https://www.ancestry.com/discoveryui-content/view/140986632:1788?tid=&pid=&queryId=275d7d9084c2f71ef9ee70972153217a&_phsrc=kyz185&_phstart=successSource

2023-03-23-ancestry-com-directory-info-140986632-1788-hellman.pdf

Alfred Hellman

in the U.S., Public Records Index, 1950-1993, Volume 1

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Detail Source

Name:

Alfred Hellman

Birth Date:

11 Oct 1931

Residence Date:

1991

Address:

PO Box 289

Residence:

Clarksburg, MD

Postal Code:

20871-0289

DetailSource

Name:

Alfred R Hellman

[Dr Hellman]

Birth Date:

Oct 1931

Residence Date:

1983-2019

Address:

24211 Peach Tree Rd

Residence:

Clarksburg, Maryland, USA

Postal Code:

20871

Second Residence Date:

1983-2019

Second Address:

24211 Peach Tree Rd Apt 289

Second Residence:

Clarksburg, Maryland, USA

Second Postal Code:

20871

Third Residence Date:

1984-2001

Third Address:

25372 Diana Cir

Third Residence:

Mission Viejo, California, USA

Third Postal Code:

92691

Fourth Residence Date:

2000

Fourth Address:

2160 Bula Dr

Fourth Residence:

Colorado Springs, Colorado, USA

Fourth Postal Code:

80915

https://www.ancestry.com/discoveryui-content/view/324781642:62209?tid=&pid=&queryId=a6cbe44707b8a9e7058cb5ad2e7d768b&_phsrc=llt727&_phstart=successSource