Dr. Carl John Scandella (born 1944)
Wikipedia NONE
First wife - Dr. Marie Dorothea (Hostettler) Scandella (born 1943)
Was married to Dr. Nancy Logan Haigwood (born 1951)
ASSOCIATIONS
Dr. Arthur Kornberg (born 1918) ( ... )
Dr. Murray Briggs Gardner (born 1945) (research collaboration, 1990s. Often included then-wife Dr. Nancy Logan Haigwood (born 1951) )
Dr. Bruce Edward Ivins (born 1946) ( Dr. Carl Scandella was mentioned with his then-wife Dr. Nancy Logan Haigwood (born 1951 (as of early 1983), as suggesting that Dr. Bruce Ivins (in early August 2008 newspapers) was "creepy" and "stalking" Dr. Haigwood back in the early 1980s. Note that Dr. Carl Scandella never met Dr. Bruce Ivins, but this (along with Dr. Nancy Haigwood's descriptions) was key in suggesting that Dr. Bruce Ivins was solely responsible and the only actor in Amerithrax.)
Carl J. Scandella
Carl J. Scandella, American Biochemistry consultant. Achievements include patents in protein purification technology. Recipient Cystic Fibrosis fellowship, Basel, Switzerland, 1972-1974, National Institutes of Health Research grant State University of New York Stony Brook, 1976-1979, National Science Foundation Research grant, 1979-1981. Member Biophysics Society, American Chemical Society, Protein Society.
1962 As a kid - BIG future !
https://www.newspapers.com/image/618573371/?terms=%22ben%20scandella%22&match=1
1967 (Jan 28) - Mother passes young (age 46)
https://www.newspapers.com/image/619195245/?terms=%22Janice%20Scandella%22&match=1
1967 (Dec 22)
Full newspaper page : [HN01RB][GDrive] / Marriage between Dr. Carl John Scandella (born 1944) and Dr. Marie Dorothea (Hostettler) Scandella (born 1943)
1968 - Marriage (first)
Full newspaper page : [HN01RD][GDrive] / Marriage between Dr. Carl John Scandella (born 1944) and Dr. Marie Dorothea (Hostettler) Scandella (born 1943)
1971 - Research paper (with Arthur Kornberg)
1972 - Studied under Kornberg !! - Going ot the Biocenter in Basel, Switzerland
https://www.newspapers.com/image/620156048/?terms=%22ben%20scandella%22&match=1
1972-07-12-the-sacramento-bee-pg-c2.jpg
1972-07-12-the-sacramento-bee-pg-c2-clip-scandella.jpg
1973 (Dec 14) neice Janice Scandella at UC Davis !
https://www.newspapers.com/image/476669334/?terms=%22ben%20scandella%22&match=1
1973-12-14-the-press-tribune-roseville-california-pg-10
1973-12-14-the-press-tribune-roseville-california-pg-10-clip-bosco
https://docplayer.net/150772463-Mary-elizabeth-hatten.html
2019-docplayer-net-autobiograhy-of-mary-elizabeth-hatten.pdf
Mary Elizabeth Hatten bio
B
orn
:
Richmond, Virginia
February 1, 1950
Graduate School at Princeton and in Basel:
Plant Lectins and Membrane Dynamics
I arrived at Princeton in 1971 as a graduate student in biochemical sciences,
one of the first years that Princeton admitted women undergraduates.
This year was also among the early years that women were admitted to
the graduate program in biochemical sciences. Coming from a southern
women’s college, I have to say that I found Princeton to be far more conservative
politically and socially than Hollins had been. That was surprising, to
say the least. I enjoyed my first two years at Princeton, especially knowing
Rudi Jaenish and Art Levinson during a stint in Arnie Levine’s lab, and
Marc Kirshner who moved into my mentor Max Burger’s old lab as a new
faculty member after Max left for Basel. In Max’s lab, I again worked on cell
surface proteins, this time using the new reagents that Max had discovered,
plant lectins, to study changes in surface properties associated with cancer.
After only two years at Princeton, I followed Max to the Biocenter in Basel,
Switzerland, to finish my thesis research.
The Biocenter was an especially exciting place, as Werner Arber was
purifying restriction enzymes across the hall and Walter Gehring was doing
exciting Drosophila genetics downstairs. Indeed, two of Gehring’s postdocs
at the time, Janni Nusslein Volhard and Eric Wieschaus, went on to win the
Nobel Prize for their discovery of genes that control the early development
of Drosophila. The Burger lab was an exciting place as well, given the buzz
at the time about plant lectins revealing key differences between normal
and transformed cancer cells. I was remarkably fortunate to work with two
talented postdocs in the lab, Rick Horwitz and Carl Scandella. With Rick,
I worked out methods to remove the lipids from serum, a step that allowed
us to manipulate the lipid composition of normal and transformed cell
membranes. We used that approach to show that the receptors for different
lectins were in different lipid domains of the membrane, a discovery that
was later credited as a prelude to the concept of membrane lipid rafts. Rick,
who trained with Britton Chance, was a spectacular mentor, who taught
me what a good experiment was, and who pushed me to think critically,
especially about my own work! After Rick went back to the United States to
become an assistant professor at the University of Pennsylvania, I worked
with Carl Scandella, a biochemist and biophysicist who trained with Harden
McConnell and Arthur Kornberg at Stanford. With Carl, who was one of the
most rigorous scientists I ever knew, I incorporated fatty acid spin labels
into the cells, a method that allowed us to show that the lipids in the vicinity
of the receptors for different lectins had different lipid phase properties.
We also used TEMPO labeling to measure how much of the membrane was
fluid in normal versus transformed cells. I really enjoyed being able to make
precise biophysical measurements of the lipids around lectin receptors. Of
course, at that time, we didn’t realize that lectins bound to a large number
of receptors. Rick and Carl were wonderful colleagues and, together with
Max, they provided me with training in membrane biochemistry as well as
in cancer biology.
Note - https://en.wikipedia.org/wiki/Harden_M._McConnell ...
also - Hatten-Baker marriage .. https://www.newspapers.com/image/233639908/?terms=Biocenter%20Basel&match=1
https://en.wikipedia.org/wiki/Biozentrum_University_of_Basel
"The Biozentrum of the University of Basel specializes in basic molecular and biomedical research and teaching. Research includes the areas of cell growth and development, infection biology, neurobiology, structural biology and biophysics, and computational and systems biology. With more than 550 employees, the Biozentrum is the largest department at the University of Basel's Faculty of Science. It is home to 30 research groups with scientists from 45 nations.[1][2]"
In 1971, at the time when the Biozentrum was founded, the concept of developing an interdisciplinary biological research facility was unique in Europe.[3] Scientists from academy and industry as well as representatives of the Canton of Basel-Stadt promoted the Biozentrum's development.[4]
In the winter semester 1972/73 the first students enrolled for the new "Biology II" curriculum.
...
In the same year, one of the founding professors, Werner Arber, was awarded the Nobel Prize for Physiology or Medicine[5] for his discovery of the restriction enzymes.[6][7]
One of the first researchers there : Dr. Werner Arber (born 1929) ( who had worked with Esther and Joshua lederberg ... )
His WIFE worked with him!
https://www.sciencedirect.com/science/article/abs/pii/0042682274900841?via%3Dihub
An Escherichia coli mutant which inhibits the injection of phage λ DNA
Author links open overlay panel
https://doi.org/10.1016/0042-6822(74)90084-1Get rights and content
Abstract
A new mutant of Escherichia coli K12, called pel−, inhibits the growth of phages λ, 434, and 82 but not of φ80. This inhibition is overcome by λhp mutants, some of which are temperature sensitive for growth in pel+ and pel− bacteria.
Phage λ adsorbs normally to the pel− host, but only 2–10% of the infected cells produce phage with a normal burst size or become lysogenic. The remainder of the cells survive the infection. The growth defect of λ cannot be complemented in trans upon simultaneous infection with λhp. When pel− strains lysogenic for λ are induced, 100% of the induced cells yield phage, and the burst size is normal in contrast to the small probability of phage growth after infection.
1974 (Sep) - Working at the University of Basel in Switzerland
1983 (Oct)
Marriage to Dr. Nancy Logan Haigwood (born 1951)
1993 (Dec 24)
https://www.newspapers.com/image/626656523/?terms=%22ben%20scandella%22&match=1
1993-12-24-the-sacramento-bee-pg-5
1993-12-24-the-sacramento-bee-pg-5-clip-lachini-merker
1995 (Feb)
https://www.newspapers.com/image/384335701/?terms=%22ben%20scandella%22&match=1
1995-02-07-the-press-tribune-roseville-california-pg-a11
1995-02-07-the-press-tribune-roseville-california-pg-a11-clip-scandella
2008 (Aug)
Mention that he, along with previous wide, thought Bruce Ivins was guilty of Amerithrax
2015 - Run for office
King County Local Voters' Pamphlet
November 3, 2015 General And Special Election
City, Town of Yarrow Point
Council Position No. 2
"Education: B.Sc. Chemistry, Caltech. Ph.D. Biochemistry, Stanford.
Occupation: biotechnology consultant
Statement:
Yarrow Point has been my home for more than twenty years. My wife, Carole, and I enjoy walking through our neighborhood and chatting with our fellow residents. As a member of the Town Council since 2008 it has been my pleasure to help bring about improvements to preserve and enhance the natural beauty of our town as well as its livability. I support the current efforts of our Mayor and Town Council to complete the pathway project along 92nd Ave NE that was started more than a decade ago, together with undergrounding utilities. I currently serve as Mayor Pro Tem and the Town’s representative on the Committee for Salmon Recovery in the Lake Washington/ Cedar/ Sammamish Watershed (WRIA 8), and Science and Education Advisor for the Pacific Science Center. If reelected I would look forward to addressing the challenges of our town and serving the people of Yarrow Point."
LinkedIn profile (Nov 2021) for "Carl Scandella" of Bellevue, Washington, United States
https://www.linkedin.com/in/carlscandella/
2021-11-linkedin-com-carl-scandella.pdf
https://drive.google.com/file/d/1fvajFEBE4tnzViG-wcqqLmyvvr1uEmcW/view?usp=sharing
2021-11-linkedin-com-carl-scandella-img-1.jpg
https://drive.google.com/file/d/15rOX7tdbBOQmZR_E-ti3UCErmALo_l87/view?usp=sharing
About
Consulting in protein purification, scale-up and manufacture of new biopharmaceutical products, including therapeutics, vaccines, diagnostics and medical devices. Development and application of new technologies for purification and analysis; process troubleshooting. Expert witness in high profile patent litigations. Specialties:
protein purification and assay
analytical methods development
enzymes
antibodies
viruses
process design, development and scale-up
validation
formulation and stability testing
patents and intellectual property
manufacture of clinical material/ cGMP
technology transfer and contract manufacturing
Experience
Town of Yarrow Point (State of Washington, USA)
Council Member ( 2008 – Present / 13 yrs / Location : Yarrow Point, WA )
Served as Mayor Pro Tem and Town Representative on WRIA 8 Salmon Recovery Council for the Puget Sound. Research on environmental matters, highway safety issues and intersection design for SR 520 project.
Carl Scandella Consulting
Owner ( Jun 1992 – Present / 29 yrs 6 mos )
Assisted more than 50 client companies in developing manufacturing processes, manufacture of new products, and related areas. Worked with >15 contract service providers to achieve these goals, including development and validation of production processes and analytical methods as well as manufacture of products. Process documentation and troubleshooting. Patents and intellectual property.
University of Washington
Visiting Scholar ( 2000 – 2006 / 6 yrs )
Assisted in planning and teaching a course in Pharmaceutical Biotechnology. Mentored graduate students.
Chiron Corporation
Senior Scientist, Process Development; Manager, Manufacturing Protein Purification ( Nov 1983 – May 1992 / 8 yrs 7 mos / Emeryville CA )
Developed purification processes for recombinant protein products; manufactured products for clinical trials under cGMP. Major projects included recombinant human superoxide dismutase (partnered with Pharmacia AB and Gruenenthal GmbH), recombinant human IGF-1 (partnered with Ciba Geigy/ Novartis), recombinant HIV-1 gp120 (partnered with Ciba Geigy/ Novartis) and Hepatitis C diagnostic (partnered with Ortho Diagnostics/ J&J).
Genex Corp.
Principal Scientist, Protein Chemistry ( Nov 1981 – Nov 1983 / 2 yrs 1 mo / Location : Gaithersburg MD )
Developed and patented novel purification processes and assay methods for recombinant protein products.
SUNY Stony Brook, Stony Brook NY
Assistant Professor of Biochemistry ( Jan 1975 – Oct 1981 / 6 yrs 10 mos )
Taught undergraduate, graduate and medical school courses in biochemistry and related subjects. Trained graduate students and postdoctorals. Conducted research program on membrane structure and function supported by grants from NIH, NSF and other agencies.
What about 1972, 1973, and 1974 ?
Education
- Stanford University School of Medicine
Degree Name
Ph.D.
Field Of Study
Biochemistry
Dates attended or expected graduation
1966 – 1971
- California Institute of Technology
Degree Name
B.Sc.
Field Of Study
Chemistry
Dates attended or expected graduation
1962 – 1966
Volunteer experience
mentor
Company Name
Youth Eastside Services
Dates volunteered
Jan 2000 – Jan 2004
Volunteer duration
4 yrs 1 mo
Cause
Children
mentor junior high school student with special needsVolunteer Scientist
Company Name
Inquiry Based Science/ Institute for Systems Biology
Dates volunteered
Jan 1993 – Present
Volunteer duration
28 yrs 11 mos
Cause
Education
As a Volunteer Scientist I participated in science education programs in the public schools in Seattle. This program was initiated by Dr. Leroy Hood and his wife, Valerie Logan, as the educational arm of what is now the Institute for Systems Biology. Currently this program is known as the Logan Center for Education in honor of its founder, Valerie Logan.Science and Education Advisor
Company Name
Pacific Science Center, Seattle WA
Dates volunteered
Nov 2013 – Present
Volunteer duration
8 yrs 1 mo
Cause
Education
mentor undergrad, grad and postdoc students
Company Name
University of Washington, Stanford University
Dates volunteered
Jan 2006 – Sep 2016
Volunteer duration
10 yrs 9 mos
Mentoring graduate students in the Department of Chemistry at the University of Washington and undergrads at Stanford concerning their development as scientists and career choices.Representative from the Town of Yarrow Point
Company Name
WRIA 8 Council for Restoration of Salmon in the Puget Sound
Dates volunteered
Jun 2008 – Present
Volunteer duration
13 yrs 6 mos
The WRIA 8 Council was created by the State of Washington in response to chinook salmon being declared a threatened species. There are about 26 Water Resource Inventory Areas in the State. WRIA 8 includes Seattle and all of communities bordering on lakes and rivers that enter the Puget Sound through the Ship Canal.
The year Lederberg arrived to head Stanford's genetics department was a pivotal one in the medical school's history. The school was in the process of moving from San Francisco to join the Stanford campus in Palo Alto. During that same time period Arthur Kornberg, PhD, who went on to win the 1959 Nobel Prize in Biochemistry, arrived to found Stanford's biochemistry department. The departments led by Kornberg and Lederberg helped establish the medical school as a leader in biomedical research.
"Dr. Josh Lederberg was one of the greatest scientists of the 20th century with staggering achievements from bacteriology and microbiology to genetics and planetary exploration," said Philip Pizzo, MD, dean of the medical school. "He was not only a world-renowned scientist but also an advocate on science and public policy. His impact on Stanford can be felt to this day and will surely continue long into the future."
https://news.stanford.edu/news/2008/february6/med-lederberg-020608.html
Microbiologist says anthrax sushttps://www.nbcnews.com/id/wbna26110089 pect was stalker
A microbiologist claims she was stalked for decades by Bruce Ivins, the suspect in the deadly anthrax mailings of 2000, according to court documents.
This undated image attached to an email sent on Nov. 14, 2001, by Bruce Ivins shows the Army scientist handling "cultures of the now infamous 'Ames' strain of Bacillus anthracis" at his lab, according to the text of the message. AP
Aug. 9, 2008, 4:34 PM EDT / Source: The Associated Press
A microbiologist claims she was stalked for decades by Bruce Ivins, the suspect in the deadly anthrax mailings of 2001 who, according to court documents, was obsessed with the sorority she joined in college.
Nancy L. Haigwood and her former husband, Carl J. Scandella, also think Ivins may have wanted to get close to her when he moved in down the street from the couple in the suburbs of Washington in the early 1980s.
Ivins, an Army scientist, committed suicide last week as federal authorities prepared to charge him with killing five people by sending anthrax spores in the mail. The letters were dropped in a mailbox near a Kappa Kappa Gamma sorority office in Princeton, N.J., and prosecutors have suggested Ivins chose that location because of its proximity to the office.
In another development, the Justice Department sent a letter to the lawyer for Steven Hatfill, another military scientist who was a colleague of Ivins, formally exonerating Hatfill after saying earlier this week that Ivins was the only suspect. In 2002, law enforcement officials called Hatfill a "person of interest" in the investigation, a claim that brought a lawsuit from Hatfill the following year.
The federal government awarded Hatfill $5.8 million to settle his violation of privacy lawsuit against the Justice Department earlier this year. Hatfill claimed the Justice Department violated his privacy rights by speaking with reporters about the case.
In the case of Haigwood, now the director of the Oregon National Primate Research Center, she said she suspected Ivins in the anthrax mailings as early as November 2001, when he e-mailed her, his immediate family and other scientists a photo of himself working with what he called "the now infamous 'Ames' strain" of anthrax, which was used in the attacks. She reported her suspicions to the FBI in 2002 and, at the behest of investigators, kept in touch with Ivins by e-mail and shared their correspondence with investigators.
'You had to stalk me'
Haigwood, 56, met Ivins in the late 1970s when he was doing a postdoctoral fellowship at the University of North Carolina, where she earned her doctorate. She was cordial to him, but she noticed that he took an unusual interest in her Kappa membership.
In the summer of 1982, Haigwood moved in with Scandella, then her fiancee, in a townhouse in the Washington, D.C., suburb of Montgomery Village. On Nov. 30 that year, Scandella awoke to find the Greek letters "KKG" spray-painted on the rear window of his car and on the sidewalk and fence in front of the home. Although a police report filed by Scandella does not mention any possible suspects, Haigwood quickly concluded that Ivins was responsible.
"My address wasn't published, and I only lived there a short while before Carl and I got married and moved out of state," Haigwood said Friday. "No one knew my address or my phone number. You had to stalk me to figure this stuff out."
Records show that Ivins was living on the same street, about a block away, shortly after the incident. It was not clear when he moved in. Scandella did not know that Ivins had been their neighbor until he was told Friday by a reporter.
"I was blown away by that," Scandella said. "I had no idea he lived anywhere in the vicinity ... I wonder if it's possible that Ivins moved to that location to be close to Nancy."
Soon after the vandalism, Haigwood bumped into Ivins — she doesn't remember where — and accused him.
"I said, 'This happened and I'm sure you're the one who did it,' and he denied it," Haigwood said. "And I said, 'Well, I'm still sure you did.' What can you do at that point?"
Ivins kept in touch with Haigwood via phone calls, letters and e-mails, and while some of the correspondence made her uncomfortable, she never cut off contact with him, a decision she later regretted. She said she sent him polite but curt replies.
"He seemed to know a lot about myself, my children, things I never remembered telling him, which always disturbed me," she said. "I kept him at arm's length as best I could."
She also suspected Ivins of writing a letter in her name to The Frederick News-Post that defended hazing by Kappa members.
Haigwood passed on her suspicions about Ivins to the FBI after the American Society for Microbiology noted that a microbiologist was probably responsible for the anthrax mailings and asked its members to think of possible suspects.
Their e-mail correspondence from 2002 on was brief and cordial, although Ivins did reveal that he was under a lot of stress.
Investigators have said that between 2000 and 2006, Ivins was prescribed antidepressants, antipsychotics and anti-anxiety drugs. The Army Medical Research Institute of Infectious Diseases at Fort Detrick in Frederick, Md., where Ivins worked, has offered no explanation for why he was allowed to work with some of the world's most dangerous toxins while suffering from serious mental health problems.
It wasn't until November 2007, after the FBI raided his Frederick home, that Fort Detrick revoked his laboratory access, effectively putting him on desk duty. In the meantime, Haigwood said she worried about what Ivins was up to in the lab.
"After a while, after I decided that he was probably the perpetrator, I was afraid of him," Haigwood said. "I thought that if he found out I had turned him in, he would go after me. And he knew how to do that. This is something his colleagues don't seem to recognize in him."
Haigwood said she was not aware of Ivins stalking any other Kappa sisters.
In an interview Friday, Kappa Kappa Gamma executive director Lauren Sullivan Paitson said the FBI asked in August 2007 for help documenting decades' worth of Ivins' contacts with the sorority, including breaking into the now-closed chapter house at the University of Maryland. The sorority disbanded at Maryland in 1992.
But before being contacted by the FBI, Paitson had been engaged in an editing war on Wikipedia.com with a writer by the name of "jimmyflathead" who threatened to post secret rituals and bad publicity about the sorority on the Web site. Court affidavits listed "jimmyflathead@yahoo.com" among Ivins personal e-mail addresses.
Only after the government asked for the sorority's help did Paitson realize that the online Kappa nemesis was the top suspect in the anthrax investigation.
"We already had firsthand experience with him, going back and forth," she said.
The sorority did not threaten Ivins with legal action as a result of the Wikipedia editing dispute, and Paitson said she was assured by the FBI that none of the Kappa chapters or members nationwide would be targeted with anthrax letters.
She declined to give more details, citing the privacy of the members of the sorority.