Kenneth Alan Myers III (born 1965) ( "Kenneth A. Myers III was the fourth and longest serving director of the Defense Threat Reduction Agency (DTRA), from September 2009 to March 2016" )
Dr. David Michael Hone (born 1960) ( Vaccines director ; DOMANE ; and more )
Andrew Charles Weber (born 1960)
( "Andrew Charles Weber (born 1960) was the Assistant Secretary of Defense for Nuclear, Chemical & Biological Defense Programs, whose areas of responsibility are US nuclear, chemical and biological defense programs. Appointed by President Obama, he was confirmed by the U.S. Senate on 18 May 2009 and served until 1 October 2014." [HK0075][GDrive] ... during that time, the Defense Threat Reduction Agency was under Andrew Charles Weber (born 1960) 's chain of command , and the DTRA director at that time was Kenneth Alan Myers III (born 1965) )
Dr. Jens Holger Kuhn (born 1972) ( Source : 2015 Resume/CV for Dr. Jens Holger Kuhn (born 1972) : [HL003T][GDrive]
Dr. Darrell Ray Galloway (born 1946) - ( Dr. Darrell Ray Galloway (born 1946) worked at Defense Threat Reduction Agency for a Total Duration : 6 yrs 3 mos ) : See his saved LinkedIn from 2021 : PDF : [HL0090][GDrive] )
Dr. Randall Lawrence Kincaid (born 1951) - [Dr. Randall Lawrence Kincaid (born 1951)] is a "scientific director at the DTRA" as of 2013... according to : https://www.centerforhealthsecurity.org/our-work/pubs_archive/pubs-pdfs/2013/2013-02-04-next-gen-monoclonal-antibodies.pdf ....
Dr. Tracey S. McNamara (born 1954) ( "In 2004 she worked on DTRA’s “Integrated Biosurveillance for Zoonotic Threats” program in Uzbekistan, Kazakhstan and Georgia. She served as lead on a project with Russian colleagues on the “Human-Animal Interface: Improving Biological Threat Detection and Surveillance in Russia” by the Nuclear Threat Initiative’s Global Health and Biosecurity program in Wash. DC." .... Source : [HE007C][GDrive] / Image : [HE007D][GDrive] )
DOMANE ( "Discovery of Medical Countermeasures Against Novel Entities" , created by the Defense Threat Reduction Agency in December of 2019 )
NewLink Genetics Corporation ( BioProtection Systems Inc. is a subsidiary of NewLink Genetics Corporation ) ... ( Contracts in 2014 for the rVSV-ZEBOV Ebola Vaccine )
....
SARS-COV2 famotidine trials (2020) ( Multiple individuals, and contributions (including DOMANE ), played a large role in COVID-19 response )
Western African Ebola virus epidemic (2013 - 2016) ( DTRA provided funding for NewLink Genetics Corporation to make rVSV-ZEBOV Ebola Vaccine available during )
....
Agency overview
Formed
October 1, 1998
Preceding agencies
•Defense Special Weapons Agency, (1996–1998)
•Defense Nuclear Agency, (1971–1996)
•Defense Atomic Support Agency, (1959–1971)
•Armed Forces Special Weapons Project, (1947–1959)
•Manhattan Project (1942–1946)
Headquarters
Employees
2,000+
Agency executives
• Dr. Rhys M. Williams, Acting Director
• RDML Ryan B. Scholl, U.S. Navy, Deputy Director
• Hunter Lutinski, Vice Director for Plans & Programs
• Michael Bruhn, Vice Director for Mission Integration
• CSM Brant C. Shyrigh, U.S. Army[1], Command Senior Enlisted Advisor
Parent agency
Website
The Defense Threat Reduction Agency (DTRA) is an agency within the United States Department of Defense (DoD) and is the official Combat Support Agency for countering weapons of mass destruction (WMD; chemical, biological, radiological, nuclear, and high explosives). According to the agency's Strategic Plan for Fiscal Years 2018 to 2022, the DTRA mission "enables DoD and the U.S. Government to prepare for and combat weapons of mass destruction and improvised threats and to ensure nuclear deterrence."[2] The agency is headquartered in Fort Belvoir, Virginia.
DTRA was officially established on October 1, 1998, as a result of the 1997 Defense Reform Initiative, by consolidating several DoD organizations, including the Defense Special Weapons Agency (successor to the Defense Nuclear Agency) and the On-Site Inspection Agency.[3] The Defense Technology Security Administration and the Nunn–Lugar Cooperative Threat Reduction program office in the Office of the Secretary of Defense were also incorporated into the new agency.[4]
In 2002, DTRA published a detailed history of its predecessor agencies, Defense's Nuclear Agency, 1947–1997, the first paragraph of which makes a brief statement about the agencies which led up to the formation of DTRA:
Defense's Nuclear Agency, 1947–1997, traces the development of the Armed Forces Special Weapons Project (AFSWP), and its descendant government organizations, from its original founding in 1947 to 1997. After the disestablishment of the Manhattan Engineering District (MED) in 1947, AFSWP was formed to provide military training in nuclear weapons' operations. Over the years, its sequential descendant organizations have been the Defense Atomic Support Agency (DASA) from 1959 to 1971, the Defense Nuclear Agency (DNA) from 1971 to 1996, and the Defense Special Weapons Agency (DSWA) from 1996 to 1998. In 1998, DSWA, the On-Site Inspection Agency, the Defense Technology Security Administration, and selected elements of the Office of Secretary of Defense were combined to form the Defense Threat Reduction Agency (DTRA).[5]
DTRA employs approximately 2,000 civilian and uniformed service members at more than a dozen permanent locations around the world. The majority of personnel are at DTRA headquarters at Fort Belvoir. Approximately 15% of the workforce is split between Kirtland Air Force Base and the White Sands Missile Range in New Mexico, and the Nevada National Security Site (formerly called the Nevada Test Site), where they do testing and support the U.S. military's nuclear mission. The remaining 15% of the workforce is stationed at locations in Germany, Kazakhstan, Azerbaijan, Uzbekistan, Georgia, Ukraine, Armenia, Kenya, South Korea, Japan, and Singapore. DTRA also has liaisons with all of the U.S. military's Combatant Commands, the National Guard Bureau, the FBI and other U.S. government interagency partners.
In 2005, the Commander, United States Strategic Command (USSTRATCOM) was designated as the lead Combatant Command for the integration and synchronization of DoD's efforts in support of U.S. government "Combating WMD" objectives. It was at this time that the SCC-WMD was co-located with DTRA.[6] The Combat Command designation was changed again in 2017, when responsibility was moved to U.S. Special Operations Command (USSOCOM).[7]
In 2012, the SJFHQ-E was relocated to the DTRA/SCC-WMD headquarters at Fort Belvoir. This centralized the DoD's Combating Weapons of Mass Destruction operations, a move recommended in the 2010 Quadrennial Defense Review.[8]
On September 30, 2016, the Joint Improvised-Threat Defeat Agency (JIDA) became part of DTRA and was renamed the Joint Improvised-Threat Defeat Organization (JIDO) in accordance with the 2016 National Defense Authorization Act (NDAA). In Section 1532 of the NDAA, Congress directed the DoD to move JIDA to a military department or under an existing defense agency.[9][10]
DTRA requested a base budget of $1.2 billion for fiscal year 2017 (FY17). The three other components of DTRA's overall resource portfolio include executing the $361 million Science and Technology portion of the DoD Chemical and Biological Defense Program (CBDP); managing the CBDP's remaining $833 million budget; and $408 million in overseas contingency operations funds requested by the JIDA (now JIDO).[9] These additional amounts bring DTRA's total resource portfolio to approximately $2.8 billion for FY17.[11]
A Ukrainian worker begins the first cut on a Kh-22 air-to-surface missile during elimination activities at an air base in Ozernoye, Ukraine. The weapon was eliminated under the Nunn–Lugar Cooperative Threat Reduction program implemented by the Defense Threat Reduction Agency. (DTRA photo)
After the end of the Cold War, DTRA and its predecessor agencies have implemented the DoD aspects of several treaties that assist former Eastern Bloc countries in the destruction of Soviet era nuclear, biological, and chemical weapons sites (such as missile silos and plutonium production facilities) in an attempt to avert potential weapons proliferation in the post-Soviet era as part of the Nunn–Lugar Cooperative Threat Reduction program. DTRA is responsible for US reporting under the New START Treaty and the Intermediate-Range Nuclear Forces Treaty.
DTRA is also responsible for reducing the threat of conventional war, especially in Europe, by participating in various arms control treaties to which the United States is a party, such as the Conventional Forces in Europe treaty and the Treaty on Open Skies, as well as the Vienna Document and Global Exchange of Military Information under the auspices of the Organization for Security and Co-operation in Europe. the Transparency in Armaments activity of the United Nations, and the Wassenaar Arrangement.
On January 26, 2006, the director of DTRA was given the extra responsibility of the director of the USSTRATCOM Center for Combating Weapons of Mass Destruction, a subordinate component to the U.S. Strategic Command.[12]
DTRA has the responsibility to manage and integrate the Department of Defense chemical and biological defense science and technology programs.[13] In accordance with the Recommendation 174 (h) of the 2005 Base Closure and Realignment Commission, part of the Chemical Biological Defense Research component of the Defense Threat Reduction Agency was re-located to Edgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland in 2011.[14][15] This represented a move of about ten percent of the staff of the Chemical Biological Defense Research component of DTRA to Aberdeen Proving Ground; the rest of the staff remain at Fort Belvoir.
DTRA and its legacy agencies have been awarded numerous Joint Meritorious Unit Awards (JMUA) since the JMUA was implemented in 1982 (made retroactive to 1979):[16][17]
Defense Nuclear Agency
1st JMUA: 1 July 1981 – 20 June 1984
2nd JMUA: 1 January 1993 – 31 May 1995
On-Site Inspection Agency
1st JMUA: 15 January 1988 – 31 December 1988
2nd JMUA: 1 January 1989 – 30 July 1993
3rd JMUA: 1 August 1993 – 31 July 1996
4th JMUA: 1998
Defense Special Weapons Agency
1st JMUA: 1 June 1995 – 30 September 1998
Defense Threat Reduction Agency
1st JMUA: 1 October 1998 – 5 March 2000
2nd JMUA: 6 March 2000 – 30 June 2003
3rd JMUA: 1 October 2009 – 20 September 2011
4th JMUA: 1 May 2012 – 1 November 2014
Ebola
DTRA has spent approximately $300 million on scientific R&D efforts since 2003 developing vaccines and therapeutic treatments against viral hemorrhagic fever, including Ebola. Starting in 2007, DTRA partnered with the National Institute of Allergy and Infectious Diseases (NIAID) of the United States Department of Health and Human Services and the United States Army Medical Research Institute of Infectious Diseases (USAMRIID) to fund research on the drug now called ZMapp, which has since been used on several patients.[18][19]
DTRA also funded and managed the research on the EZ1 assay used to detect and diagnose the presence of the Ebola Zaire virus in humans. EZ1 was given Emergency Use Authorization by the Food and Drug Administration (FDA) in August 2014. DTRA first developed EZ1 as part of a 2011 "bio-preparedness initiative" for the United States Department of Defense to prepare for a possible Ebola outbreak. EZ1 was used to identify infected patients in West Africa.[20][21]
Members of the local area media and Scott Air Force Base medical personnel tour the Transport Isolation System January 23, 2015, during a roll-out ceremony for the system on Scott AFB, Illinois. (USTRANSCOM photo)
DTRA was the program manager for designing, testing, contracting, and production of the Transport Isolation System (TIS), a sealed, self-contained patient containment system that can be loaded into United States Air Force C-17 Globemaster and C-130 Hercules cargo planes for aeromedical evacuation. The TIS was designed to deal with any U.S. troops exposed to or infected with Ebola while serving in Operation United Assistance, but it is for transporting anyone exposed to or infected with any highly contagious disease. It can hold eight patients laying down, 12 sitting, or a combination of the two.[22] DTRA worked with the Air Force Life Cycle Management Center (AFLCMC) and United States Transportation Command (USTRANSCOM) on the TIS;[23] St. Louis-based Production Products was awarded a sole-source contract to produce 25 TIS units.[24][25]
DTRA's Nunn-Lugar Cooperative Threat Reduction program awarded a $4 million contract to MRIGlobal to "configure, equip, deploy and staff two quick response mobile laboratory systems (MLS) to support the ongoing Ebola outbreak in West Africa." The labs were deployed to Sierra Leone.[26]
Syria's chemical weapons
DTRA was one of the key United States Department of Defense agencies that developed the Field Deployable Hydrolysis System (FDHS) used to destroy Syria's chemical weapons aboard the U.S.-flagged container ship MV Cape Ray in the summer of 2014[27][28] after Syria agreed to give up its chemical weapons stockpile under international pressure and in accordance with United Nations Security Council Resolution 2118. DTRA partnered with the United States Army Edgewood Chemical Biological Center (ECBC) to develop the FDHS and then modify it for ship-borne operations after Syrian President Bashar al-Assad agreed to turn over his country's poison gas arsenal and chemical weapon production equipment to the Organisation for the Prohibition of Chemical Weapons (OPCW) but no country volunteered to host the destruction process.[27]
Two FDHS units destroyed more than 600 tons of Sarin and mustard agents, completing the task several weeks ahead of schedule.[29] The remaining materials were then taken to Finland and Germany for final disposal.[30] DTRA was awarded its third Joint Meritorious Unit Award for successfully destroying Syria's declared chemical weapons.[31]
Massive Ordnance Penetrator (MOP)
DTRA funded, managed, and tested the Massive Ordnance Penetrator bomb until February 2010 when the program was turned over to the United States Air Force. DTRA developed the MOP to fulfill a long-standing Air Force requirement for a weapon that could destroy hard and deeply buried targets. The MOP is a 30,000 pound, 20.5 foot long bomb dropped from B-52 and B-2 bombers at high altitude that can reportedly penetrate 200 feet of reinforced concrete.[32][33] The MOP contains a 5,300 pound explosive charge, more than 10 times the explosive power of its predecessor, the BLU-109 "bunker buster."[34]
Project MAXIMUS
In 2003, a DTRA task force was identifying, collecting and securing radiological material in Iraq as part of Operation Iraqi Freedom, including almost two tons of low enriched uranium (LEU), several hundred tons of yellowcake (a type of uranium powder), and other radioactive sources. Code-named Project MAXIMUS, DTRA and the United States Department of Energy moved 1.77 metric tons of LEU and approximately 1,000 highly radioactive sources out of Iraq by the summer of 2004. DTRA task force members also secured the yellowcake in a bunker in Tuwaitha, Iraq, which was turned over to the Iraqi Ministry of Science and Technology; the remaining 550 tons of yellowcake were sold in 2008 to Cameco, a uranium producer in Canada.[35]
COVID-19
In late 2019, DTRA established a program called Discovery of Medical Countermeasures Against Novel Entities ([DOMANE]). Shortly afterwards, the COVID-19 pandemic began, and DOMANE started researching existing, pre-approved medications like Pepcid (famotidine) for potential cost-effective treatments for COVID-19.[36][37][38]
This section needs additional citations for verification. [...]
Jay C. Davis (1998–2001)
Robert P. Bongiovi (2001, acting)
Stephen M. Younger (2001–2004)
Trudy H. Clark (2004–2005, acting)
James A. Tegnelia (2005-2009)[39]
[Kenneth Alan Myers III (born 1965)] (2008–2016)
Shari Durand (2016-2017, acting)
Dr. Rhys M. Williams (2021–Present, Acting) [40]
DTRA, the official web site of the Defense Threat Reduction Agency
Responding to War, Terrorism, and WMD Proliferation: History of DTRA, 1998–2008, DTRA History Series
Defense's Nuclear Agency, 1947–1997, DTRA History Series
Defense's Nuclear Agency, 1947–1997, DTRA History Series
Defense Special Weapons Agency 50th Anniversary, 1947–1997, DTRA History Series
Mentioned in Andrew Charles Weber (born 1960) page (link .... )
Full page A1 : [HN01XJ][GDrive] / Full Page A9 : [HN01XL][GDrive]
See : BioProtection Systems Inc. / NewLink Genetics Corporation / Defense Threat Reduction Agency / Western African Ebola virus epidemic (2013 - 2016)
Full newspaper page : [HN01XM][GDrive]
See : BioProtection Systems Inc. / NewLink Genetics Corporation / Defense Threat Reduction Agency / Western African Ebola virus epidemic (2013 - 2016)
Since 2003, the Defense Threat Reduction Agency has invested more than $300 million to develop medical countermeasures against hemorrhagic fever viruses, and those efforts are paying off today in potential new ways to fight Ebola virus disease.
DTRA’s mission is to protect the United States and its allies from chemical, nuclear, biological and other weapons of mass destruction, and deadly pathogens fall into the WMD category, DTRA Deputy Director Air Force Maj. Gen. John Horner said during a recent interview with DoD News.
“We plan to be in this business for the long term,” he added, “and need to do biosurveillance and strengthen biosecurity worldwide, helping partner countries build their capacity to prevent, treat and monitor the threat of infectious diseases.”
More than 17,290 cases of Ebola virus disease and at least 6,128 deaths have been reported to date in West Africa, according to the World Health Organization and the Centers for Disease Control and Prevention, and the lack of licensed Ebola vaccines and treatments has accelerated efforts, including DTRA’s, to get these medical products into the regulatory approval pipeline.
This year, in coordination with DTRA, the Public Health Emergency Medical Countermeasures Enterprise working group chose three lead candidates –- two vaccines and one treatment –- to go forward in the Food and Drug Administration approval pipeline as part of the U.S. Ebola outbreak response.
The vaccine candidates are recombinant VSV-EBOV, from BioProtection Systems/Newlink Genetics, and ChAd-EBOV from GlaxoSmithKline. DTRA is supporting development of the VSV-EBOV vaccine through a contract with BioProtection Systems/Newlink Genetics. NIAID is supporting the ChAd-EBOV vaccine.
The VSV candidate is based on a recombinant, or genetically engineered, virus from an animal disease called vesicular stomatitis. An Ebola virus protein is engineered into a vesicular stomatitis virus, and the new recombinant virus acts as a vector, or carrier, to deliver the Ebola protein into the human body. Genetic engineering is a healthy way to express proteins like Ebola that prompts the body to produce antibodies to lethal Ebola virus disease without the risk of disease from either virus
The other vaccine is a recombinant chimpanzee adenovirus, or cold virus. In this vaccine, an Ebola virus protein is engineered into a chimpanzee adenovirus to deliver the ChAd-EBOV vaccine into people to produce Ebola antibodies.
Human testing to evaluate the safety of VSV-EBOV is underway at the National Institutes of Health Clinical Center in Bethesda, Maryland and the Walter Reed Army Institute of Research, or WRAIR.
Researchers at the NIH National Institute of Allergy and Infectious Diseases, or NIAID, are conducting an early phase trial to evaluate the VSV-EBOV vaccine for safety and for its ability to generate an immune-system response in healthy adults who receive two injected doses.
At the same time, the WRAIR is testing the VSV-EBOV vaccine as a single dose at its Clinical Trials Center in Silver Spring, Maryland, NIH officials said.
For the ChAd-EBOV vaccine, in early stage clinical trials, again designed to assess vaccine safety and immune response, NIAID will test two versions of ChAd-EBOV.
One is a bivalent, or two-component, version containing genetic material from Ebola Zaire and Ebola Sudan strains. The other is a monovalent, or single-component, version that contains only genetic material from Ebola Zaire, the strain now causing the outbreak in West Africa.
Both vaccines were reviewed by the FDA under an investigational new drug, or IND, application.
“We should begin to see Phase II and III clinical trials take place in West Africa, probably in the January-February timeframe,” Dr. Ronald K. Hann Jr., director of research and development in DTRA’s Chemical and Biological Technologies Department, said.
He explained that these clinical trial phases evaluate the vaccines’ efficacy, or how well they work.
“We spoke to Doctors Without Borders [recently], and they're helping to map out the Phase II-III clinical trial studies that would be taking place in West Africa,” Hann added, “and they're looking at both the [ChAd-EBOV and VSV-EBOV] vaccine candidates to go into those trials.”
Once either vaccine shows protection, according to a DTRA fact sheet, the trial will stop and the vaccine will be distributed in a mass immunization campaign to help end the Ebola epidemic.
The lead therapeutic treatment candidate that DTRA and the Public Health Emergency Medical Countermeasures Enterprise working group named to move forward into the FDA pipeline is called ZMapp, from Mapp Biopharmaceutical.
But as early as 2007, DTRA, NIAID and the U.S. Army Medical Research Institute for Infectious Diseases, or USAMRIID, were funding efforts and working hard to show that the monoclonal antibody basis for the experimental drug actually would work.
ZMapp is a cocktail of three different monoclonal, or genetically engineered, Ebola virus disease antibodies that bind to Ebola virus proteins in the body and neutralize the virus, decreasing the amount of virus the patient's immune system has to fight.
Dr. Erin Reichert, chief of the Translational Medical Division of the Chemical and Biological Technologies Department in DTRA’s Research and Development Directorate, describes the road to development for ZMapp.
“Along with our colleagues at USAMRIID and NIAID, we had a small investment in looking at whether or not monoclonal antibodies or antibody-based therapeutics in general would be an appropriate therapeutic countermeasure for Ebola,” she said.
In the scientific community, as early as 2007, researchers debated the value of this so-called passive immunotherapy, or passive transfer, for treating Ebola.
“We funded researchers at USAMRIID, and NIAD had small investments through small-business grants directly to Mapp Biopharmaceutical to determine once and for all if antibodies could be a viable countermeasure”, Reichert said.
Then in the 2012 timeframe, she added, important publications came out of USAMRIID that changed the way researchers viewed antibodies for filovirus infection. Ebola and Marburg viruses both are filoviruses.
“One of those papers was by [Dr. John M. Dye Jr., now chief in USAMRIID’s Viral Immunology Branch],” Reichert said. “He demonstrated for the first time that antibodies from primates exposed to Ebola virus could be transferred to naive primates to protect them from infection. That opened the door for this as far as a viable countermeasure.”
Also in 2012, she added, DTRA and NIAID “really started putting some dollars against the product and in a very short period of time we were able to accelerate development to a point where, while it is still a [research and development] product, we have a product that could be useful in people.”
ZMapp was developed through a DTRA contract with Mapp Biopharmaceutical and in collaboration with USAMRIID, Defyrus LLC and the Public Health Agency of Canada, according to a DTRA fact sheet.
The ZMapp three-antibody cocktail was discovered in 2014 but the monoclonal antibody research began in 2007.
BARDA is sponsoring the manufacture of ZMapp for Phase I and II clinical studies, which are expected to start in early 2015 at NIAID. Other clinical studies are scheduled to begin in affected African countries in early 2015. ZMapp has been used under an emergency investigational new drug application in Ebola-infected patients in the United States, Africa and elsewhere, according to a White House fact sheet.
“We’ve been working very closely with our interagency partners to develop these vaccines and therapeutics to protect the force against a broad range of filoviruses,” Reichert said.
In response to the West Africa Ebola epidemic, development of vaccines and ZMapp has accelerated to focus specifically on delivering something for Zaire, she added.
“Along with our interagency partners -- HHS as well as JPEO have been really critical –- we’ve been able, in a very short period of time, to push those through the regulatory process to get them to a point where they may have an impact on the current epidemic,” Reichert said.
(Follow Cheryl Pellerin on Twitter @PellerinDoDNews)
See : Defense Threat Reduction Agency / SARS-COV2 famotidine trials (2020) /