Binghamton Research Days Student Presentations
Drosophila Genes Affecting Longevity in a High Sugar Diet
Drosophila Genes Affecting Longevity in a High Sugar Diet
Alexander Robins, David Colucci, Ava Hameister, Biology 340 Students
Alexander Robins, David Colucci, Ava Hameister, Biology 340 Students
Scholars Program, First-Year Research Immersion (FRI)
Scholars Program, First-Year Research Immersion (FRI)
Science, Technology, Engineering, Math
Science, Technology, Engineering, Math
Mentor: Anthony Fiumera
Mentor: Anthony Fiumera
Abstract
Abstract
Type 2 diabetes and the associated comorbidities affect millions of individuals. Drosophila melanogaster has many orthologous metabolic pathways to humans and is a good model system to study how genetics and the environment interact to influence disease. This study will use a genome wide association study (GWAS) to identify the genes that differentially affect survival in Drosophila that have been fed either a high or low sugar diet. This was done by recording the survival of 112 genetically inbred lines of male and female D. melanogaster, with 6 replicates of each line during Fall 2021. This work demonstrated a significant effect of diet and genotype, and currently additional replicates are being completed. Once done, I will use GWAS to identify the genes affect survival. This information can be used to identify the genes in humans that affect energy metabolism and the development of T2D and other diseases that may be associated with a high sugar diet. This can lead to potential drugs target to help metabolic disorders caused by high sugar diets.
Type 2 diabetes and the associated comorbidities affect millions of individuals. Drosophila melanogaster has many orthologous metabolic pathways to humans and is a good model system to study how genetics and the environment interact to influence disease. This study will use a genome wide association study (GWAS) to identify the genes that differentially affect survival in Drosophila that have been fed either a high or low sugar diet. This was done by recording the survival of 112 genetically inbred lines of male and female D. melanogaster, with 6 replicates of each line during Fall 2021. This work demonstrated a significant effect of diet and genotype, and currently additional replicates are being completed. Once done, I will use GWAS to identify the genes affect survival. This information can be used to identify the genes in humans that affect energy metabolism and the development of T2D and other diseases that may be associated with a high sugar diet. This can lead to potential drugs target to help metabolic disorders caused by high sugar diets.