Binghamton Research Days Student Presentations
Kailee Loiodice - FINAL POSTER (2).pdf
Exercise and Diet Patterns as Factors in Forearm Trabecular and Cortical Bone Development in Pubertal Girls
Exercise and Diet Patterns as Factors in Forearm Trabecular and Cortical Bone Development in Pubertal Girls
Kailee Loiodice, Ye Lin, Alexander Ruhren
Kailee Loiodice, Ye Lin, Alexander Ruhren
First-Year Research Immersion (FRI)
First-Year Research Immersion (FRI)
Science, Technology, Engineering, Math
Science, Technology, Engineering, Math
Mentor: Jodi Dowthwaite
Mentor: Jodi Dowthwaite
Abstract
Abstract
PURPOSE: As peak bone mineral accrual velocity occurs at menarche, optimization of circum-menarcheal exercise and diet may reduce future fracture risk. We evaluated a 3-year non-dominant upper extremity bone loading index, and key nutrients, as circum-menarcheal factors in development of post-menarcheal bone properties at the distal radius – a common fragility fracture site. METHODS: A previously published circum-menarcheal bone loading index was evaluated as a predictor of indices of theoretical bone compressive and torsional strength for 48 original BLI study participants with post-menarcheal radius peripheral quantitative computed tomography (pQCT) scans. Mean intakes of lactose, zinc, total fat, magnesium, protein, calcium and potassium were tested as predictors of dual energy X-ray absorptiometry bone mineral content at comparable sites. SPSS v27 generated descriptive statistics and multiple linear regression models, with gynecological age, height and whole-body non-bone lean mass as covariates; backward stepwise regressions initially entered all predictors, plus diet factors. RESULTS: Gynecological age, height, lean mass and 3yrBLI all provided significant explanatory value in the 4% IBS model, but only lean mass and 3yrBLI were significant factors in the 33% SSI model; 3yrBLI explained substantial variance in both models (p<0.002). For DXA models, total fat, lean mass and 3yrBLI were positive factors, whereas protein and calcium intakes were negative factors (p<0.15). CONCLUSIONS: Over 3 circum-menarcheal years, greater forearm bone loading exercise was associated with higher post-menarcheal bone mass and strength indices. Future studies should evaluate interactions among fat, protein and calcium intakes in exercise studies of tissue-specific bone growth.
PURPOSE: As peak bone mineral accrual velocity occurs at menarche, optimization of circum-menarcheal exercise and diet may reduce future fracture risk. We evaluated a 3-year non-dominant upper extremity bone loading index, and key nutrients, as circum-menarcheal factors in development of post-menarcheal bone properties at the distal radius – a common fragility fracture site. METHODS: A previously published circum-menarcheal bone loading index was evaluated as a predictor of indices of theoretical bone compressive and torsional strength for 48 original BLI study participants with post-menarcheal radius peripheral quantitative computed tomography (pQCT) scans. Mean intakes of lactose, zinc, total fat, magnesium, protein, calcium and potassium were tested as predictors of dual energy X-ray absorptiometry bone mineral content at comparable sites. SPSS v27 generated descriptive statistics and multiple linear regression models, with gynecological age, height and whole-body non-bone lean mass as covariates; backward stepwise regressions initially entered all predictors, plus diet factors. RESULTS: Gynecological age, height, lean mass and 3yrBLI all provided significant explanatory value in the 4% IBS model, but only lean mass and 3yrBLI were significant factors in the 33% SSI model; 3yrBLI explained substantial variance in both models (p<0.002). For DXA models, total fat, lean mass and 3yrBLI were positive factors, whereas protein and calcium intakes were negative factors (p<0.15). CONCLUSIONS: Over 3 circum-menarcheal years, greater forearm bone loading exercise was associated with higher post-menarcheal bone mass and strength indices. Future studies should evaluate interactions among fat, protein and calcium intakes in exercise studies of tissue-specific bone growth.