Sydney Grammar Synthesis of Daraprim

Post date: Jun 7, 2019 8:39:30 PM

excerpt from the following website: https://openwetware.org/wiki/OpenSourceMalaria:Daraprim

"In 2016 a group of high school students from Sydney Grammar School worked with their teachers Dr Malcolm Binns and Dr Erin Sheridan to synthesise Daraprim in their school labs. The students were part of OSM's Breaking Good Project and successfully completed the synthetic challenged set by Dr Alice Williamson at the start of 2016. The students developed a route that obviated the requirement for a dangerous reagent (diazomethane) and published their route in open electronic laboratory notebooks."

good summary of their progress: http://malaria.ourexperiment.org/daraprim_synthesis/15813/Pyramethamine_synthesis_Status_at_the_end_of_2016.html

Additional readings:

- In the Pipeline blog covering the Sydney Grammar story: https://blogs.sciencemag.org/pipeline/archives/2016/12/01/those-australian-students-and-their-daraprim

- How are drugs priced anyways? Intro: https://blogs.sciencemag.org/pipeline/archives/2015/10/14/jack-scannell-talks-loads-of-sense-on-drug-pricing