Post date: Aug 3, 2016 6:18:26 AM
Merck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States
J. Org. Chem., Article ASAP
DOI: 10.1021/acs.joc.6b01449
Publication Date (Web): August 1, 2016
Copyright © 2016 American Chemical Society
*E-mail: dmacmill@princeton.edu.
ACS Editors' Choice - This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
In recent years, photoredox catalysis has come to the forefront in organic chemistry as a powerful strategy for the activation of small molecules. In a general sense, these approaches rely on the ability of metal complexes and organic dyes to convert visible light into chemical energy by engaging in single-electron transfer with organic substrates, thereby generating reactive intermediates. In this Perspective, we highlight the unique ability of photoredox catalysis to expedite the development of completely new reaction mechanisms, with particular emphasis placed on multicatalytic strategies that enable the construction of challenging carbon–carbon and carbon–heteroatom bonds.