Syllabus statements

C1.1.1 Enzymes as catalysts

C1.1.2 Role of enzymes in metabolism

C1.1.3 Anabolic and catabolic reactions

C1.1.4 Enzymes as globular proteins with an active site for catalysis

C1.1.5 Interactions between substrate and active site to allow induced-fit binding

C1.1.6 Role of molecular motion and substrate-active site collisions in enzyme catalysis

C1.1.7 Relationships between the structure of the active site, enzyme–substrate specificity and denaturation

C1.1.8 Effects of temperature, pH and substrate concentration on the rate of enzyme activity

C1.1.9 Measurements in enzyme-catalysed reactions

C1.1.10 Effect of enzymes on activation energy

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C1.1.11 AHL Intracellular and extracellular enzyme-catalysed reactions

C1.1.12 AHL Generation of heat energy by the reactions of metabolism

C1.1.13 AHL Cyclical and linear pathways in metabolism

C1.1.14 AHL Allosteric sites and non-competitive inhibition

C1.1.15 AHL Competitive inhibition as a consequence of an inhibitor binding reversibly to an active site

C1.1.16 AHL Regulation of metabolic pathways by feedback inhibition

C1.1.17 AHL Mechanism-based inhibition as a consequence of chemical changes to the active site caused by the irreversible binding of an inhibitor