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Malocclusions are highly prevalent conditions that can significantly impact individuals physically, socially, and psychologically, playing a crucial role in social acceptance. According to the Riset Kesehatan Dasar (RisKesDas) 2018, the prevalence of malocclusions in Indonesia ranks third, following dental caries and periodontal issues. The concept of Oral Health-Related Quality of Life (OHRQoL) is related to the impact of oral health or disease on a person’s daily functioning, well-being or overall quality of life. Research into the psychological impact of malocclusion on OHRQoL has highlighted the effects of malocclusion on people's lives, thereby enhancing the understanding of the demand for orthodontic treatment beyond mere clinical measurements. Given that psychological factors often motivate individuals to seek orthodontic care, OHRQoL is a valuable metric for assessing both the need for and the outcomes of orthodontic treatment. Several indices can be utilized to measure OHRQoL, including the Oral Health Impact Profile (OHIP), the Child Oral Health Impact Profile (COHIP), and the Oral Impacts on Daily Performance (OIDP). Notably, the COHIP index has been translated into multiple languages, including Bahasa Indonesia, and has been simplified by Nuraini et al. for public health staff as COHIP-SF19. This article will discuss the impact of malocclusion on OHRQoL across various populations.