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Orofacial muscles play a central yet often underestimated role in the success and long-term stability of orthodontic treatment. Myofunctional orthodontic therapy offers a paradigm shift by not only aligning teeth, but also addressing underlying muscular dysfunctions related to breathing, swallowing, posture, and tongue habits. This presentation explores the biological mechanisms of muscle adaptation in response to functional orthodontic stimuli, including changes at the molecular and structural levels. Evidence from electromyography (EMG), imaging studies, and clinical trials is reviewed to illustrate how targeted neuromuscular training can remodel facial musculature and enhance treatment outcomes. Integrating myofunctional principles into orthodontic protocols may reduce relapse risk, improve facial aesthetics, and support optimal orofacial function. The session highlights clinical indicators, treatment planning considerations, and challenges in interprofessional collaboration for implementing effective myofunctional orthodontics in daily practice.