Samuel Dudley, M.D., Ph.D.

Samuel C. Dudley, Jr. (sdudley@umn.edu) is Chief of Cardiology, Director of the Lillehei Heart Institute and the Fred C. and Katherine B. Anderson Chair-Adult Cardiology at the University of Minnesota. Prior to his position with the U of MN, he served as Chief of Cardiology at Brown University and Founding Director of the Lifespan Cardiovascular Institute. Previously, he served as Chief of cardiology and Co-Director of the Center for Cardiovascular Research at the University of illinois at Chicago, chief of cardiology at the Atlanta VA Medical center and as Associate professor of medicine and physiology at Emory University, both in Atlanta, Georgia. He received his medical and graduate degrees from the Medical College of Virginia, Virginia Commonwealth University, in Richmond, Virginia. He completed his residency, postdoctoral fellowship and cardiology fellowship at the University of Chicago in Chicago, Illinois. He serves on several editorial boards for publications including the Journal of the American College of cardiology and the Journal of Cardiovascular Pharmacology and Therapeutics. Dr. Dudley is a Fellow of the American College of Cardiology and the American Heart Association and is a member of the Association of University Cardiologists, and the Cardiac Muscle Society, among others. He has published over 140 manuscripts.

Dr. Dudley’s laboratory has two main areas of focus, arrhythmias and diastolic heart failure. In each area, the laboratory is developing human diagnostics and novel therapeutics to address unmet needs. The laboratory has patented a blood test for identifying and quantifying the severity of diastolic dysfunction, two new therapies for diastolic dysfunction and heart failure with preserved ejection fraction (HFpEF), a blood test to predict sudden cardiac death, and several novel approaches to antiarrhythmic therapy that avoid pro-arrhythmic risk. We are investigating the roles of diabetes, the unfolded protein response, mRNA stability, and mitochondrial calcium handling in arrhythmic risk.

Several representative publications include:

Research projects available with Dr. Dudley include the following:

  • Opportunities in the laboratory include basic, translational, and clinical trials research related to diastolic dysfunction and arrhythmias.