Daniel J. Garry, M.D., Ph.D.

Daniel Garry (garry@umn.edu) is a Professor of Medicine in the Cardiovascular Division. He is the Director of the Paul & Sheila Wellstone Muscular Dystrophy Center and the Director of the Regenerative Medicine & Sciences program at the University of Minnesota. Having obtained his M.D/Ph.D. degrees at the University of Minnesota, he completed postdoctoral research training at Cold Spring Harbor Laboratory and the University of Texas Southwestern Medical Center in Dallas. He served as the Director for the Center for Cardiac Regeneration and Stem Cell Biology at UT Southwestern and he was the holder of the Gail Griffiths Hill Endowed Chair in Cardiology. Dr. Garry’s current research interests focus on the definition of molecular pathways that regulate somatic stem cell populations both during development and postnatally to enhance myocardial and vascular regeneration in response to injury. In addition, the Garry laboratory focuses on the use of human induced pluripotent stem cells to model cardiovascular disease and evaluate emerging therapies, and as a source for cell therapy initiatives. His translational studies also focus on the use of personalized medicine to define molecular signatures for early stages of disease in patients with heart failure or following cardiac transplantation. Dr. Garry’s current clinical interests focus on advanced heart failure, mechanical device support and orthotopic heart transplantation. He trained more the 60 graduate students, postdoctoral fellows, and medical students in his laboratory. He is the director of several programmatic NIH Awards and has a 20+ year history of R01 funding. Dr. Garry serves on a number of study sections, he is an associate editor of several journals, chairs the Board of Directors of the Sarnoff Foundation and a member of the AHA Board of Directors.

He has more than 100 publications; several representative publications from his studies include:

• Singh BN, Koyano-Nakagawa N, Gong W, Moskowitz IP, Weaver CV, Braunlin E, Garry MG, Garry DJ. A conserved HH-GLI-Mycn network regulates heart regeneration from newt to human. Nature Communications. In press.

• Gong W, Rasmussen TL, Singh BN, Koyano-Nakagawa N, Pan W, Garry DJ. Dpath software reveals hierarchical haemato-endothelial lineages of Etv2 progenitors based on single-cell transcriptome analysis. Nature Communications. 2017. 9;8:14362.

• Garry MG, Garry DJ. Humanized organs in gene-edited animals. Regenerative Medicine. 2016.11(7):617-9.

• Kamdar F, Garry DJ. Dystrophin-Deficient Cardiomyopathy. J Am Coll Cardiol. 2016 May 31;67(21):2533-46. doi: 10.1016/j.jacc.2016.02.081

• Singh BN, Kawakami Y, Akiyama R, Rasmussen TL, Garry MG, Gong W, Das S, Shi X, Koyano-Nakagawa N, Garry DJ. Etv2-miR-130a network regulates mesodermanl specification. Cell Reports. 13(5):915-23.

• Garry DJ, Olson EN. A common progenitor at the heart of development. Cell. 127(6):1101-4.

Research projects available within the Garry Laboratory include the following:

• To define the molecular signatures that predict graft survival in cardiac transplant recipients

• The use of human induced pluripotent stem cells for the study of heart failure therapies

• To define the benefits of cell therapy and mechanical circulatory support

• To define transcriptional network that govern the developing and regenerating heart

• To define the factors that successfully reprogram fibroblasts to endothelial cells

• To engineer human organs in large animals as a source for transplantable organs