Mary Garry, PhD
Mary G. Garry, PhD (garry002@umn.edu) is an Associate Professor in the Department of Medicine and founder of the Summer Research Scholars Program at Lillehei Heart Institute at the University of Minnesota. Having obtained her Ph.D. degree at the University of Minnesota, she completed postdoctoral research training in the laboratory of Dr. Kenneth Hargreaves which was focused on the neurobiology of pain. At the University of Texas Southwestern Medical Center, Dr. Garry turned her research interests to neural control of the cardiovascular system. Her laboratory focuses on the definition of molecule pathways that control the dysregulation of afferent neurons and their responses to exercise in heart failure. Most recently, Dr. Garry’s laboratory also focuses on engineering chimeric animals for use as novel clinical models and for transplantation purposes. Dr. Garry’s laboratory has expertise in small and large animal surgery, cardiac imaging, measurement of invasive hemodynamics, somatic cell nuclear transfer and blastocyst complementation. Dr. Garry has trained more than 35 graduate students, postdoctoral fellows, medical students, and undergraduates in her laboratory.
Several representative publications from her studies include:
Li Q, Garry MG. A murine model of the exercise pressor reflex. J Physiol. 2020;. doi:10.1113/JP277602.
Maeng G, Gong W, Das S, Yannopoulos D, Garry DJ, Garry MG. ETV2 null porcine embryos survive to post-implantation following incomplete enucleation. Reproduction. 159(5):539-547.
Das S*, Koyano-Nakagawa N*, Gafni O, Maeng G, Singh BN, Rasmussen T, Pan X, Choi K, Mickelson D, Gong W, Pota P, Weaver C, Kren, S, Hanna J, Yannopoulos D, Garry MG**, Garry DJ**. Human endothelium in pig embryos deficient in ETV2 as a platform for exogenic organ production. Nature Biotechnology. 38(3):297-302. doi: 10.1038/s41587-019-0373-y. Epub 2020 Feb 24.**Denotes equal contribution.
Smith SA, Leal AK, Williams MA, Murphy MN, Mitchell JH, Garry MG. The TRPv1 receptor is a mediator of the exercise pressor reflex in rats. J Physiol. 588:1179-899.
Williams MA, Smith SA, O’Brien DE, Mitchell JH, Garry MG. The group IV afferent neuron expresses multiple receptor alterations in cardiomyopathy in rat: evidence at the cannabinoid CB1 receptor. J Physiol. 586:835-45.
Smith SA, Williams MA, Mitchell JH, Mammen PP, Garry MG. The Capsaicin Sensitive Afferent Neuron in Skeletal Muscle is Abnormal in Heart Failure. Circulation. 111:2056-65.
Smith SA, Mammen PP, Mitchell JH, Garry MG. The role of the exercise pressor reflex in rats with dilated cardiomyopathy. Circulation. 108:1126-1132.
Research projects available within the Garry Laboratory include the following:
To determine the mechanism(s) controlling the abnormal exercise pressor reflex (EPR) in heart failure and other cardiovascular diseases
To define the molecular signatures of specific populations of primary afferent neurons relevant to the EPR
Development of humanized organs in pig for purposes of generating unprecedented human models for use in clinical trials with an absence of human risk
Development of humanized organs in pig for purposes of generating an unlimited supply of human organs for transplantation