Markus Meyer, M.D., PhD
Markus Meyer, M.D., PhD (meye3249@umn.edu) is an Associate Professor of Medicine and physician scientist with a focus on heart failure with preserved ejection fraction. He is particularly interested in the interaction of heart rate and myocardial calcium handling. The research projects are bench-to-bedside of highly translational concepts. His main focus is the development of chronotherapy, a novel treatment approach in HFpEF.
Active Projects:
Nocturnal and rest pacing in HFpEF
Beta-blockers and HFpEF
Pharmacological chronotherapy in HFpEF
Myocardial calcium retention in HFpEF
Representative publications:
Silverman DN, Rambod M, Lustgarten DL, Lobel R, LeWinter MM, Meyer M. Heart Rate-Induced Myocardial Calcium Retention and Left Ventricular Volume Loss in Patients with HFpEF. Accepted for publication JAHA 2020.
Nambiar L, Silverman D, Vanburen P, LeWinter M, Meyer M. Beta-Blocker Cessation in Stable Outpatients With Heart Failure With a Preserved Ejection Fraction. J Card Fail. 2019 Aug 31. pii: S1071-9164(19)30616-5. doi: J Card Fail. 2020 Mar;26(3):281-282. doi: 10.1016/j.cardfail.2019.08.020
Silverman DN, Plante TB, Infeld M, Callas PW, Juraschek SP, Dougherty GB, M Meyer. Beta-blocker Use and Heart Failure Hospitalizations in Patients with Preserved Ejection Fractions: A Secondary Analysis of the TOPCAT trial. JAMA Netw Open. 2019 Dec 2;2(12):e1916598. doi: 10.1001/jamanetworkopen.2019.16598.
Meyer M, LeWinter MM. Heart Rate and Heart Failure With Preserved Ejection Fraction: Time to Slow β-Blocker Use? Circ Heart Fail. 2019 Aug;12(8):e006213. doi: 10.1161/CIRCHEARTFAILURE.119.006213. Epub 2019 Aug 1.
Wahlberg K, Arnold ME, Lustgarten D, Meyer M. Effects of a Higher Heart Rate on Quality of Life and Functional Capacity in Patients with Left Ventricular Diastolic Dysfunction. American Journal of Cardiology 2019, Am J Cardiol. 2019 Oct 1;124(7):1069-1075. doi: 10.1016/j.amjcard.2019.07.008. Epub 2019 Jul 15.
Yeshwant SC, Zile MR, Lewis MR, LeWinter M, Meyer M. Safety and Feasibility of a Nocturnal Heart Rate Elevation - Exploration of a Novel Treatment Concept. J Card Fail. 2019 Jan;25(1):67-71. doi: 10.1016/j.cardfail.2018.06.009. Epub 2018 Jul 17
Nambiar L, Li A, Howard A, LeWinter M, Meyer M. Left Ventricular End-Diastolic Volume Predicts Exercise Capacity in Patients with a Normal Ejection Fraction. Clin Cardiol. 2018 May;41(5):628-633. doi: 10.1002/clc.22928. Epub 2018 Apr 25
Meyer M, Rambod M, LeWinter M. Pharmacological Heart Rate Lowering in Patients with a Preserved Ejection Fraction – Review of a Failing Concept. Heart Fail Rev. 2018 Jul;23(4):499-506. doi: 10.1007/s10741-017-9660-1.
Runte KE, Bell SP, Selby DE, Häußler TN, Ashikaga T, LeWinter MM, Palmer BM, Meyer M. Relaxation and the Role of Calcium in Isolated Contracting Myocardium from Patients with Hypertensive Heart Disease and Heart Failure with Preserved Ejection Fraction. Circ Heart Fail. 2017 Aug;10(8). pii: e004311. doi: 10.1161/CIRCHEARTFAILURE.117.004311.
Zile MR, Baicu CF, S Ikonomidis J, Stroud RE, Nietert PJ, Bradshaw AD, Slater R, Palmer BM, Van Buren P, Meyer M, Redfield M, A Bull D, L Granzier H, LeWinter MM. Myocardial Stiffness in Patients with Heart Failure and a Preserved Ejection Fraction: Contributions of Collagen and Titin. Circulation 2015;131:1247-59. doi: 10.1161/CIRCULATIONAHA.114.013215
Selby DE, Palmer B, PhD, LeWinter MM, Meyer M. Tachycardia-induced Diastolic Contracture and Resting Tone in Isolated Myocardium from Patients with Concentric Left Ventricular Hypertrophy. J Am Coll Cardiol 2011; 58(2):147-54.