Demetris Yannopoulos, M.D.

Demetris Yannopoulos (yanno001@um.edu) is a Professor of Medicine in the Division of Cardiology. He received his M.D. from the University of Athens in Greece. He completed his medicine residency and general cardiology fellowship at the University of Minnesota. Following an interventional cardiology fellowship at Johns Hopkins University in Baltimore, Maryland, Dr. Yannopoulos joined the University of Minnesota faculty in 2008. In March 2010, he became the research director for interventional cardiology. Dr. Yannopoulos is board-certified in internal medicine, cardiology, and interventional cardiology. His clinical interests include emergent cardiac care, coronary-artery disease, and congenital and peripheral intervention. Dr. Yannopoulos’ research involves cardiopulmonary resuscitation, hypothermia, and myocardial salvage during acute coronary syndromes. He is considered an authority in cardiorespiratory interactions and hypothermia during CPR. His work in the laboratories of Dr. Keith Lurie (at the University of Minnesota) and Dr. Henry Halperin (at Johns Hopkins University) has helped change current CPR practices.

Several representative publications from his studies include:

• Duval S, Pepe PE, Aufderheide TP, Goodloe JM, Debaty G, Labarère J, Sugiyama A, Yannopoulos D. Optimal Combination of Compression Rate and Depth During Cardiopulmonary Resuscitation for Functionally Favorable Survival. JAMA Cardiol. 2019 Aug 14.

• Bartos JA, Carlson K, Carlson C, Raveendran G, John R, Aufderheide TP, Yannopoulos D. Surviving refractory out-of-hospital ventricular fibrillation cardiac arrest: Critical Care and Extracorporeal Membrane Oxygenation Management. Resuscitation. 132: 47-55, 2018. PMID 30171974

• Bartos JA, Doonan AL, Yannopoulos D. Identifying Candidates for Advanced Hemodynamic Support After Cardiac Arrest. Circulation. 2018 Jan 16;137(3):283-285. doi: 10.1161/CIRCULATIONAHA.117.031850.

• Yannopoulos D, Bartos JA, Raveendran G, Conterato M, Frascone RJ, Trembley A, John R, Connett J, Benditt DG, Lurie KG, Wilson RF, Aufderheide TP. Coronary Artery Disease in Patients With Out-of-Hospital Refractory Ventricular Fibrillation Cardiac Arrest. J Am Coll Cardiol. 2017 Aug 29;70(9):1109-1117.

• Matsuura TR, Bartos JA, Tsangaris A, Shekar KC, Olson MD, Riess ML, Bienengraeber M, Aufderheide TP, Neumar RW, Rees JN, McKnite SH, Dikalova AE, Dikalov SI, Douglas HF, Yannopoulos D. Early Effects of Prolonged Cardiac Arrest and Ischemic Postconditioning during Cardiopulmonary Resuscitation on Cardiac and Brain Mitochondrial Function in Pigs. Resuscitation. 2017 Jul;116:8-15. doi:10.1016/j.resuscitation.2017.03.033. Epub 2017 Apr 10.

• Moore JC, Bartos JA, Matsuura TR, Yannopoulos D. The future is now: neuroprotection during cardiopulmonary resuscitation. Curr Opin Crit Care. 2017 Jun;23(3):215-222. doi: 10.1097/MCC.0000000000000405. Review.

Research projects available within the Yannopoulos Laboratory include the following:

• The use of sodium nitroprusside and mechanical CPR adjuncts for cardiovascular cerebral resuscitation

• To define the novel bundled mechanical and pharmacological CPR platform

• The use reperfusion injury protection during cardiac arrest: a novel CPR method